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Clinical Rheumatology
Erschienen in: Clinical Rheumatology 7/2018

20.03.2018 | Original Article

C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population

verfasst von: Yemil Atisha-Fregoso, Guadalupe Lima, Eduardo Carrillo-Maravilla, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, Miguel Baños-Peláez, Alejandra Iturralde-Chávez, Nora Hernández-Díaz, Juan Jakez-Ocampo, José Manuel Rodríguez-Pérez, Gilberto Vargas-Alarcón, Luis Llorente, Juanita Romero-Díaz

Erschienen in: Clinical Rheumatology | Ausgabe 7/2018

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Abstract

To evaluate the association of C-reactive protein (CRP) polymorphisms with risk of development SLE in a group of Mexican individuals. Five CRP polymorphisms (rs3093059, rs3093062, rs1800947, rs1130864, and rs1205) were determined by PCR-restriction fragment length polymorphism and SNP rs3093061 by refractory mutation system PCR assay in 126 SLE patients and 131 controls. Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108–0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143–0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270–0.942, P = 0.032). The rs3091244 polymorphism was associated with decreased risk of SLE mostly under additive (OR = 0.605, 95% CI 0.393–0.931. P = 0.022) model. Our study establishes that rs3093061, rs1130864, rs1205, and rs3091244 polymorphisms are associated with decreased risk of developing SLE.
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Metadaten
Titel
C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population
verfasst von
Yemil Atisha-Fregoso
Guadalupe Lima
Eduardo Carrillo-Maravilla
Rosalinda Posadas-Sánchez
Nonanzit Pérez-Hernández
Miguel Baños-Peláez
Alejandra Iturralde-Chávez
Nora Hernández-Díaz
Juan Jakez-Ocampo
José Manuel Rodríguez-Pérez
Gilberto Vargas-Alarcón
Luis Llorente
Juanita Romero-Díaz
Publikationsdatum
20.03.2018
Verlag
Springer London
Erschienen in
Clinical Rheumatology / Ausgabe 7/2018
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-018-4059-5

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