Ausgabe 5/2017
Inhalt (22 Artikel)
Genotoxicity kinetics in murine normoblasts as an approach for the in vivo action of difluorodeoxycytidine
Pedro Morales-Ramírez, Teresita Vallarino-Kelly, Virginia Cruz-Vallejo
One-month assessment of renal cell carcinoma treated by everolimus using FDG PET/CT predicts progression-free and overall survival
Hiroki Ito, Keiichi Kondo, Takashi Kawahara, Tomohiro Kaneta, Ukihide Tateishi, Daiki Ueno, Kazuhiro Namura, Kazuki Kobayashi, Yasuhide Miyoshi, Yasushi Yumura, Kazuhide Makiyama, Narihiko Hayashi, Hisashi Hasumi, Kimito Osaka, Yumiko Yokomizo, Jun-ichi Teranishi, Yusuke Hattori, Tomio Inoue, Hiroji Uemura, Masahiro Yao, Noboru Nakaigawa
Phase Ib dose-finding trial of lapatinib plus pegylated liposomal doxorubicin in advanced HER2-positive breast cancer
Andrea Rocca, Lorenzo Cecconetto, Alessandro Passardi, Elisabetta Melegari, Daniele Andreis, Manuela Monti, Roberta Maltoni, Samanta Sarti, Elisabetta Pietri, Alessio Schirone, Francesco Fabbri, Caterina Donati, Oriana Nanni, Anna Fedeli, Marina Faedi, Dino Amadori
Randomized phase II study comparing weekly docetaxel-cisplatin vs. gemcitabine-cisplatin in elderly or poor performance status patients with advanced non-small cell lung cancer
JoungSoon Jang, Hoon-Kyo Kim, Byoung Chul Cho, Kyung Hee Lee, Hwan-Jung Yun, In Sook Woo, Hong Suk Song, Hun-Mo Ryoo, Chi-Hong Kim, Der-Sheng Sun, Jong Wook Shin
A randomized, single-blind, single-dose study evaluating the pharmacokinetic equivalence of proposed biosimilar ABP 980 and trastuzumab in healthy male subjects
Vladimir Hanes, Vincent Chow, Nan Zhang, Richard Markus
Effective chemotherapy of heterogeneous and drug-resistant early colon cancers by intermittent dose schedules: a computer simulation study
David E. Axelrod, Sudeepti Vedula, James Obaniyi
Comparative plasma and tissue distribution of Sun Pharma’s generic doxorubicin HCl liposome injection versus Caelyx® (doxorubicin HCl liposome injection) in syngeneic fibrosarcoma-bearing BALB/c mice and Sprague–Dawley rats
Vinod Burade, Subhas Bhowmick, Kuntal Maiti, Rishit Zalawadia, Deepak Jain, Thennati Rajamannar
Evaluation of the effect of the EGFR antibody-drug conjugate ABT-414 on QT interval prolongation in patients with advanced solid tumors likely to over-express EGFR
Wijith P. Munasinghe, Rajendar K. Mittapalli, Hong Li, David M. Hoffman, Kyle D. Holen, Rajeev M. Menon, Hao Xiong
A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer
Heather A. Wakelee, Scott Gettinger, Jeffrey Engelman, Pasi A. Jänne, Howard West, Deepa S. Subramaniam, Joseph Leach, Michael Wax, Yifah Yaron, Dale R. Miles, Primo N. Lara Jr.
Increased ceramide production sensitizes breast cancer cell response to chemotherapy
Jing Che, Yu Huang, Chuanrui Xu, Peng Zhang
Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: a retrospective cohort study
Kenji Ikemura, Kosuke Oshima, Tomoyuki Enokiya, Akiharu Okamoto, Hiroyasu Oda, Toshiro Mizuno, Hajime Ishinaga, Yuichi Muraki, Takuya Iwamoto, Kazuhiko Takeuchi, Naoyuki Katayama, Masahiro Okuda
A phase II trial of neoadjuvant chemoradiotherapy with intensity-modulated radiotherapy combined with gemcitabine and S-1 for borderline-resectable pancreatic cancer with arterial involvement
Yuichi Nagakawa, Yuichi Hosokawa, Hidetsugu Nakayama, Yatsuka Sahara, Chie Takishita, Tetsushi Nakajima, Yousuke Hijikata, Kazuhiko Kasuya, Kenji Katsumata, Koichi Tokuuye, Akihiko Tsuchida
Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity
Qian Tan, A. M. Joshua, M. Wang, R. G. Bristow, B. G. Wouters, C. J. Allen, Ian F. Tannock
Computed determination of the in vitro optimal chemocombinations of sphaeropsidin A with chemotherapeutic agents to combat melanomas
Aude Ingels, Carina Dinhof, Abhishek D. Garg, Lucia Maddau, Marco Masi, Antonio Evidente, Walter Berger, Bieke Dejaegher, Véronique Mathieu
Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis
Hongwen Cao, Hongjie Yu, Yigeng Feng, Lei Chen, Fang Liang
The impact of a solitary kidney on tolerability to gemcitabine plus cisplatin chemotherapy in urothelial carcinoma patients: a retrospective study
Masahiro Kondo, Yuji Hotta, Ryosuke Ando, Takahiro Yasui, Kazunori Kimura
WBP2 modulates G1/S transition in ER+ breast cancer cells and is a direct target of miR-206
Yong-qiang Ren, Hui-jun Wang, Yong-qing Zhang, Yan-bing Liu
Low plasma concentration of gefitinib in patients with EGFR exon 21 L858R point mutations shortens progression-free survival
Yuji Okuda, Kazuhiro Sato, Kazuhisa Sudo, Yukiyasu Hasegawa, Mariko Asano, Hajime Miura, Masahide Takeda, Masaaki Sano, Hiroyuki Watanabe, Hiroyuki Kobayashi, Takenori Niioka, Masatomo Miura, Hiroshi Ito
Comparison between hypersensitivity reactions to cycles of modified FOLFOX6 and XELOX therapies in patients with colorectal cancer
Hideki Ohta, Takahiro Hayashi, Sumie Murai, Hideyo Shiouchi, Yosuke Ando, Satomi Kumazawa, Kaori Ito, Yoshiaki Ikeda, Hiroshi Matsuoka, Kotaro Maeda, Kenji Kawada, Kimio Yasuda, Shigeki Yamada
Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma
Qiang Wang, Handong Wang, Yue Jia, Hao Pan, Hui Ding
Adjunction of a MEK inhibitor to Vemurafenib in the treatment of metastatic melanoma results in a 60% reduction of acute kidney injury
Cécile Teuma, Solenne Pelletier, Mona Amini-Adl, Marie Perier-Muzet, Delphine Maucort-Boulch, Luc Thomas, Maurice Laville, Denis Fouque, Stéphane Dalle
Potential drug–drug interactions with abiraterone in metastatic castration-resistant prostate cancer patients: a prevalence study in France
Clément Bonnet, Pascaline Boudou-Rouquette, Esther Azoulay-Rutman, Olivier Huillard, Jean-Louis Golmard, Edith Carton, Gaëlle Noé, Michel Vidal, Galdric Orvoen, Anne Chah Wakilian, Clémentine Villeminey, Benoit Blanchet, Jérôme Alexandre, François Goldwasser, Audrey Thomas-Schoemann