Bupropion for the treatment of fluoxetine non-responsive trichotillomania: a case report

Trichotillomania (TTM) is characterized by a compulsive urge to pull out one's own hair, leading to noticeable hair loss, distress, and social or functional impairment. TTM is usually confined to one or two sites, mainly the scalp, eyebrows, and eyelashes, but can also involve other parts of the body.

TTM is classified as an impulse control disorder in the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), and is believed to be related to obsessive-compulsive spectrum disorders [1, 2]. Patients with obsessive-compulsive disorder (OCD) and patients with TTM share overlapping comorbidity, familial transmission, treatment response, and difficulties in suppressing inappropriate repetitive behaviors, indicating that there is an underlying dysregulation in inhibitory control processes [3].

OCD has a fluctuating course with exacerbations and remissions, and the symptoms change over time in terms of focus (for example, ritualistic washing, checking stoves, and so on). Unlike OCD, TTM has both impulsive as well as compulsive elements. It does not occur in response to obsessive thoughts, but rather because of an irresistible urge to pull hair at leisure and the sense of satisfaction when the hair is pulled. Additionally, patients with TTM usually present only with hair pulling without evolution to other compulsive rituals, and usually do not have a fluctuating course. Depression and anxiety is less in TTM compared with OCD. Long-term response to treatment with specific serotonin reuptake inhibitors (SSRIs) is consistent in OCD while it is variable in TTM [4‐6].

Genetic, classificatory and pharmacological treatment studies have suggested the possibility of addictive behavior in TTM [4]. As in other addictive disorders (such as pathological gambling), bupropion may be considered in the management of TTM, as there is emerging evidence for the role of dopamine pathways in this condition [3].

Our patient was a 23-year-old unmarried, unemployed woman graduate from a middle socioeconomic status and urban Asian background. She had a six-year history of patchy hair loss from her scalp. She had earlier consulted a dermatologist who referred her to a psychiatrist.

She walked into our consultation room with her head covered with a scarf. She had a short haircut and there were many bald patches, 5 cm to 10 cm in area, on her scalp. The hair, particularly in the parietal region of both sides of the head, was very thin, brittle and uneven.

Our patient had an uncontrollable, irresistible, repetitive urge to pull out her scalp hair. The hair-pulling behavior had first appeared when she was 17 years of age, had completed school and was entering college. There was no evidence of any significant stressors in her life. The hair pulling had become particularly distressing and problematic over the past six months and she described her present condition as 'tremendously out of control'. There was a significant deterioration in her academic performance and social functioning.

The hair pulling spells occurred on a daily basis, just before bedtime, when she was alone in her room listening to the radio, or watching television. The hair pulling used to be more severe when she was stressed. She reported a feeling of mounting tension before the act of hair pulling, with an accompanied sensation of itching. The tension was alleviated when she pulled the hair out. Pulling of hair involved twisting each hair around a finger, mostly from the sides of her head near her ears. She reported a sense of satisfaction in hearing the sound of the hair being pulled out, accompanied by pleasurable sensations. She would pull out countless hairs over few hours, resulting in a bald patch on the scalp. After the hair was pulled, she would examine the root of the hair. Later, she would secretly dispose of the plucked out hair after neatly packing them in a cover.

She felt guilty and embarrassed by her hair-pulling behavior and often wore her hair tied back. She was more self-conscious about the bald patches behind the ears. She used scarves to camouflage her disfigured scalp while going out. She had good insight into her illness, and recognized that her mental state was contributing to her symptoms.

Our patient was pre-morbidly well adjusted with no significant medical or family history. There was also no history of substance use or suicide attempts. She was diagnosed to have TTM (impulse control disorder not otherwise specified) as per DSM-IV criteria [1]. There was no comorbid Axis I psychiatric disorders, including mood disorder. OCD was ruled out in our patient as the hair pulling (i) used to occur in leisure time only, (ii) was not in response to obsessive thoughts, but rather because of irresistible urges, (iii) was followed by a sense of satisfaction, (iv) was not associated with any other OCD symptoms, and (v) was not associated with depression.

At various time points, different instruments were applied to measure her treatment response (Table 1). TTM behavior was measured with The Massachusetts General Hospital Hair Pulling Scale (MGHHPS) and National Institute of Mental Health Trichotillomania Symptom Severity and Impairment Scale (NIMH-TSS and NIMH-TIS) [5, 6]. MGHHPS is a self-report measure of the severity of hair pulling urges and behavior, efforts to resist urges, control over the problem, and associated distress [5]. Higher scores reflect greater severity. The NIMH-TSS and NIMH-TIS are clinician rating scales [6]. The NIMH-TSS is a five-item measure assessing average hair-pulling episode duration during the past week and on the previous day, thoughts preceding the pulling episode, resistance to urges, distress, and interference. The NIMH-TIS is an 11-point scale assessing overall impairment in a patient's life due to TTM. Clinical Global Impression - Severity and Improvement scales (CGI-S and CGI- I) are clinician-rated instruments to assess the baseline severity and improvement in a psychiatric disorder [7]. Presence of depression was assessed with the Hospital Anxiety Depression Rating Scale - Depression subscale (HADS-D) [8].

Our patient was initially started on fluoxetine 20 mg/day (gradually increasing the dose up to 80 mg/day by week eight), clonazepam 0.5 mg/day (tapered off by week three) and continuous cognitive behavior therapy (CBT). By week eight, despite the reasonably adequate dose and treatment duration, there was minimal improvement in hair-pulling behavior. Hence, at week eight, bupropion sustained release (bupropion-SR) was initiated at 150 mg/day, and increased to 300 mg/day at week 10. Fluoxetine was tapered off by week 11. By week 12, there was a mild improvement in our patient's hair pulling behavior, and the dose of bupropion-SR was increased to 450 mg/day, in divided doses. At this dose, at week 13, our patient experienced significant clinical improvement in TTM. She continued to show sustained improvement during the 6 and 12-month follow-ups (Figure 1). CBT was started at the beginning of treatment, and was continued throughout the one-year follow-up period. Bupropion-SR was well tolerated, except for few mild adverse effects such as nausea and nervousness during the initial two weeks, which resolved without any intervention.

Our patient was initially treated with fluoxetine, a specific serotonin reuptake inhibitor (SSRI), up to 80 mg/day for adequate duration along with CBT, but there was minimal improvement. Very few case reports are available in the published literature about the use of bupropion in the treatment of TTM. In our patient, bupropion-SR was given up to 450 mg/day, the dosage used in other studies [3, 9, 10]. Bupropion-SR was well tolerated and was beneficial in reducing the hair-pulling behavior. The observed improvement does not appear to be related to the anti-depressant effect of bupropion, since the HADS-D score was within normal limits at baseline and did not change significantly at the end of the one-year follow-up. Also, clinically, there was no evidence of depression throughout the follow-up period. Similar findings were reported by Dannon et al. [3].

TTM is proposed to be a heterogeneous disorder that overlaps with OCD, impulse control disorders and also addictive disorders. There is an association of TTM with attention deficit hyperactivity disorder and impulsive behavior [3].

Traditionally, serotonin has been the principal neurotransmitter implicated in TTM and other impulse control disorders. However, recent literature strongly supports the role of dopamine in the pathophysiology of TTM [10]. Lochner et al. have theorized that TTM is more impulsive than compulsive in nature [4]. TTM is not just an impulsive-compulsive disorder, but also appears to have an addictive component to it. Dannon et al. proposed that TTM (like addictive disorders) is characterized by compulsive seeking, and consequently obtaining the substance of choice (that is, hair), with progressive loss of behavior control [3]. Thus, like pathological gambling, TTM appears to be more like an addictive disorder, where the mesolimbic dopamine reward pathway and prefrontal cortex are implicated.

Thus, TTM may be conceptualized as an impulsive-compulsive-addictive spectrum disorder. It has been hypothesized that specific subtypes of TTM exist with specific patterns of treatment response [3, 9]. Many pharmacological agents have been reported to be useful in TTM. These include SSRIs, anti-convulsants, anti-psychotics and naltrexone. Earlier studies, however, have failed to show efficacy of SSRI treatment [3].

Bupropion is useful in nicotine, caffeine, alcohol and other addictive disorders through its action on the mesolimbic pathways, where it inhibits the reuptake of dopamine and norepinephrine. There is now also evidence that bupropion similarly helps in TTM (and also pathological gambling) by diminishing the heightened arousal and pleasurable relief [10, 11]. Hence, bupropion may be considered as an effective alternative in patients with TTM not responding to SSRIs.

There is definite evidence that CBT is beneficial in TTM, and the synergistic benefit of CBT in our patient cannot be undermined [12, 13]. However, it should be noted that CBT was started from the beginning of the treatment along with fluoxetine, but significant improvement was observed only when the treatment was changed over to a combination of bupropion-SR and CBT. Thus, the therapeutic response appears more likely to be related to bupropion-SR.

A single case report has associated limitations, especially when the clinician is not blinded to treatment allocation and assessments. Also, few of the scales (such as MGHHPS, NIMH-TSS and NIMH-TIS) are not standardized for the Indian population. However, these case reports do give insight into the nature of the disorders discussed, and also help explore new treatment options. The possibility that TTM may have an addictive component needs to be studied further. Bupropion may be considered as a treatment, especially in case of patients with TTM who are non-responders to SSRIs. Further well conducted randomized trials are required to evaluate the effectiveness of bupropion-SR in TTM and other impulsive-compulsive-addictive spectrum disorders.

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.