Ausgabe 4/2013
Inhalt (32 Artikel)
Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway
Howard A. Burris III
Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer
Kyung-Hun Lee, Hye Jung Chang, Sae-Won Han, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Sun Young Kim, Keun-Wook Lee, Jee Hyun Kim, Yong Sang Hong, Tae Won Kim, Young Suk Park, Won Ki Kang, Sang Joon Shin, Joong Bae Ahn, Gyeong Hoon Kang, Seung-Yong Jeong, Kyu Joo Park, Jae-Gahb Park, Tae-You Kim
Phase I dose-escalation study of docetaxel, nedaplatin, and 5-fluorouracil combination chemotherapy in patients with advanced esophageal cancer
Tatsuya Miyazaki, Makoto Sohda, Naritaka Tanaka, Shigemasa Suzuki, Keisuke Ieta, Makoto Sakai, Akihiko Sano, Takehiko Yokobori, Takanori Inose, Masanobu Nakajima, Minoru Fukuchi, Hitoshi Ojima, Hiroyuki Kato, Hiroyuki Kuwano
Phase I and pharmacokinetic study of gefitinib and S-1 combination therapy for advanced adenocarcinoma of the lung
Hidemi Kiyota, Isamu Okamoto, Masayuki Takeda, Haruko Daga, Tateaki Naito, Masaki Miyazaki, Hideaki Okada, Hidetoshi Hayashi, Kaoru Tanaka, Masaaki Terashima, Koichi Azuma, Haruyasu Murakami, Koji Takeda, Nobuyuki Yamamoto, Kazuhiko Nakagawa
An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo
Pradip De, Nandini Dey, Breanne Terakedis, P. Leif Bergsagel, Zhi Hua Li, Daruka Mahadevan, Joseph R. Garlich, Suzanne Trudel, Milan T. Makale, Donald L. Durden
A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer
Emmanuel S. Antonarakis, Elisabeth I. Heath, Edwin M. Posadas, Evan Y. Yu, Michael R. Harrison, Justine Y. Bruce, Steve Y. Cho, Gregory E. Wilding, Gerald J. Fetterly, David G. Hangauer, Min-Fun R. Kwan, Lyn M. Dyster, Michael A. Carducci
Thrombocytosis and immunohistochemical expression of connexin 43 at diagnosis predict survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
Gangjun Du, Yingming Yang, Yaping Zhang, Ting Sun, Weijie Liu, Yingying Wang, Jiahuan Li, Houyun Zhang
A phase II study of oxaliplatin in combination with leucovorin and fluorouracil as first-line chemotherapy in patients with metastatic squamous cell carcinoma of esophagus
Jialei Wang, Jianhua Chang, Hui Yu, Xianghua Wu, Huijie Wang, Wenhua Li, Dongmei Ji, Wei Peng
All-oral combination of vinorelbine and capecitabine as first-line treatment in HER2/Neu-negative metastatic breast cancer
Hesham Tawfik, Yousri Rostom, Hesham Elghazaly
Correlation between expressions of ERCC1/TS mRNA and effects of gastric cancer to chemotherapy in the short term
Liqi Chen, Guoli Li, Jieshou Li, Chaogang Fan, Jian Xu, Bo Wu, Kun Liu, Caihua Zhang
The PPARγ agonist pioglitazone crosses the blood–brain barrier and reduces tumor growth in a human xenograft model
Christian Grommes, J. Colleen Karlo, Andrew Caprariello, D’Arbra Blankenship, Anne DeChant, Gary E. Landreth
Multicenter phase II study of S-1 and docetaxel combination chemotherapy for advanced or recurrent gastric cancer patients with peritoneal dissemination
Kunitoshi Shigeyasu, Shunsuke Kagawa, Futoshi Uno, Masahiko Nishizaki, Hiroyuki Kishimoto, Akira Gochi, Toshikazu Kimura, Takaomi Takahata, Yasuyuki Nonaka, Motoki Ninomiya, Toshiyoshi Fujiwara
Repeated radioimmunotherapy with 131I-rituximab for patients with low-grade and aggressive relapsed or refractory B cell non-Hodgkin lymphoma
Hye Jin Kang, Seung-Sook Lee, Byung Hyun Byun, Kyeong Min Kim, Ilhan Lim, Chang Woon Choi, Cheolwon Suh, Won Seog Kim, Seung-Hyun Nam, Soon Il Lee, Hyeon Seok Eom, Dong-Yeop Shin, Sang Moo Lim
A phase I study of hepatic arterial infusion of nab-paclitaxel in combination with intravenous gemcitabine and bevacizumab for patients with advanced cancers and predominant liver metastases
Apostolia M. Tsimberidou, Yang Ye, Jennifer Wheler, Aung Naing, David Hong, Uchechi Nwosu, Kenneth R. Hess, Robert A. Wolff
Pharmacodynamic stimulation of thrombogenesis by angiotensin (1–7) in recurrent ovarian cancer patients receiving gemcitabine and platinum-based chemotherapy
Huyen Pham, Benjamin M. Schwartz, James E. Delmore, Eddie Reed, Scott Cruickshank, Leanne Drummond, Kathleen E. Rodgers, Kainoa J. Peterson, Gere S. diZerega
A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer
Takashi Sasaki, Hiroyuki Isayama, Yousuke Nakai, Yukiko Ito, Ichiro Yasuda, Nobuo Toda, Hirofumi Kogure, Keiji Hanada, Hiroyuki Maguchi, Naoki Sasahira, Hideki Kamada, Tsuyoshi Mukai, Yoshihiro Okabe, Osamu Hasebe, Iruru Maetani, Kazuhiko Koike
A multi-histology trial of fostamatinib in patients with advanced colorectal, non-small cell lung, head and neck, thyroid, and renal cell carcinomas, and pheochromocytomas
Sook Ryun Park, Giovanna Speranza, Richard Piekarz, John J. Wright, Robert J. Kinders, Lihua Wang, Thomas Pfister, Jane B. Trepel, Min-Jung Lee, Sylvia Alarcon, Seth M. Steinberg, Jerry Collins, James H. Doroshow, Shivaani Kummar
A phase I study of tasisulam sodium using an albumin-tailored dose in Japanese patients with advanced solid tumors
Yutaka Fujiwara, Yuichi Ando, Toru Mukohara, Naomi Kiyota, Naoko Chayahara, Ayako Mitsuma, Megumi Inada-Inoue, Masataka Sawaki, Robert Ilaria Jr., P. Kellie Turner, Jumpei Funai, Kaijiro Maeda, Hironobu Minami
Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter
Christina Cherian, Sita Kugel Desmoulin, Lei Wang, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Aleem Gangjee, Larry H. Matherly
A mathematical model for the administration of temozolomide: comparative analysis of conventional and metronomic chemotherapy regimens
C. Faivre, D. Barbolosi, E. Pasquier, N. André
Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapies
Jane Kendrew, Rajesh Odedra, Armelle Logié, Paula J. Taylor, Sharon Pearsall, Donald J. Ogilvie, Stephen R. Wedge, Juliane M. Jürgensmeier
Combination of gemcitabine and carboplatin as first line treatment in elderly patients or those unfit for cisplatin-based chemotherapy with advanced transitional cell carcinoma of the urinary tract
Joo Hee Park, Soon Wook Lee, Hye Sook Kim, Sung Gu Kang, Young Hwii Ko, Seung Tae Kim, Seok Ho Kang, Young Je Park, In Keun Choi, Sang Cheul Oh, Deuk Jae Sung, Jae Hong Seo, Jun Cheon, Yeul Hong Kim, Jun Suk Kim, Kyong Hwa Park
A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors
Shahneen K. Sandhu, Kyri Papadopoulos, Peter C. Fong, Amita Patnaik, Christina Messiou, David Olmos, George Wang, Brenda J. Tromp, Thomas A. Puchalski, Frances Balkwill, Birge Berns, Shobha Seetharam, Johann S. de Bono, Anthony W. Tolcher
The Breast Avastin Trial: phase II study of bevacizumab maintenance therapy after induction chemotherapy with docetaxel and capecitabine for the first-line treatment of patients with locally recurrent or metastatic breast cancer
G. Bisagni, A. Musolino, M. Panebianco, A. De Matteis, F. Nuzzo, A. Ardizzoni, S. Gori, T. Gamucci, R. Passalacqua, R. Gnoni, G. Moretti, C. Boni
Multicenter phase II trial of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinoma
Hiroyuki Harada, Ken Omura, Hirofumi Tomioka, Hideki Nakayama, Akimitsu Hiraki, Masanori Shinohara, Yasuto Yoshihama, Satoru Shintani
Phase I/II study of albumin-bound nab-paclitaxel plus gemcitabine administered to Chinese patients with advanced pancreatic cancer
Dong-sheng Zhang, De-shen Wang, Zhi-qiang Wang, Feng-hua Wang, Hui-yan Luo, Miao-zhen Qiu, Feng Wang, Yu-hong Li, Rui-hua Xu
Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy
Shizhi Wang, Lulu Chen, Qinghong Zhao, Huan Rong, Meilin Wang, Weida Gong, Jianwei Zhou, Dongmei Wu, Zhengdong Zhang
Phase I study to assess the pharmacokinetics and the effect on cardiac repolarization of amrubicin and amrubicinol in patients with advanced solid tumors
Nianhang Chen, Sant P. Chawla, Elena Gabriela Chiorean, William L. Read, Mayer Gorbaty, Alain C. Mita, Lotus Yung, Peter Bryan, Richard McNally, Markus F. Renschler, Sunil Sharma
Genetic basis for the increased expression of vacuolar H+ translocating ATPase genes upon imatinib treatment in human lymphoblastoid cells
Hemant Kulkarni, Harald H. H. Göring, Joanne E. Curran, Vincent Diego, Thomas D. Dyer, Shelley Cole, Ken R. Walder, Greg R. Collier, John Blangero, Melanie A. Carless
Clusterin inhibition to enhance tumor chemosensitivity in systemic tumors
Shailendra Kapoor
Reply to: Clusterin inhibition to enhance tumor chemosensitivity in systemic tumors
Ching-Yuan Cheng, Shur-Hueih Cherng, Wen-Jun Wu, Tsung-Ying Yang, Xin-Yi Huang, Fu-Tien Liao, Ming-Fang Wu, Gwo-Tarng Sheu
Erratum to: Pharmacokinetic–pharmacodynamic relationship of bosutinib in patients with chronic-phase chronic myeloid leukemia
Poe-Hirr Hsyu, Diane R. Mould, Richard N. Upton, Michael Amantea