Cancer Immunology, Immunotherapy

Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC

• Review

Jürgen C. Becker, Andreas Stang, Axel zur Hausen, Nicole Fischer, James A. DeCaprio, Richard W. Tothill, Rikke Lyngaa, Ulla Kring Hansen, Cathrin Ritter, Paul Nghiem, Christopher K. Bichakjian, Selma Ugurel, David Schrama

Tumor-derived high-mobility group box 1 and thymic stromal lymphopoietin are involved in modulating dendritic cells to activate T regulatory cells in a mouse model

• Original Article

Yi Zhang, Zuqiang Liu, Xingxing Hao, Ang Li, Jiying Zhang, Cara D. Carey, Louis D. Falo, Zhaoyang You

Prophylactic DNA vaccine targeting Foxp3+ regulatory T cells depletes myeloid-derived suppressor cells and improves anti-melanoma immune responses in a murine model

• Original Article

Afshin Namdar, Reza Mirzaei, Arash Memarnejadian, Roobina Boghosian, Morteza Samadi, Hamid Reza Mirzaei, Hamid Farajifard, Mehdi Zavar, Kayhan Azadmanesh, Shokrollah Elahi, Farshid Noorbakhsh, Abbas Rezaei, Jamshid Hadjati

The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy

• Original Article

David Briere, Niranjan Sudhakar, David M. Woods, Jill Hallin, Lars D. Engstrom, Ruth Aranda, Harrah Chiang, Andressa L. Sodré, Peter Olson, Jeffrey S. Weber, James G. Christensen

Targeting and suppression of HER3-positive breast cancer by T lymphocytes expressing a heregulin chimeric antigen receptor

• Original Article

Bai-Le Zuo, Bo Yan, Guo-Xu Zheng, Wen-Jin Xi, Xiao Zhang, An-Gang Yang, Lin-Tao Jia

High PDL1 mRNA expression predicts better survival of stage pT1 non-muscle-invasive bladder cancer (NMIBC) patients

• Original Article

Johannes Breyer, Ralph M. Wirtz, Wolfgang Otto, Philipp Erben, Thomas S. Worst, Robert Stoehr, Markus Eckstein, Stefan Denzinger, Maximilian Burger, Arndt Hartmann

Synergistic cytotoxicity of a prostate cancer-specific immunotoxin in combination with the BH3 mimetic ABT-737

• Original Article

Theresa Noll, Susanne Schultze-Seemann, Irina Kuckuck, Marta Michalska, Philipp Wolf

Therapeutic reduction of cell-mediated immunosuppression in mycosis fungoides and Sézary syndrome

• Original Article

Larisa J. Geskin, Oleg E. Akilov, Soonyou Kwon, Michael Schowalter, Simon Watkins, Theresa L. Whiteside, Lisa H. Butterfield, Louis D. Falo Jr.

The Immunoscore system predicts prognosis after liver metastasectomy in colorectal cancer liver metastases

• Original Article

Yun Wang, Hao-cheng Lin, Ma-yan Huang, Qiong Shao, Zhi-qiang Wang, Feng-hua Wang, Yun-fei Yuan, Bin-kui Li, De-shen Wang, Pei-rong Ding, Gong Chen, Xiao-jun Wu, Zhen-hai Lu, Li-ren Li, Zhi-zhong Pan, Peng Sun, Shu-mei Yan, De-sen Wan, Rui-hua Xu, Yu-hong Li

Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors

• Original Article

Kamiya Mehla, Jarrod Tremayne, James A. Grunkemeyer, Kelly A. O’Connell, Maria M. Steele, Thomas C. Caffrey, Xinyi Zhu, Fang Yu, Pankaj K. Singh, Birgit C. Schultes, Ragupathy Madiyalakan, Christopher F. Nicodemus, Michael A. Hollingsworth

Post-treatment neutrophil-to-lymphocyte ratio at week 6 is prognostic in patients with advanced non-small cell lung cancers treated with anti-PD-1 antibody

• Original Article

Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Miso Kim, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Jong Seok Lee

Characterization of PD-L1 expression in Chinese non-small cell lung cancer patients with PTEN expression as a means for tissue quality screening

• Original Article

Xu-chao Zhang, Xu Cao, Chun Sun, Zhi Xie, Jian-jun Guo, Jin-ji Yang, Xue-ning Yang, Hang-jun Dai, Su-chun Li, Xin-ran Xu, Yun-xia Zuo, Meng Chen, Hartmut Koeppen, Jing He, Astrid Kiermaier, David Shames, Gang Cheng, Yi-long Wu

Haploidentical natural killer cells induce remissions in non-Hodgkin lymphoma patients with low levels of immune-suppressor cells

• Original Article

Veronika Bachanova, Dhifaf Sarhan, Todd E. DeFor, Sarah Cooley, Angela Panoskaltsis-Mortari, Bruce R. Blazar, Julie M. Curtsinger, Linda Burns, Daniel J. Weisdorf, Jeffrey S. Miller

High PD-L1 expression indicates poor prognosis of HIV-infected patients with non-small cell lung cancer

• Original Article

Yusuke Okuma, Tsunekazu Hishima, Jumpei Kashima, Sadamu Homma

Acknowledgements

• ACKNOWLEDGEMENT TO REVIEWERS