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Zeitschrift

Breast Cancer Research

Breast Cancer Research 1/2016

Ausgabe 1/2016

Inhaltsverzeichnis ( 131 Artikel )

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Assessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study

Dennis C. Sgroi, Judy-Anne W. Chapman, T. Badovinac-Crnjevic, Elizabeth Zarella, Shemeica Binns, Yi Zhang, Catherine A. Schnabel, Mark G. Erlander, Kathleen I. Pritchard, Lei Han, Lois E. Shepherd, Paul E. Goss, Michael Pollak

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer

Fatimah Matalkah, Elisha Martin, Hua Zhao, Yehenew M. Agazie

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01)

Stefanie de Groot, Ayoub Charehbili, Hanneke W. M. van Laarhoven, Antien L. Mooyaart, N. Geeske Dekker-Ensink, Saskia van de Ven, Laura G. M. Janssen, Jesse J. Swen, Vincent T. H. B. M. Smit, Joan B. Heijns, Lonneke W. Kessels, Tahar van der Straaten, Stefan Böhringer, Hans Gelderblom, Jacobus J. M. van der Hoeven, Henk-Jan Guchelaar, Hanno Pijl, Judith R. Kroep, on behalf of the Dutch Breast Cancer Research Group

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

ELF5 isoform expression is tissue-specific and significantly altered in cancer

Catherine L. Piggin, Daniel L. Roden, David Gallego-Ortega, Heather J. Lee, Samantha R. Oakes, Christopher J. Ormandy

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Increased peri-ductal collagen micro-organization may contribute to raised mammographic density

James C. McConnell, Oliver V. O’Connell, Keith Brennan, Lisa Weiping, Miles Howe, Leena Joseph, David Knight, Ronan O’Cualain, Yit Lim, Angela Leek, Rachael Waddington, Jane Rogan, Susan M. Astley, Ashu Gandhi, Cliona C. Kirwan, Michael J. Sherratt, Charles H. Streuli

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells

Tomonori Tanei, Dong Soon Choi, Angel A. Rodriguez, Diana Hwang Liang, Lacey Dobrolecki, Madhumita Ghosh, Melissa D. Landis, Jenny C. Chang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Breast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state

Purificación Feijoo, Mariona Terradas, David Soler, Daniel Domínguez, Laura Tusell, Anna Genescà

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Breast cancer brain metastases: biology and new clinical perspectives

Isabell Witzel, Leticia Oliveira-Ferrer, Klaus Pantel, Volkmar Müller, Harriet Wikman

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

Sharon Wang, Jeff C. Liu, Danbi Kim, Alessandro Datti, Eldad Zacksenhaus

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer

Rashmi Verma, Ruth E. Foster, Kieran Horgan, Katherine Mounsey, Helen Nixon, Natuley Smalle, Thomas A. Hughes, Clive RD. Carter

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The cell surface mucin podocalyxin regulates collective breast tumor budding

Marcia L. Graves, Jane A. Cipollone, Pamela Austin, Erin M. Bell, Julie S. Nielsen, C. Blake Gilks, Kelly M. McNagny, Calvin D. Roskelley

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

Alison K. Ward, Paul Mellor, Shari E. Smith, Stephanie Kendall, Natasha A. Just, Frederick S. Vizeacoumar, Sabuj Sarker, Zoe Phillips, Riaz Alvi, Anurag Saxena, Franco J. Vizeacoumar, Svein A. Carlsen, Deborah H. Anderson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

Emily Powell, Jiansu Shao, Yuan Yuan, Hsiang-Chun Chen, Shirong Cai, Gloria V. Echeverria, Nipun Mistry, Keith F. Decker, Christopher Schlosberg, Kim-Anh Do, John R. Edwards, Han Liang, David Piwnica-Worms, Helen Piwnica-Worms

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis

Kun Xu, Xuejun Tian, Sun Y. Oh, Mohammad Movassaghi, Stephen P. Naber, Charlotte Kuperwasser, Rachel J. Buchsbaum

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

Valentina Silvestri, Daniel Barrowdale, Anna Marie Mulligan, Susan L. Neuhausen, Stephen Fox, Beth Y. Karlan, Gillian Mitchell, Paul James, Darcy L. Thull, Kristin K. Zorn, Natalie J. Carter, Katherine L. Nathanson, Susan M. Domchek, Timothy R. Rebbeck, Susan J. Ramus, Robert L. Nussbaum, Olufunmilayo I. Olopade, Johanna Rantala, Sook-Yee Yoon, Maria A. Caligo, Laura Spugnesi, Anders Bojesen, Inge Sokilde Pedersen, Mads Thomassen, Uffe Birk Jensen, Amanda Ewart Toland, Leigha Senter, Irene L. Andrulis, Gord Glendon, Peter J. Hulick, Evgeny N. Imyanitov, Mark H. Greene, Phuong L. Mai, Christian F. Singer, Christine Rappaport-Fuerhauser, Gero Kramer, Joseph Vijai, Kenneth Offit, Mark Robson, Anne Lincoln, Lauren Jacobs, Eva Machackova, Lenka Foretova, Marie Navratilova, Petra Vasickova, Fergus J. Couch, Emily Hallberg, Kathryn J. Ruddy, Priyanka Sharma, Sung-Won Kim, Manuel R. Teixeira, Pedro Pinto, Marco Montagna, Laura Matricardi, Adalgeir Arason, Oskar Th Johannsson, Rosa B. Barkardottir, Anna Jakubowska, Jan Lubinski, Angel Izquierdo, Miguel Angel Pujana, Judith Balmaña, Orland Diez, Gabriella Ivady, Janos Papp, Edith Olah, Ava Kwong, Heli Nevanlinna, Kristiina Aittomäki, Pedro Perez Segura, Trinidad Caldes, Tom Van Maerken, Bruce Poppe, Kathleen B. M. Claes, Claudine Isaacs, Camille Elan, Christine Lasset, Dominique Stoppa-Lyonnet, Laure Barjhoux, Muriel Belotti, Alfons Meindl, Andrea Gehrig, Christian Sutter, Christoph Engel, Dieter Niederacher, Doris Steinemann, Eric Hahnen, Karin Kast, Norbert Arnold, Raymonda Varon-Mateeva, Dorothea Wand, Andrew K. Godwin, D. Gareth Evans, Debra Frost, Jo Perkins, Julian Adlard, Louise Izatt, Radka Platte, Ros Eeles, Steve Ellis, Ute Hamann, Judy Garber, Florentia Fostira, George Fountzilas, Barbara Pasini, Giuseppe Giannini, Piera Rizzolo, Antonio Russo, Laura Cortesi, Laura Papi, Liliana Varesco, Domenico Palli, Ines Zanna, Antonella Savarese, Paolo Radice, Siranoush Manoukian, Bernard Peissel, Monica Barile, Bernardo Bonanni, Alessandra Viel, Valeria Pensotti, Stefania Tommasi, Paolo Peterlongo, Jeffrey N. Weitzel, Ana Osorio, Javier Benitez, Lesley McGuffog, Sue Healey, Anne-Marie Gerdes, Bent Ejlertsen, Thomas V. O. Hansen, Linda Steele, Yuan Chun Ding, Nadine Tung, Ramunas Janavicius, David E. Goldgar, Saundra S. Buys, Mary B. Daly, Anita Bane, Mary Beth Terry, Esther M. John, Melissa Southey, Douglas F. Easton, Georgia Chenevix-Trench, Antonis C. Antoniou, Laura Ottini, kConFab Investigators, Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), EMBRACE

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer

Marsela Braunstein, Linda Liao, Nicola Lyttle, Nazleen Lobo, Karen J. Taylor, Paul M. Krzyzanowski, Irina Kalatskaya, Cindy Q. Yao, Lincoln D. Stein, Paul C. Boutros, Christopher J. Twelves, Richard Marcellus, John M. S. Bartlett, Melanie Spears

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers

Richard S. Finn, Alexey Aleshin, Dennis J. Slamon

01.12.2016 | Research Article | Ausgabe 1/2016 Open Access

High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations

Rebecca L. Johnston, Leesa Wockner, Amy E. McCart Reed, Adrian Wiegmans, Georgia Chenevix-Trench, Kum Kum Khanna, Sunil R. Lakhani, Chanel E. Smart

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Growth of human breast tissues from patient cells in 3D hydrogel scaffolds

Ethan S. Sokol, Daniel H. Miller, Anne Breggia, Kevin C. Spencer, Lisa M. Arendt, Piyush B. Gupta

01.12.2016 | Research Article | Ausgabe 1/2016 Open Access

Does primary neoadjuvant systemic therapy eradicate minimal residual disease? Analysis of disseminated and circulating tumor cells before and after therapy

Sabine Kasimir-Bauer, Ann-Kathrin Bittner, Lisa König, Katharina Reiter, Thomas Keller, Rainer Kimmig, Oliver Hoffmann

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer

H. Raza Ali, Aliakbar Dariush, Elena Provenzano, Helen Bardwell, Jean E. Abraham, Mahesh Iddawela, Anne-Laure Vallier, Louise Hiller, Janet. A. Dunn, Sarah J. Bowden, Tamas Hickish, Karen McAdam, Stephen Houston, Mike J. Irwin, Paul D. P. Pharoah, James D. Brenton, Nicholas A. Walton, Helena M. Earl, Carlos Caldas

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Genetic predisposition to ductal carcinoma in situ of the breast

Christos Petridis, Mark N. Brook, Vandna Shah, Kelly Kohut, Patricia Gorman, Michele Caneppele, Dina Levi, Efterpi Papouli, Nick Orr, Angela Cox, Simon S. Cross, Isabel dos-Santos-Silva, Julian Peto, Anthony Swerdlow, Minouk J. Schoemaker, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Javier Benitez, Anna González-Neira, Daniel C. Tessier, Daniel Vincent, Jingmei Li, Jonine Figueroa, Vessela Kristensen, Anne-Lise Borresen-Dale, Penny Soucy, Jacques Simard, Roger L. Milne, Graham G. Giles, Sara Margolin, Annika Lindblom, Thomas Brüning, Hiltrud Brauch, Melissa C. Southey, John L. Hopper, Thilo Dörk, Natalia V. Bogdanova, Maria Kabisch, Ute Hamann, Rita K. Schmutzler, Alfons Meindl, Hermann Brenner, Volker Arndt, Robert Winqvist, Katri Pylkäs, Peter A. Fasching, Matthias W. Beckmann, Jan Lubinski, Anna Jakubowska, Anna Marie Mulligan, Irene L. Andrulis, Rob A. E. M. Tollenaar, Peter Devilee, Loic Le Marchand, Christopher A. Haiman, Arto Mannermaa, Veli-Matti Kosma, Paolo Radice, Paolo Peterlongo, Frederik Marme, Barbara Burwinkel, Carolien H. M. van Deurzen, Antoinette Hollestelle, Nicola Miller, Michael J. Kerin, Diether Lambrechts, Giuseppe Floris, Jelle Wesseling, Henrik Flyger, Stig E. Bojesen, Song Yao, Christine B. Ambrosone, Georgia Chenevix-Trench, Thérèse Truong, Pascal Guénel, Anja Rudolph, Jenny Chang-Claude, Heli Nevanlinna, Carl Blomqvist, Kamila Czene, Judith S. Brand, Janet E. Olson, Fergus J. Couch, Alison M. Dunning, Per Hall, Douglas F. Easton, Paul D. P. Pharoah, Sarah E. Pinder, Marjanka K Schmidt, Ian Tomlinson, Rebecca Roylance, Montserrat García-Closas, Elinor J. Sawyer

01.12.2016 | Research Article | Ausgabe 1/2016 Open Access

LIN7A is a major determinant of cell-polarity defects in breast carcinomas

Nadège Gruel, Laetitia Fuhrmann, Catalina Lodillinsky, Vanessa Benhamo, Odette Mariani, Aurélie Cédenot, Laurent Arnould, Gaëtan Macgrogan, Xavier Sastre-Garau, Philippe Chavrier, Olivier Delattre, Anne Vincent-Salomon

01.12.2016 | Research Article | Ausgabe 1/2016 Open Access

Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease

Hisani N. Horne, Mark E. Sherman, Ruth M. Pfeiffer, Jonine D. Figueroa, Zeina G. Khodr, Roni T. Falk, Michael Pollak, Deesha A. Patel, Maya M. Palakal, Laura Linville, Daphne Papathomas, Berta Geller, Pamela M. Vacek, Donald L. Weaver, Rachael Chicoine, John Shepherd, Amir Pasha Mahmoudzadeh, Jeff Wang, Bo Fan, Serghei Malkov, Sally Herschorn, Stephen M. Hewitt, Louise A. Brinton, Gretchen L. Gierach

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Interferon-induced transmembrane protein 1 (IFITM1) overexpression enhances the aggressive phenotype of SUM149 inflammatory breast cancer cells in a signal transducer and activator of transcription 2 (STAT2)-dependent manner

Joshua Ogony, Hye Joung Choi, Asona Lui, Massimo Cristofanilli, Joan Lewis-Wambi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

Muhammad Hasan Bashari, Fengjuan Fan, Sonia Vallet, Martin Sattler, Melissa Arn, Claudia Luckner-Minden, Henning Schulze-Bergkamen, Inka Zörnig, Frederik Marme, Andreas Schneeweiss, Michael H. Cardone, Joseph T. Opferman, Dirk Jäger, Klaus Podar

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells

Karolina Holm, Johan Staaf, Martin Lauss, Mattias Aine, David Lindgren, Pär-Ola Bendahl, Johan Vallon-Christersson, Rosa Bjork Barkardottir, Mattias Höglund, Åke Borg, Göran Jönsson, Markus Ringnér

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Selective elimination of breast cancer surgery in exceptional responders: historical perspective and current trials

Raquel F. D. van la Parra, Henry M. Kuerer

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode

Raúl M. Luque, Alicia Villa-Osaba, Fernando L-López, Ana I. Pozo-Salas, Rafael Sánchez-Sánchez, Rosa Ortega-Salas, Luis de Lecea, Marina Álvarez-Benito, José López-Miranda, Manuel D. Gahete, Justo P. Castaño

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

In patients with metastatic breast cancer the identification of circulating tumor cells in epithelial-to-mesenchymal transition is associated with a poor prognosis

Michela Bulfoni, Lorenzo Gerratana, Fabio Del Ben, Stefania Marzinotto, Marisa Sorrentino, Matteo Turetta, Giacinto Scoles, Barbara Toffoletto, Miriam Isola, Carlo Alberto Beltrami, Carla Di Loreto, Antonio Paolo Beltrami, Fabio Puglisi, Daniela Cesselli

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions

Wai Jin Tan, Igor Cima, Yukti Choudhury, Xiaona Wei, Jeffrey Chun Tatt Lim, Aye Aye Thike, Min-Han Tan, Puay Hoon Tan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Selective isolation and characterization of primary cells from normal breast and tumors reveal plasticity of adipose derived stem cells

Annika Weigand, Anja M. Boos, Kereshmeh Tasbihi, Justus P. Beier, Paul D. Dalton, Michael Schrauder, Raymund E. Horch, Matthias W. Beckmann, Pamela L. Strissel, Reiner Strick

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype-specific RNAs of triple-negative breast cancer

Yi-Rong Liu, Yi-Zhou Jiang, Xiao-En Xu, Ke-Da Yu, Xi Jin, Xin Hu, Wen-Jia Zuo, Shuang Hao, Jiong Wu, Guang-Yu Liu, Gen-Hong Di, Da-Qiang Li, Xiang-Huo He, Wei-Guo Hu, Zhi-Ming Shao

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Phase 1b/2a study of trastuzumab emtansine (T-DM1), paclitaxel, and pertuzumab in HER2-positive metastatic breast cancer

Ian E. Krop, Shanu Modi, Patricia M. LoRusso, Mark Pegram, Ellie Guardino, Betsy Althaus, Dan Lu, Alexander Strasak, Anthony Elias

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

COX-2 modulates mammary tumor progression in response to collagen density

Karla Esbona, David Inman, Sandeep Saha, Justin Jeffery, Pepper Schedin, Lee Wilke, Patricia Keely

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Association of infertility and fertility treatment with mammographic density in a large screening-based cohort of women: a cross-sectional study

Frida E. Lundberg, Anna L. V. Johansson, Kenny Rodriguez-Wallberg, Judith S. Brand, Kamila Czene, Per Hall, Anastasia N. Iliadou

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Israa Salem, Manal Alsalahi, Inna Chervoneva, Lucy D. Aburto, Sankar Addya, Gregory R. Ott, Bruce A. Ruggeri, Massimo Cristofanilli, Sandra V. Fernandez

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation

Fayun Zhang, Wenjuan Dong, Wenfeng Zeng, Lei Zhang, Chao Zhang, Yuqi Qiu, Luoyang Wang, Xiaozhe Yin, Chunling Zhang, Wei Liang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Heterogeneity in global gene expression profiles between biopsy specimens taken peri-surgically from primary ER-positive breast carcinomas

Elena López-Knowles, Qiong Gao, Maggie Chon U. Cheang, James Morden, Joel Parker, Lesley-Ann Martin, Isabel Pinhel, Fiona McNeill, Margaret Hills, Simone Detre, Maria Afentakis, Lila Zabaglo, Andrew Dodson, Anthony Skene, Chris Holcombe, John Robertson, Ian Smith, Judith M. Bliss, Mitch Dowsett, on behalf of the POETIC trialists

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells

Sonia G. Das, Mathilde Romagnoli, Nora D. Mineva, Sophie Barillé-Nion, Pascal Jézéquel, Mario Campone, Gail E. Sonenshein

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition

Cedric Leroy, Pedro Ramos, Karen Cornille, Debora Bonenfant, Christine Fritsch, Hans Voshol, Mohamed Bentires-Alj

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study

Carrie B. Hruska, Christopher G. Scott, Amy Lynn Conners, Dana H. Whaley, Deborah J. Rhodes, Rickey E. Carter, Michael K. O’Connor, Katie N. Hunt, Kathleen R. Brandt, Celine M. Vachon

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Immune response in breast cancer brain metastases and their microenvironment: the role of the PD-1/PD-L axis

Renata Duchnowska, Rafał Pęksa, Barbara Radecka, Tomasz Mandat, Tomasz Trojanowski, Bożena Jarosz, Bogumiła Czartoryska-Arłukowicz, Wojciech P. Olszewski, Waldemar Och, Ewa Kalinka-Warzocha, Wojciech Kozłowski, Anna Kowalczyk, Sherene Loi, Wojciech Biernat, Jacek Jassem, for the Polish Brain Metastasis Consortium

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mitosis in circulating tumor cells stratifies highly aggressive breast carcinomas

Daniel L. Adams, Diane K. Adams, Steingrimur Stefansson, Christian Haudenschild, Stuart S. Martin, Monica Charpentier, Saranya Chumsri, Massimo Cristofanilli, Cha-Mei Tang, R. Katherine Alpaugh

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Raised mammographic density: causative mechanisms and biological consequences

Michael J. Sherratt, James C. McConnell, Charles H. Streuli

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Tumor characterization and treatment monitoring of postsurgical human breast specimens using harmonic motion imaging (HMI)

Yang Han, Shutao Wang, Hanina Hibshoosh, Bret Taback, Elisa Konofagou

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The distribution of ductal carcinoma in situ (DCIS) grade in 4232 women and its impact on overdiagnosis in breast cancer screening

P. A. van Luijt, E. A. M. Heijnsdijk, J. Fracheboud, L. I. H. Overbeek, M. J. M. Broeders, J. Wesseling, G. J. den Heeten, H. J. de Koning

01.12.2016 | Research Article | Ausgabe 1/2016 Open Access

Determining breast cancer histological grade from RNA-sequencing data

Mei Wang, Daniel Klevebring, Johan Lindberg, Kamila Czene, Henrik Grönberg, Mattias Rantalainen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment

María G. García-Mendoza, David R. Inman, Suzanne M. Ponik, Justin J. Jeffery, Dagna S. Sheerar, Rachel R. Van Doorn, Patricia J. Keely

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Phosphatidylserine-targeting antibodies augment the anti-tumorigenic activity of anti-PD-1 therapy by enhancing immune activation and downregulating pro-oncogenic factors induced by T-cell checkpoint inhibition in murine triple-negative breast cancers

Michael J. Gray, Jian Gong, Michaela M. S. Hatch, Van Nguyen, Christopher C. W. Hughes, Jeff T. Hutchins, Bruce D. Freimark

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy

Ran Rostoker, Sarit Ben-Shmuel, Rola Rashed, Zila Shen Orr, Derek LeRoith

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

Annelot Baert, Julie Depuydt, Tom Van Maerken, Bruce Poppe, Fransiska Malfait, Katrien Storm, Jenneke van den Ende, Tim Van Damme, Sylvia De Nobele, Gianpaolo Perletti, Kim De Leeneer, Kathleen B. M. Claes, Anne Vral

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Case-control study of mammographic density and breast cancer risk using processed digital mammograms

Laurel A. Habel, Jafi A. Lipson, Ninah Achacoso, Joseph H. Rothstein, Martin J. Yaffe, Rhea Y. Liang, Luana Acton, Valerie McGuire, Alice S. Whittemore, Daniel L. Rubin, Weiva Sieh

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Breast cancer and social environment: getting by with a little help from our friends

Adam Hinzey, Monica M. Gaudier-Diaz, Maryam B. Lustberg, A. Courtney DeVries

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Cancer stem cell metabolism

Maria Peiris-Pagès, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Federica Sotgia, Michael P. Lisanti

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation

Wei Xiong Wen, Jaslyn Sian-Siu Soo, Pui Yoke Kwan, Elaine Hong, Tsung Fei Khang, Shivaani Mariapun, Christine Shu-Mei Lee, Siti Norhidayu Hasan, Pathmanathan Rajadurai, Cheng Har Yip, Nur Aishah Mohd Taib, Soo Hwang Teo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Intermittent energy restriction induces changes in breast gene expression and systemic metabolism

Michelle N. Harvie, Andrew H. Sims, Mary Pegington, Katherine Spence, Adam Mitchell, Andrew A. Vaughan, J. William Allwood, Yun Xu, Nicolas J. W. Rattray, Royston Goodacre, D. Gareth R. Evans, Ellen Mitchell, Debbie McMullen, Robert B. Clarke, Anthony Howell

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer

Nikiana Simigdala, Qiong Gao, Sunil Pancholi, Hanne Roberg-Larsen, Marketa Zvelebil, Ricardo Ribas, Elizabeth Folkerd, Andrew Thompson, Amandeep Bhamra, Mitch Dowsett, Lesley-Ann Martin

01.12.2016 | Letter | Ausgabe 1/2016 Open Access

SEARCHBreast: a new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers

Bethny Morrissey, Karen Blyth, Phil Carter, Claude Chelala, Louise Jones, Ingunn Holen, Valerie Speirs

01.12.2016 | Letter | Ausgabe 1/2016 Open Access

Common genetic susceptibility to DCIS and invasive ductal carcinoma

Victoria Sopik, Steven A. Narod

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Long-term use of calcium channel blocking drugs and breast cancer risk in a prospective cohort of US and Puerto Rican women

Lauren E. Wilson, Aimee A. D’Aloisio, Dale P. Sandler, Jack A. Taylor

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Recreational physical activity and risk of triple negative breast cancer in the California Teachers Study

Huiyan Ma, Xinxin Xu, Jessica Clague, Yani Lu, Kayo Togawa, Sophia S. Wang, Christina A. Clarke, Eunjung Lee, Hannah L. Park, Jane Sullivan-Halley, Susan L. Neuhausen, Leslie Bernstein

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study

Kavitha Krishnan, Laura Baglietto, Carmel Apicella, Jennifer Stone, Melissa C. Southey, Dallas R. English, Graham G. Giles, John L. Hopper

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus

Chenjie Zeng, Xingyi Guo, Jirong Long, Karoline B. Kuchenbaecker, Arnaud Droit, Kyriaki Michailidou, Maya Ghoussaini, Siddhartha Kar, Adam Freeman, John L. Hopper, Roger L. Milne, Manjeet K. Bolla, Qin Wang, Joe Dennis, Simona Agata, Shahana Ahmed, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Adalgeir Arason, Volker Arndt, Banu K. Arun, Brita Arver, Francois Bacot, Daniel Barrowdale, Caroline Baynes, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William J. Blot, Natalia V. Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise Borresen-Dale, Judith S. Brand, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Saundra S. Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Jane Carpenter, Jenny Chang-Claude, Ji-Yeob Choi, Kathleen B. M. Claes, Christine Clarke, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Miguel de la Hoya, Kim De Leeneer, Peter Devilee, Orland Diez, Susan M. Domchek, Michele Doody, Cecilia M. Dorfling, Thilo Dörk, Isabel dos-Santos-Silva, Martine Dumont, Miriam Dwek, Bernd Dworniczak, Kathleen Egan, Ursula Eilber, Zakaria Einbeigi, Bent Ejlertsen, Steve Ellis, Debra Frost, Fiona Lalloo, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Michael Friedlander, Eitan Friedman, Gaetana Gambino, Yu-Tang Gao, Judy Garber, Montserrat García-Closas, Andrea Gehrig, Francesca Damiola, Fabienne Lesueur, Sylvie Mazoyer, Dominique Stoppa-Lyonnet, Graham G. Giles, Andrew K. Godwin, David E. Goldgar, Anna González-Neira, Mark H. Greene, Pascal Guénel, Lothar Haeberle, Christopher A. Haiman, Emily Hallberg, Ute Hamann, Thomas V. O. Hansen, Steven Hart, Jaana M. Hartikainen, Mikael Hartman, Norhashimah Hassan, Sue Healey, Frans B. L. Hogervorst, Senno Verhoef, Carolyn B. Hendricks, Peter Hillemanns, Antoinette Hollestelle, Peter J. Hulick, David J. Hunter, Evgeny N. Imyanitov, Claudine Isaacs, Hidemi Ito, Anna Jakubowska, Ramunas Janavicius, Katarzyna Jaworska-Bieniek, Uffe Birk Jensen, Esther M. John, Charles Joly Beauparlant, Michael Jones, Maria Kabisch, Daehee Kang, Beth Y. Karlan, Saila Kauppila, Michael J. Kerin, Sofia Khan, Elza Khusnutdinova, Julia A. Knight, Irene Konstantopoulou, Peter Kraft, Ava Kwong, Yael Laitman, Diether Lambrechts, Conxi Lazaro, Loic Le Marchand, Chuen Neng Lee, Min Hyuk Lee, Jenny Lester, Jingmei Li, Annelie Liljegren, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Phuong L. Mai, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Frederik Marme, Keitaro Matsuo, Lesley McGuffog, Alfons Meindl, Florence Menegaux, Marco Montagna, Kenneth Muir, Anna Marie Mulligan, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Polly A. Newcomb, Silje Nord, Robert L. Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Curtis Olswold, Ana Osorio, Laura Papi, Tjoung-Won Park-Simon, Ylva Paulsson-Karlsson, Stephanie Peeters, Bernard Peissel, Paolo Peterlongo, Julian Peto, Georg Pfeiler, Catherine M. Phelan, Nadege Presneau, Paolo Radice, Nazneen Rahman, Susan J. Ramus, Muhammad Usman Rashid, Gad Rennert, Kerstin Rhiem, Anja Rudolph, Ritu Salani, Suleeporn Sangrajrang, Elinor J. Sawyer, Marjanka K Schmidt, Rita K. Schmutzler, Minouk J. Schoemaker, Peter Schürmann, Caroline Seynaeve, Chen-Yang Shen, Martha J. Shrubsole, Xiao-Ou Shu, Alice Sigurdson, Christian F. Singer, Susan Slager, Penny Soucy, Melissa Southey, Doris Steinemann, Anthony Swerdlow, Csilla I. Szabo, Sandrine Tchatchou, Manuel R. Teixeira, Soo H. Teo, Mary Beth Terry, Daniel C. Tessier, Alex Teulé, Mads Thomassen, Laima Tihomirova, Marc Tischkowitz, Amanda E. Toland, Nadine Tung, Clare Turnbull, Ans M. W. van den Ouweland, Elizabeth J. van Rensburg, David ven den Berg, Joseph Vijai, Shan Wang-Gohrke, Jeffrey N. Weitzel, Alice S. Whittemore, Robert Winqvist, Tien Y. Wong, Anna H. Wu, Drakoulis Yannoukakos, Jyh-Cherng Yu, Paul D. P. Pharoah, Per Hall, Georgia Chenevix-Trench, Alison M. Dunning, Jacques Simard, Fergus J. Couch, Antonis C. Antoniou, Douglas F. Easton, Wei Zheng, on behalf of EMBRACE, behalf of GEMO Study Collaborators, on behalf of HEBON, on behalf of KConFab, AOCS Investigators

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Systemic therapy for breast cancer and risk of subsequent contralateral breast cancer in the WECARE Study

Rikke Langballe, Lene Mellemkjær, Kathleen E. Malone, Charles F. Lynch, Esther M. John, Julia A. Knight, Leslie Bernstein, Jennifer Brooks, Michael Andersson, Anne S. Reiner, Xiaolin Liang, Meghan Woods, Patrick J. Concannon, Jonine L. Bernstein, the WECARE Study Collaborative Group

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Clonal relationships between lobular carcinoma in situ and other breast malignancies

Colin B. Begg, Irina Ostrovnaya, Jose V. Scarpa Carniello, Rita A. Sakr, Dilip Giri, Russell Towers, Michail Schizas, Marina De Brot, Victor P. Andrade, Audrey Mauguen, Venkatraman E. Seshan, Tari A. King

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Efficacy and safety of palbociclib in combination with letrozole as first-line treatment of ER-positive, HER2-negative, advanced breast cancer: expanded analyses of subgroups from the randomized pivotal trial PALOMA-1/TRIO-18

Richard S. Finn, John P. Crown, Johannes Ettl, Marcus Schmidt, Igor M. Bondarenko, Istvan Lang, Tamas Pinter, Katalin Boer, Ravindranath Patel, Sophia Randolph, Sindy T. Kim, Xin Huang, Patrick Schnell, Sashi Nadanaciva, Cynthia Huang Bartlett, Dennis J. Slamon

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification

Emma H. Allott, Joseph Geradts, Xuezheng Sun, Stephanie M. Cohen, Gary R. Zirpoli, Thaer Khoury, Wiam Bshara, Mengjie Chen, Mark E. Sherman, Julie R. Palmer, Christine B. Ambrosone, Andrew F. Olshan, Melissa A. Troester

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Proteomic analysis of breast tumors confirms the mRNA intrinsic molecular subtypes using different classifiers: a large-scale analysis of fresh frozen tissue samples

Sofia Waldemarson, Emila Kurbasic, Morten Krogh, Paolo Cifani, Tord Berggård, Åke Borg, Peter James

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

Zhi Hu, Jian-Hua Mao, Christina Curtis, Ge Huang, Shenda Gu, Laura Heiser, Marc E. Lenburg, James E. Korkola, Nora Bayani, Shamith Samarajiwa, Jose A. Seoane, Mark A. Dane, Amanda Esch, Heidi S. Feiler, Nicholas J. Wang, Mary Ann Hardwicke, Sylvie Laquerre, Jeff Jackson, Kenneth W. Wood, Barbara Weber, Paul T. Spellman, Samuel Aparicio, Richard Wooster, Carlos Caldas, Joe W. Gray

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets

Camile Castilho Fontelles, Luiza Nicolosi Guido, Mariana Papaléo Rosim, Fábia de Oliveira Andrade, Lu Jin, Jessica Inchauspe, Vanessa Cardoso Pires, Inar Alves de Castro, Leena Hilakivi-Clarke, Sonia de Assis, Thomas Prates Ong

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom

Minouk J. Schoemaker, Michael E. Jones, Lauren B. Wright, James Griffin, Emily McFadden, Alan Ashworth, Anthony J. Swerdlow

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence

Yuichiro Miyoshi, Tadahiko Shien, Akiko Ogiya, Naoko Ishida, Kieko Yamazaki, Rie Horii, Yoshiya Horimoto, Norikazu Masuda, Hiroyuki Yasojima, Touko Inao, Tomofumi Osako, Masato Takahashi, Nobumoto Tomioka, Yumi Endo, Mitsuchika Hosoda, Hiroyoshi Doihara, Shinichiro Miyoshi, Hiroko Yamashita, Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups

Dvir Netanely, Ayelet Avraham, Adit Ben-Baruch, Ella Evron, Ron Shamir

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice

Ruben Nogales-Cadenas, Ying Cai, Jhih-Rong Lin, Quanwei Zhang, Wen Zhang, Cristina Montagna, Zhengdong D. Zhang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Breast MRI contrast enhancement kinetics of normal parenchyma correlate with presence of breast cancer

Shandong Wu, Wendie A. Berg, Margarita L. Zuley, Brenda F. Kurland, Rachel C. Jankowitz, Robert Nishikawa, David Gur, Jules H. Sumkin

01.12.2016 | Letter | Ausgabe 1/2016 Open Access

Comment on: Tan WJ, Cima I, Choudhury Y, Wei X, Lim JCT, Thicke AA, Tan MH, Tan PH. A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions. Breast Cancer Research 2016;18:31

Joseph Loane

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Quantitative assessment of the spatial heterogeneity of tumor-infiltrating lymphocytes in breast cancer

Nikita L. Mani, Kurt A. Schalper, Christos Hatzis, Ozlen Saglam, Fattaneh Tavassoli, Meghan Butler, Anees B. Chagpar, Lajos Pusztai, David L. Rimm

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Breast cancer biologic and etiologic heterogeneity by young age and menopausal status in the Carolina Breast Cancer Study: a case-control study

Lynn Chollet-Hinton, Carey K. Anders, Chiu-Kit Tse, Mary Beth Bell, Yang Claire Yang, Lisa A. Carey, Andrew F. Olshan, Melissa A. Troester

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment

Mary E. Law, Renan B. Ferreira, Bradley J. Davis, Paul J. Higgins, Jae-Sung Kim, Ronald K. Castellano, Sixue Chen, Hendrik Luesch, Brian K. Law

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway

Aarti Sethuraman, Martin Brown, Tiffany N. Seagroves, Zhao-Hui Wu, Lawrence M. Pfeffer, Meiyun Fan

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Survival is associated with complete response on MRI after neoadjuvant chemotherapy in ER-positive HER2-negative breast cancer

Claudette E. Loo, Lisanne S. Rigter, Kenneth E. Pengel, Jelle Wesseling, Sjoerd Rodenhuis, Marie-Jeanne T. F. D. Vrancken Peeters, Karolina Sikorska, Kenneth G. A. Gilhuijs

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Combination of Paclitaxel and MG1 oncolytic virus as a successful strategy for breast cancer treatment

Marie-Claude Bourgeois-Daigneault, Lauren Elizabeth St-Germain, Dominic Guy Roy, Adrian Pelin, Amelia Sadie Aitken, Rozanne Arulanandam, Theresa Falls, Vanessa Garcia, Jean-Simon Diallo, John Cameron Bell

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Tumor-associated stromal cells as key contributors to the tumor microenvironment

Karen M. Bussard, Lysette Mutkus, Kristina Stumpf, Candelaria Gomez-Manzano, Frank C. Marini

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Adolescent fiber intake and mammographic breast density in premenopausal women

Lusine Yaghjyan, Gabriela L. Ghita, Bernard Rosner, Maryam Farvid, Kimberly A. Bertrand, Rulla M. Tamimi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Predicted 25-hydroxyvitamin D in relation to incidence of breast cancer in a large cohort of African American women

Julie R. Palmer, Hanna Gerlovin, Traci N. Bethea, Kimberly A. Bertrand, Michael F. Holick, Edward N. Ruiz-Narvaez, Lauren A. Wise, Stephen A. Haddad, Lucile L. Adams-Campbell, Harvey W. Kaufman, Lynn Rosenberg, Yvette C. Cozier

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific

Rania Chehade, Rachael Pettapiece-Phillips, Leonardo Salmena, Max Kotlyar, Igor Jurisica, Steven A. Narod, Mohammad R. Akbari, Joanne Kotsopoulos

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis

Ashley S. Felix, Petra Lenz, Ruth M. Pfeiffer, Stephen M. Hewitt, Jennifer Morris, Deesha A. Patel, Berta Geller, Pamela M. Vacek, Donald L. Weaver, Rachael E. Chicoine, John Shepherd, Amir Pasha Mahmoudzadeh, Jeff Wang, Bo Fan, Serghei Malkov, Sally D. Herschorn, Jason M. Johnson, Renata L. Cora, Louise A. Brinton, Mark E. Sherman, Gretchen L. Gierach

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Circadian clocks and breast cancer

Victoria Blakeman, Jack L. Williams, Qing-Jun Meng, Charles H. Streuli

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Plasma exosome microRNAs are indicative of breast cancer

Bethany N. Hannafon, Yvonne D. Trigoso, Cameron L. Calloway, Y. Daniel Zhao, David H. Lum, Alana L. Welm, Zhizhuang J. Zhao, Kenneth E. Blick, William C. Dooley, W. Q. Ding

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Beyond breast density: a review on the advancing role of parenchymal texture analysis in breast cancer risk assessment

Aimilia Gastounioti, Emily F. Conant, Despina Kontos

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines

Matthew J. Sikora, Britta M. Jacobsen, Kevin Levine, Jian Chen, Nancy E. Davidson, Adrian V. Lee, Caroline M. Alexander, Steffi Oesterreich

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Outcomes of contralateral prophylactic mastectomy in relation to familial history: a decision analysis (BRCR-D-16-00033)

Kalatu R. Davies, Abenaa M. Brewster, Isabelle Bedrosian, Patricia A. Parker, Melissa A. Crosby, Susan K. Peterson, Yu Shen, Robert J. Volk, Scott B. Cantor

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mammographic density and breast cancer risk: a mediation analysis

Megan S. Rice, Kimberly A. Bertrand, Tyler J. VanderWeele, Bernard A. Rosner, Xiaomei Liao, Hans-Olov Adami, Rulla M. Tamimi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells

Jessica Byerly, Gwyneth Halstead-Nussloch, Koichi Ito, Igor Katsyv, Hanna Y. Irie

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Impact of type of full-field digital image on mammographic density assessment and breast cancer risk estimation: a case-control study

Marta Cecilia Busana, Amanda Eng, Rachel Denholm, Mitch Dowsett, Sarah Vinnicombe, Steve Allen, Isabel dos-Santos-Silva

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Low expression of galectin-3 is associated with poor survival in node-positive breast cancers and mesenchymal phenotype in breast cancer stem cells

Matthias Ilmer, Nachman Mazurek, Michael Z. Gilcrease, James C. Byrd, Wendy A. Woodward, Thomas A. Buchholz, Kim Acklin, Karen Ramirez, Margarete Hafley, Eckhard Alt, Jody Vykoukal, Robert S. Bresalier

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Patient survival and tumor characteristics associated with CHEK2:p.I157T – findings from the Breast Cancer Association Consortium

Taru A. Muranen, Carl Blomqvist, Thilo Dörk, Anna Jakubowska, Päivi Heikkilä, Rainer Fagerholm, Dario Greco, Kristiina Aittomäki, Stig E. Bojesen, Mitul Shah, Alison M. Dunning, Valerie Rhenius, Per Hall, Kamila Czene, Judith S. Brand, Hatef Darabi, Jenny Chang-Claude, Anja Rudolph, Børge G. Nordestgaard, Fergus J. Couch, Steven N. Hart, Jonine Figueroa, Montserrat García-Closas, Peter A. Fasching, Matthias W. Beckmann, Jingmei Li, Jianjun Liu, Irene L. Andrulis, Robert Winqvist, Katri Pylkäs, Arto Mannermaa, Vesa Kataja, Annika Lindblom, Sara Margolin, Jan Lubinski, Natalia Dubrowinskaja, Manjeet K. Bolla, Joe Dennis, Kyriaki Michailidou, Qin Wang, Douglas F. Easton, Paul D. P. Pharoah, Marjanka K. Schmidt, Heli Nevanlinna

01.12.2016 | Review | Ausgabe 1/2016 Open Access

The genetics of breast cancer risk in the post-genome era: thoughts on study design to move past BRCA and towards clinical relevance

Andrew D. Skol, Mark M. Sasaki, Kenan Onel

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Novel mammographic image features differentiate between interval and screen-detected breast cancer: a case-case study

Fredrik Strand, Keith Humphreys, Abbas Cheddad, Sven Törnberg, Edward Azavedo, John Shepherd, Per Hall, Kamila Czene

01.12.2016 | Letter | Ausgabe 1/2016 Open Access

Lack of association between bovine leukemia virus and breast cancer in Chinese patients

Rong Zhang, Jingting Jiang, Weihong Sun, Jilei Zhang, Ke Huang, Xuewen Gu, Yi Yang, Xiulong Xu, Yufang Shi, Chengming Wang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review

Rachel Denholm, Bianca De Stavola, John H. Hipwell, Simon J. Doran, Marta C. Busana, Amanda Eng, Mona Jeffreys, Martin O. Leach, David Hawkes, Isabel dos Santos Silva

01.12.2016 | Editorial | Ausgabe 1/2016 Open Access

Extending the Developmental Origins of Health and Disease theory: does paternal diet contribute to breast cancer risk in daughters?

Stephanie Romanus, Patrick Neven, Adelheid Soubry

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups

Mustapha Abubakar, Nick Orr, Frances Daley, Penny Coulson, H. Raza Ali, Fiona Blows, Javier Benitez, Roger Milne, Herman Brenner, Christa Stegmaier, Arto Mannermaa, Jenny Chang-Claude, Anja Rudolph, Peter Sinn, Fergus J. Couch, Peter Devilee, Rob A. E. M. Tollenaar, Caroline Seynaeve, Jonine Figueroa, Mark E. Sherman, Jolanta Lissowska, Stephen Hewitt, Diana Eccles, Maartje J. Hooning, Antoinette Hollestelle, John W. M. Martens, Carolien H. M. van Deurzen, kConFab Investigators, Manjeet K. Bolla, Qin Wang, Michael Jones, Minouk Schoemaker, Jelle Wesseling, Flora E. van Leeuwen, Laura Van ‘t Veer, Douglas Easton, Anthony J. Swerdlow, Mitch Dowsett, Paul D. Pharoah, Marjanka K. Schmidt, Montserrat Garcia-Closas

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The impact of in situ breast cancer and family history on risk of subsequent breast cancer events and mortality - a population-based study from Sweden

Helena Sackey, Miao Hui, Kamila Czene, Helena Verkooijen, Gustaf Edgren, Jan Frisell, Mikael Hartman

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive lesions and metastasis

Cecilia W. Huo, Mark Waltham, Christine Khoo, Stephen B. Fox, Prue Hill, Shou Chen, Grace L. Chew, John T. Price, Chau H. Nguyen, Elizabeth D. Williams, Michael Henderson, Erik W. Thompson, Kara L. Britt

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Evidence of two distinct functionally specialized fibroblast lineages in breast stroma

Mikkel Morsing, Marie Christine Klitgaard, Abbas Jafari, René Villadsen, Moustapha Kassem, Ole William Petersen, Lone Rønnov-Jessen

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities

Sara Lindström, Akweley Ablorh, Brad Chapman, Alexander Gusev, Gary Chen, Constance Turman, A. Heather Eliassen, Alkes L. Price, Brian E. Henderson, Loic Le Marchand, Oliver Hofmann, Christopher A. Haiman, Peter Kraft

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Impact of CYP19A1 and ESR1 variants on early-onset side effects during combined endocrine therapy in the TEXT trial

Harriet Johansson, Kathryn P. Gray, Olivia Pagani, Meredith M. Regan, Giuseppe Viale, Valentina Aristarco, Debora Macis, Antonella Puccio, Susanne Roux, Rudolf Maibach, Marco Colleoni, Manuela Rabaglio, Karen N. Price, Alan S. Coates, Richard D. Gelber, Aron Goldhirsch, Roswitha Kammler, Bernardo Bonanni, Barbara A. Walley, the TEXT principal investigators

01.12.2016 | Letter | Ausgabe 1/2016 Open Access

The PALB2 p.Leu939Trp mutation is not associated with breast cancer risk

Irene Catucci, Paolo Radice, Roger L. Milne, Fergus J. Couch, Melissa C. Southey, Paolo Peterlongo

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women

Timothy R. Rebbeck, Tara M. Friebel, Nandita Mitra, Fei Wan, Stephanie Chen, Irene L. Andrulis, Paraskevi Apostolou, Norbert Arnold, Banu K. Arun, Daniel Barrowdale, Javier Benitez, Raanan Berger, Pascaline Berthet, Ake Borg, Saundra S. Buys, Trinidad Caldes, Jonathan Carter, Jocelyne Chiquette, Kathleen B. M. Claes, Fergus J. Couch, Cezary Cybulski, Mary B. Daly, Miguel de la Hoya, Orland Diez, Susan M. Domchek, Katherine L. Nathanson, Katarzyna Durda, Steve Ellis, D. Gareth Evans, Lenka Foretova, Eitan Friedman, Debra Frost, Patricia A. Ganz, Judy Garber, Gord Glendon, Andrew K. Godwin, Mark H. Greene, Jacek Gronwald, Eric Hahnen, Emily Hallberg, Ute Hamann, Thomas V. O. Hansen, Evgeny N. Imyanitov, Claudine Isaacs, Anna Jakubowska, Ramunas Janavicius, Katarzyna Jaworska-Bieniek, Esther M. John, Beth Y. Karlan, Bella Kaufman, KConFab investigators, Ava Kwong, Yael Laitman, Christine Lasset, Conxi Lazaro, Jenny Lester, Niklas Loman, Jan Lubinski, Siranoush Manoukian, Gillian Mitchell, Marco Montagna, Susan L. Neuhausen, Heli Nevanlinna, Dieter Niederacher, Robert L. Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Sue Kyung Park, Marion Piedmonte, Paolo Radice, Christine Rappaport-Fuerhauser, Matti A. Rookus, Caroline Seynaeve, Jacques Simard, Christian F. Singer, Penny Soucy, Melissa Southey, Dominique Stoppa-Lyonnet, Grzegorz Sukiennicki, Csilla I. Szabo, Mariella Tancredi, Manuel R. Teixeira, Soo-Hwang Teo, Mary Beth Terry, Mads Thomassen, Laima Tihomirova, Marc Tischkowitz, Amanda Ewart Toland, Aleksandra Toloczko-Grabarek, Nadine Tung, Elizabeth J. van Rensburg, Danylo Villano, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N. Weitzel, Jamal Zidan, Kristin K. Zorn, Lesley McGuffog, Douglas Easton, Georgia Chenevix-Trench, Antonis C. Antoniou, Susan J. Ramus, EMBRACE, HEBON

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC

Nicolas I. Griffin, Gayatri Sharma, Xiangshan Zhao, Sameer Mirza, Shashank Srivastava, Bhavana J. Dave, Mohammed Aleskandarany, Emad Rakha, Shakur Mohibi, Hamid Band, Vimla Band

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI

Li-Liang Li, Ai-Min Xue, Bei-Xu Li, Yi-Wen Shen, Yu-Hua Li, Cheng-Liang Luo, Ming-Chang Zhang, Jie-Qing Jiang, Zu-De Xu, Jian-Hui Xie, Zi-Qin Zhao

01.12.2016 | Meeting report | Ausgabe 1/2016 Open Access

Complexity galore: 3D cultures, biomechanics and systems medicine at the eighth ENBDC workshop “Methods in Mammary Gland Development and Cancer”

Bethan Lloyd-Lewis, Anoeska A. A. van de Moosdijk, Mohamed Bentires-Alj, Robert B. Clarke, Renée van Amerongen

01.12.2016 | Letter | Ausgabe 1/2016 Open Access

The complexities and caveats of lineage tracing in the mammary gland

Anne C. Rios, Nai Yang Fu, Joseph Cursons, Geoffrey J. Lindeman, Jane E. Visvader

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups

Dvir Netanely, Ayelet Avraham, Adit Ben-Baruch, Ella Evron, Ron Shamir

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers

Cigdem Selli, J. Michael Dixon, Andrew H. Sims

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Propranolol and survival from breast cancer: a pooled analysis of European breast cancer cohorts

Chris R. Cardwell, Anton Pottegård, Evelien Vaes, Hans Garmo, Liam J. Murray, Chris Brown, Pauline A. J. Vissers, Michael O’Rorke, Kala Visvanathan, Deirdre Cronin-Fenton, Harlinde De Schutter, Mats Lambe, Des G. Powe, Myrthe P. P. van Herk-Sukel, Anna Gavin, Søren Friis, Linda Sharp, Kathleen Bennett

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: a case-control study

Yu-Sen Huang, Jenny Ling-Yu Chen, Chiun-Sheng Huang, Sung-Hsin Kuo, Fu-Shan Jaw, Yao-Hui Tseng, Wei-Chun Ko, Yeun-Chung Chang

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers

Giulia Bottai, Carlotta Raschioni, Agnese Losurdo, Luca Di Tommaso, Corrado Tinterri, Rosalba Torrisi, Jorge S. Reis-Filho, Massimo Roncalli, Christos Sotiriou, Armando Santoro, Alberto Mantovani, Sherene Loi, Libero Santarpia

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status

Serghei Malkov, John A. Shepherd, Christopher G. Scott, Rulla M. Tamimi, Lin Ma, Kimberly A. Bertrand, Fergus Couch, Matthew R. Jensen, Amir P. Mahmoudzadeh, Bo Fan, Aaron Norman, Kathleen R. Brandt, V. Shane Pankratz, Celine M. Vachon, Karla Kerlikowske

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors

Elodie Chantalat, Frédéric Boudou, Henrik Laurell, Gaëlle Palierne, René Houtman, Diana Melchers, Philippe Rochaix, Thomas Filleron, Alexandre Stella, Odile Burlet-Schiltz, Anne Brouchet, Gilles Flouriot, Raphaël Métivier, Jean-François Arnal, Coralie Fontaine, Françoise Lenfant

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry

Wanqing Wen, Xiao-ou Shu, Xingyi Guo, Qiuyin Cai, Jirong Long, Manjeet K. Bolla, Kyriaki Michailidou, Joe Dennis, Qin Wang, Yu-Tang Gao, Ying Zheng, Alison M. Dunning, Montserrat García-Closas, Paul Brennan, Shou-Tung Chen, Ji-Yeob Choi, Mikael Hartman, Hidemi Ito, Artitaya Lophatananon, Keitaro Matsuo, Hui Miao, Kenneth Muir, Suleeporn Sangrajrang, Chen-Yang Shen, Soo H. Teo, Chiu-chen Tseng, Anna H. Wu, Cheng Har Yip, Jacques Simard, Paul D. P. Pharoah, Per Hall, Daehee Kang, Yongbing Xiang, Douglas F. Easton, Wei Zheng

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

Adelaide I. J. Young, Andrew M. K. Law, Lesley Castillo, Sabrina Chong, Hayley D. Cullen, Martin Koehler, Sebastian Herzog, Tilman Brummer, Erinna F. Lee, Walter D. Fairlie, Morghan C. Lucas, David Herrmann, Amr Allam, Paul Timpson, D. Neil Watkins, Ewan K. A. Millar, Sandra A. O’Toole, David Gallego-Ortega, Christopher J. Ormandy, Samantha R. Oakes

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Safety and efficacy of vinorelbine in combination with pertuzumab and trastuzumab for first-line treatment of patients with HER2-positive locally advanced or metastatic breast cancer: VELVET Cohort 1 final results

Edith A. Perez, José Manuel López-Vega, Thierry Petit, Claudio Zamagni, Valerie Easton, Julia Kamber, Eleonora Restuccia, Michael Andersson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Imaging the mammary gland and mammary tumours in 3D: optical tissue clearing and immunofluorescence methods

Bethan Lloyd-Lewis, Felicity M. Davis, Olivia B. Harris, Jessica R. Hitchcock, Filipe C. Lourenco, Mathias Pasche, Christine J. Watson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Involution of breast tissue and mammographic density

Gertraud Maskarinec, Dan Ju, David Horio, Lenora W. M. Loo, Brenda Y. Hernandez

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Circulating cell-free DNA-based epigenetic assay can detect early breast cancer

Natsue Uehiro, Fumiaki Sato, Fengling Pu, Sunao Tanaka, Masahiro Kawashima, Kosuke Kawaguchi, Masahiro Sugimoto, Shigehira Saji, Masakazu Toi

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems

Anya Burton, Graham Byrnes, Jennifer Stone, Rulla M. Tamimi, John Heine, Celine Vachon, Vahit Ozmen, Ana Pereira, Maria Luisa Garmendia, Christopher Scott, John H. Hipwell, Caroline Dickens, Joachim Schüz, Mustafa Erkin Aribal, Kimberly Bertrand, Ava Kwong, Graham G. Giles, John Hopper, Beatriz Pérez Gómez, Marina Pollán, Soo-Hwang Teo, Shivaani Mariapun, Nur Aishah Mohd Taib, Martín Lajous, Ruy Lopez-Riduara, Megan Rice, Isabelle Romieu, Anath Arzee Flugelman, Giske Ursin, Samera Qureshi, Huiyan Ma, Eunjung Lee, Reza Sirous, Mehri Sirous, Jong Won Lee, Jisun Kim, Dorria Salem, Rasha Kamal, Mikael Hartman, Hui Miao, Kee-Seng Chia, Chisato Nagata, Sudhir Vinayak, Rose Ndumia, Carla H. van Gils, Johanna O. P. Wanders, Beata Peplonska, Agnieszka Bukowska, Steve Allen, Sarah Vinnicombe, Sue Moss, Anna M. Chiarelli, Linda Linton, Gertraud Maskarinec, Martin J. Yaffe, Norman F. Boyd, Isabel dos-Santos-Silva, Valerie A. McCormack

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis

Elizabeth A. Wellberg, Stevi Johnson, Jessica Finlay-Schultz, Andrew S. Lewis, Kristina L. Terrell, Carol A. Sartorius, E. Dale Abel, William J. Muller, Steven M. Anderson

01.12.2016 | Research article | Ausgabe 1/2016 Open Access

Lifetime body size and estrogen-receptor-positive breast cancer risk in the California Teachers Study cohort

Pamela L. Horn-Ross, Alison J. Canchola, Leslie Bernstein, Susan L. Neuhausen, David O. Nelson, Peggy Reynolds

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