Ausgabe 10/2024
Inhalt (25 Artikel)
Negative association of steroids with immunotherapy efficacy in a multi-tumor cohort: time and dose-dependent
- Open Access
- Research
Víctor Albarrán, Patricia Guerrero, Coral García de Quevedo, Carlos González, Jesús Chamorro, Diana Isabel Rosero, Jaime Moreno, Juan Carlos Calvo, Patricia Pérez de Aguado, Víctor Alía, Pilar Sotoca, Ana María Barrill, María San Román, Pablo Álvarez-Ballesteros, Juan José Serrano, Ainara Soria, María Eugenia Olmedo, Cristina Saavedra, Alfonso Cortés, Ana Gómez, Yolanda Lage, Álvaro Ruiz, María Reyes Ferreiro, Federico Longo, Pilar Garrido, Pablo Gajate
Highlighting immune features of the tumor ecosystem and prognostic value of Tfh and Th17 cell infiltration in head and neck squamous cell carcinoma by single-cell RNA-seq
- Open Access
- Research
Yan Tian, Chao Liu, Wenhui Yang, Xiaohui Li, Min Zhang, Yan Xiong, Xueying Ren, Zhiguo Ma, Xuan Jin, Yanping Wu, Xin Dong, Nanlin Hu, Zhijun Xie, Yong Qin, Shikai Wu
Interleukin-7 expression by CAR-T cells improves CAR-T cell survival and efficacy in chordoma
- Open Access
- Research
Huantong Wu, Zhuofan Xu, Maoyang Qi, Penghao Liu, Boyan Zhang, Zhenglin Wang, Ge Chen, Xiaohai Liu, Junqi Liu, Wei Wei, Wanru Duan, Zan Chen
Spatial cell interplay networks of regulatory T cells predict recurrence in patients with operable non-small cell lung cancer
- Open Access
- Research
Siqi Cai, Guanqun Yang, Mengyu Hu, Chaozhuo Li, Liying Yang, Wei Zhang, Jujie Sun, Fenghao Sun, Ligang Xing, Xiaorong Sun
ALK5/VEGFR2 dual inhibitor TU2218 alone or in combination with immune checkpoint inhibitors enhances immune-mediated antitumor effects
- Open Access
- Research
Nam-Hoon Kim, Jihyun Lee, Seung-Hyun Kim, Seong-Ho Kang, Sowon Bae, Chan-Hee Yu, Jeongmin Seo, Hun-Taek Kim
GP100 expression is variable in intensity in melanoma
- Open Access
- Brief Report
Jacqueline E. Mann, Nitzan Hasson, David G. Su, Adebowale J. Adeniran, Keiran S. M. Smalley, Dijana Djureinovic, Lucia B. Jilaveanu, David A. Schoenfeld, Harriet M. Kluger
TIGIT expression in renal cell carcinoma infiltrating T cells is variable and inversely correlated with PD-1 and LAG3
- Open Access
- Brief Report
Oscar Perales, Lucia Jilaveanu, Adebowale Adeniran, David G. Su, Michael Hurwitz, David A. Braun, Harriet M. Kluger, David A. Schoenfeld
Predicting recurrent glioblastoma clinical outcome to immune checkpoint inhibition and low-dose bevacizumab with tumor in situ fluid circulating tumor DNA analysis
- Open Access
- Research
Guangzhong Guo, Ziyue Zhang, Jiubing Zhang, Dayang Wang, Sensen Xu, Guanzheng Liu, Yushuai Gao, Jie Mei, Zhaoyue Yan, Ruijiao Zhao, Meiyun Wang, Tianxiao Li, Xingyao Bu
First-line treatment with KN046, chemotherapy and palliative radiotherapy for advanced esophageal squamous cell carcinoma: an open-label, dose escalation, and dose expansion phase Ib trial
- Open Access
- Research
Qi Zhao, Xi Su, Jiao Xue, Yandong Liu, Jiaxing Zhu, Xuwei Cai, Songbing Qin
Conversion of anti-tissue factor antibody sequences to chimeric antigen receptor and bi-specific T-cell engager format
- Open Access
- Research
S. C. Saunderson, J. C. Halpin, G. M. Y. Tan, P. Shrivastava, A. D. McLellan
The expression of PD-L1 on tumor-derived exosomes enhances infiltration and anti-tumor activity of αCD3 × αPD-L1 bispecific antibody-armed T cells
- Open Access
- Research
Jaewon Cho, Nara Tae, Yujeong Song, Chae-Won Kim, Seung-Joo Lee, Jae-Hee Ahn, Kwang-Ho Lee, Byung-Hyun Lee, Byung Soo Kim, Sun-Young Chang, Dae Hee Kim, Hyun-Jeong Ko
Genomic and transcriptomic profiles associated with response to eribulin and nivolumab combination in HER-2-negative metastatic breast cancer
- Open Access
- Research
Changhee Park, Koung Jin Suh, Se Hyun Kim, Kyung-Hun Lee, Seock-Ah Im, Min Hwan Kim, Joohyuk Sohn, Jae Ho Jeong, Kyung Hae Jung, Kyoung Eun Lee, Yeon Hee Park, Hee-Jun Kim, Eun Kyung Cho, In Sil Choi, Seung-Jae Noh, Inkyung Shin, Dae-Yeon Cho, Jee Hyun Kim
CD27 signaling inhibits tumor growth and metastasis via CD8 + T cell-independent mechanisms in the B16-F10 melanoma model
- Open Access
- Research
Eswara Rao Puppala, Long Wu, Xiaoxuan Fan, Xuefang Cao
Anlotinib reversed resistance to PD-1 inhibitors in recurrent and metastatic head and neck cancers: a real-world retrospective study
- Open Access
- Research
Jianyun Jiang, Bin Wu, Ying Sun, Jun Xiang, Chunying Shen, Xiayun He, Hongmei Ying, Zuguang Xia
Clinical features associated with immune checkpoint inhibitor nephritis: a single-center clinical case series
- Open Access
- Brief Report
Ramya Muddasani, Neel Talwar, Isa Mambetsariev, Jeremy Fricke, Mercury Lin, Daniel Schmolze, Andrew Yue, Amna Rizvi, Ravi Salgia
Hypofractionated radiotherapy plus PD-1 antibody and SOX chemotherapy as second-line therapy in metastatic pancreatic cancer: a single-arm, phase II clinical trial
- Open Access
- Research
Qin Wang, Fan Tong, Li Qiao, Liang Qi, Yi Sun, Yahui Zhu, Jiayao Ni, Juan Liu, Weiwei Kong, Baorui Liu, Juan Du
Impact of the interval between neoadjuvant immunotherapy and surgery on prognosis in esophageal squamous cell carcinoma (ESCC): a real-world study
- Open Access
- Research
Guozhen Yang, Yutong Hong, Xiaomin Zhang, Chufeng Zeng, Linyu Tan, Xu Zhang
Chimeric antigen receptor dendritic cells targeted delivery of a single tumoricidal factor for cancer immunotherapy
- Open Access
- Research
Rong Duan, Philip Milton, Chutamath Sittplangkoon, Xin Liu, Zhining Sui, Brendan F. Boyce, Zhenqiang Yao
Targeting PI3K-gamma in myeloid driven tumour immune suppression: a systematic review and meta-analysis of the preclinical literature
- Open Access
- Review
Haonan Xu, Shannon Nicole Russell, Katherine Steiner, Eric O’Neill, Keaton Ian Jones
Safety and clinical activity of JNJ-78306358, a human leukocyte antigen-G (HLA-G) x CD3 bispecific antibody, for the treatment of advanced stage solid tumors
- Open Access
- Research
Ravit Geva, Maria Vieito, Jorge Ramon, Ruth Perets, Manuel Pedregal, Elena Corral, Bernard Doger, Emiliano Calvo, Jorge Bardina, Elena Garralda, Regina J. Brown, James G. Greger, Shujian Wu, Douglas Steinbach, Tsun-Wen Sheena Yao, Yu Cao, Josh Lauring, Ruchi Chaudhary, Jaymala Patel, Bharvin Patel, Victor Moreno
Deciphering the interplay of HPV infection, MHC-II expression, and CXCL13+ CD4+ T cell activation in oropharyngeal cancer: implications for immunotherapy
- Open Access
- Research
Shida Yan, Xing Zhang, Qiaohong Lin, Mingyuan Du, Yiqi Li, Shuai He, Jingtao Chen, Xiyuan Li, Jinxin Bei, Shuwei Chen, Ming Song
Unlocking the potential of HHLA2: identifying functional immune infiltrating cells in the tumor microenvironment and predicting clinical outcomes in laryngeal squamous cell carcinoma
- Open Access
- Research
Wenjing Li, Jianqing You, Haixiang Xue, Yi Liu, Junjun Chen, Xiao Zheng, Lujun Chen, Changping Wu
DNA hypo-methylation and expression of GBP4 induces T cell exhaustion in pancreatic cancer
- Open Access
- Research
Yesiboli Tasiheng, Xuan Lin, Xu Wang, Xuan Zou, Yusheng Chen, Yu Yan, Mingjian Ma, Zhengjie Dai, Xu Wang, Xianjun Yu, He Cheng, Chen Liu
NKG2D-bispecific enhances NK and CD8+ T cell antitumor immunity
- Open Access
- Research
Aurelie Herault, Judy Mak, Josefa de la Cruz-Chuh, Michael A. Dillon, Diego Ellerman, MaryAnn Go, Ely Cosino, Robyn Clark, Emily Carson, Stacey Yeung, Melanie Pichery, Mylène Gador, Eugene Y. Chiang, Jia Wu, Yuxin Liang, Zora Modrusan, Gautham Gampa, Jawahar Sudhamsu, Christopher C. Kemball, Victoria Cheung, Thi Thu Thao Nguyen, Dhaya Seshasayee, Robert Piskol, Klara Totpal, Shang-Fan Yu, Genee Lee, Katherine R. Kozak, Christoph Spiess, Kevin B. Walsh
Preclinical development of a novel CCR8/CTLA-4 bispecific antibody for cancer treatment by disrupting CTLA-4 signaling on CD8 T cells and specifically depleting tumor-resident Tregs
- Open Access
- Research
Cuicui Guo, Xiaodong Dai, Yulei Du, Xiumei Xiong, Xun Gui
