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Cancer Cell International

Ausgabe 1/2014

Inhalt (142 Artikel)

Open Access Primary research

Abnormal expression of CDK11p58 in prostate cancer

Yayun Chi, Lisha Wang, Xiuying Xiao, Ping Wei, Yiqin Wang, Xiaoyan Zhou

Open Access Primary research

The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB

I-Ling Lin, Han-Lin Chou, Jin-Ching Lee, Feng-Wei Chen, Yao Fong, Wei-Chiao Chang, Hurng Wern Huang, Chang-Yi Wu, Wen-Tsan Chang, Hui-Min David Wang, Chien-Chih Chiu

Open Access Primary research

Microvessel area as a predictor of sorafenib response in metastatic renal cell carcinoma

Saadia A Aziz, Joshua A Sznol, Laurence Albiges, Christopher Zito, Lucia B Jilaveanu, Robert L Camp, Bernard Escudier, Harriet M Kluger

Open Access Primary research

Safety and efficacy of bevacizumab combined with R-CHOP regimen in seven Chinese patients with untreated diffuse large B-cell lymphoma

Zhiying Fu, Jun Zhu, Wen Zheng, Weiping Liu, Zhitao Ying, Yan Xie, Xiaopei Wang, Ningjing Lin, Meifeng Tu, Lingyan Ping, Lijuan Deng, Chen Zhang, Ning Ding, Yuqin Song

Open Access Primary research

Sorting and identification of side population cells in the human cervical cancer cell line HeLa

Wenjuan Qi, Chao Zhao, Lijun Zhao, Ning Liu, Xiaoping Li, Weidong Yu, Lihui Wei

Open Access Reviewer acknowledgement

Thanking Cancer Cell International’s 2013 reviewers

Denys Wheatley

Open Access Primary research

Correlation between HER-2/neu(erbB-2) expression level and therapeutic effect of combination treatment with HERCEPTIN and chemotherapeutic agents in gastric cancer cell lines

Hai Cui, Ying Cheng, Su-Zhou Piao, Yun-Jie Xu, Hong-Hua Sun, Xian Cui, Xiang-Zi Li, Song-Nan Zhang, Long-Zhen Piao, Yong-Min Jin, Zhen-hua Lin, Xiong-Hu Shen

Open Access Primary research

Single nucleotide polymorphism at alcohol dehydrogenase-1B is associated with risk of esophageal squamous cell carcinoma

Bo Ye, Chun-Yu Ji, Yi Zhao, Wang Li, Jian Feng, Xu Zhang

Open Access Primary research

Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss

Pablo César Ortiz-Lazareno, Alejandro Bravo-Cuellar, José Manuel Lerma-Díaz, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, Jorge Ramiro Domínguez-Rodríguez, Oscar González-Ramella, Ruth De Célis, Paulina Gómez-Lomelí, Georgina Hernández-Flores

Open Access Primary research

2D immunoblots show differential response of mouse IgG and IgM antibodies to antigens of mammary carcinoma 4 T1 cells

Mariana Díaz-Zaragoza, Ricardo Hernández, Pedro Ostoa-Saloma

Open Access Primary research

Inhibition of human lung cancer cell proliferation and survival by wine

Carly C Barron, Jessy Moore, Theodoros Tsakiridis, Gary Pickering, Evangelia Tsiani

Open Access Primary research

Liver X receptor activation induces apoptosis of melanoma cell through caspase pathway

Wenjun Zhang, Hua Jiang, Jianlin Zhang, Yinfan Zhang, Antang Liu, Yaozhong Zhao, Xiaohai Zhu, Zihao Lin, Xiangbin Yuan

Open Access Primary research

An eEF1A1 truncation encoded by PTI-1 exerts its oncogenic effect inside the nucleus

Louise D Dahl, Thomas J Corydon, Liina Ränkel, Karen Margrethe Nielsen, Ernst-Martin Füchtbauer, Charlotte R Knudsen

Open Access Review

The basal transcription machinery as a target for cancer therapy

Claudia Villicaña, Grisel Cruz, Mario Zurita

Open Access Primary research

The mitochondrial ATPase6 gene is more susceptible to mutation than the ATPase8 gene in breast cancer patients

Massoud Ghaffarpour, Reza Mahdian, Forouzandeh Fereidooni, Behnam Kamalidehghan, Nasrin Moazami, Massoud Houshmand

Open Access Primary research

Par6 is an essential mediator of apoptotic response to transforming growth factor beta in NMuMG immortalized mammary cells

Geordon Avery-Cooper, Meghan Doerr, Richard WD Gilbert, Mahmoud Youssef, Amy Richard, Patricia Huether, Alicia M Viloria-Petit

Open Access Primary research

Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties

Tsung-Hsien Wu, Yu-Wei Chou, Pei-Hung Chiu, Ming-Jer Tang, Chun-Wen Hu, Ming-Long Yeh

Open Access Primary research

MiRNA-125a-5p: a regulator and predictor of gefitinib’s effect on nasopharyngeal carcinoma

Yanyang Liu, Zhixi Li, Lu Wu, Zi Wang, Xia Wang, Yang Yu, Qian Zhao, Feng Luo

Open Access Primary research

Wnt5a promotes migration of human osteosarcoma cells by triggering a phosphatidylinositol-3 kinase/Akt signals

Ailiang Zhang, Shuanghua He, Xiaoliang Sun, Lianghua Ding, Xinnan Bao, Neng Wang

Open Access Primary research

Overexpression of cytoplasmic β-catenin inhibits the metastasis of the murine osteosarcoma cell line LM8

Teruki Kidani, Atsushi Nakamura, Setsuya Kamei, Yoshiaki Norimatsu, Hiromasa Miura, Hiroshi Masuno

Open Access Primary research

Different sensitivity of germinal center B cell-like diffuse large B cell lymphoma cells towards ibrutinib treatment

Xiaohui Zheng, Ning Ding, Yuqin Song, Lixia Feng, Jun Zhu

Open Access Primary research

Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer

Wei-Chiao Chang, Yong-Yuan Fang, Hsueh-Wei Chang, Li-Yeh Chuang, Yu-Da Lin, Ming-Feng Hou, Cheng-Hong Yang

Open Access Primary research

Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate

Chengsen Xue, Hilda A Pasolli, Irene Piscopo, Daniel J Gros, Christina Liu, Yamei Chen, Jen Wei Chiao

Open Access Primary research

Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases

Natsuko Nomura, Sandra Pastorino, Pengfei Jiang, Gage Lambert, John R Crawford, Marco Gymnopoulos, David Piccioni, Tiffany Juarez, Sandeep C Pingle, Milan Makale, Santosh Kesari

Open Access Primary research

Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma

Jie Yang, Jie Huang, Luqiao Luo, Zhenzhu Chen, Ying Guo, Linlang Guo

Open Access Primary research

The impact of COX-2 on invasion of osteosarcoma cell and its mechanism of regulation

Xing Wu, Ming Cai, Fang Ji, Lie-ming Lou

Open Access Review

Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive prostate cancer cells

Ammad Ahmad Farooqi, Ming-Feng Hou, Chien-Chi Chen, Chun-Lin Wang, Hsueh-Wei Chang

Open Access Primary research

Abnormal expression of A20 and its regulated genes in peripheral blood from patients with lymphomas

Xu Wang, Yan Xu, Lichan Liang, Yi Xu, Chunyan Wang, Liang Wang, Shaohua Chen, Lijian Yang, Xiuli Wu, Bo Li, Gengxin Luo, Huo Tan, Wenyu Li, Yangqiu Li

Open Access Primary research

The association between hypoxia-inducible factor-1 α gene G1790A polymorphism and cancer risk: a meta-analysis of 28 case–control studies

Yuqiao Zhou, Lin Lin, Yun Wang, Xin Jin, Xin Zhao, Dongjuan Liu, Ting Hu, Lu Jiang, Hongxia Dan, Xin Zeng, Jing Li, Jiayi Wang, Qianming Chen

Open Access Primary research

Epigenetic alteration by DNA-demethylating treatment restores apoptotic response to glucocorticoids in dexamethasone-resistant human malignant lymphoid cells

Aaron L Miller, Chuandong Geng, Georgiy Golovko, Meenakshi Sharma, Jason R Schwartz, Jiabin Yan, Lawrence Sowers, William R Widger, Yuriy Fofanov, Wayne V Vedeckis, E Brad Thompson

Open Access Primary research

Functional promoter -765 G > C variant in COX-2 gene is associated with the susceptibility of breast cancer in Chinese Han women

Jie Gao, Hua-Feng Kang, Xiao-Bin Ma, Wei Tang, Di Liu, Yang Zhao, Shu-Qun Zhang, Hai-Tao Guan, Shuai Lin, Hong-Tao Ren, Xi-Jing Wang, Zhi-Jun Dai

Open Access Primary research

Glutamate involvement in calcium–dependent migration of astrocytoma cells

Abdelkader Hamadi, Grégory Giannone, Kenneth Takeda, Philippe Rondé

Open Access Primary research

Effect of Furin inhibitor on lung adenocarcinoma cell growth and metastasis

Yong-Chao Ma, Wen-Juan Fan, Shu-Mei Rao, Li Gao, Zhan-Yu Bei, Song-Tao Xu

Open Access Primary research

Simulating tumor microenvironment: changes in protein expression in an in vitro co-culture system

Viviana Salvatore, Gabriella Teti, Silvia Bolzani, Stefano Focaroli, Sandra Durante, Maria Carla Mazzotti, Mirella Falconi

Open Access Review

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

Gvantsa Kharaishvili, Dana Simkova, Katerina Bouchalova, Mariam Gachechiladze, Nato Narsia, Jan Bouchal

Open Access Primary research

Effect of Ku70 expression on radiosensitivity in renal carcinoma 786-O cells

Defeng Qi, Yuan Hu, Yangde Zhang, Tao Peng, Weidong Ji

Open Access Primary research

miR-639 promotes the proliferation and invasion of breast cancer cell in vitro

Lin Li, Xin-guang Qiu, Peng-wei Lv, Fang Wang

Open Access Primary research

Anti-cancer activity of glucosamine through inhibition of N-linked glycosylation

Viktor Chesnokov, Beata Gong, Chao Sun, Keiichi Itakura

Open Access Primary research

Reduced expression of PinX1 correlates to progressive features in patients with prostate cancer

Rong Shi, Zhen Zhao, Hui Zhou, Min Wei, Wen-Li Ma, Jue-Yu Zhou, Wan-Long Tan

Open Access Primary research

Hsa-miR-574-5p negatively regulates MACC-1 expression to suppress colorectal cancer liver metastasis

Zhe Cui, Jian Tang, Jinxian Chen, Zheng Wang

Open Access Primary research

Expression of Derlin-1 and its effect on expression of autophagy marker genes under endoplasmic reticulum stress in lung cancer cells

Li Xu, Zan-Hong Wang, Dong Xu, Gang Lin, Dai-Rong Li, Tao Wan, Shu-Liang Guo

Open Access Primary research

Myricetin enhance chemosensitivity of 5-fluorouracil on esophageal carcinoma in vitro and in vivo

Lei Wang, Jianfang Feng, Xiaonan Chen, Wei Guo, Yuwen Du, Yuanyuan Wang, Wenqiao Zang, Shijie Zhang, Guoqiang Zhao

Open Access Primary research

MiR-133b regulates bladder cancer cell proliferation and apoptosis by targeting Bcl-w and Akt1

Xiao-nan Chen, Ke-feng Wang, Zhen-qun Xu, Shi-jie Li, Qiang Liu, Dong-hui Fu, Xia Wang, Bin Wu

Open Access Primary research

Hep88 mAb-initiated paraptosis-like PCD pathway in hepatocellular carcinoma cell line through the binding of mortalin (HSPA9) and alpha-enolase

Panadda Rojpibulstit, Suthathip Kittisenachai, Songchan Puthong, Sirikul Manochantr, Pornpen Gamnarai, Sarawut Jitrapakdee, Sittiruk Roytrakul

Open Access Primary research

hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3

Jason R Dobson, Hanna Taipaleenmäki, Yu-Jie Hu, Deli Hong, Andre J van Wijnen, Janet L Stein, Gary S Stein, Jane B Lian, Jitesh Pratap

Open Access Primary research

The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells

Ethan Sagher, Lidia Hernandez, Callee Heywood, Gary T Pauly, Matthew R Young, Joel Schneider, Nancy H Colburn, Christina M Annunziata

Open Access Primary research

The stimulatory activity of plasma in patients with advanced non-small cell lung cancer requires TLR-stimulating nucleic acid immunoglobulin complexes and discriminates responsiveness to chemotherapy

Zengguang Xu, Fengying Wu, Chunhong Wang, Xiyu Liu, Baoli Kang, Shan Shan, Xia Gu, Kailing Wang, Tao Ren

Open Access Primary research

K-D:rib dampens Hs 578T cancer cell chemoinvasion and proliferation

Luca Bruni, Adesola A Babarinde, Ida Ortalli, Simonetta Croci

Open Access Primary research

Inhibiting CCN1 blocks AML cell growth by disrupting the MEK/ERK pathway

Chang-Chun Niu, Chen Zhao, Zhong Yang, Xiao-Li Zhang, Jing Pan, Chen Zhao, Wei-Ke Si

Open Access Primary research

HOXA11 gene is hypermethylation and aberrant expression in gastric cancer

Yinguo Bai, Na Fang, Tingxun Gu, Yuhua Kang, Jiang Wu, Desheng Yang, Hui Zhang, Zhimin Suo, Shaoping Ji

Open Access Primary research

Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer

Aysha M Aljaberi, Jamie RM Webster, Sally P Wheatley

Open Access Primary research

Astrocytoma-associated antigens - IL13Rα2, Fra-1, and EphA2 as potential markers to monitor the status of tumour-derived cell cultures in vitro

Monika Witusik-Perkowska, Magdalena Zakrzewska, Malgorzata Szybka, Wielislaw Papierz, Dariusz J Jaskolski, Pawel P Liberski, Beata Sikorska

Open Access Primary research

Electromagnetic field investigation on different cancer cell lines

Nenad Filipovic, Tijana Djukic, Milos Radovic, Danijela Cvetkovic, Milena Curcic, Snezana Markovic, Aleksandar Peulic, Branislav Jeremic

Open Access Primary research

Serum microRNA-205 as a novel biomarker for cervical cancer patients

Quanhui Ma, Guiping Wan, Shuxia Wang, Wanwei Yang, Jiaming Zhang, Xiaoming Yao

Open Access Primary research

Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1

Paulette M Tamashiro, Hideki Furuya, Yoshiko Shimizu, Toshihiko Kawamori

Open Access Primary research

Inhibition of proliferation and migration of luminal and claudin-low breast cancer cells by PDGFR inhibitors

Leanne Stalker, James Pemberton, Roger A Moorehead

Open Access Primary research

Association between genetic polymorphisms in AURKA (rs2273535 and rs1047972) and breast cancer risk: a meta-analysis involving 37,221 subjects

Zhi-Jun Dai, Hua-Feng Kang, Xi-Jing Wang, Yong-Ping Shao, Shuai Lin, Yang Zhao, Hong-Tao Ren, Wei-Li Min, Meng Wang, Xiao-Xu Liu

Open Access Primary research

TGF-β isoforms induce EMT independent migration of ovarian cancer cells

Jingfang Gao, Yihong Zhu, Mikael Nilsson, Karin Sundfeldt

Open Access Primary research

Treatment of human hepatocellular carcinoma by the oncolytic herpes simplex virus G47delta

Jiani Wang, Lihua Xu, Weigen Zeng, Pan Hu, Musheng Zeng, Samuel D Rabkin, Renbin Liu

Open Access Primary research

Characterization of ductal carcinoma in situ cell lines established from breast tumor of a Singapore Chinese patient

Jacklyn WY Yong, Meng Ling Choong, SiFang Wang, Yu Wang, Shermaine QY Lim, May Ann Lee

Open Access Primary research

MicroRNA-492 expression promotes the progression of hepatic cancer by targeting PTEN

Jianxin Jiang, Yi Zhang, Chao Yu, Zhipeng Li, Yaozheng Pan, Chengyi Sun

Open Access Primary research

Overexpression of Chemokine (C-X-C) ligand 1 (CXCL1) associated with tumor progression and poor prognosis in hepatocellular carcinoma

Zhongwei Cao, Biao Fu, Biao Deng, Yue Zeng, Xinjian Wan, Lei Qu

Open Access Primary research

CD28-, CD45RAnull/dim and natural killer-like CD8+ T cells are increased in peripheral blood of women with low-grade cervical lesions

Maria Luisa Pita-Lopez, Pablo Cesar Ortiz-Lazareno, Monica Navarro-Meza, Felipe Santoyo-Telles, Oscar Peralta-Zaragoza

Open Access Primary research

Human umbilical cord mesenchymal stem cells promote carcinoma growth and lymph node metastasis when co-injected with esophageal carcinoma cells in nude mice

Xiaoya Yang, Zhu Li, Yintu Ma, Jun Gao, Surui Liu, Yuhua Gao, Gengyin Wang

Open Access Primary research

In vitro assessment of antitumor activities of the PI3K/mTOR inhibitor GSK2126458

Alia Albawardi, Muna Al Ayyan, Mohamed Al Bashir, Abdul-Kader Souid, Saeeda Almarzooqi

Open Access Primary research

SNP 1772 C > T of HIF-1α gene associates with breast cancer risk in a Taiwanese population

Chih-Jen Huang, Shi-Long Lian, Ming-Feng Hou, Chee-Yin Chai, Yi-Hsing Yang, Sheng-Fung Lin, Hsueh-Wei Chang

Open Access Primary research

Increase of IFN-γ and TNF-γ production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor

Paulina Gómez-Lomelí, Alejandro Bravo-Cuellar, Georgina Hernández-Flores, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Karina Sánchez-Reyes, Pablo Cesar Ortiz-Lazareno

Open Access Primary research

Evaluation of stem-like side population cells in a recurrent nasopharyngeal carcinoma cell line

Susan Ling Ling Hoe, Lu Ping Tan, Juliana Jamal, Suat Cheng Peh, Ching Ching Ng, Wen Cai Zhang, Munirah Ahmad, Alan Soo Beng Khoo

Open Access Primary research

Establishment and characterization of a novel primary hepatocellular carcinoma cell line with metastatic ability in vivo

Phyllis Fung-Yi Cheung, Chi Wai Yip, Linda Wing-Chi Ng, Kwok Wai Lo, Nathalie Wong, Kwong Wai Choy, Chit Chow, Kui Fat Chan, Tan To Cheung, Ronnie Tung-Ping Poon, Sheung Tat Fan, Siu Tim Cheung

Open Access Primary research

Enhanced breast cancer therapy with nsPEFs and low concentrations of gemcitabine

Shan Wu, Jinsong Guo, Wendong Wei, Jue Zhang, Jing Fang, Stephen J Beebe

Open Access Primary research

Interleukin-23A is associated with tumor growth in Helicobacter-pylori-related human gastric cancer

Changming Liu, Ying Zhang, Jie Zhan, Yuanyuan Zhao, Qijun Wan, Huiping Peng, Wei Zhu

Open Access Primary research

Ursolic acid induces cell cycle arrest and apoptosis of gallbladder carcinoma cells

Hao Weng, Zhu-Jun Tan, Yun-Ping Hu, Yi-Jun Shu, Run-Fa Bao, Lin Jiang, Xiang-Song Wu, Mao-Lan Li, Qian Ding, Xu-an Wang, Shan-shan Xiang, Huai-Feng Li, Yang Cao, Feng Tao, Ying-Bin Liu

Open Access Primary research

Dynamic and influential interaction of cancer cells with normal epithelial cells in 3D culture

Laura P Ivers, Brendan Cummings, Funke Owolabi, Katarzyna Welzel, Rut Klinger, Sayaka Saitoh, Darran O’Connor, Yasuyuki Fujita, Dimitri Scholz, Nobue Itasaki

Open Access Primary research

The effects of phenoxodiol on the cell cycle of prostate cancer cell lines

Simon Mahoney, Frank Arfuso, Michael Millward, Arun Dharmarajan

Open Access Primary research

Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in 12 V-Ha-Ras transgenic mouse glioma model

Alok R Singh, Shweta Joshi, Elizabeth George, Donald L Durden

Open Access Primary research

Suberoyl bis-hydroxamic acid enhances cytotoxicity induced by proteasome inhibitors in breast cancer cells

Xinmiao Yang, Zeliang Shi, Ning Zhang, Zhouluo Ou, Shen Fu, Xichun Hu, Zhenzhou Shen

Open Access Review

Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor

Shengwen Calvin Li, Lisa May Ling Tachiki, Mustafa H Kabeer, Brent A Dethlefs, Michael J Anthony, William G Loudon

Open Access Primary research

MicroRNA expression in human endometrial adenocarcinoma

Sanja Jurcevic, Björn Olsson, Karin Klinga-Levan

Open Access Primary research

Effects of suberoylanilide hydroxamic acid (SAHA) combined with paclitaxel (PTX) on paclitaxel-resistant ovarian cancer cells and insights into the underlying mechanisms

Zhaohui Liu, Ying Tong, Yuanlin Liu, Huaping Liu, Chundong Li, Yue Zhao, Yi Zhang

Open Access Primary research

The immunoglobulin heavy chain VH6-1 promoter regulates Ig transcription in non-B cells

Lina Wu, Yang Liu, Xiaohui Zhu, Li Zhang, Jinfeng Chen, Hong Zhang, Peng Hao, Shuai Zhang, Jing Huang, Jie Zheng, Yingmei Zhang, Youhui Zhang, Xiaoyan Qiu

Open Access Primary research

The involvement of miR-100 in bladder urothelial carcinogenesis changing the expression levels of mRNA and proteins of genes related to cell proliferation, survival, apoptosis and chromosomal stability

Denis R Morais, Sabrina T Reis, Nayara Viana, Camila Berfort Piantino, Cristina Massoco, Caio Moura, Nelson Dip, Iran A Silva, Miguel Srougi, Katia RM Leite

Open Access Primary research

Nucleofection optimization and in vitro anti-tumourigenic effect of TRAIL-expressing human adipose-derived mesenchymal stromal cells

Kamal Shaik Fakiruddin, Puteri Baharuddin, Moon Nian Lim, Noor Atiqah Fakharuzi, Nurul Ain Nasim M Yusof, Zubaidah Zakaria

Open Access Primary research

Role of BC040587 as a predictor of poor outcome in breast cancer

Yayun Chi, Sheng Huang, Lin Yuan, Mengying Liu, Naisi Huang, Shuling Zhou, Bingqing Zhou, Jiong Wu

Open Access Primary research

Experimental study on the regulation of erlotinib-induced radiosensitization with an anti-c-MET monoclonal antibody

Hong-Qing Zhuang, Hongxia Zhuang, Qifu Bo, Yihang Guo, Jun Wang, Lu-Jun Zhao, Zhi-Yong Yuan, Ping Wang

Open Access Review

A novel pathogenic classification of cancers

Carlos Sonnenschein, Barbara Davis, Ana M Soto

Open Access Primary research

Upregulation of death receptor 5 and activation of caspase 8/3 play a critical role in ergosterol peroxide induced apoptosis in DU 145 prostate cancer cells

Jonghyun Han, Eun Jung Sohn, Bonglee Kim, Sunhee Kim, Gunho Won, Sangwook Yoon, Jihyun Lee, Moon Joon Kim, Hojin Lee, Kyujin Chung, Sung-hoon Kim

Open Access Primary research

Chemotherapy induced microsatellite instability and loss of heterozygosity in chromosomes 2, 5, 10, and 17 in solid tumor patients

Nasir Kamat, Mohammed A Khidhir, Sabir Hussain, Mouied M Alashari, Ulf Rannug

Open Access Review

Rutin mediated targeting of signaling machinery in cancer cells

Aliye Aras Perk, Iryna Shatynska-Mytsyk, Yusuf Can Gerçek, Kadir Boztaş, Mevzule Yazgan, Sundas Fayyaz, Ammad Ahmad Farooqi

Open Access Primary research

The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway

Tao Jia, Li Zhang, Yale Duan, Min Zhang, Gang Wang, Jun Zhang, Zheng Zhao

Open Access Primary research

Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis

Xianjun Lao, Qiliu Peng, Yu Lu, Shan Li, Xue Qin, Zhiping Chen, Junqiang Chen

Open Access Primary research

Acidic extracellular pH promotes epithelial mesenchymal transition in Lewis lung carcinoma model

Atsuko Suzuki, Toyonobu Maeda, Yuh Baba, Kazuhiro Shimamura, Yasumasa Kato

Open Access Primary research

CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro

Xiangming He, Hua Xiang, Xiangyun Zong, Xuebing Yan, Yang Yu, Guan Liu, Dehong Zou, Hongjian Yang

Open Access Primary research

Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk

Yin Duan, Chi Pan, Jinan Shi, Hailong Chen, Suzhan Zhang

Open Access Primary research

N-(2-hydroxyphenyl)acetamide (NA-2) and Temozolomide synergistically induce apoptosis in human glioblastoma cell line U87

Farina Hanif, Kahkashan Perveen, Huma Jawed, Aqeel Ahmed, Saima M Malhi, Siddiqua Jamall, Shabana U Simjee

Open Access Primary research

A polymethoxyflavone from Laggera pterodonta induces apoptosis in imatinib-resistant K562R cells via activation of the intrinsic apoptosis pathway

Changshu Cao, Bailian Liu, Chengwu Zeng, Yuhong Lu, Shaohua Chen, Lijian Yang, Bo Li, Yaolan Li, Yangqiu Li

Open Access Primary research

Histone deacetylase 6 activity is critical for the metastasis of Burkitt’s lymphoma cells

Ning Ding, Lingyan Ping, Lixia Feng, Xiaohui Zheng, Yuqin Song, Jun Zhu

Open Access Primary research

Optimization of a therapeutic electromagnetic field (EMF) to retard breast cancer tumor growth and vascularity

Ivan L Cameron, Marko S Markov, W Elaine Hardman

Open Access Primary research

Osteoblast inhibition by chemokine cytokine ligand3 in myeloma-induced bone disease

Rong Fu, Hui Liu, Sijie Zhao, Yihao Wang, Lijuan Li, Shan Gao, Erbao Ruan, Guojin Wang, Huaquan Wang, Jia Song, Zonghong Shao

Open Access Primary research

EGF +61A/G polymorphism contributes to increased gastric cancer risk: evidence from a meta-analysis

Qiliu Peng, Shan Li, Xue Qin, Xianjun Lao, Zhiping Chen, Xiaolian Zhang, Junqiang Chen

Open Access Primary research

miR-22 is down-regulated in esophageal squamous cell carcinoma and inhibits cell migration and invasion

Chao Yang, Siqing Ning, Zhaoyuan Li, Xiaomin Qin, Wei Xu

Open Access Primary research

Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family

Zhong Guo, Jin Zhao, Lei Song, Jian-Xiu Ma, Chen-Jing Wang, Shu-Yan Pei, Chao Jiang, Shang-Biao Li

Open Access Primary research

Altered expression of T cell Immunoglobulin-Mucin (Tim) molecules in peripheral blood mononuclear cells in aplastic anemia

Xin Liu, Xin Cui, Dai Yuan, Ying Li, Ning-ning Shan, Xin Wang, Yu Hu

Open Access Primary research

Hypericin-mediated photodynamic therapy induces apoptosis of myoloma SP2/0 cells depended on caspase activity in vitro

Junping Zhang, Linxiang Shao, Chunlin Wu, Hongfei Lu, Ruian Xu

Open Access Primary research

Differential drug resistance acquisition to doxorubicin and paclitaxel in breast cancer cells

Feifei Xu, Fengliang Wang, Ting Yang, Yuan Sheng, Ting Zhong, Yun Chen

Open Access Primary research

A novel GFP nude rat model to investigate tumor-stroma interactions

Ning Yang, Bin Huang, Oleg Tsinkalovsky, Narve Brekkå, Huaiyang Zhu, Lina Leiss, Per Øyvind Enger, Xingang Li, Jian Wang

Open Access Primary research

Patterns of cancer cell sphere formation in primary cultures of human oral tongue squamous cell carcinoma and neck nodes

Saira Saleem, Arif Jamshed, Saima Faisal, Raza Hussain, Muhammad Tahseen, Asif Loya, Chris Sutton

Open Access Primary research

Changes of T-lymphocyte subpopulation and differential expression pattern of the T-bet and GATA-3 genes in diffuse large B-cell lymphoma patients after chemotherapy

Qingsong Yin, Lin Chen, Qianyu Li, Ruihua Mi, Yufu Li, Xudong Wei, Yongping Song

Open Access Primary research

Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes

GanLin He, ChunYan Wang, QingEn Li, Huo Tan, FuXiong Chen, ZhenQian Huang, BaoDan Yu, LiXia Zheng, RunHui Zheng, Dan Liu

Open Access Primary research

PTOP and TRF1 help enhance the radio resistance in breast cancer cell

Zheng Li, Xiaoxi Yang, Nengxing Xia, Lei Yang, Haijun Yu, Fuxiang Zhou, Conghua X, Yunfeng Zhou

Open Access Primary research

Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-α, shows antitumor effect in vitro and in vivo

Meng Li, Chunming Rao, Dening Pei, Lan Wang, Yonghong Li, Kai Gao, Minrong Wang, Junzhi Wang

Open Access Primary research

Establishment and characterization of two primary breast cancer cell lines from young Indian breast cancer patients: mutation analysis

Santhi Latha Pandrangi, Sarangadhara Appala Raju Bagadi, Navin Kumar Sinha, Manoj Kumar, Rima Dada, Meena Lakhanpal, Abha Soni, Shreshtha Malvia, Sheeba Simon, Chintamani Chintamani, Ravindar Singh Mohil, Dinesh Bhatnagar, Sunita Saxena

Open Access Primary research

Silencing of ETS1 reverses adriamycin resistance in MCF-7/ADR cells via downregulation of MDR1

Jinrong Wei, Yong Zhou, Guo-Qin Jiang, Dong Xiao

Open Access Primary research

Stabilization of circulating tumor cells in blood using a collection device with a preservative reagent

Jianbing Qin, Jodi R Alt, Bradford A Hunsley, Thomas L Williams, M Rohan Fernando

Open Access Primary research

Decreased expression of the Nkx2.8 gene correlates with tumor progression and a poor prognosis in HCC cancer

Lei Qu, Biao Deng, Yue Zeng, Zhongwei Cao

Open Access Primary research

Relationship between abnormal osteoblasts and cellular immunity in multiple myeloma

Rong Fu, Shan Gao, Fengping Peng, Jing Li, Hui Liu, Huaquan Wang, Linmin Xing, Zonghong Shao

Open Access Primary research

The RelB alternative NF-kappaB subunit promotes autophagy in 22Rv1 prostate cancer cells in vitro and affects mouse xenograft tumor growth in vivo

Ingrid Labouba, Alexis Poisson, Julie Lafontaine, Nathalie Delvoye, Philippe O Gannon, Cécile Le Page, Fred Saad, Anne-Marie Mes-Masson

Open Access Primary research

Synergistic effects of isomorellin and forbesione with doxorubicin on apoptosis induction in human cholangiocarcinoma cell lines

Chariya Hahnvajanawong, Wareeporn Wattanawongdon, Chariya Chomvarin, Natthinee Anantachoke, Sakawrat Kanthawong, Banchob Sripa, Vichai Reutrakul

Open Access Primary research

Genetic polymorphisms of STAT3 correlated with prognosis in diffuse large B-cell lymphoma patients treated with rituximab

Yunfei Hu, Ning Ding, Xuan Jin, Lixia Feng, Lingyan Ping, Yuqin Song, Jun Zhu

Open Access Primary research

Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA

Delfina Costa, Arianna Gigoni, Roberto Würth, Ranieri Cancedda, Tullio Florio, Aldo Pagano

Open Access Review

New strategy to control cell migration and metastasis regulated by CCN2/CTGF

Diego Pinheiro Aguiar, Gabriel Correa de Farias, Eduardo Branco de Sousa, Juliana de Mattos Coelho-Aguiar, Julie Calixto Lobo, Priscila Ladeira Casado, Maria Eugênia Leite Duarte, José Garcia Ribeiro Abreu Jr

Open Access Primary research

The effect of epiregulin on epidermal growth factor receptor expression and proliferation of oral squamous cell carcinoma cell lines

Darren Chyi-Hsiang Kong, Kenneth Yee Choy Chew, Eng Lai Tan, Suan Phaik Khoo

Open Access Primary research

Curcumin inhibits leptin gene expression and secretion in breast cancer cells by estrogen receptors

Kazem Nejati-Koshki, Abolfazl Akbarzadeh, Mohammad Pourhassan-Moghaddam

Open Access Primary research

Caveolin-1 induces lamellipodia formation via an Akt-dependent pathway

Pithi Chanvorachote, Preedakorn Chunhacha, Varisa Pongrakhananon

Open Access Primary research

Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation

Rong Yu, Zhi-qing Zhang, Bin Wang, Hong-xin Jiang, Lei Cheng, Li-ming Shen

Open Access Primary research

Decrease expression of microRNA-744 promotes cell proliferation by targeting c-Myc in human hepatocellular carcinoma

Feng Lin, Ruliang Ding, Shuang Zheng, Dongyi Xing, Weiwen Hong, Zhijun Zhou, Jie Shen

Open Access Primary research

Effects of siRNA targeting BMPR-II on the biological activities of human liver cancer cells and its mechanism

Peng Zeng, Sheng Cai, Jia-na Zhang, Feng-ming Yi, Wei-min Jiang, Jian-bing Wu

Open Access Primary research

Glucose restriction decreases telomerase activity and enhances its inhibitor response on breast cancer cells: possible extra-telomerase role of BIBR 1532

Layal Wardi, Nada Alaaeddine, Issam Raad, Riad Sarkis, Rim Serhal, Charbel Khalil, George Hilal

Open Access Primary research

Anti-tumor effect of ribavirin in combination with interferon-α on renal cell carcinoma cell lines in vitro

Lichen Teng, Dexin Ding, Yongsheng Chen, Hongshuang Dai, Guobin Liu, Zhongjie Qiao, Ruihua An

Open Access Primary research

The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression

Petr Chlapek, Jakub Neradil, Martina Redova, Karel Zitterbart, Jaroslav Sterba, Renata Veselska

Open Access Primary research

The same and not the same: heterogeneous functional activation of prostate tumor cells by TLR ligation

Simin Rezania, Noor Amirmozaffari, Nesa Rashidi, Ebrahim Mirzadegan, Saeed Zarei, Jamileh Ghasemi, Omid Zarei, Leila Katouzian, Amir-Hassan Zarnani

Open Access Primary research

Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis

Akimasa Takahashi, Fuminori Kimura, Akiyoshi Yamanaka, Akie Takebayashi, Nobuyuki Kita, Kentaro Takahashi, Takashi Murakami

Open Access Primary research

Contribution of nestin positive esophageal squamous cancer cells on malignant proliferation, apoptosis, and poor prognosis

Beilong Zhong, Tao Wang, Xueping Lun, Jinli Zhang, Sannv Zheng, Weilin Yang, Weiqiang Li, Andy Peng Xiang, Zhenguang Chen

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