Ausgabe 5/2015
Inhalt (24 Artikel)
Autophagy in cancer stem/progenitor cells
Yi-Hui Lin, Yu-Chun Huang, Li-Hsin Chen, Pei-Ming Chu
Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor
Kyriakos P. Papadopoulos, Randi Isaacs, Sanela Bilic, Kerstin Kentsch, Heather A. Huet, Matthias Hofmann, Drew Rasco, Nicole Kundamal, Zhongwhen Tang, Jennifer Cooksey, Amit Mahipal
Preclinical examination of clofarabine in pediatric ependymoma: intratumoral concentrations insufficient to warrant further study
Yogesh T. Patel, Megan O. Jacus, Nidal Boulos, Jason D. Dapper, Abigail D. Davis, Pradeep K. Vuppala, Burgess B. Freeman III, Kumarasamypet M. Mohankumar, Stacy L. Throm, Richard J. Gilbertson, Clinton F. Stewart
The effect of food on the pharmacokinetics of oral ibrutinib in healthy participants and patients with chronic lymphocytic leukemia
Jan de Jong, Juthamas Sukbuntherng, Donna Skee, Joe Murphy, Susan O’Brien, John C. Byrd, Danelle James, Peter Hellemans, David J. Loury, Juhui Jiao, Vijay Chauhan, Erik Mannaert
Activated STAT3 correlates with prognosis of non-small cell lung cancer and indicates new anticancer strategies
Yang Yu, Qian Zhao, Zhou Wang, Xiang-Yan Liu
Plasma and cerebrospinal fluid pharmacokinetics of the Akt inhibitor, perifosine, in a non-human primate model
Diane E. Cole, Cynthia M. Lester-McCully, Brigitte C. Widemann, Katherine E. Warren
First-in-human, phase I/IIa dose-escalation and safety study of balugrastim in breast cancer patients receiving myelosuppressive chemotherapy
Noa Avisar, Liat Adar, Jason Bock, Udo Müller, David Shen, Steve Barash, Laurie Pukac
Sequential treatment with epirubicin, oxaliplatin and 5FU (EOF) followed by docetaxel, oxaliplatin and 5FU (DOF) in patients with advanced gastric or gastroesophageal cancer: a single-institution experience
Roberto Petrioli, Edoardo Francini, Franco Roviello, Daniele Marrelli, Anna Ida Fiaschi, Letizia Laera, Giulia Rossi, V. Bianco, S. Brozzetti, Giandomenico Roviello
Ginkgolide B protects against cisplatin-induced ototoxicity: enhancement of Akt–Nrf2–HO-1 signaling and reduction of NADPH oxidase
Weijun Ma, Juan Hu, Ying Cheng, Junli Wang, Xiaotong Zhang, Min Xu
Effects of cyclosporine A on the hepatobiliary disposition and hepatic uptake of etoposide in an isolated perfused rat liver model
Mina Khezrian, Behjat Sheikholeslami, Simin Dadashzadeh, Hoda Lavasani, Mohammadreza Rouini
Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application
Zakhar Nudelman, Mordechai Findler, Dinorah Barasch, Alina Nemirovski, Anna Pikovsky, David Kirmayer, Maamoun Basheer, J. Silvio Gutkind, Michael Friedman, Rakefet Czerninski
Pharmacokinetically based dosing of weekly paclitaxel to reduce drug-related neurotoxicity based on a single sample strategy
Stefanie Kraff, Annemieke J. M. Nieuweboer, Ron H. J. Mathijssen, Florent Baty, Anne-Joy de Graan, Ron H. N. van Schaik, Ulrich Jaehde, Markus Joerger
Organic cation transporter OCT6 mediates cisplatin uptake and resistance to cisplatin in lung cancer
Eiji Kunii, Tetsuya Oguri, Daishi Kasai, Hiroaki Ozasa, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Akio Niimi
Motesanib with or without panitumumab plus FOLFIRI or FOLFOX for the treatment of metastatic colorectal cancer
Niall Tebbutt, Dusan Kotasek, Howard A. Burris, Lee S. Schwartzberg, Herbert Hurwitz, Joe Stephenson, Douglas J. Warner, Lisa Chen, Cheng-Pang Hsu, David Goldstein
Positron emission tomography imaging of human colon cancer xenografts in mice with [18F]fluorothymidine after TAS-102 treatment
Haeng Jung Lee, Seung Jun Oh, Eun Jung Lee, Jin Hwa Chung, Yeseulmi Kim, Jin-Sook Ryu, Seog Young Kim, Seung Jin Lee, Dae Hyuk Moon, Tae Won Kim
Plasma pharmacokinetics of the indenoisoquinoline topoisomerase I inhibitor, NSC 743400, in rats and dogs
Miguel Muzzio, Shu-Chieh Hu, Julianne L. Holleran, Robert A. Parise, Julie L. Eiseman, Archibong E. Yellow-Duke, Joseph M. Covey, Elizabeth R. Glaze, Kory Engelke, Merrill J. Egorin, David L. McCormick, Jan H. Beumer
Vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGFR-TKI) rechallenge for patients with metastatic renal cell carcinoma after treatment failure using both VEGFR-TKI and mTOR inhibitor
Inkeun Park, Jae-Lyun Lee, Jin-Hee Ahn, Dae-Ho Lee, Kyoo-Hyung Lee, Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn
Dose selection of siltuximab for multicentric Castleman’s disease
Christina L. Mayer, Lanyi Xie, Rajesh Bandekar, Ming Qi, Helgi van de Velde, Manjula Reddy, Xiang Qin, Hugh M. Davis, Thomas A. Puchalski
Phase I study of the safety and pharmacokinetics of trabectedin with docetaxel in patients with advanced malignancies
Margaret von Mehren, Michael Bookman, Neal J. Meropol, Louis M. Weiner, Eric Sherman, Jinhui Li, Roland Knoblauch, Trilok Parekh, Roger B. Cohen
Protective effects of C-type natriuretic peptide on cisplatin-induced nephrotoxicity in Mice
Toru Kimura, Takashi Nojiri, Hiroshi Hosoda, Shin Ishikane, Yasushi Shintani, Masayoshi Inoue, Mikiya Miyazato, Meinoshin Okumura, Kenji Kangawa
A phase I trial of intravenous catumaxomab: a bispecific monoclonal antibody targeting EpCAM and the T cell coreceptor CD3
Morten Mau-Sørensen, Christian Dittrich, Rodrigo Dienstmann, Ulrik Lassen, Wilfried Büchler, Holger Martinius, Josep Tabernero
A phase I study of intraperitoneal nanoparticulate paclitaxel (Nanotax®) in patients with peritoneal malignancies
Stephen K. Williamson, Gary A. Johnson, Holly A. Maulhardt, Kathleen M. Moore, D. S. McMeekin, Thomas K. Schulz, Gregory A. Reed, Katherine F. Roby, Christine B. Mackay, Holly J. Smith, Scott J. Weir, Jo A. Wick, Maurie Markman, Gere S. diZerega, Michael J. Baltezor, Jahna Espinosa, Charles J. Decedue
Mercaptopurine metabolite levels are predictors of bone marrow toxicity following high-dose methotrexate therapy of childhood acute lymphoblastic leukaemia
Sophia Ingeborg Vang, Kjeld Schmiegelow, Thomas Frandsen, Susanne Rosthøj, Jacob Nersting
Validation of a fast and low-cost alkaline lysis method for gDNA extraction in a pharmacogenetic context
Ruth Ramos-Díaz, Fernando Gutiérrez-Nicolás, Gloria J Nazco-Casariego, Itamar González-Perera, José A Pérez-Pérez