The online version of this article (doi:10.1186/1477-7819-10-137) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
GPS, GLR, EM and ST conceived of the study. NP, FT, VS, and MS participated in study design and clinical data collection. MA and FG carried out the histopathological evaluation. GPS, GLR and EM drafted the manuscript. All authors read and approved the final manuscript.
Metastases to the pituitary gland are rare events, and usually indicate widespread malignant disease. The lung and the breast are the most common sites of primary tumors that metastasize to the pituitary gland.
Metastases are more frequent in older patients and the most common symptoms at presentation are diabetes insipidus and visual alterations.
72-year-old white woman was treated for a breast carcinoma with right superoexternal quadrantectomy, radiotherapy, and hormone therapy. Twelve years later, the patient presented with bone pain, bilateral progressive visual decline, and onset of hypopituitarism. A diagnosis of secondary bone involvement and pituitary metastasis was made.
This was an unusual disease course, and stresses the importance of intensive follow-up in patients with breast cancer even many years after the initial diagnosis This case emphasizes that diagnosis can be difficultand controversial when relapse occurs at uncommon sites.
Fassett DR, Couldwell WT: Metastases to the pituitary gland. Neurosurg Focus. 2004, 16 (4): E8- PubMed
Sioutos P, Yen V, Arbit E: Pituitary gland metastases. Ann Surg Onco. 1996, 3 (1): 94-99. 10.1007/BF02409058. CrossRef
Hoellig A, Niehusmann P, Flacke S, Kristof RA: Metastasis to pituitary ade-noma: case report and review of the literature. Cen Eur Neurosurg. 2009, 70 (3): 149-153. 10.1055/s-0028-1082063. CrossRef
Ntyonga-Pono MP, Thomopoulos P, Luton JP: Pituitary metastases. Three cases. Presse Med. 1999, 28 (29): 1567-1571. PubMed
Saphner T, Tormey DC, Gray R: Annual hazard rates of recurrence for breast cancer after primary therapy. J Clin Oncol. 1996, 14 (10): 2738-2746. PubMed
- Breast cancer metastatic to the pituitary gland: a case report
Gian Paolo Spinelli
Giuseppe Lo Russo
- BioMed Central
Neu im Fachgebiet Chirurgie
Mail Icon II