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Cancer Chemotherapy and Pharmacology

Ausgabe 4/2015

Inhalt (25 Artikel)

Original Article

Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostere

John L. Pilon, Dane J. Clausen, Ryan J. Hansen, Paul J. Lunghofer, Brad Charles, Barbara J. Rose, Douglas H. Thamm, Daniel L. Gustafson, James E. Bradner, Robert M. Williams

Original Article

Gemcitabine, oxaliplatin, and capecitabine (GEMOXEL) compared with gemcitabine alone in metastatic pancreatic cancer: a randomized phase II study

Roberto Petrioli, Giandomenico Roviello, Anna Ida Fiaschi, Letizia Laera, Daniele Marrelli, Franco Roviello, Edoardo Francini

Original Article

Biological evaluation of 4,5-diarylimidazoles with hydroxamic acid appendages as novel dual mode anticancer agents

Katharina Mahal, Sebastian Schruefer, Gustav Steinemann, Franziska Rausch, Rainer Schobert, Bernhard Biersack, Michael Höpfner

Original Article

Phase II study of gemcitabine and S-1 combination chemotherapy in patients with metastatic biliary tract cancer

Hyeong Su Kim, Ho Young Kim, Dae Young Zang, Ho Suk Oh, Jang Yong Jeon, Ji Woong Cho, Choong Kee Park, Jong Hyeok Kim, Min-Jeong Kim, Hong Il Ha, Jung Han Kim, Boram Han, Hunho Song, Jung Hye Kwon, Dae Ro Choi, Joo Young Jung

Original Article

Stabilization of the Karenitecin ® lactone by alpha-1 acid glycoprotein

Shijie Yao, Pavankumar Petluru, Aulma Parker, Daoyuan Ding, Xinghai Chen, Qiuli Huang, Harry Kochat, Frederick Hausheer

Original Article

A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of dovitinib (TKI258)

Jeffrey R. Infante, Ramesh K. Ramanathan, Daniel George, Eugene Tan, Michelle Quinlan, Angela Liu, Jeffrey W. Scott, Sunil Sharma

Original Article

A randomized study of cisplatin and 5-FU hepatic arterial infusion chemotherapy with or without adriamycin for advanced hepatocellular carcinoma

Myeong Jun Song, Si Hyun Bae, Ho Jong Chun, Jong Young Choi, Seung Kew Yoon, Jun Young Park, Kwang Hyub Han, Young Seok Kim, Hyung Joon Yim, Soon Ho Um, Woo Jin Chung, Jae Seok Hwang, Sung-Bum Cho, Jong Ryul Eun

Original Article

Parallel phase Ib studies of two schedules of buparlisib (BKM120) plus carboplatin and paclitaxel (q21 days or q28 days) for patients with advanced solid tumors

David M. Hyman, Alexandra E. Snyder, Richard D. Carvajal, John F. Gerecitano, Martin H. Voss, Alan L. Ho, Jason Konner, Jennifer L. Winkelmann, Megan A. Stasi, Kelsey R. Monson, Alexia Iasonos, David R. Spriggs, Philip Bialer, Mario E. Lacouture, Jerrold B. Teitcher, Nora Katabi, Matthew G. Fury

Original Article

Phase II study of mFOLFOX3 (5-fluorouracil, leucovorin, oxaliplatin) as second-line treatment after gemcitabine failure in patients with unresectable/metastatic biliary tract cancer

In Gyu Hwang, Joung-Soon Jang, Sung Yong Oh, Myung Hwan Rho, Suee Lee, Young Suk Park, Joon Oh Park, Eun Mi Nam, Hyo Rak Lee, Hyun Jung Jun, Kyong-Choun Chi

Original Article

Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy

M. Joerger, A. D. R. Huitema, H. Boot, A. Cats, V. D. Doodeman, P. H. M. Smits, L. Vainchtein, H. Rosing, I. Meijerman, M. Zueger, D. Meulendijks, T. D. Cerny, J. H. Beijnen, J. H. M. Schellens

Original Article

Synthesis and biological evaluation of geldanamycin analogs against human cancer cells

Yan-ping Li, Jin-jing Chen, Jia-jia Shen, Jing Cui, Lin-zhuan Wu, Zhen Wang, Zhuo-rong Li

Original Article

Hepatitis B virus reactivation and hepatitis in gastrointestinal cancer patients after chemotherapy

Yu Yang, Yang Du, Wu-Xia Luo, Cong Li, Ye Chen, Ke Cheng, Jing Ding, Yi Zhou, Jun Ge, Xian Yang, Ji-Yan Liu

Open Access Original Article

A pharmacokinetic binding model for bevacizumab and VEGF165 in colorectal cancer patients

Eirini Panoilia, Emilie Schindler, Epaminontas Samantas, Gerasimos Aravantinos, Haralabos P. Kalofonos, Christos Christodoulou, George P. Patrinos, Lena E. Friberg, Gregory Sivolapenko

Original Article

Phase I trial of oral S-1 combined with hepatic arterial infusion of gemcitabine in unresectable biliary tract cancer

Hirotoshi Ishiwatari, Tsuyoshi Hayashi, Makoto Yoshida, Michihiro Ono, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

Original Article

Serum metallothionein in patients with testicular cancer

Blanka Tariba, Tanja Živković, Nesrete Krasnići, Vlatka Filipović Marijić, Marijana Erk, Marija Gamulin, Mislav Grgić, Alica Pizent

Original Article

Cisplatin in combination with metronomic vinorelbine as front-line treatment in advanced non-small cell lung cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)

P. Katsaounis, A. Kotsakis, S. Agelaki, E. Kontopodis, A. Agelidou, N. Kentepozidis, L. Vamvakas, A. Christopoulou, N. Karachaliou, D. Hatzidaki, V. Georgoulias

Original Article

Amrubicin monotherapy for patients with extrapulmonary neuroendocrine carcinoma after platinum-based chemotherapy

Kenta Nio, Shuji Arita, Taichi Isobe, Hitoshi Kusaba, Kenichi Kohashi, Tatsuhiro Kajitani, Shingo Tamura, Gen Hirano, Kenji Mitsugi, Akitaka Makiyama, Taito Esaki, Hiroshi Ariyama, Yoshinao Oda, Koichi Akashi, Eishi Baba

Open Access Original Article

Preclinical pharmacokinetics, pharmacodynamics, and efficacy of RG7116: a novel humanized, glycoengineered anti-HER3 antibody

Georgina Meneses-Lorente, Thomas Friess, Irene Kolm, Gabriele Hölzlwimmer, Sabine Bader, Christophe Meille, Marlene Thomas, Birgit Bossenmaier

Open Access Original Article

Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study

Herbert I. Hurwitz, David C. Smith, Henry C. Pitot, Jeffrey M. Brill, Rashmi Chugh, Elisabeth Rouits, Joseph Rubin, John Strickler, Gregoire Vuagniaux, J. Mel Sorensen, Claudio Zanna

Original Article

Prognostic value of ERCC1, RRM1, and TS proteins in patients with resected non-small cell lung cancer

Yu-Wen He, Mei-Ling Zhao, Xin-Yun Yang, Jun Zeng, Qiu-Hua Deng, Jian-Xing He

Clinical Trial Report

Phase I trial of valproic acid and lenalidomide in patients with advanced cancer

Mehmet Asim Bilen, Siqing Fu, Gerald S. Falchook, Chaan S. Ng, Jennifer J. Wheler, Maen Abdelrahim, Basak Erguvan-Dogan, David S. Hong, Apostolia M. Tsimberidou, Razelle Kurzrock, Aung Naing

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