Ausgabe 3/2014
Inhalt (31 Artikel)
Breast cancer brain metastases: evidence for neuronal-like adaptation in a ‘breast-to-brain’ transition?
Amanda ED Van Swearingen, Marni B Siegel, Carey K Anders
CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer
Olafur A Stefansson, Manel Esteller
Breast cancer intra-tumor heterogeneity
Luciano G Martelotto, Charlotte KY Ng, Salvatore Piscuoglio, Britta Weigelt, Jorge S Reis-Filho
Endocrine therapy: defining the path of least resistance
Andrew Stone, Elizabeth A Musgrove
Adjusting the incidence increase when screening for statistical lead time will always give estimates of overdiagnosis close to zero
Per-Henrik Zahl
Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers
Johnathan A Watkins, Sheeba Irshad, Anita Grigoriadis, Andrew NJ Tutt
Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy
Marieke A Vollebergh, Esther H Lips, Petra M Nederlof, Lodewyk FA Wessels, Jelle Wesseling, Marc J vd Vijver, Elisabeth GE de Vries, Harm van Tinteren, Jos Jonkers, Michael Hauptmann, Sjoerd Rodenhuis, Sabine C Linn
The mechanistic target for rapamycin pathway is related to the phosphorylation score for estrogen receptor-α in human breast tumors in vivo
Anuraag Shrivastav, Mary Christine Bruce, Danira Jaksic, Tarek Bader, Srinivas Seekallu, Carla Penner, Zoann Nugent, Peter Watson, Leigh Murphy
JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI
Li-Liang Li, Ai-Min Xue, Bei-Xu Li, Yi-Wen Shen, Yu-Hua Li, Cheng-Liang Luo, Ming-Chang Zhang, Jie-Qing Jiang, Zu-De Xu, Jian-Hui Xie, Zi-Qin Zhao
Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic human breast tumors
Alice Faversani, Valentina Vaira, Giacomina P Moro, Delfina Tosi, Alessia Lopergolo, David C Schultz, Dayana Rivadeneira, Dario C Altieri, Silvano Bosari
Breast-related effects of selective estrogen receptor modulators and tissue-selective estrogen complexes
Carolyn L Smith, Richard J Santen, Barry Komm, Sebastian Mirkin
The molecular landscape of the normal human breast – defining normal
Heidi N Hilton, J Dinny Graham
C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment
Nissar Ahmad Wani, Mohd W Nasser, Dinesh K Ahirwar, Helong Zhao, Zhenhua Miao, Konstantin Shilo, Ramesh K Ganju
VAV3 mediates resistance to breast cancer endocrine therapy
Helena Aguilar, Ander Urruticoechea, Pasi Halonen, Kazuma Kiyotani, Taisei Mushiroda, Xavier Barril, Jordi Serra-Musach, Abul Islam, Livia Caizzi, Luciano Di Croce, Ekaterina Nevedomskaya, Wilbert Zwart, Josefine Bostner, Elin Karlsson, Gizeh Pérez Tenorio, Tommy Fornander, Dennis C Sgroi, Rafael Garcia-Mata, Maurice PHM Jansen, Nadia García, Núria Bonifaci, Fina Climent, María Teresa Soler, Alejo Rodríguez-Vida, Miguel Gil, Joan Brunet, Griselda Martrat, Laia Gómez-Baldó, Ana I Extremera, Agnes Figueras, Josep Balart, Robert Clarke, Kerry L Burnstein, Kathryn E Carlson, John A Katzenellenbogen, Miguel Vizoso, Manel Esteller, Alberto Villanueva, Ana B Rodríguez-Peña, Xosé R Bustelo, Yusuke Nakamura, Hitoshi Zembutsu, Olle Stål, Roderick L Beijersbergen, Miguel Angel Pujana
A genomic analysis of mouse models of breast cancer reveals molecular features ofmouse models and relationships to human breast cancer
Daniel P Hollern, Eran R Andrechek
An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer
Misako Sato, Mitsutaka Kadota, Binwu Tang, Howard H Yang, Yu-an Yang, Mengge Shan, Jia Weng, Michael A Welsh, Kathleen C Flanders, Yoshiko Nagano, Aleksandra M Michalowski, Robert J Clifford, Maxwell P Lee, Lalage M Wakefield
Construction and evaluation of a novel humanized HER2-specific chimeric receptor
Meili Sun, Huan Shi, Chuanyong Liu, Jie Liu, Xianqiang Liu, Yuping Sun
Aldehyde dehydrogenase and estrogen receptor define a hierarchy of cellular differentiation in the normal human mammary epithelium
Gabriella Honeth, Sara Lombardi, Christophe Ginestier, Minhee Hur, Rebecca Marlow, Bharath Buchupalli, Ireneusz Shinomiya, Patrycja Gazinska, Silvia Bombelli, Vernie Ramalingam, Anand D Purushotham, Sarah E Pinder, Gabriela Dontu
Mesenchymal precursor cells maintain the differentiation and proliferation potentials of breast epithelial cells
Stephan Duss, Heike Brinkhaus, Adrian Britschgi, Erik Cabuy, Daniel M Frey, Dirk J Schaefer, Mohamed Bentires-Alj
Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells
Ylenia Lombardo, Monica Faronato, Aleksandra Filipovic, Valentina Vircillo, Luca Magnani, R Charles Coombes
Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population
Charmaine Pei Ling Lee, Astrid Irwanto, Agus Salim, Jian-min Yuan, Jianjun Liu, Woon Puay Koh, Mikael Hartman
Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: a randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer
Edith A Perez, Sara A Hurvitz, Lukas C Amler, Kirsten E Mundt, Vivian Ng, Ellie Guardino, Luca Gianni
Relationship of PIK3CA mutation and pathway activity with antiproliferative response to aromatase inhibition
Elena López-Knowles, Corrinne V Segal, Qiong Gao, Isaac Garcia-Murillas, Nicholas C Turner, Ian Smith, Lesley-Ann Martin, Mitch Dowsett
Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity
Yuhki Yokoyama, Ayaka Matsumoto, Miki Hieda, Yoshimi Shinchi, Eri Ogihara, Mai Hamada, Yu Nishioka, Hiroshi Kimura, Katsuhide Yoshidome, Masahiko Tsujimoto, Nariaki Matsuura
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells
Guelaguetza Vazquez-Ortiz, Cristine Chisholm, Xiaoling Xu, Tyler J Lahusen, Cuiling Li, Srilatha Sakamuru, Ruili Huang, Craig J Thomas, Menghang Xia, Chuxia Deng
Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models
Luigi Formisano, Lucia Nappi, Roberta Rosa, Roberta Marciano, Claudia D’Amato, Valentina D’Amato, Vincenzo Damiano, Lucia Raimondo, Francesca Iommelli, Antonella Scorziello, Giancarlo Troncone, Bianca Maria Veneziani, Sarah J Parsons, Sabino De Placido, Roberto Bianco
Polarity gene alterations in pure invasive micropapillary carcinomas of the breast
Nadège Gruel, Vanessa Benhamo, Jaydutt Bhalshankar, Tatiana Popova, Paul Fréneaux, Laurent Arnould, Odette Mariani, Marc-Henri Stern, Virginie Raynal, Xavier Sastre-Garau, Roman Rouzier, Olivier Delattre, Anne Vincent-Salomon
Novel serum protein biomarker panel revealed by mass spectrometry and its prognostic value in breast cancer
Liping Chung, Katrina Moore, Leo Phillips, Frances M Boyle, Deborah J Marsh, Robert C Baxter
Proposed new clinicopathological surrogate definitions of luminal A and luminal B (HER2-negative) intrinsic breast cancer subtypes
Patrick Maisonneuve, Davide Disalvatore, Nicole Rotmensz, Giuseppe Curigliano, Marco Colleoni, Silvia Dellapasqua, Giancarlo Pruneri, Mauro G Mastropasqua, Alberto Luini, Fabio Bassi, Gianmatteo Pagani, Giuseppe Viale, Aron Goldhirsch
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
Nichola Johnson, Frank Dudbridge, Nick Orr, Lorna Gibson, Michael E Jones, Minouk J Schoemaker, Elizabeth J Folkerd, Ben P Haynes, John L Hopper, Melissa C Southey, Gillian S Dite, Carmel Apicella, Marjanka K Schmidt, Annegien Broeks, Laura J Van’t Veer, Femke Atsma, Kenneth Muir, Artitaya Lophatananon, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Stefan P Renner, Elinor Sawyer, Ian Tomlinson, Michael Kerin, Nicola Miller, Barbara Burwinkel, Frederik Marme, Andreas Schneeweiss, Christof Sohn, Pascal Guénel, Therese Truong, Emilie Cordina, Florence Menegaux, Stig E Bojesen, Børge G Nordestgaard, Henrik Flyger, Roger Milne, M Pilar Zamora, Jose Ignacio Arias Perez, Javier Benitez, Leslie Bernstein, Hoda Anton-Culver, Argyrios Ziogas, Christina Clarke Dur, Hermann Brenner, Heiko Müller, Volker Arndt, Aida Karina Dieffenbach, Alfons Meindl, Joerg Heil, Claus R Bartram, Rita K Schmutzler, Hiltrud Brauch, Christina Justenhoven, Yon-Dschun Ko, Heli Nevanlinna, Taru A Muranen, Kristiina Aittomäki, Carl Blomqvist, Keitaro Matsuo, Thilo Dörk, Natalia V Bogdanova, Natalia N Antonenkova, Annika Lindblom, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Georgia Chenevix-Trench, Jonathan Beesley, Anna H Wu, David Van den Berg, Chiu-Chen Tseng, Diether Lambrechts, Dominiek Smeets, Patrick Neven, Hans Wildiers, Jenny Chang-Claude, Anja Rudolph, Stefan Nickels, Dieter Flesch-Janys, Paolo Radice, Paolo Peterlongo, Bernardo Bonanni, Valeria Pensotti, Fergus J Couch, Janet E Olson, Xianshu Wang, Zachary Fredericksen, Vernon S Pankratz, Graham G Giles, Gianluca Severi, Laura Baglietto, Chris Haiman, Jacques Simard, Mark S Goldberg, France Labrèche, Martine Dumont, Penny Soucy, Soo Teo, Cheng Har Yip, Sze Yee Phuah, Belinda K Cornes, Vessela N Kristensen, Grethe Grenaker Alnæs, Anne-Lise Børresen-Dale, Wei Zheng, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Peter Devillee, Jonine Figueroa, Stephen J Chanock, Jolanta Lissowska, Mark E Sherman, Per Hall, Nils Schoof, Maartje Hooning, Antoinette Hollestelle, Rogier A Oldenburg, Madeleine Tilanus-Linthorst, Jianjun Liu, Angie Cox, Ian W Brock, Malcolm WR Reed, Simon S Cross, William Blot, Lisa B Signorello, Paul DP Pharoah, Alison M Dunning, Mitul Shah, Daehee Kang, Dong-Young Noh, Sue K Park, Ji-Yeob Choi, Mikael Hartman, Hui Miao, Wei Yen Lim, Anthony Tang, Ute Hamann, Asta Försti, Thomas Rüdiger, Hans Ulrich Ulmer, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Suleeporn Sangrajrang, Valerie Gaborieau, Paul Brennan, James McKay, Susan Slager, Amanda E Toland, Celine Vachon, Drakoulis Yannoukakos, Chen-Yang Shen, Jyh-Cherng Yu, Chiun-Sheng Huang, Ming-Feng Hou, Anna González-Neira, Daniel C Tessier, Daniel Vincent, Francois Bacot, Craig Luccarini, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Jean Wang, Douglas F Easton, Montserrat García-Closas, Mitch Dowsett, Alan Ashworth, Anthony J Swerdlow, Julian Peto, Isabel dos Santos Silva, Olivia Fletcher
Rare key functional domain missense substitutions in MRE11A, RAD50, and NBNcontribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study
Francesca Damiola, Maroulio Pertesi, Javier Oliver, Florence Le Calvez-Kelm, Catherine Voegele, Erin L Young, Nivonirina Robinot, Nathalie Forey, Geoffroy Durand, Maxime P Vallée, Kayoko Tao, Terrell C Roane, Gareth J Williams, John L Hopper, Melissa C Southey, Irene L Andrulis, Esther M John, David E Goldgar, Fabienne Lesueur, Sean V Tavtigian