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Osteoporosis International

Erschienen in:

01.05.2007 | Letter to the Editor

Calcium-PTH-vitamin D axis in older patients with hip fracture

verfasst von: A. A. Fisher, M. W. Davis

Erschienen in: Osteoporosis International | Ausgabe 5/2007

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Excerpt

We read with interest the article by Sakuma and colleagues [1] dealing with the controversial issue of vitamin D-PTH status in hip fracture (HF) patients. With an ageing population and exponentially increasing numbers of HFs worldwide, it is important to clarify the contribution of abnormalities in calcium-PTH-vitamin D relationships to HFs. Adequate vitamin D-PTH status is paramount in calcium homeostasis and for bone health. However, recent large randomised controlled trials [2‐4] as well as systemic reviews [5‐7] contrary to a previous meta-analysis [8] did not find that supplementation with vitamin D and calcium reduces HFs, except in frail people confined to institutions [7]. …

Sakuma M, Endo N, Oinuma T et al (2006) Vitamin D and intact PTH status in patients with hip fracture. Osteoporosis Int 17:1608–1614CrossRef

Grant AM, Avenell A, Campbell MK et al (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365:1621–1628PubMedCrossRef

Porthouse J, Cockayne S, King C et al (2005) Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ 330:1003PubMedCrossRef

Jackson RD, LaCroix AZ, Gass M et al (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354:669–683PubMedCrossRef

Gillespie LD, Gillespie WJ, Robertson MC et al (2003) Interventions for preventing falls in elderly people. Cochrane Database Syst Rev CD000340

Latham NK, Anderson CS, Reid IR (2003) Effects of vitamin D supplementation on strength, physical performance and falls in older persons: a systematic review. J Am Geriatr Soc 51:1219–1226PubMedCrossRef

Avenell A, Gillespie WJ, Gillespie LD et al (2005) Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev 20:CD000227

Bischoff-Ferrari HA, Willett WC, Wong JB et al (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomised controlled trials. JAMA 293:2257–2264PubMedCrossRef

Heaney RP (2004) Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr 80:1706S–1709SPubMed

10.

Moniz C, Dew T, Dixon T (2005) Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London. Curr Med Res Opin 21:1891–1894PubMedCrossRef

11.

Dixon T, Mitchell P, Beringer T et al (2006) An overview of the prevalence of 25-hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom. Curr Med Res Opin 22:405–415PubMedCrossRef

12.

Sahota O, Gaynor K, Harwood RH et al (2001) Hypovitaminosis D and “functional hypoparathyroidism”- the NoNoF (Nottingham Neck of Femur) study. Age Ageing 30:467–472PubMedCrossRef

13.

Sahota O, Mundey MK, San P et al (2004) The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover and bone mineral density in postmenopausal women with established osteoporosis. Bone 35:312–319PubMedCrossRef

14.

Lips P (2001) Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22:477–501PubMedCrossRef

15.

Saleh F, Jorde R, Sundsfjord J et al (2006) Causes of secondary hyperparathyroidism in a healthy population: the Tromso study. J Bone Miner Metab 24:58–64PubMedCrossRef

16.

Silver J, Levi R (2005) Cellular and molecular mechanisms of secondary hyperparathyroidism. Clin Nephrol 63:119–126PubMed

17.

Sahota O, Mundey MK, San P et al (2006) Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency. Osteoporos Int 17:1013–1021PubMedCrossRef

18.

Delmas PD, Eastell R, Garnero P et al (2000) The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int 11:S2–S17PubMedCrossRef

19.

Iki M, Morita A, Ikeda Y et al (2006) Biochemical markers of bone turnover predict bone loss in perimenopausal women but not in postmenopausal women - the Japanese Population-based Osteoporosis (JPOS) Cohort Study. Osteoporos Int 17:1086–1095PubMedCrossRef

20.

Sambrook PN, Chen CJ, March L et al (2006) High bone turnover is an independent predictor of mortality in the frail elderly. J Bone Miner Res 21:549–555PubMedCrossRef

21.

von Muhlen DG, Greendale GA, Garland CF et al (2005) Vitamin D, parathyroid hormone levels and bone mineral density in community-dwelling older women: the Rancho Bernardo Study. Osteoporos Int 16:1721–1726CrossRef

Titel: Calcium-PTH-vitamin D axis in older patients with hip fracture
verfasst von: A. A. Fisher
M. W. Davis
Publikationsdatum: 01.05.2007
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 5/2007
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-006-0284-x

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