Cancer Immunology, Immunotherapy

Serum-free freezing media support high cell quality and excellent ELISPOT assay performance across a wide variety of different assay protocols

Helene Filbert, Sebastian Attig, Nicole Bidmon, Bernhard Y. Renard, Sylvia Janetzki, Ugur Sahin, Marij J. P. Welters, Christian Ottensmeier, Sjoerd H. van der Burg, Cécile Gouttefangeas, Cedrik M. Britten

Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas

Muhammad Baghdadi, Hiroko Nagao, Hironori Yoshiyama, Hisaya Akiba, Hideo Yagita, Hirotoshi Dosaka-Akita, Masahisa Jinushi

Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy

Daisuke Nobuoka, Toshiaki Yoshikawa, Mari Takahashi, Tatsuaki Iwama, Kazutaka Horie, Manami Shimomura, Shiro Suzuki, Noriko Sakemura, Munehide Nakatsugawa, Hiroshi Sadamori, Takahito Yagi, Toshiyoshi Fujiwara, Tetsuya Nakatsura

TRAIL suppresses tumor growth in mice by inducing tumor-infiltrating CD4+CD25+ Treg apoptosis

Zhijuan Diao, Juan Shi, Jieqing Zhu, Haiqin Yuan, Qiang Ru, Shilian Liu, Yanxin Liu, Dexian Zheng

Enhancement of the anti-melanoma response of Hu14.18K322A by αCD40 + CpG

Kory L. Alderson, Mitchell Luangrath, Megan M. Elsenheimer, Stephen D. Gillies, Fariba Navid, Alexander L. Rakhmilevich, Paul M. Sondel

Zoledronic acid-induced expansion of γδ T cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells

Tomoharu Sugie, Kaoru Murata-Hirai, Masashi Iwasaki, Craig T. Morita, Wen Li, Haruki Okamura, Nagahiro Minato, Masakazu Toi, Yoshimasa Tanaka

Impaired immunomodulatory function of chronic myeloid leukemia cancer stem cells and the possible mechanism involved in it

Zhu Xishan, Zhou Xinna, He baoxin, Ren Jun

Properties of monocytes generated from haematopoietic CD34+ stem cells from bone marrow of colon cancer patients

Malgorzata Stec, Jarosław Baran, Rafał Szatanek, Bożenna Mytar, Marzena Lenart, Antoni Czupryna, Antoni Szczepanik, Maciej Siedlar, Marek Zembala

Imatinib mesylate and nilotinib affect MHC-class I presentation by modulating the proteasomal processing of antigenic peptides

Stefanie Andrea Erika Held, Katharina Maria Duchardt, Stefan Tenzer, Thomas Rückrich, Karin von Schwarzenberg, Anita Bringmann, Christian Kurts, Hansjörg Schild, Christoph Driessen, Peter Brossart, Annkristin Heine

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails

Shicheng Yang, Yun Ji, Luca Gattinoni, Ling Zhang, Zhiya Yu, Nicholas P. Restifo, Steven A. Rosenberg, Richard A. Morgan

Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma

Roniel Cabrera, Miguel Ararat, Yiling Xu, Todd Brusko, Clive Wasserfall, Mark A. Atkinson, Lung Ji Chang, Chen Liu, David R. Nelson

CD1d-antibody fusion proteins target iNKT cells to the tumor and trigger long-term therapeutic responses

Stéphanie Corgnac, Rachel Perret, Laurent Derré, Lianjun Zhang, Kathrin Stirnemann, Maurice Zauderer, Daniel E. Speiser, Jean-Pierre Mach, Pedro Romero, Alena Donda

The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses

Claudia Durán-Aniotz, Gabriela Segal, Lorena Salazar, Cristián Pereda, Cristián Falcón, Fabián Tempio, Raquel Aguilera, Rodrigo González, Claudio Pérez, Andrés Tittarelli, Diego Catalán, Bruno Nervi, Milton Larrondo, Flavio Salazar-Onfray, Mercedes N. López

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

Emmet McCormack, Katherine J. Adams, Namir J. Hassan, Akhil Kotian, Nikolai M. Lissin, Malkit Sami, Maja Mujić, Tereza Osdal, Bjørn Tore Gjertsen, Deborah Baker, Alex S. Powlesland, Milos Aleksic, Annelise Vuidepot, Olivier Morteau, Deborah H. Sutton, Carl H. June, Michael Kalos, Rebecca Ashfield, Bent K. Jakobsen

BiVax: a peptide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses

Hyun-Il Cho, Kelly Barrios, Young-Ran Lee, Angelika K. Linowski, Esteban Celis

Functional human Th17 clones with WT1-specific helper activity

Sho Tachino, Fumihiro Fujiki, Yoshihiro Oka, Akihiro Tsuboi, Soyoko Morimoto, Yu-Hung Lin, Taichi Tamanaka, Kenta Kondo, Hiroko Nakajima, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

Inhibition of both BRAF and MEK in BRAFV600E mutant melanoma restores compromised dendritic cell (DC) function while having differential direct effects on DC properties

Patrick A. Ott, Trevor Henry, Sonja Jimenez Baranda, Davor Frleta, Olivier Manches, Dusan Bogunovic, Nina Bhardwaj

Acknowledgement