Erschienen in:
21.05.2019 | Skeletal Biology and Regulation (M Forwood and A Robling, Section Editors)
CaMKK2 Signaling in Metabolism and Skeletal Disease: a New Axis with Therapeutic Potential
verfasst von:
Justin N. Williams, Uma Sankar
Erschienen in:
Current Osteoporosis Reports
|
Ausgabe 4/2019
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Abstract
Purpose of Review
Age and metabolic disorders result in the accumulation of advanced glycation endproducts (AGEs), oxidative stress, and inflammation, which cumulatively cause a decline in skeletal health. Bone becomes increasingly vulnerable to fractures and its regenerative capacity diminishes under such conditions. With a rapidly aging population in the USA and the global increase in diabetes, efficacious, multi-dimensional therapies that can treat or prevent skeletal diseases associated with metabolic dysfunction and inflammatory disorders are acutely needed.
Recent Findings
Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a key regulator of nutrient intake, glucose metabolism, insulin production, and adipogenesis. Recent studies suggest a pivotal role for CaMKK2 in bone metabolism, fracture healing, and inflammation.
Summary
Aside from rekindling previous concepts of CaMKK2 as a potent regulator of whole-body energy homeostasis, this review emphasizes CaMKK2 as a potential therapeutic target to treat skeletal diseases that underlie metabolic conditions and inflammation.