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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Pulmonary Medicine 1/2015

Burkholderia cepacia complex: clinical course in cystic fibrosis patients

Zeitschrift:
BMC Pulmonary Medicine > Ausgabe 1/2015
Autoren:
Tania Wrobel Folescu, Claudia Henrique da Costa, Renata Wrobel Folescu Cohen, Orlando Carlos da Conceição Neto, Rodolpho Mattos Albano, Elizabeth Andrade Marques
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

TWF, CHC and EAM conceived the study, its design and coordination. TWF and RWFC collected and analyzed data. OCCN and RMA carried out the microbiology analysis of respiratory secretions. TWF, CHC, EAM, RWFC, OCCN and RMA participated in the draft of the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa.

Methods

CF patients chronically colonized with P. aeruginosa were divided into three groups: intermittent (I), chronic (II) and no colonization (III) with BCC. Body mass index (BMI) percentile and spirometric parameters were analyzed at three different times in each group.

Results

Fifty-six patients chronically colonized with P. aeruginosa were included. Of these, 27 also had evidence of BCC colonization (13 intermittent and 14 chronic). BMI percentile was significantly lower among patients chronically colonized by both P. aeruginosa and BCC. Mean values of FEV1 and FVC % were also significantly lower in these patients, both at the time of chronic BCC colonization and 24 months forward.

Conclusions

Chronic BCC colonization is associated with significant loss of lung function. Lower BMI might be a risk factor for chronic BCC colonization, preceding these events.
Literatur
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