The authors declare that they have no competing interests.
TWF, CHC and EAM conceived the study, its design and coordination. TWF and RWFC collected and analyzed data. OCCN and RMA carried out the microbiology analysis of respiratory secretions. TWF, CHC, EAM, RWFC, OCCN and RMA participated in the draft of the manuscript. All authors read and approved the final manuscript.
Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa.
CF patients chronically colonized with P. aeruginosa were divided into three groups: intermittent (I), chronic (II) and no colonization (III) with BCC. Body mass index (BMI) percentile and spirometric parameters were analyzed at three different times in each group.
Fifty-six patients chronically colonized with P. aeruginosa were included. Of these, 27 also had evidence of BCC colonization (13 intermittent and 14 chronic). BMI percentile was significantly lower among patients chronically colonized by both P. aeruginosa and BCC. Mean values of FEV1 and FVC % were also significantly lower in these patients, both at the time of chronic BCC colonization and 24 months forward.
Chronic BCC colonization is associated with significant loss of lung function. Lower BMI might be a risk factor for chronic BCC colonization, preceding these events.
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- Burkholderia cepacia complex: clinical course in cystic fibrosis patients
Tania Wrobel Folescu
Claudia Henrique da Costa
Renata Wrobel Folescu Cohen
Orlando Carlos da Conceição Neto
Rodolpho Mattos Albano
Elizabeth Andrade Marques
- BioMed Central
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