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Clinical & Experimental Metastasis

Erschienen in:

07.03.2019 | Review

Cancer-associated fibroblasts: how do they contribute to metastasis?

verfasst von: Mei Qi Kwa, Kate M. Herum, Cord Brakebusch

Erschienen in: Clinical & Experimental Metastasis | Ausgabe 2/2019

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Abstract

Cancer-associated fibroblasts (CAFs) are activated fibroblasts in the tumor microenvironment. They are one of the most prominent cell types in the stroma and produce large amounts of extracellular matrix molecules, chemokines, cytokines and growth factors. Importantly, CAFs promote cancer progression and metastasis by multiple pathways. This, together with their genetic stability, makes them an interesting target for cancer therapy. However, CAF heterogeneity and limited knowledge about the function of the different CAF subpopulations in vivo, are currently major obstacles for identifying specific molecular targets that are of value for cancer treatment. In this review, we discuss recent major findings on CAF development and their metastasis-promoting functions, as well as open questions to be addressed in order to establish successful cancer therapies targeting CAFs.

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Titel: Cancer-associated fibroblasts: how do they contribute to metastasis?
verfasst von: Mei Qi Kwa
Kate M. Herum
Cord Brakebusch
Publikationsdatum: 07.03.2019
Verlag: Springer Netherlands
Erschienen in: Clinical & Experimental Metastasis / Ausgabe 2/2019
Print ISSN: 0262-0898
Elektronische ISSN: 1573-7276
DOI: https://doi.org/10.1007/s10585-019-09959-0

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Cancer-associated fibroblasts: how do they contribute to metastasis?

Abstract

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ICI-Therapie in der Schwangerschaft wird gut toleriert

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Springer Medizin

Abstract

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