Ausgabe 3/2021
Inhalt (25 Artikel)
Varied functions of immune checkpoints during cancer metastasis
Ali Safarzadeh, Mohsen Alizadeh, Fatemeh Beyranvand, Reza Falavand Jozaaee, Khalil Hajiasgharzadeh, Amir Baghbanzadeh, Afshin Derakhshani, Antonella Argentiero, Behzad Baradaran, Nicola Silvestris
Toxicity with small molecule and immunotherapy combinations in non-small cell lung cancer
H. Adderley, F. H. Blackhall, C. R. Lindsay
A systematic scoping review on natural killer cell function in colorectal cancer
Fiona S. W. Reid, Natasha Egoroff, Peter G. Pockney, Stephen R. Smith
Chimeric antigen receptor (CAR)-T-cell therapy in non-small-cell lung cancer (NSCLC): current status and future perspectives
Jingjing Qu, Quanhui Mei, Lijun Chen, Jianying Zhou
Anti-tumor and immune modulating activity of T cell induced tumor-targeting effectors (TITE)
Archana Thakur, Sri Vidya Kondadasula, Kyungmin Ji, Dana L. Schalk, Edwin Bliemeister, Johnson Ung, Amro Aboukameel, Eli Casarez, Bonnie F. Sloane, Lawrence G. Lum
Early C-reactive protein kinetics predict survival of patients with advanced urothelial cancer treated with pembrolizumab
Toshiki Kijima, Hina Yamamoto, Kazutaka Saito, Shota Kusuhara, Soichiro Yoshida, Minato Yokoyama, Yoh Matsuoka, Noboru Numao, Yasuyuki Sakai, Nobuaki Matsubara, Takeshi Yuasa, Hitoshi Masuda, Junji Yonese, Yukio Kageyama, Yasuhisa Fujii
Unique TP53 neoantigen and the immune microenvironment in long-term survivors of Hepatocellular carcinoma
Huayu Yang, Lejia Sun, Ai Guan, Huanhuan Yin, Meixi Liu, Xinxin Mao, Haifeng Xu, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Qian Chen, Yilei Mao
Increased thyroid uptake on 18F-FDG PET/CT is associated with the development of permanent hypothyroidism in stage IV melanoma patients treated with anti-PD-1 antibodies
Alexandra Frelau, Xavier Palard-Novello, Eva Jali, Lise Boussemart, Alain Dupuy, Pandora James, Anne Devillers, Florence Le Jeune, Julien Edeline, Thierry Lesimple, Antoine Girard
Monophosphoryl lipid A-induced activation of plasmacytoid dendritic cells enhances the anti-cancer effects of anti-PD-L1 antibodies
Wei Zhang, Seong-Min Lim, Juyoung Hwang, Srinivasan Ramalingam, Myunghee Kim, Jun-O Jin
Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study
Qinchuan Wang, Yuanqing Ye, Hao Yu, Shu-Hong Lin, Huakang Tu, Dong Liang, David W. Chang, Maosheng Huang, Xifeng Wu
Post-treatment neutrophil-to-lymphocyte ratio (NLR) predicts response to anti-PD-1/PD-L1 antibody in SCLC patients at early phase
Qi Xiong, Ziwei Huang, Lingli Xin, Boyu Qin, Xiao Zhao, Jing Zhang, Weiwei Shi, Bo Yang, Guoqing Zhang, Yi Hu
Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma
Rosa Nguyen, Anand G. Patel, Lyra M. Griffiths, Jason Dapper, Elizabeth A. Stewart, Jim Houston, Melissa Johnson, Walter J. Akers, Wayne L. Furman, Michael A. Dyer
Reviving up dendritic cells can run cancer immune wheel in non-small cell lung cancer: a prospective two-arm study
Asmaa M. Zahran, Helal F. Hetta, Shimaa Mansour, Ereny S. Saad, Amal Rayan
A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC)
J. Chandra, W. P. Woo, N. Finlayson, H. Y. Liu, M. McGrath, R. Ladwa, M. Brauer, Y. Xu, S. Hanson, B. Panizza, I. H. Frazer, Sandro V. Porceddu
Flow cytometric analysis of circulating endothelial cells and endothelial progenitor cells in pediatric solid tumors: prognostic impact on treatment response and survival
Heba Abdel Razik Sayed, Helal F. Hetta, Engy A. Shafik, Asmaa M. Zahran
Phase I, first-in-human trial of programmed cell death receptor-1 (PD-1) inhibitor, JTX-4014, in adult patients with advanced, refractory, solid tumors
Kyriakos P. Papadopoulos, Nehal Lakhani, Gerald S. Falchook, Gosia Riley, Johan Baeck, Karen S. Brown, Gilad Gordon, Lidya Le, Judy S. Wang
Systematic analysis of immune-related genes based on a combination of multiple databases to build a diagnostic and a prognostic risk model for hepatocellular carcinoma
Di-guang Wen, Xiao-ping Zhao, Yu You, Zuo-jin Liu
Anti-leukemia effect associated with down-regulated CD47 and up-regulated calreticulin by stimulated macrophages in co-culture
Eman M. Hassan, Gilbert C. Walker, Chen Wang, Shan Zou
Differential gene expression of tumor-infiltrating CD33+ myeloid cells in advanced- versus early-stage colorectal cancer
Salman M. Toor, Rowaida Z. Taha, Varun Sasidharan Nair, Reem Saleh, Khaled Murshed, Mohamed Abu Nada, Eyad Elkord
Downregulated ATP6V1B1 expression acidifies the intracellular environment of cancer cells leading to resistance to antibody-dependent cellular cytotoxicity
Mariko Nishie, Eiji Suzuki, Masakazu Hattori, Kosuke Kawaguch, Tatsuki R. Kataoka, Masahiro Hirata, Fengling Pu, Takeshi Kotake, Moe Tsuda, Ayane Yamaguchi, Tomoharu Sugie, Masakazu Toi
High tumor mutational burden and T-cell activation are associated with long-term response to anti-PD1 therapy in Lynch syndrome recurrent glioblastoma patient
Elena Anghileri, Natalia Di Ianni, Rosina Paterra, Tiziana Langella, Junfei Zhao, Marica Eoli, Monica Patanè, Bianca Pollo, Valeria Cuccarini, Antonio Iavarone, Raul Rabadan, Gaetano Finocchiaro, Serena Pellegatta
PD-1/PD-L1 checkpoint inhibitors in combination with olaparib display antitumor activity in ovarian cancer patient-derived three-dimensional spheroid cultures
Kathryn M. Appleton, Ashley K. Elrod, Katy A. Lassahn, Stephen Shuford, Lillia M. Holmes, Teresa M. DesRochers
Efficacy and safety of sintilimab in combination with chemotherapy in previously untreated advanced or metastatic nonsquamous or squamous NSCLC: two cohorts of an open-label, phase 1b study
Haiping Jiang, Yulong Zheng, Jiong Qian, Chenyu Mao, Xin Xu, Ning Li, Cheng Xiao, Huan Wang, Lisong Teng, Hui Zhou, Shuyan Wang, Donglei Zhu, Tao Sun, Yingying Yu, Wenying Guo, Nong Xu
Patterns of immune checkpoint protein expression in MYC-overexpressing aggressive B-cell non-Hodgkin lymphomas
Daniel J. Landsburg, Alexa Koike, Sunita D. Nasta, Jakub Svoboda, Stephen J. Schuster, Mariusz A. Wasik, Gabriel C. Caponetti