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Neurological Sciences

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01.12.2017 | Review Article

Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment

verfasst von: Håkan Ashina, Lawrence Newman, Sait Ashina

Erschienen in: Neurological Sciences | Ausgabe 12/2017

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Abstract

Calcitonin gene-related peptide (CGRP) is a key signaling molecule involved in migraine pathophysiology. Efficacy of CGRP monoclonal antibodies and antagonists in migraine treatment has fueled an increasing interest in the prospect of treating cluster headache (CH) with CGRP antagonism. The exact role of CGRP and its mechanism of action in CH have not been fully clarified. A search for original studies and randomized controlled trials (RCTs) published in English was performed in PubMed and in ClinicalTrials.gov. The search term used was “cluster headache and calcitonin gene related peptide” and “primary headaches and calcitonin gene related peptide.” Reference lists of identified articles were also searched for additional relevant papers. Human experimental studies have reported elevated plasma CGRP levels during both spontaneous and glyceryl trinitrate-induced cluster attacks. CGRP may play an important role in cluster headache pathophysiology. More refined human studies are warranted with regard to assay validation and using larger sample sizes. The results from RCTs may reveal the therapeutic potential of CGRP monoclonal antibodies and antagonists for cluster headache treatment.

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Titel: Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment
verfasst von: Håkan Ashina
Lawrence Newman
Sait Ashina
Publikationsdatum: 01.12.2017
Verlag: Springer Milan
Erschienen in: Neurological Sciences / Ausgabe 12/2017
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-017-3101-8

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