Background
Methods
Study population
Breast cancer subtype definition
Statistical analysis
Results
Characteristic | Overall (%) | A-like (N = 1016/34%) | % | B-like (N = 989/33%) | % | HER2-enriched (N = 387/13%) | % | Triple-neg. (N = 620/20%) | % | P valuea |
---|---|---|---|---|---|---|---|---|---|---|
Age, yrs | ||||||||||
Mean (range) | 51.6 (19, 91) | 52.6 (24–90) | 51.1 (19, 90) | 51.6 (23, 91) | 51.5 (21, 87) | |||||
< 35 | 180 (5) | 47 | 4.6 | 49 | 5.0 | 26 | 6.7 | 40 | 6.5 |
0.01
|
35–45 | 711 (21) | 192 | 18.9 | 219 | 22.1 | 76 | 19.7 | 144 | 23.2 | |
45–55 | 1204 (36) | 368 | 36.2 | 366 | 37.0 | 136 | 35.1 | 203 | 32.7 | |
55–65 | 806 (24) | 241 | 23.7 | 246 | 24.9 | 105 | 27.1 | 143 | 23.1 | |
65–75 | 364 (11) | 135 | 13.3 | 90 | 9.1 | 35 | 9.1 | 65 | 10.5 | |
> 75 | 90 (3) | 33 | 3.3 | 19 | 1.9 | 9 | 2.3 | 25 | 4.0 | |
Ethnicity | ||||||||||
Chinese | 1626 (48) | 567 | 55.8 | 435 | 44 | 180 | 46.5 | 275 | 44.4 |
< 0.0001
|
Malay | 801 (24) | 204 | 20.1 | 263 | 26.6 | 104 | 26.9 | 155 | 25 | |
Native | 928 (28) | 245 | 24.1 | 291 | 29.4 | 103 | 26.6 | 190 | 30.6 | |
Menarche | ||||||||||
≤ 12 yrs | 1105 (33) | 344 | 34.1 | 326 | 33.2 | 118 | 30.8 | 190 | 30.9 | 0.20 |
13 yrs | 1117 (34) | 318 | 31.5 | 340 | 34.7 | 148 | 38.6 | 201 | 32.7 | |
14 yrs | 548 (16) | 163 | 16.2 | 167 | 17 | 60 | 15.7 | 111 | 18 | |
≥ 15 yrs | 559 (17) | 184 | 18.2 | 148 | 15.1 | 57 | 14.9 | 113 | 18.4 | |
Menopause | ||||||||||
≤ 50 yrs | 428 (29) | 146 | 32.7 | 128 | 29.7 | 38 | 23.2 | 87 | 31.6 | 0.14 |
> 50 yrs | 1031 (71) | 301 | 67.3 | 303 | 70.3 | 126 | 76.8 | 188 | 68.4 | |
Parity | ||||||||||
Nulliparous | 745 (22) | 242 | 23.8 | 224 | 22.6 | 77 | 19.9 | 128 | 20.6 | 0.29 |
Parous | 2601 (78) | 774 | 76.2 | 765 | 77.4 | 310 | 80.1 | 492 | 79.4 | |
Age at FFPb, yrs | ||||||||||
< 21 | 466 (18) | 116 | 15 | 158 | 20.7 | 54 | 17.4 | 95 | 19.3 |
0.02
|
21–24.9 | 1011 (39) | 284 | 36.7 | 287 | 37.5 | 129 | 41.6 | 199 | 40.5 | |
25–30 | 864 (33) | 275 | 35.5 | 248 | 32.4 | 103 | 33.2 | 154 | 31.4 | |
> 30 | 259 (10) | 99 | 12.8 | 72 | 9.4 | 24 | 7.7 | 43 | 8.7 | |
Breastfeeding | ||||||||||
No | 377 (14) | 133 | 17.2 | 103 | 13.5 | 31 | 10 | 64 | 13 |
0.01
|
Yes | 2224 (86) | 641 | 82.9 | 662 | 86.5 | 279 | 90 | 428 | 87 | |
Breastfeeding duration | ||||||||||
< 6 months | 927 (52) | 285 | 54.2 | 280 | 51.8 | 111 | 49.6 | 175 | 51.3 | 0.40 |
6–10 months | 374 (21) | 112 | 21.3 | 122 | 22.6 | 48 | 21.4 | 62 | 18.2 | |
> 10 months | 489 (27) | 129 | 24.5 | 138 | 25.6 | 65 | 29.0 | 104 | 30.5 | |
BMI, kg/m2 | ||||||||||
< 18.5 | 1253 (39) | 373 | 37.8 | 336 | 35.1 | 163 | 43.7 | 240 | 40.2 |
0.03
|
18.5–24.9 | 565 (17) | 160 | 16.2 | 172 | 18 | 68 | 18.2 | 114 | 19.1 | |
25–29.9 | 998 (31) | 317 | 32.2 | 301 | 31.4 | 104 | 27.9 | 177 | 29.6 | |
≥ 30 | 433 (13) | 136 | 13.8 | 148 | 15.5 | 38 | 10.2 | 66 | 11.1 | |
Family history | ||||||||||
No | 2835 (86) | 840 | 84 | 854 | 87.8 | 338 | 88 | 516 | 84.9 |
0.05
|
Yes | 468 (14) | 160 | 16 | 119 | 12.2 | 46 | 12 | 92 | 15.1 | |
Histological grade | ||||||||||
Well diff. | 365 (11) | 212 | 20.9 | 67 | 6.8 | 10 | 2.6 | 27 | 4.4 |
< 0.0001
|
Moderately diff. | 1790 (55) | 781 | 76.9 | 442 | 44.7 | 180 | 46.5 | 238 | 38.4 | |
Poorly diff. | 1123 (34) | – | – | 473 | 47.8 | 192 | 49.6 | 344 | 55.5 | |
Stage | ||||||||||
I | 454 (14) | 222 | 22.1 | 100 | 10.3 | 34 | 8.9 | 61 | 10 |
< 0.0001
|
II | 1353 (42) | 444 | 44.2 | 395 | 40.6 | 136 | 35.6 | 249 | 40.9 | |
III | 1005 (31) | 241 | 24 | 330 | 33.9 | 150 | 39.3 | 203 | 33.3 | |
IV | 421 (13) | 78 | 7.8 | 139 | 14.3 | 57 | 14.9 | 91 | 14.9 | |
Tumor size | ||||||||||
< 2 cm | 2137 (64) | 761 | 75.6 | 620 | 63.3 | 210 | 54.7 | 353 | 57.8 |
< 0.0001
|
2–5 cm | 522 (16) | 121 | 12 | 150 | 15.3 | 83 | 21.6 | 104 | 17 | |
> 5 cm | 660 (20) | 125 | 12.4 | 209 | 21.4 | 91 | 23.7 | 154 | 25.2 | |
Node status | ||||||||||
0 | 1517 (46) | 566 | 55.7 | 368 | 37.2 | 146 | 37.7 | 272 | 43.9 |
< 0.0001
|
1 | 922 (28) | 249 | 24.5 | 310 | 31.3 | 95 | 24.5 | 163 | 26.3 | |
2 | 480 (15) | 120 | 11.8 | 156 | 15.8 | 70 | 18.1 | 94 | 15.2 | |
≥ 3 | 375 (11) | 72 | 7.1 | 139 | 14.1 | 68 | 17.6 | 75 | 12.1 | |
Endocrine | ||||||||||
None | 1248 (40) | 48 | 5.1 | 126 | 14.2 | 357 | 97.5 | 584 | 97.2 |
< 0.0001
|
Tamoxifen | 1456 (47) | 687 | 72.9 | 591 | 66.7 | 7 | 1.9 | 15 | 2.5 | |
Aromatase Inhibitor | 395 (13) | 207 | 22.0 | 169 | 19.1 | 2 | 0.6 | 2 | 0.3 | |
Chemotherapy | ||||||||||
No | 799 (24) | 371 | 37.3 | 177 | 18.3 | 62 | 16.4 | 95 | 15.5 |
< 0.0001
|
Yes | 2483 (76) | 625 | 62.7 | 789 | 81.7 | 317 | 83.6 | 519 | 84.5 | |
Surgery | ||||||||||
No | 389 (12) | 80 | 10.2 | 106 | 15.8 | 53 | 19.4 | 87 | 16.3 |
< 0.0001
|
Yes | 2841 (88) | 913 | 89.8 | 833 | 84.2 | 312 | 80.6 | 519 | 83.7 | |
Radiotherapy | ||||||||||
No | 800 (26) | 261 | 27.7 | 218 | 24.6 | 79 | 23.9 | 149 | 26.4 |
0.01
|
Yes | 2235 (74) | 683 | 72.3 | 669 | 75.4 | 252 | 76.1 | 416 | 73.6 |
Distribution of risk factors and clinicopathological characteristics by tumor subtype
Risk factor | Subtype | ||||||
---|---|---|---|---|---|---|---|
A-like (comparison group) | B-like | HER2-enriched | Triple-negative | ||||
N | N | ORa (95% CI) | N | OR (95% CI) | N | OR (95% CI) | |
Ethnicity | |||||||
Chinese | 567 | 435 | 1.00 (reference) | 180 | 1.00 (reference) | 275 | 1.00 (reference) |
Malay | 204 | 263 |
1.50 (1.18, 1.90)
| 104 |
1.54 (1.13, 2.11)
| 155 |
1.51 (1.14, 1.98)
|
Native | 245 | 291 |
1.39 (1.10, 1.76)
| 103 | 1.21 (0.88, 1.66) | 190 |
1.50 (1.15, 1.95)
|
P value |
0.001
| 0.10 |
< 0.001
| ||||
Menarche | |||||||
≤ 12 yrs | 344 | 326 | 1.00 (reference) | 118 | 1.00 (reference) | 190 | 1.00 (reference) |
13 yrs | 318 | 340 | 1.14 (0.91, 1.43) | 148 | 1.31 (0.98, 1.77) | 201 | 1.15 (0.88, 1.49) |
14 yrs | 163 | 167 | 1.04 (0.79, 1.38) | 60 | 1.02 (0.70, 1.48) | 111 | 1.18 (0.86, 1.61) |
≥ 15 yrs | 184 | 148 | 0.83 (0.63, 1.10) | 57 | 0.87 (0.59, 1.28) | 113 | 1.10 (0.80, 1.50) |
P value | 0.43 | 0.51 | 0.31 | ||||
Parity and BFb | |||||||
Nulliparous | 242 | 224 | 1.00 (reference) | 77 | 1.00 (reference) | 128 | 1.00 (reference) |
Parous and No BF | 133 | 103 | 1.26 (0.84, 1.90) | 31 | 1.07 (0.76, 1.52) | 64 | 1.25 (0.77, 2.00) |
Parous and BF | 641 | 662 |
1.44 (1.05, 1.98)
| 279 |
1.64 (1.06, 2.55)
| 428 |
1.54 (1.07, 2.22)
|
P value | 0.17 |
0.005
| 0.12 | ||||
Age at FFPc | |||||||
< 21 yrs | 116 | 158 | 1.00 (reference) | 54 | 1.00 (reference) | 95 | 1.00 (reference) |
21–24.9 yrs | 284 | 287 | 0.78 (0.57, 1.05) | 129 | 1.01 (0.67, 1.51) | 199 | 0.90 (0.64, 1.26) |
25–30 yrs | 275 | 248 | 0.77 (0.57, 1.06) | 103 | 0.91 (0.60, 1.38) | 154 | 0.77 (0.54, 1.09) |
> 30 yrs | 99 | 72 |
0.63 (0.42, 0.94)
| 24 | 0.57 (0.32, 1.02) | 43 |
0.58 (0.36, 0.93)
|
P value | 0.35 | 0.06 | 0.38 | ||||
Family history | |||||||
No | 840 | 854 | 1.00 (reference) | 338 | 1.00 (reference) | 516 | 1.00 (reference) |
Yes | 160 | 119 |
0.72 (0.55, 0.94)
| 46 | 0.71 (0.49, 1.02) | 92 | 0.92 (0.69, 1.23) |
P value |
0.02
|
0.05
| 0.62 | ||||
BMI, kg/m2 | |||||||
18.5–24.9 | 160 | 172 | 1.00 (reference) | 68 | 1.00 (reference) | 114 | 1.00 (reference) |
< 18.5 | 373 | 336 | 0.89 (0.69, 1.17) | 163 | 1.07 (0.76, 1.51) | 240 | 0.96 (0.72, 1.29) |
P value | 0.38 | 0.65 | 0.76 | ||||
25–29.9 | 317 | 301 | 0.86 (0.65, 1.12) | 104 | 0.74 (0.51, 1.06) | 177 | 0.75 (0.55, 1.02) |
P value | 0.27 | 0.13 | 0.08 | ||||
≥ 30 | 136 | 148 | 0.90 (0.65, 1.24) | 38 |
0.55 (0.34, 0.89)
| 66 |
0.59 (0.40, 0.88)
|
P value | 0.62 |
0.02
|
0.01
|
Breast cancer risk factors in relation to all-cause mortality and recurrence by subtype
Risk factor1a | 10-year all-cause mortality | P hetd | |||||||
---|---|---|---|---|---|---|---|---|---|
A-like | B-like | HER2-enriched | Triple-negative | ||||||
N/events | HR (95% CI) | N/events | HR (95% CI) | N/events | HR (95% CI) | N/events | HR (95% CI) | ||
Ethnicity | |||||||||
Chinese | 567/39 | 1.00 (reference) | 435/41 | 1.00 (reference) | 180/38 | 1.00 (reference) | 275/57 | 1.00 (reference) | 0.81 |
Malay | 204/17 | 1.23 (0.65, 2.34) | 263/70 |
2.32 (1.49, 3.60)
| 104/29 | 1.11 (0.63, 1.96) | 155/54 | 1.22 (0.79, 1.89) | |
Native | 245/19 | 1.04 (0.52, 2.05) | 291/39 | 1.68 (1.02, 2.77) | 103/20 | 0.93 (0.48, 1.79) | 190/41 | 1.06 (0.67, 1.67) | |
P value | 0.80 |
0.03
| 0.87 | 0.77 | |||||
Menarche | |||||||||
≤ 12 yrs | 344/14 | 1.00 (reference) | 326/52 | 1.00 (reference) | 118/23 | 1.00 (reference) | 190/46 | 1.00 (reference) | 0.06 |
13 yrs | 318/26 | 1.53 (0.76, 3.11) | 340/44 | 0.88 (0.55, 1.40) | 148/29 | 0.84 (0.45, 1.57) | 201/46 | 1.21 (0.76, 1.92) | |
14 yrs | 163/11 | 1.25 (0.54, 2.91) | 167/27 | 0.86 (0.50, 1.48) | 60/22 | 0.92 (0.47, 1.80) | 111/26 | 1.05 (0.61, 1.80) | |
≥ 15 yrs | 184/23 |
2.25 (1.06, 4.78)
| 148/27 | 0.84 (0.49, 1.42) | 57/11 | 0.49 (0.21, 1.11) | 113/31 | 0.89 (0.52, 1.55) | |
P value |
0.06
| 0.49 | 0.15 | 0.66 | |||||
Parity and BFb | |||||||||
Nulliparous | 242/24 | 1.00 (reference) | 224/36 | 1.00 (reference) | 77/18 | 1.00 (reference) | 128/40 | 1.00 (reference) | 0.28 |
Parous and No BF | 133/10 | 0.59 (0.27, 1.32) | 103/12 | 0.81 (0.37, 1.75) | 31/8 | 0.87 (0.34, 2.25) | 64/20 | 1.02 (0.52, 1.96) | |
Parous and BF | 641/41 |
0.46 (0.26, 0.81)
| 662/102 | 0.99 (0.64, 1.56) | 279/61 | 0.61 (0.33, 1.14) | 428/92 | 0.86 (0.55, 1.34) | |
P value |
0.009
| 0.91 | 0.11 | 0.48 | |||||
Age at FFPc | |||||||||
< 21 yrs | 116/10 | 1.00 (reference) | 158/32 | 1.00 (reference) | 54/13 | 1.00 (reference) | 95/19 | 1.00 (reference) | 0.22 |
21–24.9 yrs | 284/14 | 0.99 (0.38, 2.55) | 287/33 | 1.30 (0.75, 2.25) | 129/28 | 0.83 (0.37, 1.84) | 199/42 | 0.71 (0.39, 1.29) | |
25–30 yrs | 275/23 | 0.85 (0.41, 1.73) | 248/39 | 1.14 (0.69, 1.90) | 103/22 | 0.77 (0.40, 1.49) | 154/41 | 0.98 (0.60, 1.60) | |
> 30 yrs | 99/4 | 0.36 (0.10, 1.29) | 72/10 | 1.34 (0.64, 2.81) | 24/6 | 0.78 (0.25, 2.46) | 43/9 | 0.53 (0.23, 1.24) | |
P value |
0.08
| 0.92 | 0.15 | 0.58 | |||||
Family history | |||||||||
No | 840/56 | 1.00 (reference) | 854/131 | 1.00 (reference) | 338/73 | 1.00 (reference) | 516/122 | 1.00 (reference) | 0.25 |
Yes | 160/17 | 1.70 (0.93, 3.08) | 119/17 | 1.05 (0.59, 1.88) | 46/13 | 1.47 (0.76, 2.82) | 92/22 | 0.77 (0.46, 1.27) | |
P value |
0.08
| 0.86 | |||||||
BMI, kg/m2 | |||||||||
18.5–24.9 | 160/6 | 1.00 (reference) | 172/25 | 1.00 (reference) | 68/15 | 1.00 (reference) | 114/25 | 1.00 (reference) | 0.80 |
< 18.5 | 373/38 |
3.42 (1.20, 9.71)
| 336/43 | 1.06 (0.62, 1.82) | 163/37 | 0.83 (0.44, 1.57) | 240/63 | 1.15 (0.70, 1.91) | |
P value |
0.02
| 0.83 | 0.58 | 0.56 | |||||
25–30 | 317/21 | 2.88 (0.97, 8.59) | 301/49 | 1.30 (0.77, 2.20) | 104/19 | 0.80 (0.39, 1.64) | 177/40 | 0.92 (0.54, 1.57) | |
P value |
0.06
| 0.32 | 0.54 | 0.77 | |||||
> 30 | 136/7 | 1.30 (0.37, 4.52) | 148/23 | 1.12 (0.61, 2.05) | 38/10 | 1.23 (0.52, 2.90) | 66/18 | 1.21 (0.63, 2.32) | |
P value | 0.68 | 0.71 | 0.63 | 0.57 |
Risk factora | Recurrence after 5 years | P-hetd | |||||||
---|---|---|---|---|---|---|---|---|---|
A-like | B-like | HER2-enriched | Triple-negative | ||||||
N/events | HR (95% CI) | N/events | HR (95% CI) | N/events | HR (95% CI) | N/events | HR (95% CI) | ||
Ethnicity | |||||||||
Chinese | 567/34 | 1.00 (reference) | 435/49 | 1.00 (reference) | 180/30 | 1.00 (reference) | 275/38 | 1.00 (reference) | 0.96 |
Malay | 204/8 | 1.01 (0.39, 2.60) | 263/30 | 0.81 (0.45, 1.45) | 104/17 | 0.69 (0.31, 1.51) | 155/24 | 1.11 (0.61, 2.02) | |
Native | 245/16 | 1.17 (0.49, 2.79) | 291/22 | 0.84 (0.46, 1.55) | 103/10 | 0.47 (0.18, 1.23) | 190/22 | 0.67 (0.34, 1.34) | |
P value | 0.75 | 0.55 | 0.11 | 0.32 | |||||
Menarche | |||||||||
≤ 12 yrs | 344/13 | 1.00 (reference) | 326/38 | 1.00 (reference) | 118/14 | 1.00 (reference) | 190/34 | 1.00 (reference) | 0.07 |
13 yrs | 318/17 | 1.55 (0.57, 4.23) | 340/31 | 1.03 (0.58, 1.82) | 148/21 | 1.52 (0.69, 3.33) | 201/24 | 0.72 (0.38, 1.37) | |
14 yrs | 163/14 | 2.51 (0.86, 7.33) | 167/21 | 0.81 (0.40, 1.64) | 60/9 | 0.56 (0.16, 1.92) | 111/13 | 0.65 (0.30, 1.43) | |
≥ 15 yrs | 184/13 |
3.26 (1.08, 9.92)
| 148/11 | 0.77 (0.35, 1.68) | 57/12 | 1.11 (0.38, 3.28) | 113/12 | 0.61 (0.27, 1.36) | |
P value |
0.02
| 0.41 | 0.81 | 0.18 | |||||
Parity and BFc | |||||||||
Nulliparous | 242/19 | 1.00 (reference) | 224/16 | 1.00 (reference) | 77/12 | 1.00 (reference) | 128/19 | 1.00 (reference) | 0.56 |
Parous and No BF | 133/7 | 0.55 (0.20, 1.50) | 103/14 | 1.86 (0.76, 4.56) | 31/7 | 1.35 (0.39, 4.64) | 64/17 | 1.57 (0.67, 3.66) | |
Parous and BF | 641/32 |
0.27 (0.12, 0.58)
| 662/71 | 1.63 (0.81, 3.28) | 279/38 | 0.58 (0.25, 1.34) | 428/48 | 0.77 (0.39, 1.52) | |
P value |
0.001
| 0.23 | 0.15 | 0.28 | |||||
Age at FFPd | |||||||||
< 25 | 400/13 | 1.00 (reference) | 445/44 | 1.00 (reference) | 183/30 | 1.00 (reference) | 294/41 | 1.00 (reference) | 0.52 |
≥ 25 | 374/26 | 1.69 (0.66, 4.34) | 320/41 | 1.32 (0.78, 2.22) | 127/15 | 0.50 (0.21, 1.16) | 197/23 | 0.75 (0.41, 1.39) | |
P value | 0.27 | 0.28 | 0.10 | 0.36 | |||||
Family history | |||||||||
No | 840/42 | 1.00 (reference) | 854/85 | 1.00 (reference) | 338/49 | 1.00 (reference) | 516/66 | 1.00 (reference) | 0.94 |
Yes | 160/13 | 0.77 (0.29, 2.03) | 119/14 | 1.17 (0.60, 2.28) | 46/7 | 1.24 (0.45, 3.35) | 92/12 | 0.85 (0.43, 1.70) | |
P value | 0.60 | 0.64 | 0.67 | ||||||
BMI, kg/m2 | |||||||||
18.5–24.9 | 160/6 | 1.00 (referent) | 172/14 | 1.00 (referent) | 68/11 | 1.00 (referent) | 114/16 | 1.00 (referent) | 0.98 |
< 18.5 | 373/30 | 3.97 (0.91, 17.34) | 336/29 | 1.37 (0.62, 3.03) | 163/21 | 0.50 (0.20, 1.27) | 240/30 | 1.01 (0.51, 2.01) | |
P value |
0.06
| 0.43 | 0.15 | 0.97 | |||||
25–30 | 317/16 | 3.40 (0.75, 15.42) | 301/37 | 2.02 (0.95, 4.29) | 104/15 | 0.70 (0.27, 1.81) | 177/24 | 0.83 (0.39, 1.73) | |
P value | 0.11 |
0.06
| 0.46 | 0.62 | |||||
> 30 | 136/5 | 1.65 (0.27, 10.15) | 148/15 | 1.28 (0.53, 3.12) | 38/7 | 1.41 (0.46, 4.27) | 66/13 | 0.89 (0.35, 2.25) | |
P value | 0.59 | 0.58 | 0.55 | 0.81 |
Risk factor | 10-year all-cause mortality | 5-year recurrence | ||
---|---|---|---|---|
N/events | HR1 (95% CI) | N/events | HRa (95% CI) | |
Ethnicity | ||||
Chinese | 539/38 | 1.00 (reference) | 399/21 | 1.00 (reference) |
Malay | 194/16 | 1.14 (0.59, 2.20) | 154/7 | 0.81 (0.29, 2.27) |
Native | 235/17 | 0.87 (0.41, 1.85) | 190/11 | 0.90 (0.35, 2.29) |
P value | 0.95 | 0.74 | ||
Menarche | ||||
≤ 12 yrs | 338/13 | 1.00 (reference) | 260/8 | 1.00 (reference) |
13 yrs | 302/25 | 1.45 (0.70, 3.01) | 235/13 | 1.69 (0.59, 4.81) |
14 yrs | 156/10 | 1.23 (0.52, 2.92) | 119/8 | 2.64 (0.87, 7.99) |
≥ 15 yrs | 172/23 |
2.28 (1.05, 4.95)
| 129/10 |
3.52 (1.10, 11.23)
|
P value | 0.06 |
0.02
| ||
Parity and BFb | ||||
Nulliparous | 229/23 | 1.00 (reference) | 180/15 | 1.00 (reference) |
Parous and No BF | 127/9 | 0.61 (0.26, 1.42) | 87/5 | 0.53 (0.17. 1.59) |
Parous and BF | 612/39 |
0.48 (0.27, 0.85)
| 476/19 |
0.28 (0.13, 0.64)
|
P value |
0.01
|
0.002
| ||
Age at FFPc | ||||
< 21 yrs | 111/9 | 1.00 (reference) | 85/4 | 1.00 (reference) |
21–24.9 yrs | 276/14 | 0.85 (0.31, 2.31) | 220/4 | 0.40 (0.06, 2.28) |
25–30 yrs | 262/22 | 0.71 (0.27, 1.82) | 201/17 | 1.26 (0.30, 5.22) |
> 30 yrs | 95/4 |
0.20 (0.04, 0.90)
| 73/1 | 0.26 (0.02, 3.09) |
P value | 0.06 | 0.95 | ||
Family history | ||||
No | 804/53 | 1.00 (reference) | 629/31 | 1.00 (referent) |
Yes | 155/17 | 1.68 (0.91, 3.10) | 122/7 | 0.75 (0.28, 2.02) |
P value | 0.10 | 0.57 | ||
BMI | ||||
18.5–24.9 kg/m2 | 160/6 | 1.00 (reference) | 117/2 | 1.00 (reference) |
< 18.5 kg/m2 | 365/37 |
3.46 (1.21, 9.89)
| 285/22 | 4.31 (0.94, 19.83) |
P value |
0.02
| 0.06 | ||
25–29.9 kg/m2 | 310/21 |
3.14 (1.04, 9.50)
| 235/12 |
4.74 (1.00, 22.64)
|
P value |
0.04
|
0.05
| ||
≥ 30 kg/m2 | 133/7 | 1.38 (0.39, 4.86) | 106/3 | 2.16 (0.34, 13.78) |
P value | 0.61 | 0.41 |