Ausgabe 4/2021
Inhalt (27 Artikel)
Combination therapies utilizing neoepitope-targeted vaccines
- Open Access
- Review
Karin L. Lee, Jeffrey Schlom, Duane H. Hamilton
Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma
- Open Access
- Original Article
Katharina Leuchte, Elena Staib, Martin Thelen, Philipp Gödel, Axel Lechner, Peter Zentis, Maria Garcia-Marquez, Dirk Waldschmidt, Rabi Raj Datta, Roger Wahba, Christian Wybranski, Thomas Zander, Alexander Quaas, Uta Drebber, Dirk Ludger Stippel, Christiane Bruns, Michael von Bergwelt-Baildon, Kerstin Wennhold, Hans Anton Schlößer
Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8+ T cells to enhance antitumor immunity
- Original Article
Rosmely Hernandez, Kevin H. Toomer, Janika Põder, Alicia Santos Savio, Sunnie Hsiung, Thomas R. Malek
A pan-cancer analysis of the human tumor coagulome and its link to the tumor immune microenvironment
- Original Article
Zuzana Saidak, Simon Soudet, Marine Lottin, Valéry Salle, Marie-Antoinette Sevestre, Florian Clatot, Antoine Galmiche
Tuberculosis following programmed cell death receptor-1 (PD-1) inhibitor in a patient with non-small cell lung cancer. Case report and literature review
- Open Access
- Original Article
Aasir M. Suliman, Shaza A. Bek, Mohamed S. Elkhatim, Ahmed A. Husain, Ahmad Y. Mismar, M. Z. Sharaf Eldean, Zsolt Lengyel, Shereen Elazzazy, Kakil I. Rasul, Nabil E. Omar
Novel adjuvant dendritic cell therapy with transfection of heat-shock protein 70 messenger RNA for patients with hepatocellular carcinoma: a phase I/II prospective randomized controlled clinical trial
- Original Article
Hiroto Matsui Matsui, Shoichi Hazama, Masao Nakajima, Ming Xu, Satoshi Matsukuma, Yukio Tokumitsu, Yoshitaro Shindo, Shinobu Tomochika, Shin Yoshida, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Shigefumi Yoshino, Tomio Ueno, Masaaki Oka, Hiroaki Nagano
Correction to: Novel adjuvant dendritic cell therapy with transfection of heat-shock protein 70 messenger RNA for patients with hepatocellular carcinoma: a phase I/II prospective randomized controlled clinical trial
- Correction
Hiroto Matsui, Shoichi Hazama, Masao Nakajima, Ming Xu, Satoshi Matsukuma, Yukio Tokumitsu, Yoshitaro Shindo, Shinobu Tomochika, Shin Yoshida, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Shigefumi Yoshino, Tomio Ueno, Masaaki Oka, Hiroaki Nagano
Overcoming acquired resistance to PD-1 inhibitor with the addition of metformin in small cell lung cancer (SCLC)
- Original Article
Yeseul Kim, Elena Vagia, Pedro Viveiros, Cyra Y. Kang, Ju Young Lee, Gahyun Gim, Sukjoo Cho, Horyun Choi, Leeseul Kim, Inae Park, Jaeyoun Choi, Young Kwang Chae
An immune-related gene signature for predicting survival and immunotherapy efficacy in hepatocellular carcinoma
- Original Article
Yifei Dai, Weijie Qiang, Kequan Lin, Yu Gui, Xun Lan, Dong Wang
Notch signaling defects in NK cells in patients with cancer
- Original Article
Gulnur K. Zakiryanova, Elena Kustova, Nataliya T. Urazalieva, Emile T. Baimukhametov, Valeriy A. Makarov, Gulmariya M. Turaly, Galina V. Shurin, Zarema M. Biyasheva, Narymzhan N. Nakisbekov, Michael R. Shurin
Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide
- Original Article
Ayman J. Oweida, Adam C. Mueller, Miles Piper, Dallin Milner, Benjamin Van Court, Shilpa Bhatia, Andy Phan, Thomas Bickett, Kimberly Jordan, Theresa Proia, Richard Schulick, Wells A. Messersmith, Marco Del Chiaro, Eric Clambey, Michael J. Gough, Jason Williams, Kirk Hansen, Karyn Goodman, Sana D. Karam
Next-generation sequencing-guided molecular-targeted therapy and immunotherapy for biliary tract cancers
- Original Article
Wei Zhang, Junping Shi, Yingying Wang, Hongyuan Zhou, Zewu Zhang, Zhiqiang Han, Guanghao Li, Bo Yang, Guangtai Cao, Yan Ke, Ti Zhang, Tianqiang Song, QiangLi
OSCC cell-secreted exosomal CMTM6 induced M2-like macrophages polarization via ERK1/2 signaling pathway
- Original Article
Xin Pang, Sha-sha Wang, Mei Zhang, Jian Jiang, Hua-yang Fan, Jia-shun Wu, Hao-fan Wang, Xin-hua Liang, Ya-ling Tang
Merkel cell carcinoma in Latin America: a contribution from an expanded access program for avelumab to address issues from experts’ recommendations
- Original Article
Rodrigo Ramella Munhoz, Federico Cayol, Luis Corrales, Raquel Gerson, Malena Tilli, Elluz Oliver Barreto, Jesús Oswaldo Sánchez Castillo, Rafael Aron Schmerling, Gabriela Cinat
Retinoblastoma cell-derived Twist protein promotes regulatory T cell development
- Original Article
Ruishi Zhang, Yan-Nan Song, Xiaoyan Duo, Zhihong Guo, Yanhua Sun, Zhixiong Zhang, Yongtian Lu, Beiping Miao, Ping-Chang Yang, Guohui Nie
PD-1 blockade synergizes with intratumoral vaccination of a therapeutic HPV protein vaccine and elicits regression of tumor in a preclinical model
- Original Article
Shiwen Peng, Marietta Tan, Yen-Der Li, Max A. Cheng, Emily Farmer, Louise Ferrall, Stephanie Gaillard, Richard B. S. Roden, Chien-Fu Hung, T.-C. Wu
Biphasic prognostic significance of PD-L1 expression status in patients with early- and locally advanced-stage non-small cell lung cancer
- Original Article
Koji Teramoto, Tomoyuki Igarashi, Yoko Kataoka, Mitsuaki Ishida, Jun Hanaoka, Hidetoshi Sumimoto, Yataro Daigo
Improvement of DC-based vaccines using adjuvant TLR4-binding 60S acidic ribosomal protein P2 and immune checkpoint inhibitors
- Original Article
Gun-Young Jang, Young Seob Kim, Sung Eun Lee, Ji won Lee, Hee Dong Han, Tae Heung Kang, Yeong-Min Park
Prognostic role of gamma-glutamyl transferase in metastatic melanoma patients treated with immune checkpoint inhibitors
- Original Article
Johanna Winter, Max M. Lenders, Maximilian Gassenmaier, Andrea Forschner, Ulrike Leiter, Benjamin Weide, Mette-Triin Purde, Lukas Flatz, Antonio Cozzio, Martin Röcken, Claus Garbe, Thomas K. Eigentler, Nikolaus B. Wagner
Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity
- Open Access
- Original Article
Simone Punt, Shruti Malu, Jodi A. McKenzie, Soraya Zorro Manrique, Elien M. Doorduijn, Rina M. Mbofung, Leila Williams, Deborah A. Silverman, Emily L. Ashkin, Ana Lucía Dominguez, Zhe Wang, Jie Qing Chen, Sourindra N. Maiti, Trang N. Tieu, Chengwen Liu, Chunyu Xu, Marie-Andrée Forget, Cara Haymaker, Jahan S. Khalili, Nikunj Satani, Florian Muller, Laurence J. N. Cooper, Willem W. Overwijk, Rodabe N. Amaria, Chantale Bernatchez, Timothy P. Heffernan, Weiyi Peng, Jason Roszik, Patrick Hwu
Reduction of derived neutrophil-to-lymphocyte ratio after four weeks predicts the outcome of patients receiving second-line chemotherapy for metastatic colorectal cancer
- Original Article
Giuseppe Antonio Colloca, Antonella Venturino, Domenico Guarneri
Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm
- Original Article
Nicki Panoskaltsis, Neil E. McCarthy, Andrew J. Stagg, Catherine J. Mummery, Mariwan Husni, Naila Arebi, David Greenstein, Claire L. Price, Hafid O. Al-Hassi, Michalis Koutinas, Athanasios Mantalaris, Stella C. Knight
Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells
- Original Article
Neil E. McCarthy, Andrew J. Stagg, Claire L. Price, Elizabeth R. Mann, Nichola L. Gellatly, Hafid O. Al-Hassi, Stella C. Knight, Nicki Panoskaltsis
Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm
- Research Report
Nicki Panoskaltsis, Neil E. McCarthy, Stella C. Knight
Selective CD47 targeting with a bispecific antibody
- Letter to the Editors
Walter Ferlin, Krzysztof Masternak, Limin Shang
Correction to: In-depth characterization of the tumor microenvironment in central nervous system lymphoma reveals implications for immune-checkpoint therapy
- Correction
Lukas Marcelis, Asier Antoranz, Anne-Marie Delsupehe, Pauline Biesemans, Julio Finalet Ferreiro, Koen Debackere, Peter Vandenberghe, Gregor Verhoef, Paul Clement, Steven De Vleeschouwer, Olivier Gheysens, Giorgio Cattoretti, Francesca Maria Bosisio, Xavier Sagaert, Daan Dierickx, Thomas Tousseyn
