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Zeitschrift

Breast Cancer Research

Breast Cancer Research 1/2015

Ausgabe 1/2015

Inhaltsverzeichnis ( 150 Artikel )

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The use of the Gail model, body mass index and SNPs to predict breast cancer among women with abnormal (BI-RADS 4) mammograms

Anne Marie McCarthy, Brad Keller, Despina Kontos, Leigh Boghossian, Erin McGuire, Mirar Bristol, Jinbo Chen, Susan Domchek, Katrina Armstrong

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Circulating tumor cells in newly diagnosed inflammatory breast cancer

Michal Mego, Antonio Giordano, Ugo De Giorgi, Hiroko Masuda, Limin Hsu, Mario Giuliano, Tamer M Fouad, Shaheenah Dawood, Naoto T Ueno, Vicente Valero, Eleni Andreopoulou, Ricardo H Alvarez, Wendy A Woodward, Gabriel N Hortobagyi, Massimo Cristofanilli, James M Reuben

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis

Mario Giuliano, Sabrina Herrera, Pavel Christiny, Chad Shaw, Chad J Creighton, Tamika Mitchell, Raksha Bhat, Xiaomei Zhang, Sufeng Mao, Lacey E Dobrolecki, Ahmed Al-rawi, Fengju Chen, Bianca M Veneziani, Xiang H-F Zhang, Susan G Hilsenbeck, Alejandro Contreras, Carolina Gutierrez, Rinath M Jeselsohn, Mothaffar F Rimawi, C Kent Osborne, Michael T Lewis, Rachel Schiff, Meghana V Trivedi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation

Angela Burleigh, Steven McKinney, Jazmine Brimhall, Damian Yap, Peter Eirew, Steven Poon, Viola Ng, Adrian Wan, Leah Prentice, Lois Annab, J Carl Barrett, Carlos Caldas, Connie Eaves, Samuel Aparicio

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers

Zannel Blanchard, Bibbin T Paul, Barbara Craft, Wael M ElShamy

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Targeting interferon response genes sensitizes aromatase inhibitor resistant breast cancer cells to estrogen-induced cell death

Hye Joung Choi, Asona Lui, Joshua Ogony, Rifat Jan, Peter J Sims, Joan Lewis-Wambi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity

Roshan Sriram, Vivian Lo, Benjamin Pryce, Lilia Antonova, Alan J Mears, Manijeh Daneshmand, Bruce McKay, Simon J Conway, William J Muller, Luc A Sabourin

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer

Reuben S Harris

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: “A novel role for ezrin in breast cancer angio/lymphangiogenesis”

Abdi Ghaffari, Victoria Hoskin, Alvin Szeto, Maaike Hum, Navid Liaghati, Kanji Nakatsu, David LeBrun, Yolanda Madarnas, Sandip SenGupta, Bruce E Elliott

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Markers for the identification of late breast cancer recurrence

Ivana Sestak, Jack Cuzick

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Multigene prognostic tests in breast cancer: past, present, future

Balázs Győrffy, Christos Hatzis, Tara Sanft, Erin Hofstatter, Bilge Aktas, Lajos Pusztai

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Invasive lobular carcinoma of the breast: morphology, biomarkers and ’omics

Amy E McCart Reed, Jamie R Kutasovic, Sunil R Lakhani, Peter T Simpson

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MicroRNA-125b upregulation confers aromatase inhibitor resistance and is a novel marker of poor prognosis in breast cancer

Paul Vilquin, Caterina F Donini, Marie Villedieu, Evelyne Grisard, Laura Corbo, Thomas Bachelot, Julie A Vendrell, Pascale A Cohen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/+WAPCre mouse model

Bas ter Braak, Christine Siezen, Ewoud N Speksnijder, Esmee Koedoot, Harry van Steeg, Daniela CF Salvatori, Bob van de Water, Jan Willem van der Laan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Nirmala Bhoo-Pathy, Petra HM Peeters, Cuno SPM Uiterwaal, H Bas Bueno-de-Mesquita, Awang M Bulgiba, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Anja Olsen, Françoise Clavel-Chapelon, Guy Fagherazzi, Florence Perquier, Birgit Teucher, Rudolf Kaaks, Madlen Schütze, Heiner Boeing, Pagona Lagiou, Philippos Orfanos, Antonia Trichopoulou, Claudia Agnoli, Amalia Mattiello, Domenico Palli, Rosario Tumino, Carlotta Sacerdote, Franzel JB van Duijnhoven, Tonje Braaten, Eiliv Lund, Guri Skeie, María-Luisa Redondo, Genevieve Buckland, Maria José Sánchez Pérez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Elisabet Wirfält, Peter Wallström, Ingegerd Johansson, Lena Maria Nilsson, Kay-Tee Khaw, Nick Wareham, Naomi E Allen, Timothy J Key, Sabina Rinaldi, Isabelle Romieu, Valentina Gallo, Elio Riboli, Carla H van Gils

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Lobular breast cancer: molecular basis, mouse and cellular models

Matthias Christgen, Patrick WB Derksen

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Patient-derived xenograft models of breast cancer and their predictive power

James R Whittle, Michael T Lewis, Geoffrey J Lindeman, Jane E Visvader

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

Jieping Lei, Anja Rudolph, Kirsten B Moysich, Sajjad Rafiq, Sabine Behrens, Ellen L Goode, Paul PD Pharoah, Petra Seibold, Peter A Fasching, Irene L Andrulis, Vessela N Kristensen, Fergus J Couch, Ute Hamann, Maartje J Hooning, Heli Nevanlinna, Ursula Eilber, Manjeet K Bolla, Joe Dennis, Qin Wang, Annika Lindblom, Arto Mannermaa, Diether Lambrechts, Montserrat García-Closas, Per Hall, Georgia Chenevix-Trench, Mitul Shah, Robert Luben, Lothar Haeberle, Arif B Ekici, Matthias W Beckmann, Julia A Knight, Gord Glendon, Sandrine Tchatchou, Grethe I Grenaker Alnæs, Anne-Lise Borresen-Dale, Silje Nord, Janet E Olson, Emily Hallberg, Celine Vachon, Diana Torres, Hans-Ulrich Ulmer, Thomas Rüdiger, Agnes Jager, Carolien HM van Deurzen, Madeleine MA Tilanus-Linthorst, Taru A Muranen, Kristiina Aittomäki, Carl Blomqvist, Sara Margolin, Veli-Matti Kosma, Jaana M Hartikainen, Vesa Kataja, Sigrid Hatse, Hans Wildiers, Ann Smeets, Jonine Figueroa, Stephen J Chanock, Jolanta Lissowska, Jingmei Li, Keith Humphreys, Kelly-Anne Phillips, Sabine Linn, Sten Cornelissen, Sandra Alexandra J van den Broek, Daehee Kang, Ji-Yeob Choi, Sue K Park, Keun-Young Yoo, Chia-Ni Hsiung, Pei-Ei Wu, Ming-Feng Hou, Chen-Yang Shen, Soo Hwang Teo, Nur Aishah Mohd Taib, Cheng Har Yip, Gwo Fuang Ho, Keitaro Matsuo, Hidemi Ito, Hiroji Iwata, Kazuo Tajima, Alison M Dunning, Javier Benitez, Kamila Czene, Lara E Sucheston, Tom Maishman, William J Tapper, Diana Eccles, Douglas F Easton, Marjanka K Schmidt, Jenny Chang-Claude, kConFab Investigators

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy

Betsy T Kren, Gretchen M Unger, Md J Abedin, Rachel I Vogel, Christine M Henzler, Khalil Ahmed, Janeen H Trembley

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth

Xiu-Rong Ren, Jiangbo Wang, Takuya Osada, Robert A Mook Jr, Michael A Morse, Larry S Barak, Herbert Kim Lyerly, Wei Chen

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

Eleni van Schooneveld, Hans Wildiers, Ignace Vergote, Peter B Vermeulen, Luc Y Dirix, Steven J Van Laere

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A case–control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium

Traci N Bethea, Lynn Rosenberg, Chi-Chen Hong, Melissa A Troester, Kathryn L Lunetta, Elisa V Bandera, Pepper Schedin, Laurence N Kolonel, Andrew F Olshan, Christine B Ambrosone, Julie R Palmer

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic stromal gene signatures in breast cancer

Sofia Winslow, Karin Leandersson, Anders Edsjö, Christer Larsson

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy

Hatem A Azim Jr, Fedro A Peccatori, Sylvain Brohée, Daniel Branstetter, Sherene Loi, Giuseppe Viale, Martine Piccart, William C Dougall, Giancarlo Pruneri, Christos Sotiriou

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer

Sergio Granados-Principal, Yi Liu, Maria L Guevara, Elvin Blanco, Dong Soon Choi, Wei Qian, Tejal Patel, Angel A Rodriguez, Joseph Cusimano, Heidi L Weiss, Hong Zhao, Melissa D Landis, Bhuvanesh Dave, Steven S Gross, Jenny C Chang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression

Paromita Raha, Scott Thomas, K Ted Thurn, Jeenah Park, Pamela N Munster

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

In silico discovery and validation of potent small-molecule inhibitors targeting the activation function 2 site of human oestrogen receptor α

Kriti Singh, Ravi Shashi Nayana Munuganti, Eric Leblanc, Yu Lun Lin, Euphemia Leung, Nada Lallous, Miriam Butler, Artem Cherkasov, Paul S Rennie

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models

Yihao Li, Yvette Drabsch, Philippe Pujuguet, Jiang Ren, Theo van Laar, Long Zhang, Hans van Dam, Philippe Clément-Lacroix, Peter ten Dijke

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Molecular subtyping for clinically defined breast cancer subgroups

Xi Zhao, Einar Andreas Rødland, Robert Tibshirani, Sylvia Plevritis

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

FOXF2 deficiency promotes epithelial-mesenchymal transition and metastasis of basal-like breast cancer

Qing-Shan Wang, Peng-Zhou Kong, Xiao-Qing Li, Fan Yang, Yu-Mei Feng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mouse mammary stem cells express prognostic markers for triple-negative breast cancer

Kelly J Soady, Howard Kendrick, Qiong Gao, Andrew Tutt, Marketa Zvelebil, Liliana D Ordonez, Jelmar Quist, David Wei-Min Tan, Clare M Isacke, Anita Grigoriadis, Matthew J Smalley

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study

Ryan JO Dowling, Saroj Niraula, Martin C Chang, Susan J Done, Marguerite Ennis, David R McCready, Wey L Leong, Jaime M Escallon, Michael Reedijk, Pamela J Goodwin, Vuk Stambolic

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells

Ahrum Min, Seock-Ah Im, Debora Keunyoung Kim, Sang-Hyun Song, Hee-Jun Kim, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Do-Youn Oh, Tae-You Kim, Mark J O’Connor, Yung-Jue Bang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients

Jithendra Kini Bailur, Brigitte Gueckel, Evelyna Derhovanessian, Graham Pawelec

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer

Elena López-Knowles, Paul M Wilkerson, Ricardo Ribas, Helen Anderson, Alan Mackay, Zara Ghazoui, Aradhana Rani, Peter Osin, Ash Nerurkar, Lorna Renshaw, Alexey Larionov, William R Miller, J Michael Dixon, Jorge S Reis-Filho, Anita K Dunbier, Lesley-Ann Martin, Mitch Dowsett

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Lectin RCA-I specifically binds to metastasis-associated cell surface glycans in triple-negative breast cancer

Shu-Min Zhou, Li Cheng, Shu-Juan Guo, Yang Wang, Daniel M Czajkowsky, Huafang Gao, Xiao-Fang Hu, Sheng-Ce Tao

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Lobular breast cancer: incidence and genetic and non-genetic risk factors

Laure Dossus, Patrick R Benusiglio

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice

Julie Decock, Wouter Hendrickx, Sally Thirkettle, Ana Gutiérrez-Fernández, Stephen D Robinson, Dylan R Edwards

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Estimated dietary dioxin exposure and breast cancer risk among women from the French E3N prospective cohort

Aurélie MN Danjou, Béatrice Fervers, Marie-Christine Boutron-Ruault, Thierry Philip, Françoise Clavel-Chapelon, Laure Dossus

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Mechanisms of endocrine resistance in breast cancer: an overview of the proposed roles of noncoding RNA

Erin L Hayes, Joan S Lewis-Wambi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Quantitative measurement of HER2 expression in breast cancers: comparison with ‘real-world’ routine HER2 testing in a multicenter Collaborative Biomarker Study and correlation with overall survival

Denise A Yardley, Peter A Kaufman, Weidong Huang, Lea Krekow, Michael Savin, William E Lawler, Stephen Zrada, Alexander Starr, Harvey Einhorn, Lee S Schwartzberg, John W Adams, Yolanda Lie, Agnes C Paquet, Jeff Sperinde, Mojgan Haddad, Steve Anderson, Marlon Brigino, Rick Pesano, Michael P Bates, Jodi Weidler, Linda Bosserman

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model

Lara Lacerda, Bisrat G Debeb, Daniel Smith, Richard Larson, Travis Solley, Wei Xu, Savitri Krishnamurthy, Yun Gong, Lawrence B Levy, Thomas Buchholz, Naoto T Ueno, Ann Klopp, Wendy A Woodward

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response

Pascal Jézéquel, Delphine Loussouarn, Catherine Guérin-Charbonnel, Loïc Campion, Antoine Vanier, Wilfried Gouraud, Hamza Lasla, Catherine Guette, Isabelle Valo, Véronique Verrièle, Mario Campone

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF

Mari Tinholt, Hans Kristian Moen Vollan, Kristine Kleivi Sahlberg, Sandra Jernström, Fatemeh Kaveh, Ole Christian Lingjærde, Rolf Kåresen, Torill Sauer, Vessela Kristensen, Anne-Lise Børresen-Dale, Per Morten Sandset, Nina Iversen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases

Sébastien Tabariès, Véronique Ouellet, Brian E Hsu, Matthew G Annis, April AN Rose, Liliane Meunier, Euridice Carmona, Christine E Tam, Anne-Marie Mes-Masson, Peter M Siegel

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy

Kimberly A Snyder, Michael R Hughes, Bradley Hedberg, Jill Brandon, Diana Canals Hernaez, Peter Bergqvist, Frederic Cruz, Kelvin Po, Marcia L Graves, Michelle E Turvey, Julie S Nielsen, John A Wilkins, Shaun R McColl, John S Babcook, Calvin D Roskelley, Kelly M McNagny

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

Isabelle Tancioni, Nichol LG Miller, Sean Uryu, Christine Lawson, Christine Jean, Xiao Lei Chen, Elizabeth G Kleinschmidt, David D Schlaepfer

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Enhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(D,L-lactic-co-glycolic) acid nanoparticles

Diahnn F Campbell, Rebecca Saenz, Ila S Bharati, Daniel Seible, Liangfang Zhang, Sadik Esener, Bradley Messmer, Marie Larsson, Davorka Messmer

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study

Kaja Tikk, Disorn Sookthai, Renée T Fortner, Theron Johnson, Sabina Rinaldi, Isabelle Romieu, Anne Tjønneland, Anja Olsen, Kim Overvad, Françoise Clavel-Chapelon, Laura Baglietto, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Giovanna Masala, Vittorio Krogh, Rosario Tumino, Fulvio Ricceri, Amalia Mattiello, Antonio Agudo, Virginia Menéndez, María-José Sánchez, Pilar Amiano, Maria-Dolores Chirlaque, Aurelio Barricarte, HBas Bueno-de-Mesquita, Evelyn M Monninkhof, N Charlotte Onland-Moret, Anne Andresson, Malin Sund, Elisabete Weiderpass, Kay-Tee Khaw, Timothy J Key, Ruth C Travis, Melissa A Merritt, Elio Riboli, Laure Dossus, Rudolf Kaaks

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Background risk of breast cancer and the association between physical activity and mammographic density

Thang Trinh, Mikael Eriksson, Hatef Darabi, Stephanie E Bonn, Judith S Brand, Jack Cuzick, Kamila Czene, Arvid Sjölander, Katarina Bälter, Per Hall

01.12.2015 | Editorial | Ausgabe 1/2015 Open Access

Targeting PTEN-defined breast cancers with a one-two punch

Leonard B Maggi Jr, Jason D Weber

01.12.2015 | Review | Ausgabe 1/2015 Open Access

The clinical and functional significance of c-Met in breast cancer: a review

Colan M Ho-Yen, J Louise Jones, Stephanie Kermorgant

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Quantification of HER family receptors in breast cancer

Paolo Nuciforo, Nina Radosevic-Robin, Tony Ng, Maurizio Scaltriti

01.12.2015 | Letter | Ausgabe 1/2015 Open Access

The E2F4 prognostic signature is also predictive of the pathological response of breast cancer to chemotherapy

François Bertucci, Pascal Finetti, Daniel Birnbaum

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Long non-coding RNA expression profiles predict metastasis in lymph node-negative breast cancer independently of traditional prognostic markers

Kristina P Sørensen, Mads Thomassen, Qihua Tan, Martin Bak, Søren Cold, Mark Burton, Martin J Larsen, Torben A Kruse

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Long-term hazard of recurrence in HER2+ breast cancer patients untreated with anti-HER2 therapy

Kathrin Strasser-Weippl, Nora Horick, Ian E Smith, Joyce O’Shaughnessy, Bent Ejlertsen, Frances Boyle, Aman U Buzdar, Pierre Fumoleau, William Gradishar, Miguel Martin, Beverly Moy, Martine Piccart-Gebhart, Kathleen I Pritchard, Deborah Lindquist, Erica Rappold, Dianne M Finkelstein, Paul E Goss

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Adipose cells promote resistance of breast cancer cells to trastuzumab-mediated antibody-dependent cellular cytotoxicity

Minh Ngoc Duong, Aurore Cleret, Eva-Laure Matera, Kamel Chettab, Doriane Mathé, Sandrine Valsesia-Wittmann, Béatrice Clémenceau, Charles Dumontet

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Common germline polymorphisms associated with breast cancer-specific survival

Ailith Pirie, Qi Guo, Peter Kraft, Sander Canisius, Diana M Eccles, Nazneen Rahman, Heli Nevanlinna, Constance Chen, Sofia Khan, Jonathan Tyrer, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Alison M Dunning, Mitul Shah, Kamila Czene, Hatef Darabi, Mikael Eriksson, Dieter Lambrechts, Caroline Weltens, Karin Leunen, Chantal van Ongeval, Børge G Nordestgaard, Sune F Nielsen, Henrik Flyger, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Carl Blomqvist, Kristiina Aittomäki, Rainer Fagerholm, Taru A Muranen, Janet E Olsen, Emily Hallberg, Celine Vachon, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Annegien Broeks, Sten Cornelissen, Christopher A Haiman, Brian E Henderson, Frederick Schumacher, Loic Le Marchand, John L Hopper, Helen Tsimiklis, Carmel Apicella, Melissa C Southey, Simon S Cross, Malcolm WR Reed, Graham G Giles, Roger L Milne, Catriona McLean, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Maartje J Hooning, Antoinette Hollestelle, John WM Martens, Ans MW van den Ouweland, Federick Marme, Andreas Schneeweiss, Rongxi Yang, Barbara Burwinkel, Jonine Figueroa, Stephen J Chanock, Jolanta Lissowska, Elinor J Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, Hermann Brenner, Katja Butterbach, Bernd Holleczek, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Jingmei Li, Judith S Brand, Keith Humphreys, Peter Devilee, Robert AEM Tollenaar, Caroline Seynaeve, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Filomena Ficarazzi, Matthias W Beckmann, Alexander Hein, Arif B Ekici, Rosemary Balleine, Kelly-Anne Phillips, Javier Benitez, M Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menéndez, Anna Jakubowska, Jan Lubinski, Jacek Gronwald, Katarzyna Durda, Ute Hamann, Maria Kabisch, Hans Ulrich Ulmer, Thomas Rüdiger, Sara Margolin, Vessela Kristensen, Siljie Nord, D Gareth Evans, Jean Abraham, Helena Earl, Christopher J Poole, Louise Hiller, Janet A Dunn, Sarah Bowden, Rose Yang, Daniele Campa, W Ryan Diver, Susan M Gapstur, Mia M Gaudet, Susan Hankinson, Robert N Hoover, Anika Hüsing, Rudolf Kaaks, Mitchell J Machiela, Walter Willett, Myrto Barrdahl, Federico Canzian, Suet-Feung Chin, Carlos Caldas, David J Hunter, Sara Lindstrom, Montserrat Garcia-Closas, Fergus J Couch, Georgia Chenevix-Trench, Arto Mannermaa, Irene L Andrulis, Per Hall, Jenny Chang-Claude, Douglas F Easton, Stig E Bojesen, Angela Cox, Peter A Fasching, Paul DP Pharoah, Marjanka K Schmidt, kConFab Investigators, NBCS Investigators

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

Christy C Ong, Sarah Gierke, Cameron Pitt, Meredith Sagolla, Christine K Cheng, Wei Zhou, Adrian M Jubb, Laura Strickland, Maike Schmidt, Sergio G Duron, David A Campbell, Wei Zheng, Seameen Dehdashti, Min Shen, Nora Yang, Mark L Behnke, Wenwei Huang, John C McKew, Jonathan Chernoff, William F Forrest, Peter M Haverty, Suet-Feung Chin, Emad A Rakha, Andrew R Green, Ian O Ellis, Carlos Caldas, Thomas O’Brien, Lori S Friedman, Hartmut Koeppen, Joachim Rudolph, Klaus P Hoeflich

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Molecular characterization and targeted therapeutic approaches in breast cancer

Angela Toss, Massimo Cristofanilli

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

Sophie Blein, Claire Bardel, Vincent Danjean, Lesley McGuffog, Sue Healey, Daniel Barrowdale, Andrew Lee, Joe Dennis, Karoline B Kuchenbaecker, Penny Soucy, Mary Beth Terry, Wendy K Chung, David E Goldgar, Saundra S Buys, Ramunas Janavicius, Laima Tihomirova, Nadine Tung, Cecilia M Dorfling, Elizabeth J van Rensburg, Susan L Neuhausen, Yuan Chun Ding, Anne-Marie Gerdes, Bent Ejlertsen, Finn C Nielsen, Thomas VO Hansen, Ana Osorio, Javier Benitez, Raquel Andrés Conejero, Ena Segota, Jeffrey N Weitzel, Margo Thelander, Paolo Peterlongo, Paolo Radice, Valeria Pensotti, Riccardo Dolcetti, Bernardo Bonanni, Bernard Peissel, Daniela Zaffaroni, Giulietta Scuvera, Siranoush Manoukian, Liliana Varesco, Gabriele L Capone, Laura Papi, Laura Ottini, Drakoulis Yannoukakos, Irene Konstantopoulou, Judy Garber, Ute Hamann, Alan Donaldson, Angela Brady, Carole Brewer, Claire Foo, D Gareth Evans, Debra Frost, Diana Eccles, Fiona Douglas, Jackie Cook, Julian Adlard, Julian Barwell, Lisa Walker, Louise Izatt, Lucy E Side, M John Kennedy, Marc Tischkowitz, Mark T Rogers, Mary E Porteous, Patrick J Morrison, Radka Platte, Ros Eeles, Rosemarie Davidson, Shirley Hodgson, Trevor Cole, Andrew K Godwin, Claudine Isaacs, Kathleen Claes, Kim De Leeneer, Alfons Meindl, Andrea Gehrig, Barbara Wappenschmidt, Christian Sutter, Christoph Engel, Dieter Niederacher, Doris Steinemann, Hansjoerg Plendl, Karin Kast, Kerstin Rhiem, Nina Ditsch, Norbert Arnold, Raymonda Varon-Mateeva, Rita K Schmutzler, Sabine Preisler-Adams, Nadja Bogdanova Markov, Shan Wang-Gohrke, Antoine de Pauw, Cédrick Lefol, Christine Lasset, Dominique Leroux, Etienne Rouleau, Francesca Damiola, Hélène Dreyfus, Laure Barjhoux, Lisa Golmard, Nancy Uhrhammer, Valérie Bonadona, Valérie Sornin, Yves-Jean Bignon, Jonathan Carter, Linda Van Le, Marion Piedmonte, Paul A DiSilvestro, Miguel de la Hoya, Trinidad Caldes, Heli Nevanlinna, Kristiina Aittomäki, Agnes Jager, Ans MW van den Ouweland, Carolien M Kets, Cora M Aalfs, Flora E van Leeuwen, Frans BL Hogervorst, Hanne EJ Meijers-Heijboer, Jan C Oosterwijk, Kees EP van Roozendaal, Matti A Rookus, Peter Devilee, Rob B van der Luijt, Edith Olah, Orland Diez, Alex Teulé, Conxi Lazaro, Ignacio Blanco, Jesús Del Valle, Anna Jakubowska, Grzegorz Sukiennicki, Jacek Gronwald, Jan Lubinski, Katarzyna Durda, Katarzyna Jaworska-Bieniek, Bjarni A Agnarsson, Christine Maugard, Alberto Amadori, Marco Montagna, Manuel R Teixeira, Amanda B Spurdle, William Foulkes, Curtis Olswold, Noralane M Lindor, Vernon S Pankratz, Csilla I Szabo, Anne Lincoln, Lauren Jacobs, Marina Corines, Mark Robson, Joseph Vijai, Andreas Berger, Anneliese Fink-Retter, Christian F Singer, Christine Rappaport, Daphne Geschwantler Kaulich, Georg Pfeiler, Muy-Kheng Tea, Mark H Greene, Phuong L Mai, Gad Rennert, Evgeny N Imyanitov, Anna Marie Mulligan, Gord Glendon, Irene L Andrulis, Sandrine Tchatchou, Amanda Ewart Toland, Inge Sokilde Pedersen, Mads Thomassen, Torben A Kruse, Uffe Birk Jensen, Maria A Caligo, Eitan Friedman, Jamal Zidan, Yael Laitman, Annika Lindblom, Beatrice Melin, Brita Arver, Niklas Loman, Richard Rosenquist, Olufunmilayo I Olopade, Robert L Nussbaum, Susan J Ramus, Katherine L Nathanson, Susan M Domchek, Timothy R Rebbeck, Banu K Arun, Gillian Mitchell, Beth Y Karlan, Jenny Lester, Sandra Orsulic, Dominique Stoppa-Lyonnet, Gilles Thomas, Jacques Simard, Fergus J Couch, Kenneth Offit, Douglas F Easton, Georgia Chenevix-Trench, Antonis C Antoniou, Sylvie Mazoyer, Catherine M Phelan, Olga M Sinilnikova, David G Cox, Breast Cancer Family Registry, EMBRACE, GEMO Study Collaborators, HEBON

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Omega-3 fatty acids for breast cancer prevention and survivorship

Carol J Fabian, Bruce F Kimler, Stephen D Hursting

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Benefits and harms of mammography screening

Magnus Løberg, Mette Lise Lousdal, Michael Bretthauer, Mette Kalager

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Metformin increases survival in hormone receptor-positive, HER2-positive breast cancer patients with diabetes

Hee Jeong Kim, Hyunwook Kwon, Jong Won Lee, Hwa Jung Kim, Sae Byul Lee, Hee Sung Park, Guiyun Sohn, Yura Lee, Beom Seok Koh, Jong Han Yu, Byung Ho Son, Sei Hyun Ahn

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer

Xiaolan Feng, Haocheng Li, Michelle Dean, Holly E Wilson, Elizabeth Kornaga, Emeka K Enwere, Patricia Tang, Alexander Paterson, Susan P Lees-Miller, Anthony M Magliocco, Gwyn Bebb

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery

Susanne Kossatz, Julia Grandke, Pierre Couleaud, Alfonso Latorre, Antonio Aires, Kieran Crosbie-Staunton, Robert Ludwig, Heidi Dähring, Volker Ettelt, Ana Lazaro-Carrillo, Macarena Calero, Maha Sader, José Courty, Yuri Volkov, Adriele Prina-Mello, Angeles Villanueva, Álvaro Somoza, Aitziber L Cortajarena, Rodolfo Miranda, Ingrid Hilger

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Quantitative assessment of background parenchymal enhancement in breast MRI predicts response to risk-reducing salpingo-oophorectomy: preliminary evaluation in a cohort of BRCA1/2 mutation carriers

Shandong Wu, Susan P Weinstein, Michael J DeLeo III, Emily F Conant, Jinbo Chen, Susan M Domchek, Despina Kontos

01.12.2015 | Viewpoint | Ausgabe 1/2015 Open Access

Anti-CCL2: building a reservoir or opening the floodgates to metastasis?

Jessica R Hitchcock, Christine J Watson

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells

Jie Yuan, Manran Liu, Li Yang, Gang Tu, Qing Zhu, Maoshan Chen, Hong Cheng, Haojun Luo, Weijie Fu, Zhenhua Li, Guanglun Yang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis

Stefania Croci, Patrizia Nanni, Arianna Palladini, Giordano Nicoletti, Valentina Grosso, Giorgia Benegiamo, Lorena Landuzzi, Alessia Lamolinara, Marianna L. Ianzano, Dario Ranieri, Massimiliano Dall’Ora, Manuela Iezzi, Carla De Giovanni, Pier-Luigi Lollini

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Anti-HER2 CD4+ T-helper type 1 response is a novel immune correlate to pathologic response following neoadjuvant therapy in HER2-positive breast cancer

Jashodeep Datta, Erik Berk, Shuwen Xu, Elizabeth Fitzpatrick, Cinthia Rosemblit, Lea Lowenfeld, Noah Goodman, David A Lewis, Paul J Zhang, Carla Fisher, Robert E Roses, Angela DeMichele, Brian J Czerniecki

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures

So Hyun Chung, Michael D. Feldman, Daniel Martinez, Helen Kim, Mary E. Putt, David R. Busch, Julia Tchou, Brian J. Czerniecki, Mitchell D. Schnall, Mark A. Rosen, Angela DeMichele, Arjun G. Yodh, Regine Choe

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response

Mark Jesus M. Magbanua, Denise M. Wolf, Christina Yau, Sarah E. Davis, Julia Crothers, Alfred Au, Christopher M. Haqq, Chad Livasy, Hope S. Rugo, Laura Esserman, John W. Park, Laura J. van ’t Veer, I-SPY 1 TRIAL Investigators

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The effect of weight change on changes in breast density measures over menopause in a breast cancer screening cohort

Johanna Olga Pauline Wanders, Marije Fokje Bakker, Wouter Bernard Veldhuis, Petra Huberdina Maria Peeters, Carla Henrica van Gils

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Identification of two novel mammographic density loci at 6Q25.1

Judith S Brand, Jingmei Li, Keith Humphreys, Robert Karlsson, Mikael Eriksson, Emma Ivansson, Per Hall, Kamila Czene

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Molecular drivers of lobular carcinoma in situ

Greg J. Logan, David J. Dabbs, Peter C. Lucas, Rachel C. Jankowitz, Daniel D. Brown, Beth Z. Clark, Steffi Oesterreich, Priscilla F. McAuliffe

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Adolescent endogenous sex hormones and breast density in early adulthood

Seungyoun Jung, Brian L. Egleston, D. Walt Chandler, Linda Van Horn, Nola M. Hylton, Catherine C. Klifa, Norman L. Lasser, Erin S. LeBlanc, Kenneth Paris, John A. Shepherd, Linda G. Snetselaar, Frank Z. Stanczyk, Victor J. Stevens, Joanne F. Dorgan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

CD24+ cells fuel rapid tumor growth and display high metastatic capacity

Ran Rostoker, Sagi Abelson, Inna Genkin, Sarit Ben-Shmuel, Ravi Sachidanandam, Eyal J. Scheinman, Keren Bitton-Worms, Zila Shen Orr, Avishay Caspi, Maty Tzukerman, Derek LeRoith

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium

Cecilia W. Huo, Grace Chew, Prue Hill, Dexing Huang, Wendy Ingman, Leigh Hodson, Kristy A. Brown, Astrid Magenau, Amr H. Allam, Ewan McGhee, Paul Timpson, Michael A. Henderson, Erik W. Thompson, Kara Britt

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast

Jia-Min B. Pang, Kylie L. Gorringe, Stephen Q. Wong, Alexander Dobrovic, Ian G. Campbell, Stephen B. Fox

01.12.2015 | Review | Ausgabe 1/2015 Open Access

nab-Paclitaxel dose and schedule in breast cancer

Miguel Martín

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Genetic risk variants associated with in situ breast cancer

Daniele Campa, Myrto Barrdahl, Mia M. Gaudet, Amanda Black, Stephen J. Chanock, W. Ryan Diver, Susan M. Gapstur, Christopher Haiman, Susan Hankinson, Aditi Hazra, Brian Henderson, Robert N. Hoover, David J. Hunter, Amit D. Joshi, Peter Kraft, Loic Le Marchand, Sara Lindström, Walter Willett, Ruth C. Travis, Pilar Amiano, Afshan Siddiq, Dimitrios Trichopoulos, Malin Sund, Anne Tjønneland, Elisabete Weiderpass, Petra H. Peeters, Salvatore Panico, Laure Dossus, Regina G. Ziegler, Federico Canzian, Rudolf Kaaks

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene

Yu Wei Phua, Akira Nguyen, Daniel L. Roden, Benjamin Elsworth, Niantao Deng, Iva Nikolic, Jessica Yang, Andrea Mcfarland, Roslin Russell, Warren Kaplan, Mark J. Cowley, Radhika Nair, Elena Zotenko, Sandra O’Toole, Shi-xiong Tan, David E. James, Susan J. Clark, Hosein Kouros-Mehr, Alexander Swarbrick

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Can the breast screening appointment be used to provide risk assessment and prevention advice?

D. Gareth Evans, Anthony Howell

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits

Bhupinder Pal, Yunshun Chen, Andrew Bert, Yifang Hu, Julie M. Sheridan, Tamara Beck, Wei Shi, Keith Satterley, Paul Jamieson, Gregory J. Goodall, Geoffrey J. Lindeman, Gordon K. Smyth, Jane E. Visvader

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2+ breast cancer cells by inducing Bim

Sun Hee Park, Koichi Ito, William Olcott, Igor Katsyv, Gwyneth Halstead-Nussloch, Hanna Y. Irie

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence

Joseph A Caruso, Cansu Karakas, Jing Zhang, Min Yi, Constance Albarracin, Aysegul Sahin, Melissa Bondy, Jinsong Liu, Kelly K. Hunt, Khandan Keyomarsi

01.12.2015 | Editorial | Ausgabe 1/2015 Open Access

Metformin in breast cancer - an evolving mystery

Laura Camacho, Atreyi Dasgupta, Sao Jiralerspong

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia?

Joshua Bauml, Lu Chen, Jinbo Chen, Jean Boyer, Michael Kalos, Susan Q. Li, Angela DeMichele, Jun J. Mao

01.12.2015 | Letter | Ausgabe 1/2015 Open Access

Reduced proliferation in breast cancer cells contacting the neighboring adipocytes in human breast cancer tissues

Han Suk Ryu, Han-Byoel Lee, Wonshik Han, Dong-Young Noh, Hyeong-Gon Moon

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance

Shenduo Li, Sturgis Payne, Fang Wang, Peter Claus, Zuowei Su, Jeffrey Groth, Joseph Geradts, Gustaaf de Ridder, Rebeca Alvarez, Paul Kelly Marcom, Salvatore V. Pizzo, Robin E. Bachelder

01.12.2015 | Viewpoint | Ausgabe 1/2015 Open Access

Tipping the balance between good and evil: aberrant 14-3-3ζ expression drives oncogenic TGF-β signaling in metastatic breast cancers

Chevaun D. Morrison, William P. Schiemann

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mammographic density and breast cancer in women from high risk families

Teresa Ramón y Cajal, Isabel Chirivella, Josefa Miranda, Alexandre Teule, Ángel Izquierdo, Judith Balmaña, Ana Beatriz Sánchez-Heras, Gemma Llort, David Fisas, Virginia Lope, Elena Hernández-Agudo, María José Juan-Fita, Isabel Tena, Luis Robles, Carmen Guillén-Ponce, Pedro Pérez-Segura, Mari Sol Luque-Molina, Susana Hernando-Polo, Mónica Salinas, Joan Brunet, María Dolores Salas-Trejo, Agustí Barnadas, Marina Pollán

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Lobular breast cancer series: imaging

Karen Johnson, Deba Sarma, E Shelley Hwang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Body fatness during childhood and adolescence and breast density in young women: a prospective analysis

Kimberly A. Bertrand, Heather J. Baer, E. John Orav, Catherine Klifa, John A. Shepherd, Linda Van Horn, Linda Snetselaar, Victor J. Stevens, Nola M. Hylton, Joanne F. Dorgan

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL

Luke Piggott, Nader Omidvar, Salvador Martí Pérez, Rhiannon French, Matthias Eberl, Richard WE Clarkson

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

Bas ter Braak, Steven Wink, Esmee Koedoot, Chantal Pont, Christine Siezen, Jan Willem van der Laan, Bob van de Water

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis

Panagiotis Papageorgis, Sait Ozturk, Arthur W. Lambert, Christiana M. Neophytou, Alexandros Tzatsos, Chen K. Wong, Sam Thiagalingam, Andreas I. Constantinou

01.12.2015 | Editorial | Ausgabe 1/2015 Open Access

Lobular breast cancer - the most common special subtype or a most special common subtype?

Ulrich Lehmann

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

Heleen K Bronsveld, Bas ter Braak, Øystein Karlstad, Peter Vestergaard, Jakob Starup-Linde, Marloes T Bazelier, Marie L De Bruin, Anthonius de Boer, Christine L E Siezen, Bob van de Water, Jan Willem van der Laan, Marjanka K Schmidt

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Human breast cancer cells educate macrophages toward the M2 activation status

Sofia Sousa, Régis Brion, Minnamaija Lintunen, Pauliina Kronqvist, Jouko Sandholm, Jukka Mönkkönen, Pirkko-Liisa Kellokumpu-Lehtinen, Susanna Lauttia, Olli Tynninen, Heikki Joensuu, Dominique Heymann, Jorma A. Määttä

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Contralateral breast cancer can represent a metastatic spread of the first primary tumor: determination of clonal relationship between contralateral breast cancers using next-generation whole genome sequencing

Sara Alkner, Man-Hung Eric Tang, Christian Brueffer, Malin Dahlgren, Yilun Chen, Eleonor Olsson, Christof Winter, Sara Baker, Anna Ehinger, Lisa Rydén, Lao H. Saal, Mårten Fernö, Sofia K. Gruvberger-Saal

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women

Hanne Frydenberg, Vidar G. Flote, Ine M. Larsson, Emily S. Barrett, Anne-Sofie Furberg, Giske Ursin, Tom Wilsgaard, Peter T. Ellison, Anne McTiernan, Anette Hjartåker, Grazyna Jasienska, Inger Thune

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The molecular landscape of premenopausal breast cancer

Serena Liao, Ryan J. Hartmaier, Kandace P. McGuire, Shannon L. Puhalla, Soumya Luthra, Uma R. Chandran, Tianzhou Ma, Rohit Bhargava, Francesmary Modugno, Nancy E. Davidson, Steve Benz, Adrian V. Lee, George C. Tseng, Steffi Oesterreich

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Micro-anatomical quantitative optical imaging: toward automated assessment of breast tissues

Jessica L. Dobbs, Jenna L. Mueller, Savitri Krishnamurthy, Dongsuk Shin, Henry Kuerer, Wei Yang, Nirmala Ramanujam, Rebecca Richards-Kortum

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence

Beatriz Morancho, Águeda Martínez-Barriocanal, Josep Villanueva, Joaquín Arribas

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Targeting lysyl oxidase for molecular imaging in breast cancer

Melinda Wuest, Manuela Kuchar, Sai Kiran Sharma, Susan Richter, Ingrit Hamann, Monica Wang, Larissa Vos, John R. Mackey, Frank Wuest, Reik Löser

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Chromosomal copy number alterations for associations of ductal carcinoma in situ with invasive breast cancer

Anosheh Afghahi, Erna Forgó, Aya A. Mitani, Manisha Desai, Sushama Varma, Tina Seto, Joseph Rigdon, Kristin C. Jensen, Megan L. Troxell, Scarlett Lin Gomez, Amar K. Das, Andrew H. Beck, Allison W. Kurian, Robert B. West

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Decoding breast cancer tissue–stroma interactions using species-specific sequencing

Indira V. Chivukula, Daniel Ramsköld, Helena Storvall, Charlotte Anderberg, Shaobo Jin, Veronika Mamaeva, Cecilia Sahlgren, Kristian Pietras, Rickard Sandberg, Urban Lendahl

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density

Anja Rudolph, Peter A. Fasching, Sabine Behrens, Ursula Eilber, Manjeet K. Bolla, Qin Wang, Deborah Thompson, Kamila Czene, Judith S. Brand, Jingmei Li, Christopher Scott, V. Shane Pankratz, Kathleen Brandt, Emily Hallberg, Janet E. Olson, Adam Lee, Matthias W. Beckmann, Arif B. Ekici, Lothar Haeberle, Gertraud Maskarinec, Loic Le Marchand, Fredrick Schumacher, Roger L. Milne, Julia A. Knight, Carmel Apicella, Melissa C. Southey, Miroslav K. Kapuscinski, John L. Hopper, Irene L. Andrulis, Graham G. Giles, Christopher A. Haiman, Kay-Tee Khaw, Robert Luben, Per Hall, Paul D. P. Pharoah, Fergus J. Couch, Douglas F. Easton, Isabel dos-Santos-Silva, Celine Vachon, Jenny Chang-Claude

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls

Ella R. Thompson, Kylie L. Gorringe, Simone M. Rowley, Michelle W. Wong-Brown, Simone McInerny, Na Li, Alison H. Trainer, Lisa Devereux, Maria A. Doyle, Jason Li, Richard Lupat, Martin B. Delatycki, Gillian Mitchell, Paul A. James, Rodney J. Scott, Ian G. Campbell, LifePool Investigators

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers

Amy L. Strong, Jason F. Ohlstein, Brandi A. Biagas, Lyndsay V. Rhodes, Dorothy T. Pei, H. Alan Tucker, Claire Llamas, Annie C. Bowles, Maria F. Dutreil, Shijia Zhang, Jeffrey M. Gimble, Matthew E. Burow, Bruce A. Bunnell

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Expression of truncated human epidermal growth factor receptor 2 on circulating tumor cells of breast cancer patients

Galatea Kallergi, Sofia Agelaki, Maria A. Papadaki, Dimitris Nasias, Alexios Matikas, Dimitris Mavroudis, Vassilis Georgoulias

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Assessing breast cancer cell lines as tumour models by comparison of mRNA expression profiles

Krista Marie Vincent, Scott D. Findlay, Lynne Marie Postovit

01.12.2015 | Letter | Ausgabe 1/2015 Open Access

Lack of epidermal growth factor receptor (EGFR)-activating mutations in triple-negative breast cancer in China

Wen-Ming Cao, Yun Gao, Xiao-Jia Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Breast cancer tumour growth modelling for studying the association of body size with tumour growth rate and symptomatic detection using case-control data

Linda Abrahamsson, Kamila Czene, Per Hall, Keith Humphreys

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Preliminary evaluation of the publicly available Laboratory for Breast Radiodensity Assessment (LIBRA) software tool: comparison of fully automated area and volumetric density measures in a case–control study with digital mammography

Brad M. Keller, Jinbo Chen, Dania Daye, Emily F. Conant, Despina Kontos

01.12.2015 | Letter | Ausgabe 1/2015 Open Access

Breast bruises and breast cancer

Nancy Krieger

01.12.2015 | Meeting report | Ausgabe 1/2015 Open Access

The seventh ENBDC workshop on methods in mammary gland development and cancer

Marina A. Glukhova, Nancy Hynes, Maria dM Vivanco, Renée van Amerongen, Robert B. Clarke, Mohamed Bentires-Alj

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effect of weight loss, with or without exercise, on body composition and sex hormones in postmenopausal women: the SHAPE-2 trial

Willemijn AM. van Gemert, Albertine J. Schuit, Job van der Palen, Anne M. May, Jolein A. Iestra, Harriet Wittink, Petra H. Peeters, Evelyn M. Monninkhof

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Bisphosphonates as anticancer agents in early breast cancer: preclinical and clinical evidence

Daniele Santini, Luciano Stumbo, Chiara Spoto, Loretta D’Onofrio, Francesco Pantano, Michele Iuliani, Marco fioramonti, Alice Zoccoli, Giulia Ribelli, Vladimir Virzì, Bruno Vincenzi, Giuseppe Tonini

01.12.2015 | Viewpoint | Ausgabe 1/2015 Open Access

A hypoxic ticket to the bone metastatic niche

Sakari Vanharanta

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer

Azlena Ali, Laura Creevey, Yuan Hao, Damian McCartan, Peadar O’Gaora, Arnold Hill, Leonie Young, Marie McIlroy

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study

Minoru Miyashita, Hironobu Sasano, Kentaro Tamaki, Hisashi Hirakawa, Yayoi Takahashi, Saki Nakagawa, Gou Watanabe, Hiroshi Tada, Akihiko Suzuki, Noriaki Ohuchi, Takanori Ishida

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Applicability of HIN-1, MGMT and RASSF1A promoter methylation as biomarkers for detecting field cancerization in breast cancer

Melanie Spitzwieser, Elisabeth Holzweber, Georg Pfeiler, Stefan Hacker, Margit Cichna-Markl

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells

Stephanie Verbeke, Elodie Richard, Elodie Monceau, Xenia Schmidt, Benoit Rousseau, Valerie Velasco, David Bernard, Herve Bonnefoi, Gaetan MacGrogan, Richard D Iggo

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

ALK alteration is a frequent event in aggressive breast cancers

Abdul K. Siraj, Shaham Beg, Zeenath Jehan, Sarita Prabhakaran, Maqbool Ahmed, Azhar R.Hussain, Fouad Al-Dayel, Asma Tulbah, Dahish Ajarim, Khawla S. Al-Kuraya

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion

Hanan S. Elsarraj, Yan Hong, Kelli E. Valdez, Whitney Michaels, Marcus Hook, William P. Smith, Jeremy Chien, Jason I. Herschkowitz, Melissa A. Troester, Moriah Beck, Marc Inciardi, Jason Gatewood, Lisa May, Therese Cusick, Marilee McGinness, Lawrence Ricci, Fang Fan, Ossama Tawfik, Jeffrey R. Marks, Jennifer R. Knapp, Hung-Wen Yeh, Patricia Thomas, D. R. Carrasco, Timothy A. Fields, Andrew K. Godwin, Fariba Behbod

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial

Peter Widschwendter, Thomas WP Friedl, Lukas Schwentner, Nikolaus DeGregorio, Bernadette Jaeger, Amelie Schramm, Inga Bekes, Miriam Deniz, Krisztian Lato, Tobias Weissenbacher, Bernd Kost, Ulrich Andergassen, Julia Jueckstock, Julia Neugebauer, Elisabeth Trapp, Peter A. Fasching, Matthias W. Beckmann, Andreas Schneeweiss, Ines Schrader, Brigitte Rack, Wolfgang Janni, Christoph Scholz

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer

Meliha Mehmeti, Roni Allaoui, Caroline Bergenfelz, Lao H. Saal, Stephen P. Ethier, Martin E. Johansson, Karin Jirström, Karin Leandersson

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer

Carlo C. Maley, Konrad Koelble, Rachael Natrajan, Athena Aktipis, Yinyin Yuan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Transformation of enriched mammary cell populations with polyomavirus middle T antigen influences tumor subtype and metastatic potential

Daria Drobysheva, Brittni Alise Smith, Maria McDowell, Katrin P. Guillen, Huseyin Atakan Ekiz, Bryan E. Welm

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The relationship between quantitative human epidermal growth factor receptor 2 gene expression by the 21-gene reverse transcriptase polymerase chain reaction assay and adjuvant trastuzumab benefit in Alliance N9831

Edith A. Perez, Frederick L. Baehner, Steven M. Butler, E. Aubrey Thompson, Amylou C. Dueck, Farid Jamshidian, Diana Cherbavaz, Carl Yoshizawa, Steven Shak, Peter A. Kaufman, Nancy E. Davidson, Julie Gralow, Yan W. Asmann, Karla V. Ballman

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

Esther H. Lips, Magali Michaut, Marlous Hoogstraat, Lennart Mulder, Nicolle JM Besselink, Marco J. Koudijs, Edwin Cuppen, Emile E. Voest, Rene Bernards, Petra M. Nederlof, Jelle Wesseling, Sjoerd Rodenhuis, Lodewyk FA Wessels, On behalf of the Center for Personalized Cancer Treatment

01.12.2015 | Viewpoint | Ausgabe 1/2015 Open Access

Tumor-induced inflammation alters neutrophil phenotype and disease progression

Charaf Benarafa

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Circulating DNA as biomarker in breast cancer

Heidi Schwarzenbach, Klaus Pantel

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Multipotent luminal mammary cancer stem cells model tumor heterogeneity

Lei Bao, Robert D. Cardiff, Paul Steinbach, Karen S. Messer, Lesley G. Ellies

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet

Mark D. Aupperlee, Yong Zhao, Ying Siow Tan, Yirong Zhu, Ingeborg M. Langohr, Erin L. Kirk, Jason R. Pirone, Melissa A. Troester, Richard C. Schwartz, Sandra Z. Haslam

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials

Kaoutar Ennour-Idrissi, Elizabeth Maunsell, Caroline Diorio

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The benefit of HER2-targeted therapies on overall survival of patients with metastatic HER2-positive breast cancer – a systematic review

Diogo Mendes, Carlos Alves, Noémia Afonso, Fátima Cardoso, José Luís Passos-Coelho, Luís Costa, Sofia Andrade, Francisco Batel-Marques

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer

Xue B. Holdman, Thomas Welte, Kimal Rajapakshe, Adam Pond, Cristian Coarfa, Qianxing Mo, Shixia Huang, Susan G. Hilsenbeck, Dean P. Edwards, Xiang Zhang, Jeffrey M. Rosen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mammographic density defined by higher than conventional brightness threshold better predicts breast cancer risk for full-field digital mammograms

Tuong Linh Nguyen, Ye Kyaw Aung, Christopher Francis Evans, Choi Yoon-Ho, Mark Anthony Jenkins, Joohon Sung, John Llewelyn Hopper, Yun-Mi Song

01.12.2015 | Letter | Ausgabe 1/2015 Open Access

Longer term effects of the Angelina Jolie effect: increased risk-reducing mastectomy rates in BRCA carriers and other high-risk women

D. Gareth Evans, Julie Wisely, Tara Clancy, Fiona Lalloo, Mary Wilson, Richard Johnson, Jonathon Duncan, Lester Barr, Ashu Gandhi, Anthony Howell

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: Quantitative assessment of background parenchymal enhancement in breast MRI predicts response to risk-reducing salpingo-oophorectomy: preliminary evaluation in a cohort of BRCA1/2 mutation carriers

Shandong Wu, Susan P. Weinstein, Michael J. DeLeo, Emily F. Conant, Jinbo Chen, Susan M. Domchek, Despina Kontos

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

Sarah J. Creed, Caroline P. Le, Mona Hassan, Cindy K. Pon, Sabine Albold, Keefe T. Chan, Matthew E. Berginski, Zhendong Huang, James E. Bear, J. Robert Lane, Michelle L. Halls, Davide Ferrari, Cameron J. Nowell, Erica K. Sloan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features

Andrea Aloia, Evgeniya Petrova, Stefan Tomiuk, Ute Bissels, Olivier Déas, Massimo Saini, Franziska Maria Zickgraf, Steve Wagner, Saskia Spaich, Marc Sütterlin, Andreas Schneeweiss, Manuel Reitberger, Silvia Rüberg, Bernhard Gerstmayer, David Agorku, Sebastian Knöbel, Annalisa Terranegra, Monica Falleni, Laura Soldati, Martin Ronald Sprick, Andreas Trumpp, Jean-Gabriel Judde, Andreas Bosio, Stefano Cairo, Olaf Hardt

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mammographic density adds accuracy to both the Tyrer-Cuzick and Gail breast cancer risk models in a prospective UK screening cohort

Adam R. Brentnall, Elaine F. Harkness, Susan M. Astley, Louise S. Donnelly, Paula Stavrinos, Sarah Sampson, Lynne Fox, Jamie C. Sergeant, Michelle N. Harvie, Mary Wilson, Ursula Beetles, Soujanya Gadde, Yit Lim, Anil Jain, Sara Bundred, Nicola Barr, Valerie Reece, Anthony Howell, Jack Cuzick, D. Gareth R. Evans

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers

Christian D. Young, Carlos L. Arteaga, Rebecca S. Cook

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers

Preeti Putcha, Jiyang Yu, Ruth Rodriguez-Barrueco, Laura Saucedo-Cuevas, Patricia Villagrasa, Eva Murga-Penas, Steven N. Quayle, Min Yang, Veronica Castro, David Llobet-Navas, Daniel Birnbaum, Pascal Finetti, Wendy A. Woodward, François Bertucci, Mary L. Alpaugh, Andrea Califano, Jose Silva

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

“New” metastases are associated with a poorer prognosis than growth of pre-existing metastases in patients with metastatic breast cancer treated with chemotherapy

Christopher Twelves, Javier Cortes, Peter A. Kaufman, Louise Yelle, Ahmad Awada, Terri A. Binder, Martin Olivo, James Song, Joyce A. O’Shaughnessy, Maria Jove, Edith A. Perez

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