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20.06.2020 | Original Contribution | Ausgabe 2/2021 Open Access

European Journal of Nutrition 2/2021

Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis

Zeitschrift:
European Journal of Nutrition > Ausgabe 2/2021
Autoren:
Lenie van Rossem, Henriette A. Smit, Martine Armand, Jonathan Y. Bernard, Hans Bisgaard, Klaus Bønnelykke, Signe Bruun, Barbara Heude, Steffen Husby, Henriette B. Kyhl, Kim F. Michaelsen, Ken D. Stark, Carel Thijs, Rebecca K. Vinding, Alet H. Wijga, Lotte Lauritzen
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00394-020-02310-4) contains supplementary material, which is available to authorized users.

Abstract

Purpose

It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts.

Methods

We searched https://​www.​birthcohort.​net for studies that had collected breast milk samples, and had at least one BP measurement in childhood. Principal investigators were contacted, and all agreed to share data. One additional study was identified by contacts with the principal investigators. For each cohort, we analyzed the association of breast milk n-3 LC PUFAs with systolic and diastolic BP with linear mixed effects models or linear regression, and pooled the estimates with a random effects model. We also investigated age-specific and sex-specific associations.

Results

A total of 2188 participants from 7 cohorts were included. Overall, no associations between breast milk n-3 LC PUFAs and BP were observed. In the pooled analysis, each 0.1 wt% increment in breast milk docosahexaenoic acid (DHA) was associated with a 1.19 (95% CI − 3.31, 0.94) mmHg lower systolic BP. Associations were similar for boys and girls and at different ages.

Conclusion

In this individual participant meta-analysis, we found no evidence for an association between breast milk n-3 LC PUFAs and BP.

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