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Erschienen in: Obesity Surgery 8/2018

02.03.2018 | Original Contributions

Can Helicobacter pylori Eradication Treatment Modify the Metabolic Response to Bariatric Surgery?

verfasst von: Alberto Goday, Olga Castañer, David Benaiges, Anna Busquets Pou, José M. Ramón, Maria del Mar Iglesias, Luis Barranco Priego, Juana A. Flores Le-Roux

Erschienen in: Obesity Surgery | Ausgabe 8/2018

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Abstract

Background

Helicobacter pylori (HP) colonization is common in severely obese patients undergoing bariatric surgery. HP eradication treatment could influence the evolution of weight loss and metabolic markers after bariatric surgery.

Objective

To assess the influence of HP eradication in the clinical course of morbid obesity patients treated with bariatric surgery (gastric bypass (LRYGB) and sleeve gastrectomy (LSG))

Methods

Retrospective analysis of a prospective cohort of 229 patients that underwent bariatric surgery between 2010 and 2013 in Hospital del Mar. HP infection was tested preoperatively by gastric biopsy and, if positive, treated with omeprazole, clarithromycin, and amoxicillin for 14 days. Patients were followed at 3, 6, 12, 18, and 24 months after bariatric surgery. Short-term weight loss and metabolic outcomes were evaluated.

Results

HP treated (HPt) patients had a greater reduction in BMI at 3 months after LSG (ΔBMI (kg/cm2) 8.5 ± 4.1 vs 11.3 ± 3.05 kg/m2; p = 0.004) and a reduction in the evolution of triglyceride levels from baseline to 12 months (p = 0.014) compared to HP-negative (HP−) subjects. Also, non-diabetic HPt patients had a greater reduction in glucose levels at all time points that was maintained up to 24 months after LRYGB (p = 0.003). No differences were observed in total and LDL cholesterol levels, HOMA-IR, or HbA1C.

Conclusions

Preoperative HP eradication has a short-term influence on some metabolic parameters after bariatric surgery.
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Metadaten
Titel
Can Helicobacter pylori Eradication Treatment Modify the Metabolic Response to Bariatric Surgery?
verfasst von
Alberto Goday
Olga Castañer
David Benaiges
Anna Busquets Pou
José M. Ramón
Maria del Mar Iglesias
Luis Barranco Priego
Juana A. Flores Le-Roux
Publikationsdatum
02.03.2018
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 8/2018
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-018-3170-7

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