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Zeitschrift

Cancer Cell International

Cancer Cell International 1/2019

Ausgabe 1/2019

Inhaltsverzeichnis ( 340 Artikel )

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization

Rustelle Janse van Vuuren, Mandie Botes, Tamarin Jurgens, Anna Margaretha Joubert, Iman van den Bout

01.12.2019 | Review | Ausgabe 1/2019 Open Access

T cell receptor-engineered T cells for leukemia immunotherapy

Yikai Zhang, Yangqiu Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation

Tingting Wang, Feiyan Lin, Xuecheng Sun, Lei Jiang, Ruibo Mao, Shenyue Zhou, Wenjing Shang, Ruichun Bi, Fengying Lu, Shaotang Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response

Shi-chun Du, Lan Zhu, Yu-xing Wang, Jie Liu, Die Zhang, Yu-lu Chen, Qing Peng, Wei Liu, Bin Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Relationship between the upregulation of Notch1 signaling and the clinical characteristics of patients with papillary thyroid carcinoma in East Asia: a systematic review and meta-analysis

Libing Yuan, Lei Ma, Haibo Xue, Shoujun Song

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of a 6-gene signature predicting prognosis for colorectal cancer

Shuguang Zuo, Gongpeng Dai, Xuequn Ren

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

Hongcheng Wang, Zhi Zhao, Shizhou Lei, Shaoli Li, Zhen Xiang, Xiaoyu Wang, Xiuyan Huang, Guanggai Xia, Xinyu Huang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Overexpression of chloride channel-3 (ClC-3) is associated with human cervical carcinoma development and prognosis

Yu-tao Guan, Yong Xie, Hui Zhou, Hai-yan Shi, Yu-yuan Zhu, Xiao-lu Zhang, Yi Luan, Xi-ming Shen, Yang-ping Chen, Li-jiang Xu, Zhong-qiu Lin, Gang Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway

Yanfei Jia, Yan Qi, Yunshan Wang, Xiaoli Ma, Yihui Xu, Jun Wang, Xiaoqian Zhang, Meihua Gao, Beibei Cong, Shuyi Han

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target

Marta Llaurado Fernandez, Amy Dawson, Joshua Hoenisch, Hannah Kim, Sylvia Bamford, Clara Salamanca, Gabriel DiMattia, Trevor Shepherd, Mattia Cremona, Bryan Hennessy, Shawn Anderson, Stanislav Volik, Colin C. Collins, David G. Huntsman, Mark S. Carey

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women

Zhijun Dai, Tian Tian, Meng Wang, Tielin Yang, Hongtao Li, Shuai Lin, Qian Hao, Peng Xu, Yujiao Deng, Linghui Zhou, Na Li, Yan Diao

01.12.2019 | Review | Ausgabe 1/2019 Open Access

CRISPR–Cas9 a boon or bane: the bumpy road ahead to cancer therapeutics

Debarati Ghosh, Prabhadevi Venkataramani, Saikat Nandi, Sonali Bhattacharjee

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway

Yuyang Liu, Xiangnan Hu, Xuefeng Shan, Ke Chen, Hua Tang

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Next-generation sequencing-based genetic landscape and its clinical implications for Chinese acute myeloid leukemia patients

Xin-xin Cao, Hao Cai, Yue-ying Mao, Qi Wu, Lu Zhang, Dao-bin Zhou, Jian Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MicroRNA-144 inhibits cell proliferation, migration and invasion in human hepatocellular carcinoma by targeting CCNB1

Junsheng Gu, Xiaorui Liu, Juan Li, Yuting He

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer

Styliani Melissaridou, Emilia Wiechec, Mustafa Magan, Mayur Vilas Jain, Man Ki Chung, Lovisa Farnebo, Karin Roberg

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial–mesenchymal transition

Zhou Yang, Weiping Yu, Renhong Huang, Min Ye, Zhijun Min

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long non-coding RNA CASC2 upregulates PTEN to suppress pancreatic carcinoma cell metastasis by downregulating miR-21

Hui Zhang, Xielin Feng, Mingyi Zhang, Aixiang Liu, Lang Tian, Wentao Bo, Haiqing Wang, Yong Hu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Potential new biomarkers for endometrial cancer

Michelle H. Townsend, Zac E. Ence, Abigail M. Felsted, Alyssa C. Parker, Stephen R. Piccolo, Richard A. Robison, Kim L. O’Neill

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long noncoding RNA PXN-AS1-L promotes non-small cell lung cancer progression via regulating PXN

Zhifa Zhang, Zhaohui Peng, Junying Cao, Jiaqi Wang, Yongyu Hao, Kai Song, Yan Wang, Wei Hu, Xuesong Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Establishment and characterization of a patient-derived circulating lung tumor cell line in vitro and in vivo

Zujun Que, Bin Luo, Zhiyi Zhou, Changsheng Dong, Yi Jiang, Lin Wang, Qihui Shi, Jianhui Tian

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Prognostic role of PD-L1 for HCC patients after potentially curative resection: a meta-analysis

Gao-Min Liu, Xu-Gang Li, Yao-Min Zhang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Expression signatures and roles of microRNAs in inflammatory breast cancer

Yihang Qi, Xiangyu Wang, Xiangyi Kong, Jie Zhai, Yi Fang, Xiaoxiang Guan, Jing Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

SOX2 interferes with the function of CDX2 in bile acid-induced gastric intestinal metaplasia

Ting Yuan, Zhen Ni, Chuan Han, Yali Min, Nina Sun, Caifang Liu, Miao Shi, Wenquan Lu, Na Wang, Feng Du, Qiong Wu, Ning Xie, Yongquan Shi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway

Minghui Xue, Guangyan Li, Xiangjie Fang, Lili Wang, Yuhong Jin, Qinglan Zhou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death

Alexander H. Chung, Tina M. Leisner, Gabrielle J. Dardis, Marissa M. Bivins, Alana L. Keller, Leslie V. Parise

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

ZEB1-AS1 initiates a miRNA-mediated ceRNA network to facilitate gastric cancer progression

Ming-Hui Ma, Jia-Xiang An, Cheng Zhang, Jie Liu, Yu Liang, Chun-Dong Zhang, Zhen Zhang, Dong-Qiu Dai

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Low-dose zoledronate for the treatment of bone metastasis secondary to prostate cancer

Elie Akoury, Pouyan Ahangar, Antone Nour, Jacques Lapointe, Karl-Philippe Guérard, Lisbet Haglund, Derek H. Rosenzweig, Michael H. Weber

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies

Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Velazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison, Kim L. O’Neill

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Chemosensitizing and nephroprotective effect of resveratrol in cisplatin-treated animals

Abdel-Moneim M. Osman, Suad A. Telity, Zoheir A. Damanhouri, Sameer E. Al-Harthy, Huda M. Al-Kreathy, Wafaa S. Ramadan, Mohamed F. Elshal, Lateef M. Khan, Fatemah Kamel

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Role of microRNA-92a in metastasis of osteosarcoma cells in vivo and in vitro by inhibiting expression of TCF21 with the transmission of bone marrow derived mesenchymal stem cells

Shuai Cao, Liangde Jiang, Lulu Shen, Zhizheng Xiong

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

Yalu Liu, Xiaogan Wang, Lijuan Deng, Lingyan Ping, Yunfei Shi, Wen Zheng, Ningjing Lin, Xiaopei Wang, Meifeng Tu, Yan Xie, Weiping Liu, Zhitao Ying, Chen Zhang, Zhengying Pan, Xi Wang, Ning Ding, Yuqin Song, Jun Zhu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

SLC25A22 promotes proliferation and metastasis by activating MAPK/ERK pathway in gallbladder cancer

Pengcheng Du, Haibin Liang, Xiaowei Fu, Peng Wu, Chao Wang, Haimin Chen, Bingbing Zheng, Jun Zhang, Shuanghui Hu, Rengui Zeng, Bo Liang, Lu Fang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Expression of the Wnt ligands gene family and its relationship to prognosis in hepatocellular carcinoma

Jia-Jia Dong, Li Ying, Ke-Qing Shi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior

Ana Laura Sanchez-Sandoval, Juan Carlos Gomora

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Raltitrexed increases radiation sensitivity of esophageal squamous carcinoma cells

Wen-Xiu Ding, Shu Liu, Jian-Xin Ma, Juan Pu, Hai-Jing Wang, Shu Zhang, Xin-chen Sun

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Metabolic characteristics revealing cell differentiation of nasopharyngeal carcinoma by combining NMR spectroscopy with Raman spectroscopy

Yang Chen, Zhong Chen, Ying Su, Donghong Lin, Min Chen, Shangyuan Feng, Changyan Zou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

miR-96 exerts carcinogenic effect by activating AKT/GSK-3β/β-catenin signaling pathway through targeting inhibition of FOXO1 in hepatocellular carcinoma

Nanmu Yang, Jinxue Zhou, Qingjun Li, Feng Han, Zujiang Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

High expression of Linc00959 predicts poor prognosis in breast cancer

Weiru Chi, Sheng Huang, Bingqiu Xiu, Qi Zhang, Zhiming Shao, Jiong Wu, Yayun Chi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

A novel long non-coding RNA-KAT7 is low expressed in colorectal cancer and acts as a tumor suppressor

Qingmei Wang, Rongzhang He, Tan Tan, Jia Li, Zheng Hu, Weihao Luo, Lili Duan, Wenna Luo, Dixian Luo

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Knockdown of AGGF1 inhibits the invasion and migration of gastric cancer via epithelial–mesenchymal transition through Wnt/β-catenin pathway

Han-Hui Yao, Ya-Jun Zhao, Yi-Fu He, Da-Bing Huang, Wei Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

miR-182-5p affects human bladder cancer cell proliferation, migration and invasion through regulating Cofilin 1

Fei Wang, Dinglan Wu, Zhanping Xu, Jianxiang Chen, Jiye Zhang, Xiaojuan Li, Shiliang Chen, Fengrong He, Jianbing Xu, Liangju Su, Defan Luo, Shufang Zhang, Weifu Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway

Dongdong Wu, Zhengguo Liu, Jianmei Li, Qianqian Zhang, Peiyu Zhong, Tieshan Teng, Mingliang Chen, Zhongwen Xie, Ailing Ji, Yanzhang Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

FOXD3 may be a new cellular target biomarker as a hypermethylation gene in human ovarian cancer

Gui-fang Luo, Chang-ye Chen, Juan Wang, Hai-yan Yue, Yong Tian, Ping Yang, Yu-kun Li, Yan Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Up-regulated lncRNA XIST contributes to progression of cervical cancer via regulating miR-140-5p and ORC1

Xing Chen, Dongsheng Xiong, Liya Ye, Kai Wang, Lingfei Huang, Shuangshuang Mei, Jinhong Wu, Shanshan Chen, Xiaoli Lai, Lingzhi Zheng, Meifen Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Establishment of primary human breast cancer cell lines using “pulsed hypoxia” method and development of metastatic tumor model in immunodeficient mice

Anna A. Nushtaeva, Anastasia A. Karpushina, Mikhail S. Ermakov, Ludmila F. Gulyaeva, Alexey V. Gerasimov, Sergey V. Sidorov, Tatyana A. Gayner, Anastasia Y. Yunusova, Anastasia V. Tkachenko, Vladimir A. Richter, Olga A. Koval

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Functional polymorphisms in LncRNA HOTAIR contribute to susceptibility of pancreatic cancer

Dawei Jiang, Liu Xu, Jianqi Ni, Jie Zhang, Min Cai, Lan Shen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Roles of β-catenin, TCF-4, and survivin in nasopharyngeal carcinoma: correlation with clinicopathological features and prognostic significance

Pei-Ying Jin, Zi-Hui Zheng, Hong-Jie Lu, Jing Yan, Gui-Hong Zheng, Yuan-Lin Zheng, Dong-Mei Wu, Jun Lu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma

Qiqing Sun, Wenyan Xu, Shunrong Ji, Yi Qin, Wensheng Liu, Qiangsheng Hu, Zheng Zhang, Mengqi Liu, Xianjun Yu, Xiaowu Xu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Combined analysis and validation for DNA methylation and gene expression profiles associated with prostate cancer

Yanqiu Tong, Yang Song, Shixiong Deng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics

Kai Wu, Xiaotao Yin, Yipeng Jin, Fangfang Liu, Jiangping Gao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of DNA methylation-driven genes in esophageal squamous cell carcinoma: a study based on The Cancer Genome Atlas

Tong Lu, Di Chen, Yuanyong Wang, Xiao Sun, Shicheng Li, Shuncheng Miao, Yang Wo, Yanting Dong, Xiaoliang Leng, Wenxing Du, Wenjie Jiao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response

Chiao-En Wu, Tsin Shue Koay, Yi-Hsuan Ho, Penny Lovat, John Lunec

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase

Belén G. Sánchez, Alicia Bort, Pedro A. Mateos-Gómez, Nieves Rodríguez-Henche, Inés Díaz-Laviada

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

A DAAM1 3′-UTR SNP mutation regulates breast cancer metastasis through affecting miR-208a-5p-DAAM1-RhoA axis

Jie Mei, Ting Yan, Yifu Huang, Tiansong Xia, Fei Chang, Shuning Shen, Leiyu Hao, Yin Chen, Zhongyuan Wang, Xiaozheng Jiang, Bujie Xu, Yichao Zhu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia

Hao Luo, Bo Jing, Yu Xia, Yugen Zhang, Meng Hu, Haiyan Cai, Yin Tong, Li Zhou, Li Yang, Junmei Yang, Hu Lei, Hanzhang Xu, Chuanxu Liu, Yingli Wu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

TRIM52 promotes colorectal cancer cell proliferation through the STAT3 signaling

Shengli Pan, Yingying Deng, Jun Fu, Yuhao Zhang, Zhijin Zhang, Xiaokun Ru, Xianju Qin

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis

Qinghe Zhao, Wuliang Wang, Jinquan Cui

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Megakaryocytic dysfunction in immune thrombocytopenia is linked to autophagy

Rui-jie Sun, Ning-ning Shan

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

RETRACTED ARTICLE: LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib-mediated death via inhibiting the AMPK–Mfn2 signaling pathway

Jie Song, Wei Zhao, Chang Lu, Xue Shao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway

Zhongyi Shen, Chengliang Zhang, Lishuai Qu, Cuihua Lu, Mingbing Xiao, Runzhou Ni, Jinxia Liu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The prognostic value of serum amyloid A in solid tumors: a meta-analysis

Hai-yingjie Lin, Guo-qiang Tan, Yan Liu, Shao-qiang Lin

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

High long non-coding RNA NORAD expression predicts poor prognosis and promotes breast cancer progression by regulating TGF-β pathway

Ke Zhou, Qin Ou, Geng Wang, Wenqi Zhang, Yin Hao, Wenfang Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Pepsin promotes IL-8 signaling-induced epithelial–mesenchymal transition in laryngeal carcinoma

Jia-Jie Tan, Lu Wang, Ting-Ting Mo, Jie Wang, Mei-Gui Wang, Xiang-Ping Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China

Xiangyi Zhe, Huizhen Xin, Zhenzhen Pan, Fuyuan Jin, Weinan Zheng, Hongtao Li, Dongmei Li, Dongdong Cao, Ying Li, Chunhe Zhang, Shaowei Fu, Renfu Shao, Zemin Pan

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MiR-1180 from bone marrow MSCs promotes cell proliferation and glycolysis in ovarian cancer cells via SFRP1/Wnt pathway

Jinghui Hu, Wei Zhao, Yujie Huang, Zhe Wang, Tingting Jiang, Li Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy

Nagaja Capitani, Giulia Lori, Paolo Paoli, Laura Patrussi, Arianna Troilo, Cosima T. Baldari, Giovanni Raugei, Mario Milco D’Elios

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells

Xiufeng Jiang, Hui Wu, Wei Zhao, Xiao Ding, Qian You, Feng Zhu, Meifang Qian, Ping Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Palmitate acid promotes gastric cancer metastasis via FABP5/SP1/UCA1 pathway

Jiaomeng Pan, Qingqiang Dai, Tianqi Zhang, Chen Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Prognostic significance of elevated pretreatment systemic inflammatory markers for patients with prostate cancer: a meta-analysis

Hao Peng, Xiaogang Luo

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Tumor-associated macrophages modulate resistance to oxaliplatin via inducing autophagy in hepatocellular carcinoma

Xiu-Tao Fu, Kang Song, Jian Zhou, Ying-Hong Shi, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Zhen-Bin Ding, Jia Fan

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LncRNA BCAR4, targeting to miR-665/STAT3 signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal cancer

Shurui Ouyang, Xin Zhou, Zhengquan Chen, Maijian Wang, Xinbin Zheng, Ming Xie

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

An age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia

Andrea Diviney, Boris I. Chobrutskiy, Saif Zaman, George Blanck

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma

Jing Wei, Lincui Wang, Jun Zhu, Aiqin Sun, Guanzhen Yu, Miao Chen, Pan Huang, Hanqing Liu, Genbao Shao, Wannian Yang, Qiong Lin

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

TMED3 promotes cell proliferation and motility in breast cancer and is negatively modulated by miR-188-3p

Jing Pei, Jing Zhang, Xiaowei Yang, Zhengsheng Wu, Chenyun Sun, Zhaorui Wang, Benzhong Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

GSTM1 and GSTT1 null genotype increase the risk of hepatocellular carcinoma: evidence based on 46 studies

Shanli Li, Feng Xue, Yi Zheng, Pengtao Yang, Shuai Lin, Yujiao Deng, Peng Xu, Linghui Zhou, Qian Hao, Zhen Zhai, Ying Wu, Zhijun Dai, Shu Chen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells

Katharina Stock, Rebekka Borrink, Jan-Henrik Mikesch, Anna Hansmeier, Jan Rehkämper, Marcel Trautmann, Eva Wardelmann, Wolfgang Hartmann, Jan Sperveslage, Konrad Steinestel

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Predictive and prognostic value of ZEB1 protein expression in breast cancer patients with neoadjuvant chemotherapy

Ziping Wu, Lei Zhang, Shuguang Xu, Yanping Lin, Wenjin Yin, Jinglu Lu, Rui Sha, Xiaonan Sheng, Liheng Zhou, Jinsong Lu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis

Jiayi Zhang, Aiming Xu, Chenkui Miao, Jie Yang, Min Gu, Ninghong Song

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Cell migration and proliferation are regulated by miR-26a in colorectal cancer via the PTEN–AKT axis

Jossimar Coronel-Hernández, Eduardo López-Urrutia, Carlos Contreras-Romero, Izamary Delgado-Waldo, Gabriela Figueroa-González, Alma D. Campos-Parra, Rebeca Salgado-García, Antonio Martínez-Gutierrez, Miguel Rodríguez-Morales, Nadia Jacobo-Herrera, Luis Ignacio Terrazas, Abraham Silva-Carmona, César López-Camarillo, Carlos Pérez-Plasencia

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

A new Schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer

Yan Xia, Xingkai Liu, Luping Zhang, Jinzhu Zhang, Chaoying Li, Nan Zhang, Hong Xu, Yan Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Silencing of SNHG6 induced cell autophagy by targeting miR-26a-5p/ULK1 signaling pathway in human osteosarcoma

Xin Zhu, Guangling Yang, Jisheng Xu, Chuanlin Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The assessment of minimal residual disease versus that of somatic mutations for predicting the outcome of acute myeloid leukemia patients

Serena Salehzadeh, Francesca Guerrini, Umberto Pizzano, Susanna Grassi, Elena Ciabatti, Lorenzo Iovino, Gabriele Buda, Francesco Caracciolo, Edoardo Benedetti, Enrico Orciuolo, Matteo Pelosini, Giovanni Consani, Giovanni Carulli, Maria Rita Metelli, Francesca Martini, Francesco Mazziotta, Elisa Mazzantini, Pietro Rossi, Rita Tavarozzi, Federica Ricci, Mario Petrini, Sara Galimberti

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance

Wenzhe Yan, Ji Li, Yang Zhang, Yafei Yin, Zhao Cheng, Jiayi Wang, Guoyu Hu, Sufang Liu, Yewei Wang, Yunxiao Xu, Hongling Peng, Guangsen Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague–Dawley rats

Keshab Kumar Karna, Bo Ram Choi, Jae Hyung You, Yu Seob Shin, Kiran Kumar Soni, Wan Shou Cui, Sung Won Lee, Chul Young Kim, Hye Kyung Kim, Jong Kwan Park

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Stimulative role of ST6GALNAC1 in proliferation, migration and invasion of ovarian cancer stem cells via the Akt signaling pathway

Wen-Yan Wang, Yun-Xia Cao, Xiao Zhou, Bing Wei, Lei Zhan, Shi-Ying Sun

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression

Chia-Cheng Yu, Lih-Chyang Chen, Chih-Yung Chiou, Yu-Jia Chang, Victor C. Lin, Chao-Yuan Huang, I-Ling Lin, Ta-Yuan Chang, Te-Ling Lu, Cheng-Hsueh Lee, Shu-Pin Huang, Bo-Ying Bao

01.12.2019 | Retraction Note | Ausgabe 1/2019 Open Access

Retraction Note: Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines

Yuanyuan Wang, Xiaonan Chen, Qianqian Sun, Wenqiao Zang, Min Li, Ziming Dong, Guoqiang Zhao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression

Kashif Rafiq Zahid, Mingyang Su, Abdur Rehman Raza Khan, Shiming Han, Gou Deming, Umar Raza

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma

Junyu Long, Yi Bai, Xiaobo Yang, Jianzhen Lin, Xu Yang, Dongxu Wang, Li He, Yongchang Zheng, Haitao Zhao

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The role of photodynamic therapy on multidrug resistant breast cancer

Eric Chekwube Aniogo, Blassan Plackal Adimuriyil George, Heidi Abrahamse

01.12.2019 | Review | Ausgabe 1/2019 Open Access

New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin

Chien-shan Cheng, Jiaqiang Wang, Jie Chen, Kuei Ting Kuo, Jian Tang, Huifeng Gao, Lianyu Chen, Zhen Chen, Zhiqiang Meng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells

Jia Cao, Xi Wang, Danni Wang, Rong Ma, Xiaohan Li, Huimin Feng, Jia Wang, Shihai Liu, Libin Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long non-coding RNA LINC01314 represses cell migration, invasion, and angiogenesis in gastric cancer via the Wnt/β-catenin signaling pathway by down-regulating KLK4

Lin Tang, Jian-Bo Wen, Ping Wen, Xing Li, Min Gong, Qiang Li

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: ZEB1‑AS1 initiates a miRNA‑mediated ceRNA network to facilitate gastric cancer progression

Ming-Hui Ma, Jia-Xiang An, Cheng Zhang, Jie Liu, Yu Liang, Chun-Dong Zhang, Zhen Zhang, Dong-Qiu Dai

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathway

Jing Luo, Yu Yao, Saiguang Ji, Qi Sun, Yang Xu, Kaichao Liu, Qiang Diao, Yong Qiang, Yi Shen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

Weilong Yao, Shengtao Zhu, Peng Li, Shutian Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways

Ian T. Saunders, Hina Mir, Neeraj Kapur, Shailesh Singh

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair

Zhiqiang Wu, Minghan Qiu, Yu Guo, Jinlin Zhao, Zhuang Liu, Hui Wang, Maobin Meng, Zhiyong Yuan, Zeyun Mi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis

Yanfang Wang, Quanli Zhang, Zhaojia Gao, Shan Xin, Yanbo Zhao, Kai Zhang, Run Shi, Xuanwen Bao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients

Lujun Chen, Dawei Zhu, Jun Feng, You Zhou, Qi Wang, Huijing Feng, Junping Zhang, Jingting Jiang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Tre2 (USP6NL) promotes colorectal cancer cell proliferation via Wnt/β-catenin pathway

Kang Sun, Song-Bing He, Yi-Zhou Yao, Jian-Guo Qu, Rong Xie, Yu-Qiao Ma, Ming-Hui Zong, Ji-Xiang Chen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

Kelin She, Shenghua Fang, Wei Du, Xingxing Fan, Jiaxi He, Hui Pan, Liyan Huang, Ping He, Jun Huang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

miR-328-3p mediates the anti-tumor effect in osteosarcoma via directly targeting MMP-16

Jianhui Shi, Gang An, Ying Guan, Tianli Wei, Zhibin Peng, Min Liang, Yansong Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Association of TNFAIP8 gene polymorphisms with endometrial cancer in northern Chinese women

Tianbo Liu, Liangliang Jiang, Libo Yu, Tingting Ge, Jing Wang, Hongyu Gao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

Haifeng Deng, Hongbing Shi, Lujun Chen, You Zhou, Jingting Jiang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The DNA methylation profile of non-coding RNAs improves prognosis prediction for pancreatic adenocarcinoma

Jie Zhang, Keqing Shi, Weiguo Huang, Wanqing Weng, Zhongjing Zhang, Yangyang Guo, Tuo Deng, Yukai Xiang, Xiaofeng Ni, Bicheng Chen, Mengtao Zhou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MiR-591 functions as tumor suppressor in breast cancer by targeting TCF4 and inhibits Hippo-YAP/TAZ signaling pathway

Xin Huang, Fen Tang, Zeping Weng, Mengyao Zhou, Qing Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Inhibition of microRNA-103a inhibits the activation of astrocytes in hippocampus tissues and improves the pathological injury of neurons of epilepsy rats by regulating BDNF

Ping Zheng, He Bin, Wei Chen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

An improved advanced fragment analysis-based classification and risk stratification of pediatric acute lymphoblastic leukemia

Yanran Sun, Qiaosheng Zhang, Guoshuang Feng, Zhen Chen, Chao Gao, Shuguang Liu, Ruidong Zhang, Han Zhang, Xueling Zheng, Wenyu Gong, Yadong Wang, Yong Wu, Jie Li, Huyong Zheng

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Impaired redox regulation of estrogen metabolizing proteins is important determinant of human breast cancers

Smarajit Maiti, Aarifa Nazmeen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype

Tânia Soraia Vieira-Silva, Sara Monteiro-Reis, Daniela Barros-Silva, João Ramalho-Carvalho, Inês Graça, Isa Carneiro, Ana Teresa Martins, Jorge Oliveira, Luis Antunes, Sarah Hurtado-Bagès, Marcus Buschbeck, Rui Henrique, Carmen Jerónimo

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Establishment and characterization of a novel childhood acute lymphoblastic leukemia cell line, HXEX-ALL1, with chromosome 9p and 17p deletions

Yiping Zhu, Rong Yang, Ju Gao, Yanle Zhang, Ge Zhang, Ling Gu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Silencing long non-coding RNA HOTAIR exerts anti-oncogenic effect on human acute myeloid leukemia via demethylation of HOXA5 by inhibiting Dnmt3b

Si-Li Wang, Yun Huang, Rui Su, Yong-Yang Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

miR-429 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by downregulation of TLN1

Zhihui Wang, Zhiquan Zhu, Zhong Lin, Youli Luo, Zibin Liang, Caibin Zhang, Jianxu Chen, Peijian Peng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent manner

Shentong Yu, Ru Zhou, Tong Yang, Shuang Liu, Zhuqing Cui, Qing Qiao, Jing Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Apatinib preferentially inhibits PC9 gefitinib-resistant cancer cells by inducing cell cycle arrest and inhibiting VEGFR signaling pathway

Yong-An Song, Ting Ma, Xue-Yan Zhang, Xiang-Song Cheng, Ayobami-Matthew Olajuyin, Zhi-Fu Sun, Xiao-Ju Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of ESM1 overexpressed in head and neck squamous cell carcinoma

Hongbo Xu, Xiaohong Chen, Zhigang Huang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

New insights into the association between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G variants and cancer risk

Bin Xu, Wei Yuan, Li Shi, Li Zuo, Xing-Yu Wu, Wei Zhang, Qiaxian Wen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of the xenograft and its ascendant sphere-forming cell line as belonging to EBV-induced lymphoma, and characterization of the status of sphere-forming cells

Evgeniya V. Dolgova, Daria D. Petrova, Anastasia S. Proskurina, Genrikh S. Ritter, Polina E. Kisaretova, Ekaterina A. Potter, Yaroslav R. Efremov, Sergey I. Bayborodin, Tatiana V. Karamysheva, Margarita V. Romanenko, Sergey V. Netesov, Oleg S. Taranov, Aleksandr A. Ostanin, Elena R. Chernykh, Sergey S. Bogachev

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Peripheral memory and naïve T cells in non-small cell lung cancer patients with lung metastases undergoing stereotactic body radiotherapy: predictors of early tumor response

Chao Liu, Qinyong Hu, Bin Xu, Xiaoyu Hu, Huichao Su, Qian Li, Xiaoling Zhang, Jinbo Yue, Jinming Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

High expression of miR-25 predicts favorable chemotherapy outcome in patients with acute myeloid leukemia

Mingshan Niu, Yuan Feng, Ninghan Zhang, Tingting Shao, Huihui Zhang, Rong Wang, Yao Yao, Ruosi Yao, Qingyun Wu, Jiang Cao, Xuejiao Liu, Yubo Liu, Kailin Xu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Integrated analysis reveals potential long non-coding RNA biomarkers and their potential biological functions for disease free survival in gastric cancer patients

Canchang Cheng, Qicai Wang, Minggu Zhu, Kelong Liu, Zhiqiao Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy

Yeying Liu, Yuan Huang, Jie Ding, Nannan Liu, Shuang Peng, Jiangang Wang, Feng Wang, Yingjie Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer

Yihan Sun, Endong Chen, Yuefeng Li, Danrong Ye, Yefeng Cai, Qingxuan Wang, Quan Li, Xiaohua Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer

Ya-li Zhao, Shen-Rong Zhong, Shi-Hong Zhang, Jia-Xin Bi, Zhi-Yuan Xiao, Shu-Yang Wang, Hong-Li Jiao, Dan Zhang, Jun-Feng Qiu, Ling-Jie Zhang, Cheng-Mei Huang, Xiao-Ling Chen, Yan-Qing Ding, Ya-Ping Ye, Li Liang, Wen-ting Liao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Adjuvant chemotherapy for rectal cancer with complete pathological response (pCR) may not be necessary: a pooled analysis of 5491 patients

Xiang Hu, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai, Jun-Jie Peng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Overexpression of SNHG12 regulates the viability and invasion of renal cell carcinoma cells through modulation of HIF1α

Qiguang Chen, Wei Zhou, Shu-qi Du, Da-xin Gong, Jun Li, Jian-bin Bi, Zhen-hua Li, Zhe Zhang, Ze-liang Li, Xian-kui Liu, Chui-ze Kong

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells

Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He, Xinping Cao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Bursopentin (BP5) induces G1 phase cell cycle arrest and endoplasmic reticulum stress/mitochondria-mediated caspase-dependent apoptosis in human colon cancer HCT116 cells

Jing Li, Tian-xiang Li, Yao Ma, Yong Zhang, De-yuan Li, Hai-rong Xu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Melatonin and non-small cell lung cancer: new insights into signaling pathways

Mohammad Hossein Pourhanifeh, Mehran Sharifi, Russel J. Reiter, Abdoulhossein Davoodabadi, Zatollah Asemi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The ubiquitin ligase CHIP modulates cellular behaviors of gastric cancer cells by regulating TRAF2

Hanjue Dai, Hao Chen, Jingjing Xu, Jun Zhou, Zhili Shan, Hengying Yang, Xiaojun Zhou, Feng Guo

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway

Xiao-Feng Xu, Feng Gao, Jian-Jiang Wang, Cong Long, Xing Chen, Lan Tao, Liu Yang, Li Ding, Yong Ji

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Decreased SATB1 expression promotes AML cell proliferation through NF-κB activation

Xiaodan Luo, Lihua Xu, Xiaohong Wu, Huo Tan, Lian Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Effect of cold atmospheric plasma treatment on the metabolites of human leukemia cells

Dehui Xu, Ning Ning, Yujing Xu, Bingchuan Wang, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen, Michael G. Kong

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Eleven genes associated with progression and prognosis of endometrial cancer (EC) identified by comprehensive bioinformatics analysis

JinHui Liu, ShuLin Zhou, SiYue Li, Yi Jiang, YiCong Wan, XiaoLing Ma, WenJun Cheng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Low expression of SPARC in gastric cancer-associated fibroblasts leads to stemness transformation and 5-fluorouracil resistance in gastric cancer

Yongchen Ma, Jing Zhu, Shanwen Chen, Ju Ma, Xiaoqian Zhang, Sixia Huang, Jianwen Hu, Taohua Yue, Junling Zhang, Pengyuan Wang, Xin Wang, Long Rong, Hongjie Guo, Guowei Chen, Yucun Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma

Gao-Min Liu, Hua-Dong Zeng, Cai-Yun Zhang, Ji-Wei Xu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Ally to adversary: mesenchymal stem cells and their transformation in leukaemia

Mugdha Sharma, Cecil Ross, Sweta Srivastava

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

HOXA11-AS promotes the progression of oral squamous cell carcinoma by targeting the miR-518a-3p/PDK1 axis

Baojun Li, Wei Wang, Susheng Miao, Guofu Li, Yuanjing Lv, Cheng Xiang, Rong Pei

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The prognostic significance of PD-L1 and PD-1 expression in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

Zi-Lu Huang, Shan Liu, Guan-Nan Wang, Shuo-Han Zheng, Shi-Rong Ding, Ya-lan Tao, Chen Chen, Song-Ran Liu, Xin Yang, Hui Chang, Xiao-Hui Wang, Yun-Fei Xia

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of hub genes and therapeutic drugs in esophageal squamous cell carcinoma based on integrated bioinformatics strategy

Wanli Yang, Xinhui Zhao, Yu Han, Lili Duan, Xin Lu, Xiaoqian Wang, Yujie Zhang, Wei Zhou, Jinqiang Liu, Hongwei Zhang, Qingchuan Zhao, Liu Hong, Daiming Fan

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway

Xiaoli Zhang, Fei Li, Yeqing Cui, Shuang Liu, Haichen Sun

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The histone H3 lysine-27 demethylase UTX plays a critical role in colorectal cancer cell proliferation

Xin Tang, Wenwei Cai, Jing Cheng, Ping Lu, Shaojun Ma, Chaoting Chen, Yi Chen, Yun Sun, Caofeng Wang, Ping Hu, Xiaomin Lv, G. Sun, Yu Wang, Jing Sheng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The ionophore antibiotic gramicidin A inhibits pancreatic cancer stem cells associated with CD47 down-regulation

Rui-Qi Wang, Jing Geng, Wei-Jin Sheng, Xiu-Jun Liu, Min Jiang, Yong-Su Zhen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer

Xiaobin Gu, Meilian Dong, Zheyan Liu, Yin Mi, Jing Yang, Zhigang Zhang, Ke Liu, Li Jiang, Yue Zhang, Shiliang Dong, Yonggang Shi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1

Hui Miao, Nuan Wang, Lin-Xin Shi, Zheng Wang, Wen-Bo Song

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LncRNA H19 regulates PI3K–Akt signal pathway by functioning as a ceRNA and predicts poor prognosis in colorectal cancer: integrative analysis of dysregulated ncRNA-associated ceRNA network

Min-Er Zhong, Yanyu Chen, Guannan Zhang, Lai Xu, Wei Ge, Bin Wu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Upregulation of NPL4 promotes bladder cancer cell proliferation by inhibiting DXO destabilization of cyclin D1 mRNA

Bao-Sai Lu, Yue-Wei Yin, Yan-Ping Zhang, Ping-Ying Guo, Wei Li, Kai-Long Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Overexpression of lncRNA PIK3CD-AS1 promotes expression of LATS1 by competitive binding with microRNA-566 to inhibit the growth, invasion and metastasis of hepatocellular carcinoma cells

Wei Song, Jingjing Zhang, Jianbo Zhang, Miaomiao Sun, Qingxin Xia

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells

Wenyuan Huang, Yan Liang, Xiaofeng Ma

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The lncRNA TDRG1 promotes cell proliferation, migration and invasion by targeting miR-326 to regulate MAPK1 expression in cervical cancer

Hui Jiang, Min liang, Yanqiong Jiang, Ting Zhang, Kexin Mo, Suwen Su, Aiping Wang, Yongyi Zhu, Guanqun Huang, Rujian Zhou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

β-Asarone increases doxorubicin sensitivity by suppressing NF-κB signaling and abolishes doxorubicin-induced enrichment of stem-like population by destabilizing Bmi1

Li-Na Lv, Xiao-Chao Wang, Li-Ju Tao, Hong-Wen Li, Shu-You Li, Fei-Meng Zheng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Effect of Gallic acid in potentiating chemotherapeutic effect of Paclitaxel in HeLa cervical cancer cells

Nora M. Aborehab, Nada Osama

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Systematically profiling the expression of eIF3 subunits in glioma reveals the expression of eIF3i has prognostic value in IDH-mutant lower grade glioma

Rui-Chao Chai, Ning Wang, Yu-Zhou Chang, Ke-Nan Zhang, Jing-Jun Li, Jun-Jie Niu, Fan Wu, Yu-Qing Liu, Yong-Zhi Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LncRNA TUBA4B functions as a competitive endogenous RNA to inhibit gastric cancer progression by elevating PTEN via sponging miR-214 and miR-216a/b

Jianbo Guo, Yan Li, He Duan, Lu Yuan

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The role of fibromodulin in cancer pathogenesis: implications for diagnosis and therapy

Mohammad Hossein Pourhanifeh, Rezvan Mohammadi, Somaye Noruzi, Seyede Atefe Hosseini, Sahar Fanoudi, Yousef Mohamadi, Milad Hashemzehi, Zatollah Asemi, Hamid Reza Mirzaei, Reza Salarinia, Hamed Mirzaei

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Prognostic significance of cyclin D3 expression in malignancy patients: a meta-analysis

Bo Wang, Zijian Wang, Lizhi Han, Song Gong, Yanxue Wang, Zhiwen He, Yong Feng, Zhaohui Yang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

Jiaojiao Ji, Jiang Yuan, Xiaoyu Guo, Ruifang Ji, Qinghua Quan, Mei Ding, Xia Li, Yonggang Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial–mesenchymal transition

Wan He, Jun Tang, Wenwen Li, Yong Li, Yi Mei, Lisheng He, Keli Zhong, Ruilian Xu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Interaction of HE4 and ANXA2 exists in various malignant cells—HE4–ANXA2–MMP2 protein complex promotes cell migration

Jing Wang, Lu Deng, Huiyu Zhuang, Juanjuan Liu, Dawo Liu, Xiao Li, Shan Jin, Liancheng Zhu, Huimin Wang, Bei Lin

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells

Zhou-hua Jiang, Tao Peng, Hai-long Qian, Cai-de Lu, Feng Qiu, Su-zhan Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer

Huihua Cao, Qing Wang, Zhenyan Gao, Xiang Xu, Qicheng Lu, Yugang Wu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MiR-503 suppresses cell proliferation and invasion of gastric cancer by targeting HMGA2 and inactivating WNT signaling pathway

Wenjing Li, Jun Li, Hong Mu, Meiqi Guo, Haixia Deng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer

Ling Yao, Lei Wang, Zhi-Gang Cao, Xin Hu, Zhi-Ming Shao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Relation of AURKB over-expression to low survival rate in BCRA and reversine-modulated aurora B kinase in breast cancer cell lines

Di Huang, Yu Huang, Zisheng Huang, Jiefeng Weng, Shuai Zhang, Weili Gu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Protective potential of miR-146a-5p and its underlying molecular mechanism in diverse cancers: a comprehensive meta-analysis and bioinformatics analysis

Mei-wei Li, Li Gao, Yi-wu Dang, Ping Li, Zu-yun Li, Gang Chen, Dian-zhong Luo

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

DKK1 inhibits breast cancer cell migration and invasion through suppression of β-catenin/MMP7 signaling pathway

Jie Niu, Xiao-Meng Li, Xiao Wang, Chao Liang, Yi-Dan Zhang, Hai-Ying Li, Fan-Ye Liu, Hua Sun, Song-Qiang Xie, Dong Fang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Long noncoding RNAs as potential biomarkers and therapeutic targets in gallbladder cancer: a systematic review and meta-analysis

Yuan Zhong, Xiaochao Wu, Quanpeng Li, Xianxiu Ge, Fei Wang, Peiyao Wu, Xueting Deng, Lin Miao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells

Chen Guo, Tao Huang, Qing-Hai Wang, Hong Li, Aashish Khanal, En-Hao Kang, Wei Zhang, Hai-Tao Niu, Zhen Dong, Yan-Wei Cao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Caveolin-1 enhances brain metastasis of non-small cell lung cancer, potentially in association with the epithelial-mesenchymal transition marker SNAIL

Yeong-Jin Kim, Ju-Hwi Kim, Ok Kim, Eun-Jung Ahn, Se-Jeong Oh, Md Rashedunnabi Akanda, In-Jae Oh, Shin Jung, Kyung-Keun Kim, Jae-Hyuk Lee, Hyung-Seok Kim, Hangun Kim, Kyung-Hwa Lee, Kyung-Sub Moon

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of potential key genes and pathways predicting pathogenesis and prognosis for triple-negative breast cancer

Xuemei Lv, Miao He, Yanyun Zhao, Liwen Zhang, Wenjing Zhu, Longyang Jiang, Yuanyuan Yan, Yue Fan, Hongliang Zhao, Shuqi Zhou, Heyao Ma, Yezhi Sun, Xiang Li, Hong Xu, Minjie Wei

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Effects of pericytes and colon cancer stem cells in the tumor microenvironment

Elsa N. Garza Treviño, Paulina Delgado González, Carlos I. Valencia Salgado, Alejandra Martinez Garza

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Comprehensive bioinformatics analysis reveals potential lncRNA biomarkers for overall survival in patients with hepatocellular carcinoma: an on-line individual risk calculator based on TCGA cohort

Zhiqiao Zhang, Yanling Ouyang, Yiyan Huang, Peng Wang, Jing Li, Tingshan He, Qingbo Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long non-coding RNA MEG3 inhibits cervical cancer cell growth by promoting degradation of P-STAT3 protein via ubiquitination

Jun Zhang, Yali Gao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Smoking history influences the prognostic value of peripheral naïve CD4+ T cells in advanced non-small cell lung cancer

Chao Liu, Bin Xu, Qian Li, Aijie Li, Lan Li, Jinbo Yue, Qinyong Hu, Jinming Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Down-regulation of miR-29c is a prognostic biomarker in acute myeloid leukemia and can reduce the sensitivity of leukemic cells to decitabine

Li-juan Tang, Guo-kang Sun, Ting-juan Zhang, De-hong Wu, Jing-dong Zhou, Bei-bei Ma, Zi-jun Xu, Xiang-mei Wen, Qin Chen, Dong-ming Yao, Jun Qian, Ji-chun Ma, Jiang Lin

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MiR-369-3p participates in endometrioid adenocarcinoma via the regulation of autophagy

Ping Liu, Chengbin Ma, Qiongwei Wu, Wenying Zhang, Cao Wang, Li Yuan, Xiaowei Xi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway

Yuan Zhou, Yubo Wang, Wuhua Zhou, Tianchi Chen, Qinchuan Wu, Vikram Kumar Chutturghoon, Bingyi Lin, Lei Geng, Zhe Yang, Lin Zhou, Shusen Zheng

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms

Mohadese Honari, Rana Shafabakhsh, Russel J. Reiter, Hamed Mirzaei, Zatollah Asemi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Integrated analyses of microRNA-29 family and the related combination biomarkers demonstrate their widespread influence on risk, recurrence, metastasis and survival outcome in colorectal cancer

Qiliang Peng, Zhengyang Feng, Yi Shen, Jiahao Zhu, Li Zou, Yuntian Shen, Yaqun Zhu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression

Jian Wang, Shujing Li, Xiahui Li, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Miao Wang, Huijian Wu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of circRNA–miRNA–mRNA regulatory network in gastric cancer by analysis of microarray data

Yong-jun Guan, Jian-ying Ma, Wei Song

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Oncogenic effect of PHLDB2 is associated with epithelial–mesenchymal transition and E-cadherin regulation in colorectal cancer

Geng Chen, Tong Zhou, Tantan Ma, Tingting Cao, Zhenxiang Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

DNA methylation-based classification and identification of renal cell carcinoma prognosis-subgroups

Wenbiao Chen, Jia Zhuang, Peizhong Peter Wang, Jingjing Jiang, Chenhong Lin, Ping Zeng, Yan Liang, Xujun Zhang, Yong Dai, Hongyan Diao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

In silico analysis excavates potential biomarkers by constructing miRNA-mRNA networks between non-cirrhotic HCC and cirrhotic HCC

Bisha Ding, Weiyang Lou, Jingxing Liu, Ruohan Li, Jing Chen, Weimin Fan

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Strand-specific miR-28-3p and miR-28-5p have differential effects on nasopharyngeal cancer cells proliferation, apoptosis, migration and invasion

Yan Lv, Huijun Yang, Xingkai Ma, Geping Wu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling

Yize Zhang, Chae Young Han, Fu Gang Duan, Xing-Xing Fan, Xiao-Jun Yao, Robin J. Parks, Yi-Jun Tang, Mei-Fang Wang, Liang Liu, Benjamin K. Tsang, Elaine Lai-Han Leung

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Rony A. Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K. Batra, Domenico Coppola, Said M. Sebti, Mokenge P. Malafa

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Characteristics of a novel cell line ZJU-0430 established from human gallbladder carcinoma

Fei Zhou, Yanhua Zhang, Jihong Sun, Xiaoming Yang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Hamdan S. Al-malky, Abdel-Moneim M. Osman, Zoheir A. Damanhouri, Huda M. Alkreathy, Jumana Y. Al Aama, Wafaa S. Ramadan, Ali A. Al Qahtani, Hadiah B. Al Mahdi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF

Rongsheng Zhang, Fan Qi, Shengli Shao, Geng Li, Yongdong Feng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

Lu Hou, Yi Zhao, Guo-qing Song, Ying-han Ma, Xiao-hu Jin, Si-li Jin, Yi-han Fang, Yi-chong Chen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long non-coding RNA MIAT promotes papillary thyroid cancer progression through upregulating LASP1

Wei Liu, Zhenglin Wang, Cong Wang, Zhilong Ai

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells

Jian Zhu, Hanhui Zou, Wei Yu, Yuluan Huang, Bing Liu, Tao Li, Chengzhen Liang, Huimin Tao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Upregulation of circFLNA contributes to laryngeal squamous cell carcinoma migration by circFLNA–miR-486-3p-FLNA axis

Jian-Xing Wang, Yan Liu, Xin-Ju Jia, Shu-Xia Liu, Jin-Hui Dong, Xiu-Min Ren, Ou Xu, Hai-Zhong Zhang, Hui-Jun Duan, Chun-Guang Shan

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Mfn2 inhibits proliferation and cell-cycle in Hela cells via Ras-NF-κB signal pathway

Xiaowen Liu, Jun Sun, Ping Yuan, Kangquan Shou, Yuanhong Zhou, Wenqi Gao, Jin She, Jun Hu, Jun Yang, Jian Yang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4

Yixi Zhang, Zebin Zhu, Shanzhou Huang, Qiang Zhao, Changjun Huang, Yunhua Tang, Chengjun Sun, Zhiheng Zhang, Linhe Wang, Huadi Chen, Maogen Chen, Weiqiang Ju, Xiaoshun He

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Inhibition LC3B can increase chemosensitivity of ovarian cancer cells

Jing Tang, Jiang Zhu, Yuguang Ye, Yu Liu, Yan He, Lei Zhang, Dai Tang, Cong Qiao, Xinxin Feng, Junyi Li, Yanni Kan, Xiaobo Li, Xiaoming Jin, Dan Kong

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer

Fangxuan Li, Jinchao Huang, Juntian Liu, Wengui Xu, Zhiyong Yuan

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LPAR1 regulates the development of intratumoral heterogeneity in ovarian serous cystadenocarcinoma by activating the PI3K/AKT signaling pathway

Ran Cui, Guangming Cao, Huimin Bai, Zhenyu Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long noncoding RNA DIO3OS interacts with miR-122 to promote proliferation and invasion of pancreatic cancer cells through upregulating ALDOA

Kang Cui, Shuiling Jin, Yabing Du, Junlin Yu, Han Feng, Qingxia Fan, Wang Ma

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1

Shengni Hua, Yingyao Quan, Meixiao Zhan, Huaxin Liao, Yong Li, Ligong Lu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Expression of ANGPTL2 and its impact on papillary thyroid cancer

Longyan Yang, Rongxin Sun, Yan Wang, Ying Fu, Yuanyuan Zhang, Zhaohui Zheng, Zhili Ji, Dong Zhao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

miR-450b-5p loss mediated KIF26B activation promoted hepatocellular carcinoma progression by activating PI3K/AKT pathway

Hua Li, Shen Shen, Xiaolong Chen, Zhigang Ren, Zhiqin Li, Zujiang Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The roles of kinetochore of micronucleus in mitosis of HeLa cells: a live cell imaging study

Erkang Jiang, Lianping Wei, Fang Tao, Mei Yu, Shu Wang, Xiuhong Zhou, Daxiang Li, Zhongwen Xie

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The diverse mechanisms and anticancer potential of naphthoquinones

Carolina Escardó Pereyra, Rafael Ferreira Dantas, Sabrina Baptista Ferreira, Luciano Pinho Gomes, Floriano Paes Silva-Jr

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

A nomogram based on 9-lncRNAs signature for improving prognostic prediction of clear cell renal cell carcinoma

Wen Jiang, Qing Guo, Chenghe Wang, Yu Zhu

01.12.2019 | Minireview | Ausgabe 1/2019 Open Access

Tumor mutation burden: from comprehensive mutational screening to the clinic

Francesca Galuppini, Carlo Alberto Dal Pozzo, Jutta Deckert, Fotios Loupakis, Matteo Fassan, Raffaele Baffa

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LINC00309 is associated with short disease-free survival in breast cancer

Sheng Huang, Yayun Chi, Weiru Chi, Rong Guo, Yonghui Su, Jingyan Xue, Shaoqiang Zhou, Jiankui Wang, Zhuangqing Yang, Jianyun Nie, Zhimin Shao, Dedian Chen, Jiong Wu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p

Zhiqin Li, Yushu Hu, Qinglei Zeng, Hongyan Wang, Jingya Yan, Hua Li, Zujiang Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The E2F3/miR-125a/DKK3 regulatory axis promotes the development and progression of gastric cancer

Yihua Pei, Zhiteng Tang, Minjing Cai, Qin Yao, Bozhen Xie, Xin Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

RASSF-1A modulates proliferation-mediated oral squamous cell carcinoma progression

Jianli Sun

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Transregulation of microRNA miR-21 promoter by AP-1 transcription factor in cervical cancer cells

Sacnite del Mar Díaz-González, Eduardo Daniel Rodríguez-Aguilar, Angélica Meneses-Acosta, Viviana Valadez-Graham, Jessica Deas, Claudia Gómez-Cerón, Carlos Alberto Tavira-Montalván, Alitzel Arizmendi-Heras, Julián Ramírez-Bello, Mario Enrique Zurita-Ortega, Berenice Illades-Aguiar, Marco Antonio Leyva-Vázquez, Gloria Fernández-Tilapa, Víctor Hugo Bermúdez-Morales, Vicente Madrid-Marina, Mauricio Rodríguez-Dorantes, Carlos Pérez-Plasencia, Oscar Peralta-Zaragoza

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Functional polymorphisms of the lncRNA H19 promoter region contribute to the cancer risk and clinical outcomes in advanced colorectal cancer

Wenyan Qin, Xiaodong Wang, Yilin Wang, Yalun Li, Qiuchen Chen, Xiaoyun Hu, Zhikun Wu, Pengfei Zhao, Shanqiong Li, Haishan Zhao, Weifan Yao, Jian Ding, Minjie Wei, Huizhe Wu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors

Helei Hou, Dantong Sun, Xiaochun Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

NEAT1/miR-23a-3p/KLF3: a novel regulatory axis in melanoma cancer progression

Fei Ding, Jindong Lai, Yang Gao, Genhui Wang, Jingwen Shang, Daojun Zhang, Shumao Zheng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage

Haowen Xiao, Yingying Ding, Yang Gao, Li-Mengmeng Wang, Huafang Wang, Lijuan Ding, Xiaoqing Li, Xiaohong Yu, He Huang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

miR-21 promotes non-small cell lung cancer cells growth by regulating fatty acid metabolism

Kewei Ni, Dimin Wang, Heyun Xu, Fuyang Mei, Changhao Wu, Zhifang Liu, Bing Zhou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways

Yu Jin, Yuexiu Li, Xin Wang, Ya Yang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy

Yongchang Lai, Tao Zeng, Xiongfa Liang, Weizou Wu, Fangling Zhong, Wenqi Wu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein

Lanqin Wu, Yingying Lin, Jinan Feng, Yuanlin Qi, Xinrui Wang, Qiaofa Lin, Wanyan Shi, Enrun Zheng, Wei Wang, Zhenzhu Hou, Hanbin Lin, Cheng Yu, Yan He, Yan Xu, Hong Yang, Ling Lin, Lisheng Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Dabrafenib and Trametinib prolong coagulation through the inhibition of tissue factor in BRAFv600e mutated melanoma cells in vitro

Cristian Scatena, Sara Franceschi, Maria Franzini, Chiara Sanguinetti, Nadia Romiti, Laura Caponi, Mario Mandalà, Chiara Maria Mazzanti, Antonio Giuseppe Naccarato

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?

Praveen Kumar Jaiswal, Sweaty Koul, Nallasivam Palanisamy, Hari K. Koul

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The survival analysis and oncogenic effects of CFP1 and 14-3-3 expression on gastric cancer

Jingyue Sun, Yao Long, Xin Peng, Desheng Xiao, Jianhua Zhou, Yongguang Tao, Shuang Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC

Xiangyu Zhang, Jiali Wang, Yunlong Jia, Tianxu Liu, Mengjie Wang, Wei Lv, Rong Zhang, Juan Shi, Lihua Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Interaction between 17β-estradiol, prolactin and human papillomavirus induce E6/E7 transcript and modulate the expression and localization of hormonal receptors

Inocencia Guadalupe Ramírez-López, Adrián Ramírez de Arellano, Luis Felipe Jave-Suárez, Christian David Hernández-Silva, Mariel García-Chagollan, Jorge Hernández-Bello, Edgar I. Lopez-Pulido, José Macias-Barragan, Margarita Montoya-Buelna, José Francisco Muñoz-Valle, Ana Laura Pereira-Suárez

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

NAP1L1 is a prognostic biomarker and contribute to doxorubicin chemotherapy resistance in human hepatocellular carcinoma

Yong Le, Anna Kan, Qi-Jiong Li, Min-Ke He, Hai-Long Chen, Ming Shi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

A six-gene prognostic model predicts overall survival in bladder cancer patients

Liwei Wang, Jiazhong Shi, Yaqin Huang, Sha Liu, Jingqi Zhang, Hua Ding, Jin Yang, Zhiwen Chen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

miR-145 supports cancer cell survival and shows association with DDR genes, methylation pattern, and epithelial to mesenchymal transition

Siddharth Manvati, Kailash Chandra Mangalhara, Ponnuswamy Kalaiarasan, Rupali Chopra, Gaurav Agarwal, Rakesh Kumar, Sunil Kumar Saini, Monika Kaushik, Ankita Arora, Usha Kumari, Rameshwar Nath Koul Bamezai, Pawan Kumar Dhar

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Up-regulation of microRNA-200c-3p inhibits invasion and migration of renal cell carcinoma cells via the SOX2-dependent Wnt/β-catenin signaling pathway

Shuai Li, Ziyu Feng, Xuechong Zhang, Dongyang Lan, Yudong Wu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine

Liu Wensheng, Zhang Bo, Hu Qiangsheng, Xu Wenyan, Ji Shunrong, Xu Jin, Ni Quanxing, Yu Xianjun, Xu Xiaowu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer

Cui Jiang, SunRun Cao, Na Li, Lei Jiang, Tao Sun

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells

Xinke Wang, Zhixian Lan, Juan He, Qiuhua Lai, Xiang Yao, Qingyuan Li, Yongfeng Liu, Huasheng Lai, Chuncai Gu, Qun Yan, Yuxin Fang, Yue Zhang, Aimin Li, Side Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Effect of hyperoside on cervical cancer cells and transcriptome analysis of differentially expressed genes

Weikang Guo, Hui Yu, Lu Zhang, Xiuwei Chen, Yunduo Liu, Yaoxian Wang, Yunyan Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Development of transplantable B-cell lymphomas in the MHC-defined miniature swine model

Alec R. Andrews, Zhaohui Wang, Robert A. Wilkinson, Jay A. Fishman, David H. Sachs, Nalu Navarro-Alvarez, Christene A. Huang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Cell-type specific concentration regulation of the basal transcription factor TFIIH in XPBy/y mice model

Lise-Marie Donnio, Catherine Miquel, Wim Vermeulen, Giuseppina Giglia-Mari, Pierre-Olivier Mari

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients

Jingping Yuan, Huihua He, Chuang Chen, Juan Wu, Jie Rao, Honglin Yan

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Prognostic significance of TOP2A in non-small cell lung cancer revealed by bioinformatic analysis

Wenxia Ma, Bin Wang, Yaping Zhang, Ziyue Wang, Dan Niu, Siyu Chen, Zhirong Zhang, Ningning Shen, Weixia Han, Xiaoqin Zhang, Rong Wei, Chen Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long non-coding RNA LINC00485 acts as a microRNA-195 sponge to regulate the chemotherapy sensitivity of lung adenocarcinoma cells to cisplatin by regulating CHEK1

Wei Zuo, Wei Zhang, Fei Xu, Jing Zhou, Wei Bai

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Phenyllactic acid promotes cell migration and invasion in cervical cancer via IKK/NF-κB-mediated MMP-9 activation

Chao Li, Yanfei Li, Lanxia Sui, Jian Wang, Fang Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway

Weiguang Liu, Jianjun Han, Sufang Shi, Yuna Dai, Jianchao He

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients

Yi-feng Zou, Yu-ming Rong, Ying-xin Tan, Jian Xiao, Zhao-liang Yu, Yu-feng Chen, Jia Ke, Cheng-hang Li, Xi Chen, Xiao-jian Wu, Ping Lan, Xu-tao Lin, Feng Gao

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases

Matteo Fassan, Luca Vianello, Diana Sacchi, Giuseppe N. Fanelli, Giada Munari, Marco Scarpa, Rocco Cappellesso, Fotios Loupakis, Cristiano Lanza, Roberta Salmaso, Claudia Mescoli, Nicola Valeri, Marco Agostini, Edoardo D’Angelo, Sara Lonardi, Salvatore Pucciarelli, Nicola Veronese, Claudio Luchini, Massimo Rugge

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Prognostic impact of platelet-to-lymphocyte ratio on diffuse large B-cell lymphoma: a meta-analysis

Ying Chen, Zongxin Zhang, Qiu Fang, Huiqin Jian

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Ethanol extract of Ligustrum lucidum Ait. leaves suppressed hepatocellular carcinoma in vitro and in vivo

Guoyan Tian, Jin Chen, Yan Luo, Jin Yang, Tao Gao, Junping Shi

01.12.2019 | Review | Ausgabe 1/2019 Open Access

CD146 T cells in lung cancer: its function, detection, and clinical implications as a biomarker and therapeutic target

Ayobami Matthew Olajuyin, Adefunke Kafayat Olajuyin, Ziqi Wang, Xingru Zhao, Xiaoju Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The miR-141/neuropilin-1 axis is associated with the clinicopathology and contributes to the growth and metastasis of pancreatic cancer

Lixin Ma, Bo Zhai, Huaqiang Zhu, Weidong Li, Wenjing Jiang, Liwang Lei, Shujun Zhang, Haiquan Qiao, Xian Jiang, Xueying Sun

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma

Tao Yan, Fang Liu, Jiajia Gao, Haizhen Lu, Jianqiang Cai, Xiaohang Zhao, Yulin Sun

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

miR-145 sensitizes esophageal squamous cell carcinoma to cisplatin through directly inhibiting PI3K/AKT signaling pathway

Tian-Liang Zheng, De-Ping Li, Zhan-Feng He, Song Zhao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Selecting short length nucleic acids localized in exosomes improves plasma EGFR mutation detection in NSCLC patients

Yoonjung Kim, Saeam Shin, Boyeon Kim, Kyung-A Lee

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Circular RNA CDR1as sponges miR-7-5p to enhance E2F3 stability and promote the growth of nasopharyngeal carcinoma

Qiong Zhong, Juncong Huang, Jiawang Wei, Renrui Wu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

PGM5 is a promising biomarker and may predict the prognosis of colorectal cancer patients

Yifan Sun, Haihua Long, Lin Sun, Xiujuan Sun, Liping Pang, Jianlin Chen, Qingqun Yi, Tianwei Liang, Yongqi Shen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Extracellular and macropinocytosis internalized ATP work together to induce epithelial–mesenchymal transition and other early metastatic activities in lung cancer

Yanyang Cao, Xuan Wang, Yunsheng Li, Maria Evers, Haiyun Zhang, Xiaozhuo Chen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Leucine-rich repeat and sterile alpha motif containing 1 promotes the oncogenic growth of human hepatocellular carcinoma cells

Lili Pian, Xiaofeng Huang, Min Zhao, Yaolin Zhang, Cheng Qin, Jiyan Zhang, Jun Zhang, Qingyang Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARα

Xinrui Wang, Huiyong Fan, Congling Xu, Guojuan Jiang, Haiwei Wang, Ji Zhang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

miR-190-5p in human diseases

Yue Yu, Xu-Chen Cao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

KLF8 overexpression promotes the growth of human lung cancer cells by promoting the expression of JMJD2A

Dongjie Ma, Hongsheng Liu, Yingzhi Qin, Zhenhuan Tian, Shanqing Li, Naixin Liang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Prognostic value of YKL-40 in solid tumors: a meta-analysis of 41 cohort studies

Bingxian Bian, Li Li, Junyao Yang, Yi Liu, Guohua Xie, Yingxia Zheng, Liang Zeng, Junxiang Zeng, Lisong Shen

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Why are olfactory ensheathing cell tumors so rare?

Mariyam Murtaza, Anu Chacko, Ali Delbaz, Ronak Reshamwala, Andrew Rayfield, Brent McMonagle, James A. St John, Jenny A. K. Ekberg

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The prognostic value of long noncoding RNA SNHG16 on clinical outcomes in human cancers: a systematic review and meta-analysis

Chenghao Zhang, Xiaolei Ren, Jieyu He, Wanchun Wang, Chao Tu, Zhihong Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Differential secretome of pancreatic cancer cells in serum-containing conditioned medium reveals CCT8 as a new biomarker of pancreatic cancer invasion and metastasis

Peng Liu, Lingming Kong, Haoyi Jin, Yunhao Wu, Xiaodong Tan, Bing Song

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Suboptimal concordance in testing and retesting results of triple-negative breast carcinoma cases among laboratories: one institution experience

Jose De Jesus, Marilin Rosa

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer

Jingbo Sun, Jingzhan Huang, Jin Lan, Kun Zhou, Yuan Gao, Zhigao Song, Yunyao Deng, Lixin Liu, Ying Dong, Xiaolong Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of 3 subpopulations of tumor-infiltrating immune cells for malignant transformation of low-grade glioma

Jiacheng Lu, Hailin Li, Zhengxin Chen, Ligang Fan, Shuang Feng, Xiaomin Cai, Huibo Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

(−)-Epigallocatechin-3-gallate derivatives combined with cisplatin exhibit synergistic inhibitory effects on non-small-cell lung cancer cells

Jing Wang, Peiyuan Sun, Qi Wang, Pan Zhang, Yuna Wang, Chengting Zi, Xuanjun Wang, Jun Sheng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Potential Role of circPVT1 as a proliferative factor and treatment target in esophageal carcinoma

Rongrong Zhong, Zhuozhi Chen, Ting Mo, Zimo Li, Peng Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of differentially expressed circRNAs and a novel hsa_circ_0000144 that promote tumor growth in gastric cancer

Jianming Wei, Jinmiao Wang, Xibo Gao, Feng Qi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Histone methyltransferase SUV39H2 regulates cell growth and chemosensitivity in glioma via regulation of hedgehog signaling

Ran Wang, Lilin Cheng, Xi Yang, Xin Chen, Yifeng Miao, Yongming Qiu, Zhiyi Zhou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long non-coding RNA HOTAIR functions as a competitive endogenous RNA to regulate PRAF2 expression by sponging miR-326 in cutaneous squamous cell carcinoma

Guo-Jun Yu, Yong Sun, Da-Wei Zhang, Peng Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Inactivation of the Wnt/β-catenin signaling pathway underlies inhibitory role of microRNA-129-5p in epithelial–mesenchymal transition and angiogenesis of prostate cancer by targeting ZIC2

Zhenming Jiang, Yuxi Zhang, Xi Chen, Pingeng Wu, Dong Chen

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The predictive value of dynamic monitoring of peripheral blood lymphocyte to monocyte ratio in patients with extranodal NK/T cell lymphoma

Shengnan Zhang, Mengjuan Li, Fangfang Yuan, Lin Chen, Ruihua Mi, Xudong Wei, Yongping Song, Qingsong Yin

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Role of XIAP gene overexpressed bone marrow mesenchymal stem cells in the treatment of cerebral injury in rats with cerebral palsy

Wenjing Deng, Chenghe Fan, Yanbo Fang, Yanan Zhao, Yamin Wei, Meng Li, Junfang Teng

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

PIK3CA-CDKN2A clonal evolution in metastatic breast cancer and multiple points cell-free DNA analysis

Maria Palmieri, Margherita Baldassarri, Francesca Fava, Alessandra Fabbiani, Giuseppe Maria Campennì, Maria Antonietta Mencarelli, Rossella Tita, Stefania Marsili, Alessandra Renieri, Elisa Frullanti

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long non-coding RNA UCA1 promotes breast cancer by upregulating PTP1B expression via inhibiting miR-206

Yi Li, Qingan Zeng, Jiliang Qiu, Ting Pang, Jianzhong Xian, Xuexia Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer

Dao-xiong Ye, Si-si Wang, Ying Huang, Pan Chi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer

Zhengbin Chai, Li Wang, Yabing Zheng, Na Liang, Xiwei Wang, Yingying Zheng, Zhiwei Zhang, Chuanxi Zhao, Tingting Zhu, Chunyan Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Expression profile analysis of two antisense lncRNAs to improve prognosis prediction of colorectal adenocarcinoma

Milad Shademan, Azam Naseri Salanghuch, Khadijeh Zare, Morteza Zahedi, Mohammad Ali Foroughi, Kambiz Akhavan Rezayat, Hooman Mosannen Mozaffari, Kamran Ghaffarzadegan, Ladan Goshayeshi, Hesam Dehghani

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Evaluating the role of RAD52 and its interactors as novel potential molecular targets for hepatocellular carcinoma

Ping Li, YanZhen Xu, Qinle Zhang, Yu Li, Wenxian Jia, Xiao Wang, Zhibin Xie, Jiayi Liu, Dong Zhao, Mengnan Shao, Suixia Chen, Nanfang Mo, Zhiwen Jiang, Liuyan Li, Run Liu, Wanying Huang, Li Chang, Siyu Chen, Hongtao Li, Wenpu Zuo, Jiaquan Li, Ruoheng Zhang, Xiaoli Yang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

p62 acts as an oncogene and is targeted by miR-124-3p in glioma

Danni Deng, Kaiming Luo, Hongmei Liu, Xichen Nie, Lian Xue, Rong Wang, Yuan Xu, Jun Cui, Naiyuan Shao, Feng Zhi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Exosomal microRNA-205 is involved in proliferation, migration, invasion, and apoptosis of ovarian cancer cells via regulating VEGFA

Lijun Wang, Fei Zhao, Zhongqing Xiao, Liang Yao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

CDK5RAP3 inhibits angiogenesis in gastric neuroendocrine carcinoma by modulating AKT/HIF-1α/VEGFA signaling

Jian-Xian Lin, Xiong-Feng Weng, Xin-Sheng Xie, Ning-Zi Lian, Sheng-Liang Qiu, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Si-Jia Liu, Min Hu, Yi-Ke Lin, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

TRIM27 promotes the development of esophagus cancer via regulating PTEN/AKT signaling pathway

Liang Ma, Ninghua Yao, Ping Chen, Zhixiang Zhuang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Silencing of TRIM11 suppresses the tumorigenicity of chordoma cells through improving the activity of PHLPP1/AKT

Bin Wang, Gang Wang, Qingfeng Wang, Ziqiang Zhu, Yunqing Wang, Kangwu Chen, Huilin Yang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MMP3 activity rather than cortical stiffness determines NHE1-dependent invasiveness of melanoma cells

Dennis Keurhorst, Ivan Liashkovich, Fabian Frontzek, Svenja Nitzlaff, Verena Hofschröer, Rita Dreier, Christian Stock

01.12.2019 | Retraction Note | Ausgabe 1/2019 Open Access

Retraction Note to: Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC‑1 cell apoptosis via activating the mROS‑HtrA2/Omi pathways

Jun Wan, Jie Cui, Lei Wang, Kunpeng Wu, Xiaoping Hong, Yulin Zou, Shuang Zhao, Hong Ke

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MicroRNA-96-3p promotes metastasis of papillary thyroid cancer through targeting SDHB

Xupeng Zhao, Yingjie Li, Yong Zhou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case–control study

Da Pan, Ming Su, Guiling Huang, Pengfei Luo, Ting Zhang, Lingmeng Fu, Jie Wei, Shaokang Wang, Guiju Sun

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of upstream miRNAs of SNAI2 and their influence on the metastasis of gastrointestinal stromal tumors

Jie Ding, Yu Xia, Zhaoyan Yu, Jing Wen, Zhuxue Zhang, Zhongmin Zhang, Zhenhua Liu, Zhuan Jiang, Hang Liu, Guoqing Liao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Two predictive precision medicine tools for hepatocellular carcinoma

Zhiqiao Zhang, Jing Li, Tingshan He, Yanling Ouyang, Yiyan Huang, Qingbo Liu, Peng Wang, Jianqiang Ding

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Circ_ZNF124 promotes non-small cell lung cancer progression by abolishing miR-337-3p mediated downregulation of JAK2/STAT3 signaling pathway

Qianping Li, Qin Huang, Shaofei Cheng, Song Wu, Hongyang Sang, Junyi Hou

01.12.2019 | Hypothesis | Ausgabe 1/2019 Open Access

The influence of PFK-II overexpression on neuroblastoma patients’ survival may be dependent on the particular isoenzyme expressed, PFKFB3 or PFKFB4

Sonia E. Trojan, Michał J. Markiewicz, Katarzyna Leśkiewicz, Kinga A. Kocemba-Pilarczyk

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Clinical-biological characteristics and treatment outcomes of pediatric pro-B ALL patients enrolled in BCH-2003 and CCLG-2008 protocol: a study of 121 Chinese children

Chao Gao, Shu-Guang Liu, Zhi-Xia Yue, Yi Liu, Jing Liang, Jun Li, Yuan-Yuan Zhang, Jiao-Le Yu, Ying Wu, Wei Lin, Hu-Yong Zheng, Rui-Dong Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MicroRNA-346 inhibits the growth of glioma by directly targeting NFIB

Yangyang Li, Jia Xu, Jiale Zhang, Jie Zhang, Jian Zhang, Xiaoming Lu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Roles of sphingosine-1-phosphate signaling in cancer

Peng Wang, Yonghui Yuan, Wenda Lin, Hongshan Zhong, Ke Xu, Xun Qi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification of novel cell glycolysis related gene signature predicting survival in patients with endometrial cancer

Zi-Hao Wang, Yun-Zheng Zhang, Yu-Shan Wang, Xiao-Xin Ma

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

A panel of Transcription factors identified by data mining can predict the prognosis of head and neck squamous cell carcinoma

Boxin Zhang, Haihui Wang, Ziyan Guo, Xinhai Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

β-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation

Dongping Wang, Qi Zhang, Fenfen Li, Chan Wang, Changming Yang, Hong Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Highly versatile cancer photoimmunotherapy using photosensitizer-conjugated avidin and biotin-conjugated targeting antibodies

Naoto Shirasu, Hirotomo Shibaguchi, Hiromi Yamada, Masahide Kuroki, Shin’ichiro Yasunaga

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Role of the complement system in the tumor microenvironment

Ronghua Zhang, Qiaofei Liu, Tong Li, Quan Liao, Yupei Zhao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MicroRNA-140-5p inhibits salivary adenoid cystic carcinoma progression and metastasis via targeting survivin

Zhu Qiao, Yue Zou, Hu Zhao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LncRNA DANCR promotes the proliferation, migration, and invasion of tongue squamous cell carcinoma cells through miR-135a-5p/KLF8 axis

Ying Zheng, Bowen Zheng, Xue Meng, Yuwen Yan, Jia He, Yi Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via Integrin β3

Amata Amy Soriano, Tiziana de Cristofaro, Tina Di Palma, Serena Dotolo, Priyanka Gokulnath, Antonella Izzo, Gaetano Calì, Angelo Facchiano, Mariastella Zannini

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The long noncoding RNA PCGEM1 promotes cell proliferation, migration and invasion via targeting the miR-182/FBXW11 axis in cervical cancer

Qian Zhang, Jindan Zheng, Lili Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

SWAP-70 promotes glioblastoma cellular migration and invasion by regulating the expression of CD44s

Lin Shi, Huize Liu, Yifeng Wang, Yulong Chong, Jie Wang, Guanzheng Liu, Xu Zhang, Xiangyu Chen, Huan Li, Mingshan Niu, Jun Liang, Rutong Yu, Xuejiao Liu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Enhanced osteopontin splicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypes in NSCLC cells

Jing Huang, Siyuan Chang, Yabin Lu, Jing Wang, Yang Si, Lijian Zhang, Shan Cheng, Wen G. Jiang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Expression profile analysis identifies IER3 to predict overall survival and promote lymph node metastasis in tongue cancer

Fang Xiao, Yinhua Dai, Yujiao Hu, Mengmeng Lu, Qun Dai

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MicroRNA-1269 promotes cell proliferation via the AKT signaling pathway by targeting RASSF9 in human gastric cancer

Wen-Li Liu, Hu-xia Wang, Cheng-xin Shi, Fei-yu Shi, Ling-yu Zhao, Wei Zhao, Guang-hui Wang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Prognostic and diagnostic significance of galectins in pancreatic cancer: a systematic review and meta-analysis

Qiqing Sun, Yiyin Zhang, Mengqi Liu, Zeng Ye, Xianjun Yu, Xiaowu Xu, Yi Qin

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Amphicrine carcinoma of the stomach and intestine: a clinicopathologic and pan-cancer transcriptome analysis of a distinct entity

Dan Huang, Fei Ren, Shujuan Ni, Cong Tan, Weiwei Weng, Meng Zhang, Midie Xu, Lei Wang, Qinghua Xu, Weiqi Sheng

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p

Zhuo Ye, Jiachen Duan, Lihui Wang, Yanli Ji, Baoping Qiao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The lncRNA DLX6-AS1 promoted cell proliferation, invasion, migration and epithelial-to-mesenchymal transition in bladder cancer via modulating Wnt/β-catenin signaling pathway

Jinan Guo, Zhixin Chen, Hongtao Jiang, Zhou Yu, Junming Peng, Jing Xie, ZaiShang Li, Weiqing Wu, Zhiqiang Cheng, Kefeng Xiao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Long noncoding RNA DLX6-AS1 promotes neuroblastoma progression by regulating miR-107/BDNF pathway

Huan-yu Zhang, Mao-qing Xing, Jing Guo, Jin-chuan Zhao, Xin Chen, Zhong Jiang, Hong Zhang, Qian Dong

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Silencing expression of PHF14 in glioblastoma promotes apoptosis, mitigates proliferation and invasiveness via Wnt signal pathway

Shuai Wu, Chen Luo, Fengjiao Li, N. U. Farrukh Hameed, Qiuyan Jin, Jie Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Prognostic significance of platelet-to-lymphocyte ratio in urothelial carcinoma patients: a meta-analysis

Yuhai Bao, Yin Wang, Xiaodong Li, Mingjun Pan, Hongze Zhang, Zegen Cheng, Xueyi Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LncRNA UCA1 facilitated cell growth and invasion through the miR-206/CLOCK axis in glioma

Zhi Huang, Xuya Zhao, Xiaowen Wu, Lei Xiang, Yingnan Yuan, Shi Zhou, Wenfeng Yu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment

Yanyun Gao, Patrick Dorn, Shengchen Liu, Haibin Deng, Sean R. R. Hall, Ren-Wang Peng, Ralph A. Schmid, Thomas M. Marti

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

High CTHRC1 expression may be closely associated with angiogenesis and indicates poor prognosis in lung adenocarcinoma patients

Yangshan Chen, Yu Sun, Yongmei Cui, Yiyan Lei, Neng Jiang, Wenting Jiang, Han Wang, Lili Chen, Jiping Luo, Yanyang Chen, Kejing Tang, Chengzhi Zhou, Zunfu Ke

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Melatonin: an anti-tumor agent for osteosarcoma

Hadis Fathizadeh, Hamed Mirzaei, Zatollah Asemi

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

LINC01006 promotes cell proliferation and metastasis in pancreatic cancer via miR-2682-5p/HOXB8 axis

Luyang Zhang, Yunjian Wang, Ling Zhang, Guohua You, Congyu Li, Bo Meng, Minghe Zhou, Min Zhang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells

Dongling Zou, Lei Dong, Chenying Li, Zhe Yin, Shuan Rao, Qi Zhou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

S-15 in combination of Akt inhibitor promotes the expansion of CD45RA−CCR7+ tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1+Tim-3+ cells as well as regulatory T cells

Benling Xu, Long Yuan, Guangyu Chen, Tiepeng Li, Jinxue Zhou, Chengjuan Zhang, Peng Qin, Musleh M. Muthana, Shengdian Wang, Xuexiang Du, Quanli Gao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Exosomal lncRNA HNF1A-AS1 affects cisplatin resistance in cervical cancer cells through regulating microRNA-34b/TUFT1 axis

Xiaoqiong Luo, Jingxi Wei, Feng-lian Yang, Xiao-xia Pang, Feng Shi, Yu-xia Wei, Bi-yun Liao, Jun-li Wang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

SKA1 promotes malignant phenotype and progression of glioma via multiple signaling pathways

Xizhao Wang, Yu Zeng, Mingfeng Zhou, Xian Zhang, Anqi Xu, Jie Lin, Zhiyong Wu, Cheng Xie, Jie Luo, Shengfeng Ding, Zhengming Zhan, Hao Long, Ye Song

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

KCNQ1OT1 aggravates cell proliferation and migration in bladder cancer through modulating miR-145-5p/PCBP2 axis

Jingyu Wang, Hao Zhang, Jie Situ, Mingzhao Li, Hua Sun

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Silencing lncRNA ZFAS1 or elevated microRNA-135a represses proliferation, migration, invasion and resistance to apoptosis of osteosarcoma cells

Zilong Zhao, Xiafei Lin, Yunhui Tong, Wenxia Li

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Identification and analysis of long non-coding RNA related miRNA sponge regulatory network in bladder urothelial carcinoma

Jiawu Wang, Chengyao Zhang, Yan Wu, Weiyang He, Xin Gou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p

Xuegang Wang, Rong Wang, Zhun Wu, Peide Bai

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways

Jafar Ai, Neda Ketabchi, Javad Verdi, Nematollah Gheibi, Hossein Khadem Haghighian, Maria Kavianpour

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Low BCL9 expression inhibited ovarian epithelial malignant tumor progression by decreasing proliferation, migration, and increasing apoptosis to cancer cells

Jing Wang, Mingjun Zheng, Liancheng Zhu, Lu Deng, Xiao Li, Linging Gao, Caixia Wang, Huimin Wang, Juanjuan Liu, Bei Lin

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway

Zhaojia Wu, Tong Niu, Wei Xiao

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Abiraterone and MDV3100 inhibits the proliferation and promotes the apoptosis of prostate cancer cells through mitophagy

Jingli Han, Junhua Zhang, Wei Zhang, Dalei Zhang, Ying Li, Jinsong Zhang, Yaqun Zhang, Tongxiang Diao, Luwei Cui, Wenqing Li, Fei Xiao, Ming Liu, Lihui Zou

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

MiR-566 mediates cell migration and invasion in colon cancer cells by direct targeting of PSKH1

Ying Zhang, Siqi Zhang, Jian Yin, Ruisi Xu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1)

Chuanfeng Zhang, Baosheng Wang, Xiuqin Wang, Xiugui Sheng, Yongchun Cui

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Correlations between chromobox homolog 8 and key factors of epithelial–mesenchymal transition in hepatocellular carcinoma

Xiaonian Zhu, Wei Luo, Chunhua Bei, Juan Kong, Shidong Zhang, Yuanyuan Fu, Di Li, Shengkui Tan

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

TGF-β1 stimulates epithelial–mesenchymal transition and cancer-associated myoepithelial cell during the progression from in situ to invasive breast cancer

Li Wang, Cong Xu, Xia Liu, Yang Yang, Lu Cao, Guomin Xiang, Fang Liu, Shuling Wang, Jing Liu, Qingxiang Meng, Jiao Jiao, Yun Niu

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Hyperglycemia promotes Snail-induced epithelial–mesenchymal transition of gastric cancer via activating ENO1 expression

Xin Xu, Bang Chen, Shaopu Zhu, Jiawei Zhang, Xiaobo He, Guodong Cao, Bo Chen

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

SNHG29 regulates miR-223-3p/CTNND1 axis to promote glioblastoma progression via Wnt/β-catenin signaling pathway

Lizhang Han, Zhonggang Li, Yuquan Jiang, Zheng Jiang, Ling Tang

01.12.2019 | Primary research | Ausgabe 1/2019 Open Access

Cancer-associated fibroblast-derived exosomal microRNA-98-5p promotes cisplatin resistance in ovarian cancer by targeting CDKN1A

Hua Guo, Chunfang Ha, Hui Dong, Zhijuan Yang, Yuan Ma, Yonghui Ding

01.12.2019 | Retraction Note | Ausgabe 1/2019 Open Access

Retraction Note to: IL‑2 augments the sorafenib‑induced apoptosis in liver cancer by promoting mitochondrial fission and activating the JNK/TAZ pathway

Xiaoyan Ding, Wei Sun, Jinglong Chen

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