Ausgabe 2/2021
Inhalt (18 Artikel)
Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever
H. R. Wardill, C. E. M. de Mooij, A. R. da Silva Ferreira, I. P. van de Peppel, R. Havinga, H. J. M. Harmsen, W. J. E. Tissing, N. M. A. Blijlevens
Population pharmacokinetics and exposure–response of selumetinib and its N‐desmethyl metabolite in pediatric patients with neurofibromatosis type 1 and inoperable plexiform neurofibromas
Stein Schalkwijk, Li Zhou, Sarit Cohen‐Rabbie, Lokesh Jain, Tomoko Freshwater, Karen So, Zhongqing He, Ioanna Gioni, Helen Tomkinson, Karthick Vishwanathan, Diansong Zhou
Tissue distribution of epirubicin after severe extravasation in humans
Jakob Nedomansky, Werner Haslik, Ursula Pluschnig, Christoph Kornauth, Christine Deutschmann, Stefan Hacker, Günther G. Steger, Rupert Bartsch, Robert M. Mader
Time-dependent population PK models of single-agent atezolizumab in patients with cancer
Mathilde Marchand, Rong Zhang, Phyllis Chan, Valerie Quarmby, Marcus Ballinger, Nitzan Sternheim, Benjamin Wu, Jin Y. Jin, René Bruno
Downregulation of SELENBP1 enhances oral squamous cell carcinoma chemoresistance through KEAP1–NRF2 signaling
Hui Zeng, Xubing Zhao, Chengfang Tang
Glaucocalyxin A induces apoptosis and autophagy in tongue squamous cell carcinoma cells by regulating ROS
Fanzhe Shi, Danfeng Xue, Qingkun Jiang, Jiaxuan Qiu
Population pharmacokinetic model of irinotecan and its four main metabolites in patients treated with FOLFIRI or FOLFIRINOX regimen
Laure Deyme, Dominique Barbolosi, Litaty Céphanoée Mbatchi, Nicole Tubiana-Mathieu, Marc Ychou, Alexandre Evrard, Florence Gattacceca
Pharmacokinetics and safety of rucaparib in patients with advanced solid tumors and hepatic impairment
Nikolay Grechko, Viera Skarbova, Monika Tomaszewska-Kiecana, Rodryg Ramlau, Piotr Centkowski, Yvette Drew, Rafal Dziadziuszko, Milada Zemanova, Jeri Beltman, Eileen Nash, Jenn Habeck, Mingxiang Liao, Jim Xiao
No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study
Stine Nygaard Nielsen, Linea Natalie Toksvang, Kathrine Grell, Jacob Nersting, Jonas Abrahamsson, Bendik Lund, Jukka Kanerva, Ólafur Gísli Jónsson, Goda Vaitkeviciene, Kaie Pruunsild, Malin Lindqvist Appell, Lisa Lyngsie Hjalgrim, Kjeld Schmiegelow
Exploratory analysis of target concentration of lenvatinib in the treatment of hepatocellular carcinoma
Satoshi Noda, Hiroya Iida, Takehide Fujimoto, Yoshinori Wakasugi, Naoki Yabuta, Masatomo Sudou, Daiki Hira, Masaji Tani, Akira Andoh, Shin-ya Morita, Tomohiro Terada
NCTR25 fusion facilitates the formation of TRAIL polymers that selectively activate TRAIL receptors with higher potency and efficacy than TRAIL
Yan Wang, Qiong Lei, Cangjie Shen, Nan Wang
An exploration of the impact of ethanol diluent on breath alcohol concentration in patients receiving paclitaxel chemotherapy
R. J. Keogh, M. Milewski, K. Browne, K. Egan, M. A. Hennessy, Z. Coyne, D. Cowzer, A. Linehan, B. T. Hennessy, L. Grogan, P. G. Morris, O. S. Breathnach
Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia
Yomna H. Youssef, Sara M. Makkeyah, Ahmed F. Soliman, Nefissa H. Meky
Autophagy inhibitor potentiates the antitumor efficacy of apatinib in uterine sarcoma by stimulating PI3K/Akt/mTOR pathway
Shucheng Chen, Lan Yao
Phase 1 study of alisertib (MLN8237) and weekly irinotecan in adults with advanced solid tumors
Thomas J. Semrad, Edward J. Kim, I-Yeh Gong, Tianhong Li, Scott Christensen, Mili Arora, Jonathan W. Riess, David R. Gandara, Karen Kelly
MiRNA-3662 reverses the gemcitabine resistance in pancreatic cancer through regulating the tumor metabolism
An Liu, Yonggui Zhou, Tian Zhao, Xu Tang, Binbin Zhou, Jia Xu
Toxicity and pharmacokinetics of actinomycin-D and vincristine in children and adolescents: Children’s Oncology Group Study ADVL06B1
Jeffrey Skolnik, David Hall, Donald A. Barkauskas, Ganesh Moorthy, Thomas R. Larson, Elizabeth Fox, Brenda J. Weigel, Stacey L. Berg, Joel M. Reid
Correction to: Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-α and translocating PKC-δ
Xian-Ming Zhang, Jia Chen, Yu-Gui Xia, Qiang Xu