Breast Arterial Calcification: A Potential Biomarker for Atherosclerotic Cardiovascular Disease Risk? | springermedizin.de

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Current Atherosclerosis Reports

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01.05.2021 | Women and Ischemic Heart Disease (J.M. Peña and F. Lin, Section Editors)

Breast Arterial Calcification: A Potential Biomarker for Atherosclerotic Cardiovascular Disease Risk?

verfasst von: Yeonyee E. Yoon, Bo La Yun, Kyoung Min Kim, Jung-Won Suh

Erschienen in: Current Atherosclerosis Reports | Ausgabe 5/2021

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Abstract

Purpose of Review

We aimed to summarize the current evidence regarding the association between breast arterial calcification (BAC) and atherosclerotic cardiovascular disease (ASCVD) in women and discuss the potential role of BAC in the risk stratification and preventive approaches for ASCVD.

Recent Findings

BAC has emerged as a potential women-specific risk marker for ASCVD. Although BAC presents as a medial calcification of the arteries, notably different from the intimal atherosclerotic process, current evidence supports a correlation between BAC and ASCVD risk factors or subclinical and clinical ASCVD, such as coronary artery disease or stroke. As millions of women undergo mammograms each year, the potential clinical application of BAC in enhanced ASCVD risk estimation, with no additional cost or radiation, has tremendous appeal.

Summary

Although further research regarding optimal risk assessment and management in women with BAC is required, the presence of BAC should prompt healthy cardiovascular lifestyle modifications.

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1.

Heron M. Deaths: leading causes for 2017. Natl Vital Stat Rep. 2019;68(6):1–77.PubMed

2.

World Health Organization. World Health Statistics 2019: monitoring health for the SDGs, sustainable development goals. World Health Organization. 2019. https://apps.who.int/iris/handle/10665/324835.

3.

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937–52. https://doi.org/10.1016/s0140-6736(04)17018-9.CrossRefPubMed

4.

• Brown HL, Warner JJ, Gianos E, Gulati M, Hill AJ, Hollier LM, et al. Promoting risk identification and reduction of cardiovascular disease in women through collaboration with obstetricians and gynecologists: a presidential advisory from the American Heart Association and the American College of Obstetricians and Gynecologists. Circulation. 2018;137(24):e843–e52. https://doi.org/10.1161/cir.0000000000000582This article proposed a set of principles to guide risk stratification and prevention of ASCVD in women.CrossRefPubMed

5.

Bairey Merz CN, Andersen H, Sprague E, Burns A, Keida M, Walsh MN, et al. Knowledge, attitudes, and beliefs regarding cardiovascular disease in women. J Am Coll Cardiol. 2017;70(2):123–32. https://doi.org/10.1016/j.jacc.2017.05.024.CrossRefPubMed

6.

Wilmot KA, O’Flaherty M, Capewell S, Ford ES, Vaccarino V. Coronary heart disease mortality declines in the United States from 1979 through 2011 clinical perspective. Circulation. 2015;132(11):997–1002. https://doi.org/10.1161/circulationaha.115.015293.CrossRefPubMedPubMedCentral

7.

Schlendorf KH, Nasir K, Blumenthal RS. Limitations of the Framingham risk score are now much clearer. Prev Med. 2009;48(2):115–6. https://doi.org/10.1016/j.ypmed.2008.12.002.CrossRefPubMed

8.

Kavousi M, Desai CS, Ayers C, Blumenthal RS, Budoff MJ, Mahabadi AA, et al. Prevalence and prognostic implications of coronary artery calcification in low-risk women: a meta-analysis. Jama. 2016;316(20):2126–34. https://doi.org/10.1001/jama.2016.17020.CrossRefPubMed

9.

Navar-Boggan AM, Peterson ED, D’Agostino RB, Pencina MJ, Sniderman AD. Using age- and sex-specific risk thresholds to guide statin therapy. J Am Coll Cardiol. 2015;65(16):1633–9. https://doi.org/10.1016/j.jacc.2015.02.025.CrossRefPubMedPubMedCentral

10.

Baber U, Mehran R, Sartori S, Schoos MM, Sillesen H, Muntendam P, et al. Prevalence, impact, and predictive value of detecting subclinical coronary and carotid atherosclerosis in asymptomatic adults: the BioImage study. J Am Coll Cardiol. 2015;65(11):1065–74. https://doi.org/10.1016/j.jacc.2015.01.017.CrossRefPubMed

11.

Hendriks EJ, de Jong PA, van der Graaf Y, Mali WP, van der Schouw YT, Beulens JW. Breast arterial calcifications: a systematic review and meta-analysis of their determinants and their association with cardiovascular events. Atherosclerosis. 2015;239(1):11–20. https://doi.org/10.1016/j.atherosclerosis.2014.12.035.CrossRefPubMed

12.

Lee SC, Phillips M, Bellinge J, Stone J, Wylie E, Schultz C. Is breast arterial calcification associated with coronary artery disease?—a systematic review and meta-analysis. PLOS One. 2020;15(7):e0236598. https://doi.org/10.1371/journal.pone.0236598.CrossRefPubMedPubMedCentral

13.

Suh JW, Yun B. Breast arterial calcification: a potential surrogate marker for cardiovascular disease. J Cardiovasc Imaging. 2018;26(3):125–34. https://doi.org/10.4250/jcvi.2018.26.e20.CrossRefPubMedPubMedCentral

14.

•• Yoon YE, Kim KM, Han JS, Kang S-H, Chun EJ, Ahn S, et al. Prediction of subclinical coronary artery disease with breast arterial calcification and low bone mass in asymptomatic women. JACC Cardiovasc Imaging. 2019;12(7):1202–11. https://doi.org/10.1016/j.jcmg.2018.07.004This study suggests that BAC has a strong association with subclinical CAD in asymptomatic women.CrossRefPubMed

15.

•• Margolies L, Salvatore M, Hecht HS, Kotkin S, Yip R, Baber U, et al. Digital mammography and screening for coronary artery disease. JACC Cardiovasc Imaging. 2016;9(4):350–60. https://doi.org/10.1016/j.jcmg.2015.10.022This study suggests the potential significance of BAC quantification.CrossRefPubMed

16.

Pace LE, He Y, Keating NL. Trends in mammography screening rates after publication of the 2009 US Preventive Services Task Force recommendations. Cancer. 2013;119(14):2518–23. https://doi.org/10.1002/cncr.28105.CrossRefPubMed

17.

Smith RA, Saslow D, Sawyer KA, Burke W, Costanza ME, Evans WP 3rd, et al. American Cancer Society guidelines for breast cancer screening: update 2003. CA Cancer J Clin. 2003;53(3):141–69. https://doi.org/10.3322/canjclin.53.3.141.CrossRefPubMed

18.

Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2009;151(10):716–26, w-236. https://doi.org/10.7326/0003-4819-151-10-200911170-00008.CrossRef

19.

Kerlikowske K. Evidence-based breast cancer prevention: the importance of individual risk. Ann Intern Med. 2009;151(10):750–2. https://doi.org/10.7326/0003-4819-151-10-200911170-00012.CrossRefPubMed

20.

Bui QM, Daniels LB. A review of the role of breast arterial calcification for cardiovascular risk stratification in women. Circulation. 2019;139(8):1094–101. https://doi.org/10.1161/circulationaha.118.038092.CrossRefPubMed

21.

Polonsky TS, Greenland P. Breast arterial calcification: expanding the reach of cardiovascular prevention. Circulation. 2017;135(6):499–501. https://doi.org/10.1161/circulationaha.116.025277.CrossRefPubMed

22.

Quispe R, Al-Rifai M, Di Carlo PA, Michos ED, Amin NP, Kianoush S, et al. Breast arterial calcium: a game changer in women’s cardiovascular health? JACC Cardiovasc Imaging. 2019;12(12):2538–48. https://doi.org/10.1016/j.jcmg.2018.07.035.CrossRefPubMed

23.

Lanzer P, Boehm M, Sorribas V, Thiriet M, Janzen J, Zeller T, et al. Medial vascular calcification revisited: review and perspectives. Eur Heart J. 2014;35(23):1515–25. https://doi.org/10.1093/eurheartj/ehu163.CrossRefPubMedPubMedCentral

24.

Iribarren C, Molloi S. Breast arterial calcification: a new marker of cardiovascular risk? Curr Cardiovasc Risk Rep. 2013;7(2):126–35. https://doi.org/10.1007/s12170-013-0290-4.CrossRefPubMedPubMedCentral

25.

Abou-Hassan N, Tantisattamo E, D’Orsi ET, O’Neill WC. The clinical significance of medial arterial calcification in end-stage renal disease in women. Kidney Int. 2015;87(1):195–9. https://doi.org/10.1038/ki.2014.187.CrossRefPubMed

26.

Hendriks EJE, Beulens JWJ, Mali W, Beijerinck D, van der Graaf Y, de Jong PA, et al. Breast arterial calcifications and their association with incident cardiovascular disease and diabetes: the Prospect-EPIC cohort. J Am Coll Cardiol. 2015;65(8):859–60. https://doi.org/10.1016/j.jacc.2014.12.015.CrossRefPubMed

27.

Drüeke TB. Arterial intima and media calcification: distinct entities with different pathogenesis or all the same? Clin J Am Soc Nephrol. 2008;3(6):1583–4. https://doi.org/10.2215/cjn.03250708.CrossRefPubMed

28.

Reddy J, Son H, Smith SJ, Paultre F, Mosca L. Prevalence of breast arterial calcifications in an ethnically diverse population of women. Ann Epidemiol. 2005;15(5):344–50. https://doi.org/10.1016/j.annepidem.2004.11.006.CrossRefPubMed

29.

Faridah Y. Digital versus screen film mammography: a clinical comparison. Biomed Imaging Interv J. 2008;4(4):e31. https://doi.org/10.2349/biij.4.4.e31.CrossRefPubMedPubMedCentral

30.

Sedighi N, Radmard AR, Radmehr A, Hashemi P, Hajizadeh A, Taheri APH. Breast arterial calcification and risk of carotid atherosclerosis: focusing on the preferentially affected layer of the vessel wall. Eur J Radiol. 2011;79(2):250–6. https://doi.org/10.1016/j.ejrad.2010.04.007.CrossRefPubMed

31.

Reddy J, Bilezikian JP, Smith SJ, Mosca L. Reduced bone mineral density is associated with breast arterial calcification. J Clin Endocrinol Metab. 2008;93(1):208–11. https://doi.org/10.1210/jc.2007-0693.CrossRefPubMed

32.

Janssen T, Bannas P, Herrmann J, Veldhoen S, Busch JD, Treszl A, et al. Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: a PET/CT study. J Nucl Cardiol. 2013;20(4):569–77. https://doi.org/10.1007/s12350-013-9680-8.CrossRefPubMed

33.

Lilly SM, Qasim AN, Mulvey CK, Churchill TW, Reilly MP, Eraso LH. Non-compressible arterial disease and the risk of coronary calcification in type-2 diabetes. Atherosclerosis. 2013;230(1):17–22. https://doi.org/10.1016/j.atherosclerosis.2013.06.004.CrossRefPubMed

34.

Kemmeren JM, Van Noord PAH, Beijerinck D, Fracheboud J, Banga JD, Van Der Graaf Y. Arterial calcification found on breast cancer screening mammograms and cardiovascular mortality in women: the DOM project. Am J Epidemiol. 1998;147(4):333–41. https://doi.org/10.1093/oxfordjournals.aje.a009455.CrossRefPubMed

35.

Iribarren C, Go AS, Tolstykh I, Sidney S, Johnston SC, Spring DB. Breast vascular calcification and risk of coronary heart disease, stroke, and heart failure. J Womens Health (Larchmt). 2004;13(4):381–9; discussion 90-2. https://doi.org/10.1089/154099904323087060.CrossRef

36.

Schnatz PF, Marakovits KA, O’Sullivan DM. The association of breast arterial calcification and coronary heart disease. Obstet Gynecol. 2011;117(2 Pt 1):233–41. https://doi.org/10.1097/AOG.0b013e318206c8cb.CrossRefPubMed

37.

• Hendriks EJE, Beulens JWJ, De Jong PA, Van Der Schouw YT, Sun W-N, Wright CM, et al. Calcification of the splenic, iliac, and breast arteries and risk of all-cause and cardiovascular mortality. Atherosclerosis. 2017;257:120. https://doi.org/10.1016/j.atherosclerosis.2017.01.029This study suggested an independent prognostic value of BAC evaluated on CT for ASCVD mortality.CrossRef

38.

van Noord PA, Beijerinck D, Kemmeren JM, van der Graaf Y. Mammograms may convey more than breast cancer risk: breast arterial calcification and arterio-sclerotic related diseases in women of the DOM cohort. Eur J Cancer Prev. 1996;5(6):483–7.PubMed

39.

Crystal P, Crystal E, Leor J, Friger M, Katzinovitch G, Strano S. Breast artery calcium on routine mammography as a potential marker for increased risk of cardiovascular disease. Am J Cardiol. 2000;86(2):216–7. https://doi.org/10.1016/s0002-9149(00)00860-2.CrossRefPubMed

40.

Kataoka M, Warren R, Luben R, Camus J, Denton E, Sala E, et al. How predictive is breast arterial calcification of cardiovascular disease and risk factors when found at screening mammography? AJR Am J Roentgenol. 2006;187(1):73–80. https://doi.org/10.2214/ajr.05.0365.CrossRefPubMed

41.

Taşkin F, Akdilli A, Karaman C, Unsal A, Köseoğlu K, Ergin F. Mammographically detected breast arterial calcifications: indicators for arteriosclerotic diseases? Eur J Radiol. 2006;60(2):250–5. https://doi.org/10.1016/j.ejrad.2006.06.006.CrossRefPubMed

42.

Fiuza Ferreira EM, Szejnfeld J, Faintuch S. Correlation between intramammary arterial calcifications and CAD. Acad Radiol. 2007;14(2):144–50. https://doi.org/10.1016/j.acra.2006.10.017.CrossRefPubMed

43.

Dale PS, Mascarhenas C, Richards M, Mackie G. Mammography as a screening tool for coronary artery disease. J Surg Res. 2008;148(1):1–6. https://doi.org/10.1016/j.jss.2007.08.022.CrossRefPubMed

44.

Rotter MA, Schnatz PF, Currier AA Jr, O’Sullivan DM. Breast arterial calcifications (BACs) found on screening mammography and their association with cardiovascular disease. Menopause. 2008;15(2):276–81. https://doi.org/10.1097/gme.0b013e3181405d0a.CrossRefPubMed

45.

Ferreira JA, Pompei LM, Fernandes CE, Azevedo LH, Peixoto S. Breast arterial calcification is a predictive factor of cardiovascular disease in Brazilian postmenopausal women. Climacteric. 2009;12(5):439–44. https://doi.org/10.1080/13697130902957287.CrossRefPubMed

46.

Karm D, Marks DS, Wein M, Kong AL. Benign arterial calcification on screening mammogram: a marker for coronary artery disease? J Womens Health (Larchmt). 2015;24(10):795–800. https://doi.org/10.1089/jwh.2014.4905.CrossRef

47.

Yalçin Şafak K, Eratalay A, Dülger İliş E, Umarusman TN. The relationship of breast arterial calcification detected in mammographic examinations with cardiovascular diseases, cardiovascular risk factors, parity, and breastfeeding. Turk J Med Sci. 2016;46(3):641–5. https://doi.org/10.3906/sag-1502-126.CrossRefPubMed

48.

Topal U, Kaderli A, Topal NB, Ozdemir B, Yeşilbursa D, Cordan J, et al. Relationship between the arterial calcification detected in mammography and coronary artery disease. Eur J Radiol. 2007;63(3):391–5. https://doi.org/10.1016/j.ejrad.2007.01.035.CrossRefPubMed

49.

Oliveira EL, Freitas-Junior R, Afiune-Neto A, Murta EF, Ferro JE, Melo AF. Vascular calcifications seen on mammography: an independent factor indicating coronary artery disease. Clinics (Sao Paulo). 2009;64(8):763–7. https://doi.org/10.1590/s1807-59322009000800009.CrossRefPubMedCentral

50.

Abi Rafeh N, Castellanos MR, Khoueiry G, Meghani M, El-Sayegh S, Wetz RV, et al. Association between coronary artery disease diagnosed by coronary angiography and breast arterial calcifications on mammography: meta-analysis of the data. J Womens Health (Larchmt). 2012;21(10):1053–8. https://doi.org/10.1089/jwh.2011.3388.CrossRef

51.

Jiang X, Clark M, Singh RK, Juhn A, Schnatz PF. Association of breast arterial calcification with stroke and angiographically proven coronary artery disease: a meta-analysis. Menopause. 2015;22(2):136–43. https://doi.org/10.1097/gme.0000000000000300.CrossRefPubMed

52.

Penugonda N, Billecke SS, Yerkey MW, Rebner M, Marcovitz PA. Usefulness of breast arterial calcium detected on mammography for predicting coronary artery disease or cardiovascular events in women with angina pectoris and/or positive stress tests. Am J Cardiol. 2010;105(3):359–61. https://doi.org/10.1016/j.amjcard.2009.09.039.CrossRefPubMed

53.

Zgheib MH, Buchbinder SS, Abi Rafeh N, Elya M, Raia C, Ahern K, et al. Breast arterial calcifications on mammograms do not predict coronary heart disease at coronary angiography. Radiology. 2010;254(2):367–73. https://doi.org/10.1148/radiol.09090102.CrossRefPubMed

54.

Henkin Y, Abu-Ful A, Shai I, Crystal P. Lack of association between breast artery calcification seen on mammography and coronary artery disease on angiography. J Med Screen. 2003;10(3):139–42. https://doi.org/10.1177/096914130301000308.CrossRefPubMed

55.

Newallo D, Meinel FG, Schoepf UJ, Baumann S, De Cecco CN, Leddy RJ, et al. Mammographic detection of breast arterial calcification as an independent predictor of coronary atherosclerotic disease in a single ethnic cohort of African American women. Atherosclerosis. 2015;242(1):218–21. https://doi.org/10.1016/j.atherosclerosis.2015.07.004.CrossRefPubMed

56.

Chadashvili T, Litmanovich D, Hall F, Slanetz PJ. Do breast arterial calcifications on mammography predict elevated risk of coronary artery disease? Eur J Radiol. 2016;85(6):1121–4. https://doi.org/10.1016/j.ejrad.2016.03.006.CrossRefPubMed

57.

Moradi M, Adibi A, Abedi M. Relationship between breast arterial calcification on mammography with CT Calcium scoring and coronary CT angiography results. Adv Biomed Res. 2014;3:79. https://doi.org/10.4103/2277-9175.127992.CrossRefPubMedPubMedCentral

58.

Matsumura ME, Maksimik C, Martinez MW, Weiss M, Newcomb J, Harris K, et al. Breast artery calcium noted on screening mammography is predictive of high risk coronary calcium in asymptomatic women: a case control study. Vasa. 2013;42(6):429–33. https://doi.org/10.1024/0301-1526/a000312.CrossRefPubMed

59.

Maas AH, van der Schouw YT, Atsma F, Beijerinck D, Deurenberg JJ, Mali WP, et al. Breast arterial calcifications are correlated with subsequent development of coronary artery calcifications, but their aetiology is predominantly different. Eur J Radiol. 2007;63(3):396–400. https://doi.org/10.1016/j.ejrad.2007.02.009.CrossRefPubMed

60.

Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, et al. AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2018;2019:139(25)–e1143. https://doi.org/10.1161/cir.0000000000000625.CrossRef

61.

Yoon YE, Kim KM, Lee W, Han JS, Chun EJ, Ahn S, et al. Breast arterial calcification is associated with the progression of coronary atherosclerosis in asymptomatic women: a preliminary retrospective cohort study. Sci Rep. 2020;10(1). https://doi.org/10.1038/s41598-020-59606-y.

62.

Margolies LR, Yip R, Hwang E, Oudsema RH, Subramaniam VR, Hecht H, et al. Breast arterial calcification in the mammogram report: the patient perspective. AJR Am J Roentgenol. 2019;212(1):209–14. https://doi.org/10.2214/ajr.18.20171.CrossRefPubMed

63.

McKinney SM, Sieniek M, Godbole V, Godwin J, Antropova N, Ashrafian H, et al. International evaluation of an AI system for breast cancer screening. Nature. 2020;577(7788):89–94. https://doi.org/10.1038/s41586-019-1799-6.CrossRefPubMed

64.

Goff DC, Lloyd-Jones DM, Bennett G, Coady S, D’Agostino RB, Gibbons R, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk. Circulation. 2014;129(25 suppl 2):S49–73. https://doi.org/10.1161/01.cir.0000437741.48606.98.CrossRefPubMed

65.

Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2016;37(29):2315–81. https://doi.org/10.1093/eurheartj/ehw106.CrossRefPubMedPubMedCentral

66.

Byrne D, O’Connor L, Jennings S, Bennett K, Murphy AW. A survey of GPs awareness and use of risk assessment tools and cardiovascular disease prevention guidelines. Ir Med J. 2015;108(7):204–7.PubMed

67.

Nasir K, McEvoy JW. Recognizing breast arterial calcification as atherosclerotic CVD risk equivalent. JACC Cardiovasc Imaging. 2016;9(4):361–3. https://doi.org/10.1016/j.jcmg.2015.09.017.CrossRefPubMed

68.

Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111–88. https://doi.org/10.1093/eurheartj/ehz455.CrossRefPubMed

69.

Rozanski A, Gransar H, Shaw LJ, Kim J, Miranda-Peats L, Wong ND, et al. Impact of coronary artery calcium scanning on coronary risk factors and downstream testing. J Am Coll Cardiol. 2011;57(15):1622–32. https://doi.org/10.1016/j.jacc.2011.01.019.CrossRefPubMedPubMedCentral

70.

Kalia NK, Miller LG, Nasir K, Blumenthal RS, Agrawal N, Budoff MJ. Visualizing coronary calcium is associated with improvements in adherence to statin therapy. Atherosclerosis. 2006;185(2):394–9. https://doi.org/10.1016/j.atherosclerosis.2005.06.018.CrossRefPubMed

71.

Sandwell JC, Wingard DL, Laughlin GA, Barrett-Connor E. Electron beam computed tomography screening and heart disease risk factor modification. Prev Cardiol. 2006;9(3):133–7. https://doi.org/10.1111/j.1520-037x.2006.04862.x.CrossRefPubMed

72.

Ravenel JG, Nance JW. Coronary artery calcification in lung cancer screening. Transl Lung Cancer Res. 2018;7(3):361–7. https://doi.org/10.21037/tlcr.2018.05.05.CrossRefPubMedPubMedCentral

Titel: Breast Arterial Calcification: A Potential Biomarker for Atherosclerotic Cardiovascular Disease Risk?
verfasst von: Yeonyee E. Yoon
Bo La Yun
Kyoung Min Kim
Jung-Won Suh
Publikationsdatum: 01.05.2021
Verlag: Springer US
Erschienen in: Current Atherosclerosis Reports / Ausgabe 5/2021
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI: https://doi.org/10.1007/s11883-021-00924-5

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