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Erschienen in: International Ophthalmology 10/2020

01.06.2020 | Original Paper

Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography?

verfasst von: Hakan Öztürk, Bediz Özen, Hayrullah Manyas, Gönül Çatlı, Bumin Dündar

Erschienen in: International Ophthalmology | Ausgabe 10/2020

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Abstract

Purpose

To determine early ocular changes in children and adolescents with type 1 diabetes mellitus without retinopathy (T1DM-woR) by optical biometry (OB) and optical coherence tomography (OCT).

Methods

Seventy children and adolescents with T1DM-woR (patient group) and 72 healthy children and adolescents (control group) were included. Demographic data, anthropometric measurements and anterior–posterior segment parameters of groups were compared. Correlations between ocular parameters and glycosylated hemoglobin (HbA1c) level, age at diabetes mellitus (DM) onset and DM duration were evaluated.

Results

Patients with T1DM-woR had significantly shallower anterior chambers (3.50 ± 0.12 vs 3.67 ± 0.11 mm, p < 0.001), thicker lenses (3.65 ± 0.15 vs 3.37 ± 0.14 mm, p < 0.001), thinner central retinal nerve fiber layer (RNFL) thicknesses (95.3 ± 6.7 vs 104.8 ± 6.2 µm, p < 0.001) and thinner central choroidal thicknesses (292.8 ± 23.6 vs 325.1 ± 24.7 µm, p < 0.001) than healthy individuals. As the lens thickness (LT) increased, anterior chamber depth (ACD) decreased in patient group (r = − 0.368, p = 0.040). Other anterior (central corneal thickness, axial length, keratometry, spherical equivalent) and posterior (superior temporal, superior nasal, nasal, inferior nasal, inferior temporal, temporal RNFL thicknesses; nasal and temporal choroidal thicknesses; central part’s and inner–outer macular segments’ thickness and volume measurements) segment parameters of groups were similar (p > 0.05). In patient group, as HbA1c level increased, central RNFL and choroidal thicknesses decreased (r = − 0.639, p < 0.001; r = − 0.486, p = 0.010, respectively).

Conclusions

In patients with T1DM, we found that LT increased, and ACD, central RNFL and choroidal thicknesses decreased by OB and OCT before visible findings appeared in routine ophthalmological examination. Determination of early changes is warning to physician and patient in order to prevent more serious damages occurring later.
Literatur
1.
Zurück zum Zitat American Diabetes Association (2014) Diagnosis and classification of diabetes mellitus. Diabetes Care 37(Suppl 1):81–90 American Diabetes Association (2014) Diagnosis and classification of diabetes mellitus. Diabetes Care 37(Suppl 1):81–90
2.
Zurück zum Zitat Barber AJ (2003) A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 27:283–290PubMed Barber AJ (2003) A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 27:283–290PubMed
3.
Zurück zum Zitat Cheung N, Mitchell P, Wong TY (2010) Diabetic retinopathy. Lancet 376(9735):124–136PubMed Cheung N, Mitchell P, Wong TY (2010) Diabetic retinopathy. Lancet 376(9735):124–136PubMed
4.
Zurück zum Zitat Araszkiewicz A, Zozulinska-Ziolkiewicz D, Meller M, Bernardczyk-Meller J, Pilacinski S, Rogowicz-Frontczak A, Naskret D, Wierusz-Wysocka B (2012) Neurodegeneration of the retina in type 1 diabetic patients. Pol Arch Med Wewn 122(10):464–470PubMed Araszkiewicz A, Zozulinska-Ziolkiewicz D, Meller M, Bernardczyk-Meller J, Pilacinski S, Rogowicz-Frontczak A, Naskret D, Wierusz-Wysocka B (2012) Neurodegeneration of the retina in type 1 diabetic patients. Pol Arch Med Wewn 122(10):464–470PubMed
5.
Zurück zum Zitat Stem MS, Gardner TW (2013) Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications. Curr Med Chem 20:3241–3250PubMedPubMedCentral Stem MS, Gardner TW (2013) Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications. Curr Med Chem 20:3241–3250PubMedPubMedCentral
6.
Zurück zum Zitat Xiao Y, Li T, Jia Y, Wang S, Yang C, Zou H (2019) Influence of type 1 diabetes mellitus on the ocular biometry of Chinese children. J Ophthalmol 2019:Article Id: 7216490 Xiao Y, Li T, Jia Y, Wang S, Yang C, Zou H (2019) Influence of type 1 diabetes mellitus on the ocular biometry of Chinese children. J Ophthalmol 2019:Article Id: 7216490
7.
Zurück zum Zitat Wiemer NG, Dubbelman M, Kostense PJ, Ringens PJ, Polak BC (2008) The influence of diabetes mellitus type 1 and 2 on the thickness, shape, and equivalent refractive index of the human crystalline lens. Ophthalmology 115(10):1679–1686PubMed Wiemer NG, Dubbelman M, Kostense PJ, Ringens PJ, Polak BC (2008) The influence of diabetes mellitus type 1 and 2 on the thickness, shape, and equivalent refractive index of the human crystalline lens. Ophthalmology 115(10):1679–1686PubMed
8.
Zurück zum Zitat Yoon KC, Im SK, Seo MS (2004) Changes of tear film and ocular surface in diabetes mellitus. Korean J Ophthalmol 18:168–174PubMed Yoon KC, Im SK, Seo MS (2004) Changes of tear film and ocular surface in diabetes mellitus. Korean J Ophthalmol 18:168–174PubMed
9.
Zurück zum Zitat Bikbova G, Oshitari T, Tawada A, Yamamoto S (2012) Corneal changes in diabetes mellitus. Curr Diabetes Rev 8:294–302PubMed Bikbova G, Oshitari T, Tawada A, Yamamoto S (2012) Corneal changes in diabetes mellitus. Curr Diabetes Rev 8:294–302PubMed
10.
Zurück zum Zitat Saw SM, Wong TY, Ting S, Foong AW, Foster PJ (2007) The relationship between anterior chamber depth and the presence of diabetes in the Tanjong Pagar Survey. Am J Ophthalmol 144:325–326PubMed Saw SM, Wong TY, Ting S, Foong AW, Foster PJ (2007) The relationship between anterior chamber depth and the presence of diabetes in the Tanjong Pagar Survey. Am J Ophthalmol 144:325–326PubMed
11.
Zurück zum Zitat Oshitari T, Hanawa K, Adachi-Usami E (2009) Changes of macular and RNFL thicknesses measured by stratus OCT in patients with early stage diabetes. Eye 23(4):884–889PubMed Oshitari T, Hanawa K, Adachi-Usami E (2009) Changes of macular and RNFL thicknesses measured by stratus OCT in patients with early stage diabetes. Eye 23(4):884–889PubMed
12.
Zurück zum Zitat Xu J, Xu L, Du KF, Shao L, Chen CX, Zhou JQ, Wang YX, You QS, Jonas JB, Wei WB (2013) Subfoveal choroidal thickness in diabetes and diabetic retinopathy. Ophthalmology 120(10):2023–2028PubMed Xu J, Xu L, Du KF, Shao L, Chen CX, Zhou JQ, Wang YX, You QS, Jonas JB, Wei WB (2013) Subfoveal choroidal thickness in diabetes and diabetic retinopathy. Ophthalmology 120(10):2023–2028PubMed
13.
Zurück zum Zitat Yolcu U, Çağıltay E, Toyran S, Akay F, Uzun S, Gundogan FC (2016) Choroidal and macular thickness changes in type 1 diabetes mellitus patients without diabetic retinopathy. Postgrad Med 128(8):755–760PubMed Yolcu U, Çağıltay E, Toyran S, Akay F, Uzun S, Gundogan FC (2016) Choroidal and macular thickness changes in type 1 diabetes mellitus patients without diabetic retinopathy. Postgrad Med 128(8):755–760PubMed
14.
Zurück zum Zitat Calvo-Maroto AM, Perez-Cambrodi RJ, Albaran-Diego C, Pons A, Cerviño A (2014) Optical quality of the diabetic eye: a review. Eye (Lond) 28(11):1271–1280 Calvo-Maroto AM, Perez-Cambrodi RJ, Albaran-Diego C, Pons A, Cerviño A (2014) Optical quality of the diabetic eye: a review. Eye (Lond) 28(11):1271–1280
15.
Zurück zum Zitat Geloneck MM, Forbes BJ, Shaffer J, Ying GS, Binenbaum G (2015) Ocular complications in children with diabetes mellitus. Ophthalmology 122(12):2457–2464PubMedPubMedCentral Geloneck MM, Forbes BJ, Shaffer J, Ying GS, Binenbaum G (2015) Ocular complications in children with diabetes mellitus. Ophthalmology 122(12):2457–2464PubMedPubMedCentral
16.
Zurück zum Zitat Donaghue KC, Marcovecchio ML, Wadwa RP, Chew EY, Wong TY, Calliari LE, Zabeen B, Salem MA, Craig ME (2018) ISPAD clinical practice consensus guidelines 2018: Microvascular and macrovascular complications in children and adolescents. Pediatr Diabetes 19(Suppl 27):262–274PubMed Donaghue KC, Marcovecchio ML, Wadwa RP, Chew EY, Wong TY, Calliari LE, Zabeen B, Salem MA, Craig ME (2018) ISPAD clinical practice consensus guidelines 2018: Microvascular and macrovascular complications in children and adolescents. Pediatr Diabetes 19(Suppl 27):262–274PubMed
17.
Zurück zum Zitat Altemir I, Pueyo V, Elía N, Polo V, Larrosa JM, Oros D (2013) Reproducibility of optical coherence tomography measurements in children. Am J Ophthalmol 155(1):171–176PubMed Altemir I, Pueyo V, Elía N, Polo V, Larrosa JM, Oros D (2013) Reproducibility of optical coherence tomography measurements in children. Am J Ophthalmol 155(1):171–176PubMed
18.
Zurück zum Zitat Cruysberg LP, Doors M, Verbakel F, Berendschot TT, De Brabander J, Nuijts RM (2010) Evaluation of the Lenstar LS 900 non-contact biometer. Br J Ophthalmol 94(1):106–110PubMed Cruysberg LP, Doors M, Verbakel F, Berendschot TT, De Brabander J, Nuijts RM (2010) Evaluation of the Lenstar LS 900 non-contact biometer. Br J Ophthalmol 94(1):106–110PubMed
19.
Zurück zum Zitat Tanner JM, Whitehouse RH (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty. Arch Dis Child 51(3):170–179PubMedPubMedCentral Tanner JM, Whitehouse RH (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty. Arch Dis Child 51(3):170–179PubMedPubMedCentral
20.
Zurück zum Zitat Neyzi O, Bundak R, Gökçay G, Günöz H, Furman A, Darendeliler F, Baş F (2015) Reference values for weight, height, head circumference and body mass index in Turkish children. J Clin Res Pediatr Endocrinol 7(4):280–293PubMedPubMedCentral Neyzi O, Bundak R, Gökçay G, Günöz H, Furman A, Darendeliler F, Baş F (2015) Reference values for weight, height, head circumference and body mass index in Turkish children. J Clin Res Pediatr Endocrinol 7(4):280–293PubMedPubMedCentral
21.
Zurück zum Zitat Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, de Ferranti SD, Dionne JM, Falkner B, Flinn SK, Gidding SS, Goodwin C, Leu MG, Powers ME, Rea C, Samuels J, Simasek M, Thaker VV, Urbina EM, Subcommittee on screening and management of high blood pressure in children (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140(3):e20171904PubMed Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, de Ferranti SD, Dionne JM, Falkner B, Flinn SK, Gidding SS, Goodwin C, Leu MG, Powers ME, Rea C, Samuels J, Simasek M, Thaker VV, Urbina EM, Subcommittee on screening and management of high blood pressure in children (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140(3):e20171904PubMed
22.
Zurück zum Zitat Demir K, Konakçı E, Özkaya G, Kasap Demir B, Özen S, Aydın M, Darendeliler F (2020) New features for child metrics: further growth references and blood pressure calculations. J Clin Res Pediatr Endocrinol 12(2):125–129PubMedPubMedCentral Demir K, Konakçı E, Özkaya G, Kasap Demir B, Özen S, Aydın M, Darendeliler F (2020) New features for child metrics: further growth references and blood pressure calculations. J Clin Res Pediatr Endocrinol 12(2):125–129PubMedPubMedCentral
23.
Zurück zum Zitat Boonarpha N, Zheng Y, Stangos AN, Lu H, Raj A, Czanner G, Harding SP, Nair-Sahni J (2015) Standardization of choroidal thickness measurements using enhanced depth imaging optical coherence tomography. Int J Ophthalmol 8(3):484–491PubMedPubMedCentral Boonarpha N, Zheng Y, Stangos AN, Lu H, Raj A, Czanner G, Harding SP, Nair-Sahni J (2015) Standardization of choroidal thickness measurements using enhanced depth imaging optical coherence tomography. Int J Ophthalmol 8(3):484–491PubMedPubMedCentral
24.
Zurück zum Zitat Early Treatment Diabetic Retinopathy Study Research Group (1991) Early treatment diabetic retinopathy study design and baseline patient characteristics. ETDRS report number 7. Ophthalmology 98(Suppl 5):741–756 Early Treatment Diabetic Retinopathy Study Research Group (1991) Early treatment diabetic retinopathy study design and baseline patient characteristics. ETDRS report number 7. Ophthalmology 98(Suppl 5):741–756
25.
Zurück zum Zitat Akil H, Bulus AD, Andiran N, Alp MN (2016) Ocular manifestations of type 1 diabetes mellitus in pediatric population. Indian J Ophthalmol 64:654–658PubMedPubMedCentral Akil H, Bulus AD, Andiran N, Alp MN (2016) Ocular manifestations of type 1 diabetes mellitus in pediatric population. Indian J Ophthalmol 64:654–658PubMedPubMedCentral
26.
Zurück zum Zitat Sayin N, Kara N, Pirhan D, Vural A, Ersan HB, Onal H, Cınar S (2014) Evaluation of subfoveal choroidal thickness in children with type 1 diabetes mellitus: an EDI-OCT study. Semin Ophthalmol 29(1):27–31PubMed Sayin N, Kara N, Pirhan D, Vural A, Ersan HB, Onal H, Cınar S (2014) Evaluation of subfoveal choroidal thickness in children with type 1 diabetes mellitus: an EDI-OCT study. Semin Ophthalmol 29(1):27–31PubMed
27.
Zurück zum Zitat Li T, Jia Y, Wang S, Wang A, Gao L, Yang C, Zou H (2019) Retinal microvascular abnormalities in children with type 1 diabetes mellitus without visual impairment or diabetic retinopathy. Invest Ophthalmol Vis Sci 60(4):990–998PubMed Li T, Jia Y, Wang S, Wang A, Gao L, Yang C, Zou H (2019) Retinal microvascular abnormalities in children with type 1 diabetes mellitus without visual impairment or diabetic retinopathy. Invest Ophthalmol Vis Sci 60(4):990–998PubMed
28.
Zurück zum Zitat Pekel E, Altıncık SA, Pekel G (2018) Evaluation of optic disc, retinal nerve fiber and macular ganglion cell layers in pediatric diabetes. Int Ophthalmol 38(5):1955–1961PubMed Pekel E, Altıncık SA, Pekel G (2018) Evaluation of optic disc, retinal nerve fiber and macular ganglion cell layers in pediatric diabetes. Int Ophthalmol 38(5):1955–1961PubMed
29.
Zurück zum Zitat Wiemer NG, Dubbelman M, Hermans EA, Ringens PJ, Polak BC (2008) Changes in the internal structure of the human crystalline lens with diabetes mellitus type 1 and type 2. Ophthalmology 115:2017–2023PubMed Wiemer NG, Dubbelman M, Hermans EA, Ringens PJ, Polak BC (2008) Changes in the internal structure of the human crystalline lens with diabetes mellitus type 1 and type 2. Ophthalmology 115:2017–2023PubMed
30.
Zurück zum Zitat Uzel MM, Elgin U, Sen E, Keskin M, Sağsak E, Aycan Z (2016) Comparison of anterior segment parameters in juvenile diabetes mellitus and healthy eyes. Eur J Ophthalmol 26(6):618–622PubMed Uzel MM, Elgin U, Sen E, Keskin M, Sağsak E, Aycan Z (2016) Comparison of anterior segment parameters in juvenile diabetes mellitus and healthy eyes. Eur J Ophthalmol 26(6):618–622PubMed
31.
Zurück zum Zitat Nalcacioglu-Yuksekkaya P, Sen E, Cetinkaya S, Bas V, Aycan Z, Ozturk F (2014) Corneal biomechanical characteristics in children with diabetes mellitus. Int Ophthalmol 34(4):881–886PubMed Nalcacioglu-Yuksekkaya P, Sen E, Cetinkaya S, Bas V, Aycan Z, Ozturk F (2014) Corneal biomechanical characteristics in children with diabetes mellitus. Int Ophthalmol 34(4):881–886PubMed
32.
Zurück zum Zitat Rodrigues EB, Urias MG, Penha FM, Badarò E, Novais E, Mereilles R, Farah ME (2015) Diabetes induces changes in neuroretina before retinal vessels: a spectral-domain optical coherence tomography study. Int J Retina Vitreous 1:4PubMedPubMedCentral Rodrigues EB, Urias MG, Penha FM, Badarò E, Novais E, Mereilles R, Farah ME (2015) Diabetes induces changes in neuroretina before retinal vessels: a spectral-domain optical coherence tomography study. Int J Retina Vitreous 1:4PubMedPubMedCentral
33.
Zurück zum Zitat Verma A, Rani PK, Raman R, Pal SS, Laxmi G, Gupta M, Sahu C, Vaitheeswaran K, Sharma T (2009) Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and spectral domain optical coherence tomography (SD-OCT) study in individuals with diabetes, but no diabetic retinopathy. Eye (London) 23(9):1824–1830 Verma A, Rani PK, Raman R, Pal SS, Laxmi G, Gupta M, Sahu C, Vaitheeswaran K, Sharma T (2009) Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and spectral domain optical coherence tomography (SD-OCT) study in individuals with diabetes, but no diabetic retinopathy. Eye (London) 23(9):1824–1830
34.
Zurück zum Zitat Park SH, Park JW, Park SJ, Kim KY, Chung JW, Chun MH, Oh SJ (2003) Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina. Diabetologia 46(9):1260–1268PubMed Park SH, Park JW, Park SJ, Kim KY, Chung JW, Chun MH, Oh SJ (2003) Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina. Diabetologia 46(9):1260–1268PubMed
35.
Zurück zum Zitat Fletcher EL, Phipps JA, Wilkinson-Berka JL (2005) Dysfunction of retinal neurons and glia during diabetes. Clin Exp Optom 88(3):132–145PubMed Fletcher EL, Phipps JA, Wilkinson-Berka JL (2005) Dysfunction of retinal neurons and glia during diabetes. Clin Exp Optom 88(3):132–145PubMed
36.
Zurück zum Zitat Villarroel M, Ciudin A, Hernandez C, Simo R (2010) Neurodegeneration: an early event of diabetic retinopathy. World J Diabetes 1(2):57–64PubMedPubMedCentral Villarroel M, Ciudin A, Hernandez C, Simo R (2010) Neurodegeneration: an early event of diabetic retinopathy. World J Diabetes 1(2):57–64PubMedPubMedCentral
37.
Zurück zum Zitat Martin PM, Roon P, Van Ells TK, Ganapathy V, Smith SB (2004) Death of retinal neurons in streptozotocin-induced diabetic mice. Invest Ophthalmol Vis Sci 45(9):3330–3336PubMed Martin PM, Roon P, Van Ells TK, Ganapathy V, Smith SB (2004) Death of retinal neurons in streptozotocin-induced diabetic mice. Invest Ophthalmol Vis Sci 45(9):3330–3336PubMed
38.
Zurück zum Zitat Simo R, Hernandez C (2012) European consortium for the early treatment of diabetic retinopathy (EUROCONDOR). Neurodegeneration is an early event in diabetic retinopathy: therapeutic implicaitons. Br J Ophthalmol 96(10):1285–1290PubMed Simo R, Hernandez C (2012) European consortium for the early treatment of diabetic retinopathy (EUROCONDOR). Neurodegeneration is an early event in diabetic retinopathy: therapeutic implicaitons. Br J Ophthalmol 96(10):1285–1290PubMed
39.
Zurück zum Zitat Reis A, Mateus C, Melo P, Figueira J, Cunha-Vaz J, CasteloBranco M (2014) Neuroretinal dysfunction with intact blood-retinal barrier and absent vasculopathy in diabetes type 1. Diabetes 63:3926–3937PubMed Reis A, Mateus C, Melo P, Figueira J, Cunha-Vaz J, CasteloBranco M (2014) Neuroretinal dysfunction with intact blood-retinal barrier and absent vasculopathy in diabetes type 1. Diabetes 63:3926–3937PubMed
40.
Zurück zum Zitat Carbonell M, Alonso N, Castelblanco E, Real J, Ramírez-Morros A, Simó R, Hernández C, Jurjo C, Traveset A, Valldeperas X, Mauricio D (2019) Assessment of inner retinal layers and choroidal thickness in type 1 diabetes mellitus: a cross-sectional study. J Clin Med 8(9):1412PubMedCentral Carbonell M, Alonso N, Castelblanco E, Real J, Ramírez-Morros A, Simó R, Hernández C, Jurjo C, Traveset A, Valldeperas X, Mauricio D (2019) Assessment of inner retinal layers and choroidal thickness in type 1 diabetes mellitus: a cross-sectional study. J Clin Med 8(9):1412PubMedCentral
41.
Zurück zum Zitat Van Djik HW, Kok PH, Garvin M, Sonka M, Devries JH, Michels RP, van Velthoven ME, Schlingemann RO, Verbraak FD (2009) Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy. Invest Ophthalmol Vis Sci 50(7):3404–3409 Van Djik HW, Kok PH, Garvin M, Sonka M, Devries JH, Michels RP, van Velthoven ME, Schlingemann RO, Verbraak FD (2009) Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy. Invest Ophthalmol Vis Sci 50(7):3404–3409
42.
Zurück zum Zitat Barber AJ, Nakamura M, Wolpert EB, Reiter CE, Seigel GM, Antonetti DA, Gardner TW (2001) Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J Biol Chem 276(35):32814–32821PubMed Barber AJ, Nakamura M, Wolpert EB, Reiter CE, Seigel GM, Antonetti DA, Gardner TW (2001) Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J Biol Chem 276(35):32814–32821PubMed
43.
Zurück zum Zitat Nakamura M, Barber AJ, Antonetti DA, LaNoue KF, Robinson KA, Buse MG, Gardner TW (2001) Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. J Biol Chem 276(47):43748–43755PubMed Nakamura M, Barber AJ, Antonetti DA, LaNoue KF, Robinson KA, Buse MG, Gardner TW (2001) Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. J Biol Chem 276(47):43748–43755PubMed
44.
Zurück zum Zitat Tekin K, Inanc M, Kurnaz E, Bayramoglu E, Aydemir E, Koc M, Kiziltoprak H, Aycan Z (2018) Quantitative evaluation of early retinal changes in children with type 1 diabetes mellitus without retinopathy. Clin Exp Optom 101(5):680–685PubMed Tekin K, Inanc M, Kurnaz E, Bayramoglu E, Aydemir E, Koc M, Kiziltoprak H, Aycan Z (2018) Quantitative evaluation of early retinal changes in children with type 1 diabetes mellitus without retinopathy. Clin Exp Optom 101(5):680–685PubMed
45.
Zurück zum Zitat El-Fayoumi D, Badr Eldine NM, Esmael AF, Ghalwash D, Soliman HM (2016) Retinal nerve fiber layer and ganglion cell complex thicknesses are reduced in children with type 1 diabetes with no evidence of vascular retinopathy. Invest Ophthalmol Vis Sci 57(13):5355–5360PubMed El-Fayoumi D, Badr Eldine NM, Esmael AF, Ghalwash D, Soliman HM (2016) Retinal nerve fiber layer and ganglion cell complex thicknesses are reduced in children with type 1 diabetes with no evidence of vascular retinopathy. Invest Ophthalmol Vis Sci 57(13):5355–5360PubMed
46.
Zurück zum Zitat Pittasch D, Lobmann R, Behrens-Baumann W, Lehnert H (2002) Pupil signs of sympathetic autonomic neuropathy in patients with type 1 diabetes. Diabetes Care 25(9):1545–1550PubMed Pittasch D, Lobmann R, Behrens-Baumann W, Lehnert H (2002) Pupil signs of sympathetic autonomic neuropathy in patients with type 1 diabetes. Diabetes Care 25(9):1545–1550PubMed
47.
Zurück zum Zitat Pemp B, Palkovits S, Howorka K, Pumprla J, Sacu S, Garhöfer G, Bayerle-Eder M, Schmetterer L, Schmidt-Erfurth U (2018) Correlation of retinal neurodegeneration with measures of peripheral autonomic neuropathy in type 1 diabetes. Acta Ophthalmol 96(7):e804–e810PubMedPubMedCentral Pemp B, Palkovits S, Howorka K, Pumprla J, Sacu S, Garhöfer G, Bayerle-Eder M, Schmetterer L, Schmidt-Erfurth U (2018) Correlation of retinal neurodegeneration with measures of peripheral autonomic neuropathy in type 1 diabetes. Acta Ophthalmol 96(7):e804–e810PubMedPubMedCentral
48.
Zurück zum Zitat Park HY, Jung KI, Na KS, Park SH, Park CK (2012) Visual field characteristics in normal-tension glaucoma patients with autonomic dysfunction and abnormal peripheral microcirculation. Am J Ophthalmol 154(3):466–475PubMed Park HY, Jung KI, Na KS, Park SH, Park CK (2012) Visual field characteristics in normal-tension glaucoma patients with autonomic dysfunction and abnormal peripheral microcirculation. Am J Ophthalmol 154(3):466–475PubMed
49.
Zurück zum Zitat Gołębiewska J, Olechowski A, Wysocka-Mincewicz M, Baszyńska-Wilk M, Groszek A, Czeszyk-Piotrowicz A, Szalecki M, Hautz W (2018) Choroidal thickness and ganglion cell complex in pubescent children with type 1 diabetes without diabetic retinopathy analyzed by spectral domain optical coherence tomography. J Diabetes Res 2018: Article Id 5458015 Gołębiewska J, Olechowski A, Wysocka-Mincewicz M, Baszyńska-Wilk M, Groszek A, Czeszyk-Piotrowicz A, Szalecki M, Hautz W (2018) Choroidal thickness and ganglion cell complex in pubescent children with type 1 diabetes without diabetic retinopathy analyzed by spectral domain optical coherence tomography. J Diabetes Res 2018: Article Id 5458015
50.
Zurück zum Zitat Chen Y, Li J, Yan Y, Shen X (2016) Diabetic macular morphology changes may occur in the early stage of diabetes. BMC Ophthalmol 16:12PubMedPubMedCentral Chen Y, Li J, Yan Y, Shen X (2016) Diabetic macular morphology changes may occur in the early stage of diabetes. BMC Ophthalmol 16:12PubMedPubMedCentral
51.
Zurück zum Zitat Esmaeelpour M, Brunner S, Ansari-Shahrezaei S, Nemetz S, Povazay B, Kajic V, Drexler W, Binder S (2012) Choroidal thinning in diabetes type 1 detected by 3-dimensional 1060 nm optical coherence tomography. Invest Ophthalmol Vis Sci 53(11):6803–6809PubMed Esmaeelpour M, Brunner S, Ansari-Shahrezaei S, Nemetz S, Povazay B, Kajic V, Drexler W, Binder S (2012) Choroidal thinning in diabetes type 1 detected by 3-dimensional 1060 nm optical coherence tomography. Invest Ophthalmol Vis Sci 53(11):6803–6809PubMed
52.
Zurück zum Zitat Nagaoka T, Kitaya N, Sugawara R, Yokota H, Mori F, Hikichi T, Fujio N, Yoshida A (2004) Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes. Br J Ophthalmol 88(8):1060–1063PubMedPubMedCentral Nagaoka T, Kitaya N, Sugawara R, Yokota H, Mori F, Hikichi T, Fujio N, Yoshida A (2004) Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes. Br J Ophthalmol 88(8):1060–1063PubMedPubMedCentral
53.
Zurück zum Zitat Kim M, Ha MJ, Choi SY, Park YH (2018) Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography. Sci Rep 8(1):70PubMedPubMedCentral Kim M, Ha MJ, Choi SY, Park YH (2018) Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography. Sci Rep 8(1):70PubMedPubMedCentral
54.
Zurück zum Zitat Ruiz-Ocaña P, Espinoza Requena P, Alonso-Ojembarrena A, Alemany Márquez P, Jiménez Carmona S, Lechuga-Sancho AM (2018) Decreased retinal thickness in type 1 diabetic children with signs of nonproliferative diabetic retinopathy. Int J Endocrinol 2018:Article Id: 1078531 Ruiz-Ocaña P, Espinoza Requena P, Alonso-Ojembarrena A, Alemany Márquez P, Jiménez Carmona S, Lechuga-Sancho AM (2018) Decreased retinal thickness in type 1 diabetic children with signs of nonproliferative diabetic retinopathy. Int J Endocrinol 2018:Article Id: 1078531
55.
Zurück zum Zitat Biallosterski C, van Velthoven ME, Michels RP, Schlingemann RO, DeVries JH, Verbraak FD (2007) Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy. Br J Ophthalmol 91(9):1135–1138PubMedPubMedCentral Biallosterski C, van Velthoven ME, Michels RP, Schlingemann RO, DeVries JH, Verbraak FD (2007) Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy. Br J Ophthalmol 91(9):1135–1138PubMedPubMedCentral
56.
Zurück zum Zitat Gundogan FC, Akay F, Uzun S, Yolcu U, Çağıltay E, Toyran S (2016) Early neurodegeneration of the inner retinal layers in type 1 diabetes mellitus. Ophthalmologica 235(3):125–132PubMed Gundogan FC, Akay F, Uzun S, Yolcu U, Çağıltay E, Toyran S (2016) Early neurodegeneration of the inner retinal layers in type 1 diabetes mellitus. Ophthalmologica 235(3):125–132PubMed
Metadaten
Titel
Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography?
verfasst von
Hakan Öztürk
Bediz Özen
Hayrullah Manyas
Gönül Çatlı
Bumin Dündar
Publikationsdatum
01.06.2020
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 10/2020
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-020-01430-4

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