Ausgabe 2/2014
Inhalt (25 Artikel)
Role of pregnane X receptor in chemotherapeutic treatment
Wei Zhuo, Lei Hu, Jinfeng Lv, Hongbing Wang, Honghao Zhou, Lan Fan
A phase II study of metronomic paclitaxel/cyclophosphamide/capecitabine followed by 5-fluorouracil/epirubicin/cyclophosphamide as preoperative chemotherapy for triple-negative or low hormone receptor expressing/HER2-negative primary breast cancer
N. Masuda, K. Higaki, T. Takano, N. Matsunami, T. Morimoto, S. Ohtani, M. Mizutani, T. Miyamoto, K. Kuroi, S. Ohno, S. Morita, M. Toi
Cimetidine attenuates vinorelbine-induced phlebitis in mice by militating E-selectin expression
Zhuo Wang, Lijuan Ma, Xuebin Wang, Heping Cai, Jin Huang, Jiyong Liu, Jinhong Hu, Dingfeng Su
Differential regulation of bladder cancer growth by various glucocorticoids: corticosterone and prednisone inhibit cell invasion without promoting cell proliferation or reducing cisplatin cytotoxicity
Hitoshi Ishiguro, Takashi Kawahara, Yichun Zheng, Eiji Kashiwagi, Yi Li, Hiroshi Miyamoto
Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors
Ruth Plummer, Peter Stephens, Louiza Aissat-Daudigny, Anne Cambois, Gilbert Moachon, Peter D. Brown, Mario Campone
Pharmacokinetics of afatinib in subjects with mild or moderate hepatic impairment
David Schnell, Susanne Buschke, Holger Fuchs, Dietmar Gansser, Rainer-Georg Goeldner, Martina Uttenreuther-Fischer, Peter Stopfer, Sven Wind, Marc Petersen-Sylla, Atef Halabi, Rüdiger Koenen
A phase II trial of Cremorphor EL-free paclitaxel (Genexol-PM) and gemcitabine in patients with advanced non-small cell lung cancer
Hee Kyung Ahn, Minkyu Jung, Sun Jin Sym, Dong Bok Shin, Shin Myung Kang, Sun Young Kyung, Jeong-Woong Park, Sung Hwan Jeong, Eun Kyung Cho
Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia
Shu-mei Wang, Lu-lu Sun, Wei-xin Zeng, Wan-shui Wu, Guo-liang Zhang
Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4′-thio-2′-deoxycytidine and 5-aza-4′-thio-2′-deoxycytidine
Jaideep V. Thottassery, Vijaya Sambandam, Paula W. Allan, Joseph A. Maddry, Yulia Y. Maxuitenko, Kamal Tiwari, Melinda Hollingshead, William B. Parker
Enhanced skin toxicity associated with the combination of clofarabine plus cytarabine for the treatment of acute leukemia
Bingnan Zhang, Jean Bolognia, Peter Marks, Nikolai Podoltsev
Supplementation of fish oil augments efficacy and attenuates toxicity of 5-fluorouracil in 1,2-dimethylhydrazine dihydrochloride/dextran sulfate sodium-induced colon carcinogenesis
Isha Rani, Kim Vaiphei, Navneet Agnihotri
Circulating biomarkers in hepatocellular carcinoma
Karen L. Morris, Jonathan D. Tugwood, Leila Khoja, Matthew Lancashire, Robert Sloane, Debbie Burt, Patrick Shenjere, Cong Zhou, Clare Hodgson, Toshihiko Ohtomo, Atsuhiko Katoh, Takahiro Ishiguro, Juan W. Valle, Caroline Dive
Frontline treatment with gemcitabine, oxaliplatin and erlotinib for the treatment of advanced or metastatic pancreatic cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)
O. Katopodis, J. Souglakos, E. Stathopoulos, A. Christopoulou, E. Kontopodis, A. Kotsakis, K. Kalbakis, N. Kentepozidis, A. Polyzos, D. Hatzidaki, V. Georgoulias
Evaluation of pharmacokinetics and safety of ponatinib in subjects with chronic hepatic impairment and matched healthy subjects
Narayana I. Narasimhan, David J. Dorer, Jeffrey Davis, Christopher D. Turner, Thomas C. Marbury, Daryl Sonnichsen
Third-space fluid distribution of pemetrexed in non-small cell lung cancer patients
Per Hartvig Honoré, Sigrid Jóhansdóttir Joensen, Michelle Olsen, Steen Honoré Hansen, Anders Mellemgaard
Impact of patient ethnicity on the metabolic and immunologic effects of PI3K–mTOR pathway inhibition in patients with solid tumor malignancies
Rahul Aggarwal, Jennifer Grabowsky, Noah Strait, Alyson Cockerill, Pamela Munster
Comparative pharmacokinetic/pharmacodynamic characterisation of a new pegylated recombinant E. coli l-asparaginase preparation (MC0609) in Beagle dog
Stephan Borghorst, Georg Hempel, Sabine Poppenborg, Dieter Franke, Thorsten König, Joachim Baumgart
Phase II trial of vatalanib in patients with advanced or metastatic pancreatic adenocarcinoma after first-line gemcitabine therapy (PCRT O4-001)
T. Dragovich, D. Laheru, F. Dayyani, V. Bolejack, L. Smith, J. Seng, H. Burris, P. Rosen, M. Hidalgo, P. Ritch, A. F. Baker, N. Raghunand, J. Crowley, D. D. Von Hoff
Hypothyroidism as a potential biomarker of efficacy of famitinib, a novel VEGFR-2 inhibitor in metastatic breast cancer
Jun Cao, Jian Zhang, Zhonghua Wang, Biyun Wang, Fangfang Lv, Leiping Wang, Xichun Hu
Population pharmacokinetics of trastuzumab emtansine (T-DM1), a HER2-targeted antibody–drug conjugate, in patients with HER2-positive metastatic breast cancer: clinical implications of the effect of covariates
Dan Lu, Sandhya Girish, Yuying Gao, Bei Wang, Joo-Hee Yi, Ellie Guardino, Meghna Samant, Melody Cobleigh, Mothaffar Rimawi, Pierfranco Conte, Jin Yan Jin
Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteers
M. Naveed Shaik, Robert R. LaBadie, Dan Rudin, Wendy J. Levin
A phase I study of pegylated liposomal doxorubicin and temsirolimus in patients with refractory solid malignancies
Andrea Wang-Gillam, Nilay Thakkar, A. Craig Lockhart, Kerry Williams, Maria Baggstrom, Michael Naughton, Rama Suresh, Cynthia Ma, Benjamin Tan, Wooin Lee, Xuntian Jiang, Tibu Mwandoro, Lauren Trull, Stefanie Belanger, Allison N. Creekmore, Feng Gao, Paula M. Fracasso, Joel Picus
In vitro testing of drug combinations employing nilotinib and alkylating agents with regard to pretransplant conditioning treatment of advanced-phase chronic myeloid leukemia
Aleksandar Radujkovic, Thomas Luft, Peter Dreger, Anthony D. Ho, W. Jens Zeller, Stefan Fruehauf, Julian Topaly
Gastric cancer with para-aortic lymph node metastases: do not miss a chance of cure!
Daniele Marrelli, Maria Antonietta Mazzei, Franco Roviello
Gastric cancer with para-aortic lymph nodes metastasis: curable dissection possible but be cautiously selected
Tianshu Liu, Yihong Sun, Yan Wang