Skip to main content
Erschienen in: European Journal of Nutrition 2/2018

17.12.2016 | Original Contribution

Calcium and vitamin D3 combinations improve fatty liver disease through AMPK-independent mechanisms

verfasst von: Sara Shojaei Zarghani, Hamid Soraya, Mohammad Alizadeh

Erschienen in: European Journal of Nutrition | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Some research findings suggest that calcium plus vitamin D (VitD) might have a preventive effect on nonalcoholic fatty liver disease development. Moreover, contradictory evidence also exists regarding calcium and VitD deficient diets. This study aimed to evaluate the effect of four different dietary calcium and VitD3 (cholecalciferol) levels on the development of high-fat, high-fructose (HFHFr) diet-induced nonalcoholic fatty liver disease and AMP-activated protein kinase (AMPK) phosphorylation.

Methods

Thirty male Wistar rats were fed with normal or HFHFr diet containing low calcium (0.2%) and VitD3 (250 IU/kg) (LCD), normal calcium (0.5%) and VtD3 (1000 IU/kg) (CN), high calcium (1.2%) and VitD3 (4000 IU/kg) (HCD) or very high amount of calcium (2.4%) and VitD3 (10,000 IU/kg) (VHCD). After 60 days, anthropometric, metabolic and hepatic parameters were evaluated. The effect of the experimental diets on liver AMPK phosphorylation was also investigated.

Results

Rats fed on high calcium plus VitD3 diets, especially VHCD, demonstrated lower adiposity, serum liver enzymes, hepatic lipid accumulation and steatosis. The LCD diet also decreased hepatic lipid content and fatty changes. No evidence indicating the involvement of AMPK in the observed associations was found (P value = 0.51).

Conclusions

The results showed high calcium plus VitD3 intakes considerably prevent biochemical and hepatic changes induced by HFHFr diet, probably via an insulin and AMPK-independent pathway. A low intake of these two nutrients was also linked with a significant decrease in HFHFr diet-induced hepatic steatosis.
Literatur
1.
Zurück zum Zitat Lazo M, Clark JM (2008) The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis 28:339–350CrossRef Lazo M, Clark JM (2008) The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis 28:339–350CrossRef
2.
Zurück zum Zitat Fabbrini E, Sullivan S, Klein S (2010) Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51:679–689CrossRef Fabbrini E, Sullivan S, Klein S (2010) Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51:679–689CrossRef
3.
Zurück zum Zitat Keast DR, Gallant KMH, Albertson AM, Gugger CK, Holschuh NM (2015) Associations between yogurt, dairy, calcium, and vitamin D intake and obesity among us children aged 8–18 years: NHANES, 2005–2008. Nutrients 7:1577–1593CrossRef Keast DR, Gallant KMH, Albertson AM, Gugger CK, Holschuh NM (2015) Associations between yogurt, dairy, calcium, and vitamin D intake and obesity among us children aged 8–18 years: NHANES, 2005–2008. Nutrients 7:1577–1593CrossRef
4.
Zurück zum Zitat Tidwell DK, Valliant MW (2011) Higher amounts of body fat are associated with inadequate intakes of calcium and vitamin D in African American women. Nutr Res 31:527–536CrossRef Tidwell DK, Valliant MW (2011) Higher amounts of body fat are associated with inadequate intakes of calcium and vitamin D in African American women. Nutr Res 31:527–536CrossRef
5.
Zurück zum Zitat Samadi M, Sadrzadeh-Yeganeh H, Azadbakht L, Feizi A, Jafarian K, Sotoudeh G (2012) Dietary calcium intake and risk of obesity in school girls aged 8–10 years. J Res Med Sci 17:1102 Samadi M, Sadrzadeh-Yeganeh H, Azadbakht L, Feizi A, Jafarian K, Sotoudeh G (2012) Dietary calcium intake and risk of obesity in school girls aged 8–10 years. J Res Med Sci 17:1102
6.
Zurück zum Zitat Ferreira TDS, Rocha TM, Klein MRST, Sanjuliani AF (2015) Vitamin D deficiency is associated with insulin resistance independent of intracellular calcium, dietary calcium and serum levels of parathormone, calcitriol and calcium in premenopausal women. Nutr Hosp 31:1491–1498 Ferreira TDS, Rocha TM, Klein MRST, Sanjuliani AF (2015) Vitamin D deficiency is associated with insulin resistance independent of intracellular calcium, dietary calcium and serum levels of parathormone, calcitriol and calcium in premenopausal women. Nutr Hosp 31:1491–1498
7.
Zurück zum Zitat da Silva FerreiraT, Torres MRSG, Sanjuliani AF (2013) Dietary calcium intake is associated with adiposity, metabolic profile, inflammatory state and blood pressure, but not with erythrocyte intracellular calcium and endothelial function in healthy pre-menopausal women. Brit J Nutr 110:1079–1088CrossRef da Silva FerreiraT, Torres MRSG, Sanjuliani AF (2013) Dietary calcium intake is associated with adiposity, metabolic profile, inflammatory state and blood pressure, but not with erythrocyte intracellular calcium and endothelial function in healthy pre-menopausal women. Brit J Nutr 110:1079–1088CrossRef
8.
Zurück zum Zitat Moore-Schiltz L, Albert JM, Singer ME, Swain J, Nock NL (2015) Dietary intake of calcium and magnesium and the metabolic syndrome in the National Health and Nutrition Examination (NHANES) 2001–2010 data. Brit J Nutr 114:924–935CrossRef Moore-Schiltz L, Albert JM, Singer ME, Swain J, Nock NL (2015) Dietary intake of calcium and magnesium and the metabolic syndrome in the National Health and Nutrition Examination (NHANES) 2001–2010 data. Brit J Nutr 114:924–935CrossRef
9.
Zurück zum Zitat Kim KJ, Kim YJ, Kim SH, An JH, Yoo HJ, Kim HY, Seo JA, Kim SG, Kim NH, Choi KM (2015) Vitamin D status and associated metabolic risk factors among North Korean refugees in South Korea: a cross-sectional study. BMJ Open. doi:10.1136/bmjopen-2015-009140 Kim KJ, Kim YJ, Kim SH, An JH, Yoo HJ, Kim HY, Seo JA, Kim SG, Kim NH, Choi KM (2015) Vitamin D status and associated metabolic risk factors among North Korean refugees in South Korea: a cross-sectional study. BMJ Open. doi:10.​1136/​bmjopen-2015-009140
10.
Zurück zum Zitat Küçükazman M, Ata N, Dal K, Yeniova AÖ, Kefeli A, Basyigit S, Aktas B, Akin KO, Üre ÖS, Topal F (2014) The association of vitamin D deficiency with non-alcoholic fatty liver disease. Clinics 69:542–546CrossRef Küçükazman M, Ata N, Dal K, Yeniova AÖ, Kefeli A, Basyigit S, Aktas B, Akin KO, Üre ÖS, Topal F (2014) The association of vitamin D deficiency with non-alcoholic fatty liver disease. Clinics 69:542–546CrossRef
11.
Zurück zum Zitat Lu Z, Pan X, Hu Y, Hao Y, Luo Y, Hu X, Ma X, Bao Y, Jia W (2015) Serum vitamin D levels are inversely related with non-alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women. Clin Exp Pharmacol 42:139–145CrossRef Lu Z, Pan X, Hu Y, Hao Y, Luo Y, Hu X, Ma X, Bao Y, Jia W (2015) Serum vitamin D levels are inversely related with non-alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women. Clin Exp Pharmacol 42:139–145CrossRef
12.
Zurück zum Zitat Sergeev IN, Song Q (2014) High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. Mol Nutr Food Res 58:1342–1348CrossRef Sergeev IN, Song Q (2014) High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. Mol Nutr Food Res 58:1342–1348CrossRef
13.
Zurück zum Zitat Siddiqui SM, Chang E, Li J, Burlage C, Zou M, Buhman KK, Koser S, Donkin SS, Teegarden D (2008) Dietary intervention with vitamin D, calcium, and whey protein reduced fat mass and increased lean mass in rats. Nutr Res 28:783–790CrossRef Siddiqui SM, Chang E, Li J, Burlage C, Zou M, Buhman KK, Koser S, Donkin SS, Teegarden D (2008) Dietary intervention with vitamin D, calcium, and whey protein reduced fat mass and increased lean mass in rats. Nutr Res 28:783–790CrossRef
14.
Zurück zum Zitat Yin Y, Yu Z, Xia M, Luo X, Lu X, Ling W (2012) Vitamin D attenuates high fat diet–induced hepatic steatosis in rats by modulating lipid metabolism. Eur J Clin Invest 42:1189–1196CrossRef Yin Y, Yu Z, Xia M, Luo X, Lu X, Ling W (2012) Vitamin D attenuates high fat diet–induced hepatic steatosis in rats by modulating lipid metabolism. Eur J Clin Invest 42:1189–1196CrossRef
15.
Zurück zum Zitat Hidayat M, Prahastuti S, Tiono H, Dianawati D (2013) Effect of calcium against weight gain and improved histopathologic fatty liver on male Wistar rats that fed high fat food. Obes Res Clin Pract 7:15–16CrossRef Hidayat M, Prahastuti S, Tiono H, Dianawati D (2013) Effect of calcium against weight gain and improved histopathologic fatty liver on male Wistar rats that fed high fat food. Obes Res Clin Pract 7:15–16CrossRef
16.
Zurück zum Zitat Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017–2029CrossRef Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017–2029CrossRef
17.
Zurück zum Zitat Thomas AP, Dunn TN, Drayton JB, Oort PJ, Adams SH (2013) A dairy-based high calcium diet improves glucose homeostasis and reduces steatosis in the context of preexisting obesity. Obesity 21:E229–E235CrossRef Thomas AP, Dunn TN, Drayton JB, Oort PJ, Adams SH (2013) A dairy-based high calcium diet improves glucose homeostasis and reduces steatosis in the context of preexisting obesity. Obesity 21:E229–E235CrossRef
18.
Zurück zum Zitat Thomas AP, Dunn TN, Drayton JB, Oort PJ, Adams SH (2012) A high calcium diet containing nonfat dry milk reduces weight gain and associated adipose tissue inflammation in diet-induced obese mice when compared to high calcium alone. Nutr Metab (Lond) 9:3. doi:10.1186/1743-7075-9-3 CrossRef Thomas AP, Dunn TN, Drayton JB, Oort PJ, Adams SH (2012) A high calcium diet containing nonfat dry milk reduces weight gain and associated adipose tissue inflammation in diet-induced obese mice when compared to high calcium alone. Nutr Metab (Lond) 9:3. doi:10.​1186/​1743-7075-9-3 CrossRef
19.
20.
Zurück zum Zitat Liu X-J, Wang B-W, Zhang C, Xia M-Z, Chen Y-H, Hu C-Q, Wang H, Chen X, Xu D-X (2015) Vitamin D deficiency attenuates high-fat diet-induced hyperinsulinemia and hepatic lipid accumulation in male mice. Endocrinology 156:2103–2113CrossRef Liu X-J, Wang B-W, Zhang C, Xia M-Z, Chen Y-H, Hu C-Q, Wang H, Chen X, Xu D-X (2015) Vitamin D deficiency attenuates high-fat diet-induced hyperinsulinemia and hepatic lipid accumulation in male mice. Endocrinology 156:2103–2113CrossRef
21.
Zurück zum Zitat Shirwany NA, Zou M-H (2014) AMPK: a cellular metabolic and redox sensor. A minireview. Front Biosci (Landmark Ed) 19:447CrossRef Shirwany NA, Zou M-H (2014) AMPK: a cellular metabolic and redox sensor. A minireview. Front Biosci (Landmark Ed) 19:447CrossRef
22.
Zurück zum Zitat Oakhill J, Scott J, Kemp B (2009) Structure and function of AMP-activated protein kinase. Acta Physiol 196:3–14CrossRef Oakhill J, Scott J, Kemp B (2009) Structure and function of AMP-activated protein kinase. Acta Physiol 196:3–14CrossRef
23.
Zurück zum Zitat He Y-H, Li S-T, Wang Y-Y, Wang G, He Y, Liao X-L, Sun C-H, Li Y (2012) Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet. J Nutr Biochem 23:1238–1244CrossRef He Y-H, Li S-T, Wang Y-Y, Wang G, He Y, Liao X-L, Sun C-H, Li Y (2012) Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet. J Nutr Biochem 23:1238–1244CrossRef
24.
Zurück zum Zitat Gao L, Cao J-T, Liang Y, Zhao Y-C, Lin X-H, Li X-C, Tan Y-J, Li J-Y, Zhou C-L, Xu H-Y (2015) Calcitriol attenuates cardiac remodeling and dysfunction in a murine model of polycystic ovary syndrome. Endocrine 52:363–373CrossRef Gao L, Cao J-T, Liang Y, Zhao Y-C, Lin X-H, Li X-C, Tan Y-J, Li J-Y, Zhou C-L, Xu H-Y (2015) Calcitriol attenuates cardiac remodeling and dysfunction in a murine model of polycystic ovary syndrome. Endocrine 52:363–373CrossRef
25.
Zurück zum Zitat Shojaei Zarghani S, Soraya H, Zarei L, Alizadeh M (2015) Comparison of three different diet-induced non alcoholic fatty liver disease protocols in rats: a pilot study. Pharm Sci 22:9–15CrossRef Shojaei Zarghani S, Soraya H, Zarei L, Alizadeh M (2015) Comparison of three different diet-induced non alcoholic fatty liver disease protocols in rats: a pilot study. Pharm Sci 22:9–15CrossRef
26.
Zurück zum Zitat National Research Council (1995) Nutrient requirements of laboratory animals, 4th edn. The National Academy Press, Washington, p 13 National Research Council (1995) Nutrient requirements of laboratory animals, 4th edn. The National Academy Press, Washington, p 13
27.
Zurück zum Zitat Fleet JC, Gliniak C (2007) Modeling human vitamin D status in experimental rodents [abstract]. FASEB J 21(6):A1110 Fleet JC, Gliniak C (2007) Modeling human vitamin D status in experimental rodents [abstract]. FASEB J 21(6):A1110
28.
Zurück zum Zitat Folch J, Lees M, Sloane-Stanley G (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497–509 Folch J, Lees M, Sloane-Stanley G (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497–509
29.
Zurück zum Zitat Yousefi K, Soraya H, Fathiazad F, Khorrami A, Hamedeyazdan S, Maleki-Dizaji N, Garjani A (2013) Cardioprotective effect of methanolic extract of Marrubium vulgare L. on isoproterenol-induced acute myocardial infarction in rats. Indian J Exp Biol 51:653–660 Yousefi K, Soraya H, Fathiazad F, Khorrami A, Hamedeyazdan S, Maleki-Dizaji N, Garjani A (2013) Cardioprotective effect of methanolic extract of Marrubium vulgare L. on isoproterenol-induced acute myocardial infarction in rats. Indian J Exp Biol 51:653–660
30.
Zurück zum Zitat Soraya H, Farajnia S, Khani S, Rameshrad M, Khorrami A, Banani A, Maleki-Dizaji N, Garjani A (2012) Short-term treatment with metformin suppresses toll like receptors (TLRs) activity in isoproterenol-induced myocardial infarction in rat: are AMPK and TLRs connected? Int Immunopharmacol 14:785–791CrossRef Soraya H, Farajnia S, Khani S, Rameshrad M, Khorrami A, Banani A, Maleki-Dizaji N, Garjani A (2012) Short-term treatment with metformin suppresses toll like receptors (TLRs) activity in isoproterenol-induced myocardial infarction in rat: are AMPK and TLRs connected? Int Immunopharmacol 14:785–791CrossRef
31.
32.
Zurück zum Zitat Han H, Cui M, You X, Chen M, Piao X, Jin G (2015) A role of 1, 25 (OH) 2 D 3 supplementation in rats with nonalcoholic steatohepatitis induced by choline-deficient diet. Nutr Metab Cardiovasc Dis 25:556–561CrossRef Han H, Cui M, You X, Chen M, Piao X, Jin G (2015) A role of 1, 25 (OH) 2 D 3 supplementation in rats with nonalcoholic steatohepatitis induced by choline-deficient diet. Nutr Metab Cardiovasc Dis 25:556–561CrossRef
33.
Zurück zum Zitat Sun C, Wang L, Yan J, Liu S (2012) Calcium ameliorates obesity induced by high-fat diet and its potential correlation with p38 MAPK pathway. Mol Biol Rep 39:1755–1763CrossRef Sun C, Wang L, Yan J, Liu S (2012) Calcium ameliorates obesity induced by high-fat diet and its potential correlation with p38 MAPK pathway. Mol Biol Rep 39:1755–1763CrossRef
34.
Zurück zum Zitat Parra P, Bruni G, Palou A, Serra F (2008) Dietary calcium attenuation of body fat gain during high-fat feeding in mice. J Nutr Biochem 19:109–117CrossRef Parra P, Bruni G, Palou A, Serra F (2008) Dietary calcium attenuation of body fat gain during high-fat feeding in mice. J Nutr Biochem 19:109–117CrossRef
35.
Zurück zum Zitat de Wit NJ, Bosch-Vermeulen H, Oosterink E, Müller M, van der Meer R (2011) Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice. Brit J Nutr 105:1005–1011CrossRef de Wit NJ, Bosch-Vermeulen H, Oosterink E, Müller M, van der Meer R (2011) Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice. Brit J Nutr 105:1005–1011CrossRef
36.
Zurück zum Zitat Browning JD, Horton JD (2004) Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114:147–152CrossRef Browning JD, Horton JD (2004) Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114:147–152CrossRef
37.
Zurück zum Zitat Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106:473–481CrossRef Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106:473–481CrossRef
38.
Zurück zum Zitat Gagnon C, Daly RM, Carpentier A, Lu ZX, Shore-Lorenti C, Sikaris K, Jean S, Ebeling PR (2014) Effects of combined calcium and vitamin D supplementation on insulin secretion, insulin sensitivity and β-cell function in multi-ethnic vitamin D-deficient adults at risk for type 2 diabetes: a pilot randomized, placebo-controlled trial. PLoS ONE. doi:10.1371/journal.pone.0109607 Gagnon C, Daly RM, Carpentier A, Lu ZX, Shore-Lorenti C, Sikaris K, Jean S, Ebeling PR (2014) Effects of combined calcium and vitamin D supplementation on insulin secretion, insulin sensitivity and β-cell function in multi-ethnic vitamin D-deficient adults at risk for type 2 diabetes: a pilot randomized, placebo-controlled trial. PLoS ONE. doi:10.​1371/​journal.​pone.​0109607
39.
Zurück zum Zitat Ryu O-H, Chung W, Lee S, Hong K-S, Choi M-G, Yoo HJ (2014) The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes. Korean J Intern Med 29:620–629CrossRef Ryu O-H, Chung W, Lee S, Hong K-S, Choi M-G, Yoo HJ (2014) The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes. Korean J Intern Med 29:620–629CrossRef
40.
Zurück zum Zitat Alkharfy KM, Al-Daghri NM, Yakout SM, Hussain T, Mohammed AK, Krishnaswamy S (2013) Influence of vitamin D treatment on transcriptional regulation of insulin-sensitive genes. Metab Syndr Relat Disord 11:283–288CrossRef Alkharfy KM, Al-Daghri NM, Yakout SM, Hussain T, Mohammed AK, Krishnaswamy S (2013) Influence of vitamin D treatment on transcriptional regulation of insulin-sensitive genes. Metab Syndr Relat Disord 11:283–288CrossRef
41.
Zurück zum Zitat Geldenhuys S, Hart PH, Endersby R, Jacoby P, Feelisch M, Weller RB, Matthews V, Gorman S (2014) Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet. Diabetes 63:3759–3769CrossRef Geldenhuys S, Hart PH, Endersby R, Jacoby P, Feelisch M, Weller RB, Matthews V, Gorman S (2014) Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet. Diabetes 63:3759–3769CrossRef
42.
Zurück zum Zitat Brink EJ, Beynen AC, Dekker PR, Van Beresteijn E, van der Meer R (1992) Interaction of calcium and phosphate decreases ileal magnesium solubility and apparent magnesium absorption in rats. ‎J Nutr 122:580–586 Brink EJ, Beynen AC, Dekker PR, Van Beresteijn E, van der Meer R (1992) Interaction of calcium and phosphate decreases ileal magnesium solubility and apparent magnesium absorption in rats. ‎J Nutr 122:580–586
43.
Zurück zum Zitat Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF, Kanoni S, Lehtimäki T (2013) Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. ‎J. Nutr 143:345–353 Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF, Kanoni S, Lehtimäki T (2013) Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. ‎J. Nutr 143:345–353
44.
Zurück zum Zitat Jeddi S, Syedmoradi L, Bagheripour F, Ghasemi A (2015) The effects of vitamin D on insulin release from isolated islets of rats. Int J Endocrinol Metab. doi:10.5812/ijem.20620 Jeddi S, Syedmoradi L, Bagheripour F, Ghasemi A (2015) The effects of vitamin D on insulin release from isolated islets of rats. Int J Endocrinol Metab. doi:10.​5812/​ijem.​20620
45.
Zurück zum Zitat Peterson JM, Seldin MM, Wei Z, Aja S, Wong GW (2013) CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol 305:G214–G224CrossRef Peterson JM, Seldin MM, Wei Z, Aja S, Wong GW (2013) CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol 305:G214–G224CrossRef
46.
Zurück zum Zitat Peterson JM, Wei Z, Wong GW (2010) C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem 285:39691–39701CrossRef Peterson JM, Wei Z, Wong GW (2010) C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem 285:39691–39701CrossRef
47.
Zurück zum Zitat Akiyama H, Furukawa S, Wakisaka S, Maeda T (2007) CTRP3/cartducin promotes proliferation and migration of endothelial cells. Mol Cell Biochem 304:243–248CrossRef Akiyama H, Furukawa S, Wakisaka S, Maeda T (2007) CTRP3/cartducin promotes proliferation and migration of endothelial cells. Mol Cell Biochem 304:243–248CrossRef
48.
Zurück zum Zitat Choi KM, Hwang SY, Hong HC, Yang SJ, Choi HY, Yoo HJ, Lee KW, Nam MS, Park YS, Woo JT (2012) C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome. Diabetes 61:2932–2936CrossRef Choi KM, Hwang SY, Hong HC, Yang SJ, Choi HY, Yoo HJ, Lee KW, Nam MS, Park YS, Woo JT (2012) C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome. Diabetes 61:2932–2936CrossRef
49.
Zurück zum Zitat Ban B, Bai B, Zhang M, Hu J, Ramanjaneya M, Tan BK, Chen J (2014) Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose. PLoS ONE. doi:10.1371/journal.pone.0112931 Ban B, Bai B, Zhang M, Hu J, Ramanjaneya M, Tan BK, Chen J (2014) Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose. PLoS ONE. doi:10.​1371/​journal.​pone.​0112931
50.
Zurück zum Zitat Wolf RM, Steele KE, Peterson LA, Magnuson TH, Schweitzer MA, Wong GW (2015) Lower circulating C1q/TNF-related protein-3 (CTRP3) levels are associated with obesity: a cross-sectional study. PLoS ONE. doi:10.1371/journal.pone.0133955 Wolf RM, Steele KE, Peterson LA, Magnuson TH, Schweitzer MA, Wong GW (2015) Lower circulating C1q/TNF-related protein-3 (CTRP3) levels are associated with obesity: a cross-sectional study. PLoS ONE. doi:10.​1371/​journal.​pone.​0133955
51.
Zurück zum Zitat Li X, Jiang L, Yang M, Y-w Wu, S-x Sun, J-z Sun (2014) Expression of CTRP3, a novel adipokine, in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it. J Diabetes Res. doi:10.1155/2014/398518 Li X, Jiang L, Yang M, Y-w Wu, S-x Sun, J-z Sun (2014) Expression of CTRP3, a novel adipokine, in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it. J Diabetes Res. doi:10.​1155/​2014/​398518
52.
Zurück zum Zitat Eliades M, Spyrou E, Agrawal N, Lazo M, Brancati F, Potter J, Koteish A, Clark J, Guallar E, Hernaez R (2013) Meta-analysis: vitamin D and non-alcoholic fatty liver disease. Aliment Pharmacol Ther 38:246–254CrossRef Eliades M, Spyrou E, Agrawal N, Lazo M, Brancati F, Potter J, Koteish A, Clark J, Guallar E, Hernaez R (2013) Meta-analysis: vitamin D and non-alcoholic fatty liver disease. Aliment Pharmacol Ther 38:246–254CrossRef
53.
Zurück zum Zitat Targher G, Bertolini L, Scala L, Cigolini M, Zenari L, Falezza G, Arcaro G (2007) Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 17:517–524CrossRef Targher G, Bertolini L, Scala L, Cigolini M, Zenari L, Falezza G, Arcaro G (2007) Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 17:517–524CrossRef
54.
Zurück zum Zitat Black LJ, Jacoby P, She Ping-Delfos WC, Mori TA, Beilin LJ, Olynyk JK, Ayonrinde OT, Huang RC, Holt PG, Hart PH, Oddy WH, Adams LA (2014) Low serum 25-hydroxyvitamin D concentrations are associated with non-alcoholic fatty liver disease in adolescents independent of adiposity. J Gastroenterol Hepatol 29:1215–1222. doi:10.1111/jgh.12541 CrossRef Black LJ, Jacoby P, She Ping-Delfos WC, Mori TA, Beilin LJ, Olynyk JK, Ayonrinde OT, Huang RC, Holt PG, Hart PH, Oddy WH, Adams LA (2014) Low serum 25-hydroxyvitamin D concentrations are associated with non-alcoholic fatty liver disease in adolescents independent of adiposity. J Gastroenterol Hepatol 29:1215–1222. doi:10.​1111/​jgh.​12541 CrossRef
55.
Zurück zum Zitat Bril F, Maximos M, Portillo-Sanchez P, Biernacki D, Lomonaco R, Subbarayan S, Correa M, Lo M, Suman A, Cusi K (2015) Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis. J Hepatol 62:405–411CrossRef Bril F, Maximos M, Portillo-Sanchez P, Biernacki D, Lomonaco R, Subbarayan S, Correa M, Lo M, Suman A, Cusi K (2015) Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis. J Hepatol 62:405–411CrossRef
56.
Zurück zum Zitat Li L, Zhang L, Pan S, Wu X, Yin X (2013) No significant association between vitamin D and nonalcoholic fatty liver disease in a Chinese population. Dig Dis Sci 58:2376–2382CrossRef Li L, Zhang L, Pan S, Wu X, Yin X (2013) No significant association between vitamin D and nonalcoholic fatty liver disease in a Chinese population. Dig Dis Sci 58:2376–2382CrossRef
57.
Zurück zum Zitat Roth CL, Elfers CT, Figlewicz DP, Melhorn SJ, Morton GJ, Hoofnagle A, Yeh MM, Nelson JE, Kowdley KV (2012) Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and toll-like receptor activation. Hepatology 55:1103–1111CrossRef Roth CL, Elfers CT, Figlewicz DP, Melhorn SJ, Morton GJ, Hoofnagle A, Yeh MM, Nelson JE, Kowdley KV (2012) Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and toll-like receptor activation. Hepatology 55:1103–1111CrossRef
58.
Zurück zum Zitat Kong M, Zhu L, Bai L, Zhang X, Chen Y, Liu S, Zheng S, Pandol SJ, Han Y-P, Duan Z (2014) Vitamin D deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model. Am J Physiol Gastrointest Liver Physiol 307:G883–G893CrossRef Kong M, Zhu L, Bai L, Zhang X, Chen Y, Liu S, Zheng S, Pandol SJ, Han Y-P, Duan Z (2014) Vitamin D deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model. Am J Physiol Gastrointest Liver Physiol 307:G883–G893CrossRef
59.
Zurück zum Zitat Marotte C, Weisstaub A, Bryk G, Olguin MC, Posadas M, Lucero D, Schreier L, De Portela MLPM, Zeni SN (2013) Effect of dietary calcium (Ca) on body composition and Ca metabolism during growth in genetically obese (β) male rats. Eur J Nutr 52:297–305CrossRef Marotte C, Weisstaub A, Bryk G, Olguin MC, Posadas M, Lucero D, Schreier L, De Portela MLPM, Zeni SN (2013) Effect of dietary calcium (Ca) on body composition and Ca metabolism during growth in genetically obese (β) male rats. Eur J Nutr 52:297–305CrossRef
60.
Zurück zum Zitat Bhat M, Noolu B, Qadri SS, Ismail A (2014) Vitamin D deficiency decreases adiposity in rats and causes altered expression of uncoupling proteins and steroid receptor coactivator3. J Steroid Biochem Mol Biol 144:304–312CrossRef Bhat M, Noolu B, Qadri SS, Ismail A (2014) Vitamin D deficiency decreases adiposity in rats and causes altered expression of uncoupling proteins and steroid receptor coactivator3. J Steroid Biochem Mol Biol 144:304–312CrossRef
61.
Zurück zum Zitat Winder W, Hardie D (1999) AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol Endocrinol Metab 277:E1–E10CrossRef Winder W, Hardie D (1999) AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol Endocrinol Metab 277:E1–E10CrossRef
62.
Zurück zum Zitat Steinberg GR, Kemp BE (2009) AMPK in health and disease. Physiol Rev 89:1025–1078CrossRef Steinberg GR, Kemp BE (2009) AMPK in health and disease. Physiol Rev 89:1025–1078CrossRef
63.
Zurück zum Zitat Guo T, Woo S-L, Guo X, Li H, Zheng J, Botchlett R, Liu M, Pei Y, Xu H, Cai Y (2016) Berberine ameliorates hepatic steatosis and suppresses liver and adipose tissue inflammation in mice with diet-induced obesity. Sci Rep. doi:10.1038/srep22612 Guo T, Woo S-L, Guo X, Li H, Zheng J, Botchlett R, Liu M, Pei Y, Xu H, Cai Y (2016) Berberine ameliorates hepatic steatosis and suppresses liver and adipose tissue inflammation in mice with diet-induced obesity. Sci Rep. doi:10.​1038/​srep22612
64.
Zurück zum Zitat Muse ED, Obici S, Bhanot S, Monia BP, McKay RA, Rajala MW, Scherer PE, Rossetti L (2004) Role of resistin in diet-induced hepatic insulin resistance. J Clin Invest 114:232–239CrossRef Muse ED, Obici S, Bhanot S, Monia BP, McKay RA, Rajala MW, Scherer PE, Rossetti L (2004) Role of resistin in diet-induced hepatic insulin resistance. J Clin Invest 114:232–239CrossRef
65.
Zurück zum Zitat Yamin HB, Barnea M, Genzer Y, Chapnik N, Froy O (2014) Long-term commercial cow’s milk consumption and its effects on metabolic parameters associated with obesity in young mice. Mol Nutr Food Res 58:1061–1068CrossRef Yamin HB, Barnea M, Genzer Y, Chapnik N, Froy O (2014) Long-term commercial cow’s milk consumption and its effects on metabolic parameters associated with obesity in young mice. Mol Nutr Food Res 58:1061–1068CrossRef
66.
Zurück zum Zitat Matsumoto M, Hagio M, Inoue R, Mitani T, Yajima M, Hara H, Yajima T (2014) Long-term oral feeding of lutein-fortified milk increases voluntary running distance in rats. PLoS ONE. doi:10.1371/journal.pone.0093529 Matsumoto M, Hagio M, Inoue R, Mitani T, Yajima M, Hara H, Yajima T (2014) Long-term oral feeding of lutein-fortified milk increases voluntary running distance in rats. PLoS ONE. doi:10.​1371/​journal.​pone.​0093529
Metadaten
Titel
Calcium and vitamin D3 combinations improve fatty liver disease through AMPK-independent mechanisms
verfasst von
Sara Shojaei Zarghani
Hamid Soraya
Mohammad Alizadeh
Publikationsdatum
17.12.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 2/2018
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-016-1360-4

Weitere Artikel der Ausgabe 2/2018

European Journal of Nutrition 2/2018 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.