Ausgabe 2/2013
Inhalt (17 Artikel)
Proposed mechanism of off-target toxicity for antibody–drug conjugates driven by mannose receptor uptake
Boris Gorovits, Corinna Krinos-Fiorotti
Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer
Stephanie K. Bunt, Ashley M. Mohr, Jennifer M. Bailey, Paul M. Grandgenett, Michael A. Hollingsworth
The antitumor effect of the Toll-like receptor 3 ligand polyinosinic-cytidylic acid as an adjuvant
Yu-Kun Huang, Zhi Zheng, Chun-Xia Cheng, Lu-Ying Wang, Yue-Ran Li, Fu Qiu
T cell profiling reveals high CD4+CTLA-4+ T cell frequency as dominant predictor for survival after Prostate GVAX/ipilimumab treatment
Saskia J. A. M. Santegoets, Anita G. M. Stam, Sinéad M. Lougheed, Helen Gall, Petra E. T. Scholten, Martine Reijm, Karin Jooss, Natalie Sacks, Kristen Hege, Israel Lowy, Jean-Marie Cuillerot, B. Mary E. von Blomberg, Rik J. Scheper, Alfons J. M. van den Eertwegh, Winald R. Gerritsen, Tanja D. de Gruijl
Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells
Ilseyar Akhmetzyanova, Gennadiy Zelinskyy, Simone Schimmer, Sven Brandau, Petra Altenhoff, Tim Sparwasser, Ulf Dittmer
CD40 pathway activation reveals dual function for macrophages in human endometrial cancer cell survival and invasion
Geneviève Dumas, Mathieu Dufresne, Éric Asselin, Julie Girouard, Christian Carrier, Carlos Reyes-Moreno
Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation
Willemijn Hobo, Tatiana I. Novobrantseva, Hanny Fredrix, Jamie Wong, Stuart Milstein, Hila Epstein-Barash, Ju Liu, Nicolaas Schaap, Robbert van der Voort, Harry Dolstra
Comparative analysis of monocytic and granulocytic myeloid-derived suppressor cell subsets in patients with gastrointestinal malignancies
Austin Duffy, Fei Zhao, Lydia Haile, Jaba Gamrekelashvili, Suzanne Fioravanti, Chi Ma, Tamar Kapanadze, Kathryn Compton, William D. Figg, Tim F. Greten
Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation
Katja Hattar, Rajkumar Savai, Florentine S. B. Subtil, Jochen Wilhelm, Anja Schmall, Dagmar S. Lang, Torsten Goldmann, Bastian Eul, Gabriele Dahlem, Ludger Fink, Ralph-Theo Schermuly, Gamal-Andre Banat, Ulf Sibelius, Friedrich Grimminger, Ekkehard Vollmer, Werner Seeger, Ulrich Grandel
Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy
Ashley J. Knights, Jitka Fucikova, Anupama Pasam, Sandra Koernig, Jonathan Cebon
DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer
Xavier Tekpli, Nina E. Landvik, Kristine H. Anmarkud, Vidar Skaug, Aage Haugen, Shanbeh Zienolddiny
CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells
Masayasu Naito, Ursula Hainz, Ute E. Burkhardt, Buyin Fu, Deborah Ahove, Kristen E. Stevenson, Mohini Rajasagi, Baogong Zhu, Anselmo Alonso, Elizabeth Witten, Ken-ichi Matsuoka, Donna Neuberg, Jonathan S. Duke-Cohan, Catherine J. Wu, Gordon J. Freeman
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR
Carolina M. Soto, Jennifer D. Stone, Adam S. Chervin, Boris Engels, Hans Schreiber, Edward J. Roy, David M. Kranz
The role of gamma interferon in DNA vaccine-induced tumor immunity targeting simian virus 40 large tumor antigen
Joel F. Aldrich, Michael H. Shearer, Devin B. Lowe, Richard E. Winn, Cynthia A. Jumper, Ronald C. Kennedy, Robert K. Bright
Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo
Miki Tongu, Nanae Harashima, Hiroyuki Monma, Touko Inao, Takaya Yamada, Hideyuki Kawauchi, Mamoru Harada
Identification of a novel HLA-A2-restricted mutated Survivin epitope and induction of specific anti-HCC CTLs that could effectively cross-recognize wild-type Survivin antigen
Han Shen, Hong-Wei Shao, Xiao-Hua Chen, Feng-Lin Wu, Hui Wang, Zhao-Liang Huang, Juan Shen, Teng Wang, Wen-Feng Zhang, Shu-Lin Huang