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Erschienen in:
04.07.2020 | Original Article – Clinical Oncology
Camrelizumab in advanced or metastatic solid tumour patients with DNA mismatch repair deficient or microsatellite instability high: an open-label prospective pivotal trial
Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 10/2020
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Purpose
Patients with DNA mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) cancers are prone to response to programmed cell death-1 (PD-1) checkpoint inhibitors. Therefore, we explored the efficacy and safety of a PD-1 checkpoint inhibitor camrelizumab in advanced or metastatic solid tumour with dMMR/MSI-H.
Methods
Patients with dMMR/MSI-H advanced or metastatic solid tumours who had received at least one line of prior systemic chemotherapy were recruited. Camrelizumab was given intravenously 200 mg every 2-week treatment cycle. The primary endpoint was objective response rate according to Response Evaluation Criteria in Solid Tumours v1.1.
Results
Twelve patients were enrolled. As data cutoff, eight patients (66.7%, 95% CI 34.9–90.1) achieved objective response. Disease control rate reached 100% (95% CI 73.5–100). Progression-free survival rate at 12 months was 83.3% (95% CI 48.2–95.6), and overall survival rate at 12 months was 90% (95% CI 47.3–98.5). The most common treatment-related adverse events were reactive cutaneous capillary endothelial proliferation (100%), increased alanine aminotransferase (41.7%), and increased aspartate aminotransferase (41.7%).
Conclusions
Camrelizumab provided durable objective response and disease control in pre-treated patients with dMMR/MSI-H advanced or metastatic solid tumour, being a promising treatment option for these patients.