Ausgabe 4/2025
Inhalt (36 Artikel)
Exploring correlations between gut mycobiome and lymphocytes in melanoma patients undergoing anti-PD-1 therapy
- Open Access
- Research
Natalia Szóstak, Michał Budnik, Katarzyna Tomela, Luiza Handschuh, Anna Samelak-Czajka, Bernadeta Pietrzak, Marcin Schmidt, Mariusz Kaczmarek, Łukasz Galus, Jacek Mackiewicz, Andrzej Mackiewicz, Piotr Kozlowski, Anna Philips
CDX2 and SATB2 loss are associated with myeloid cell infiltration and poor survival in colorectal cancer
- Open Access
- Research
Päivi Sirniö, Hanna Elomaa, Anne Tuomisto, Ville K. Äijälä, Henna Karjalainen, Meeri Kastinen, Vilja V. Tapiainen, Onni Sirkiä, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Markus J. Mäkinen, Juha P. Väyrynen
An integrated prognosis prediction model based on real-word clinical characteristics for immunotherapy in advanced esophageal squamous cell carcinoma
- Open Access
- Research
Liyuan Dong, Yue Ma, Guang Cao, Dongze Chen, Fengxiao Dong, Xi Jiao, Yanshuo Cao, Chang Liu, Yanni Wang, Na Zhuo, Fengyuan Wang, Yixuan Guo, Tingting Dai, Shuwei Zhang, Hao Jiao, Xingyue Zou, Jian Li, Lin Shen, Zhonghu He, Yanqiao Zhang, Zhihao Lu
Machine learning-derived prognostic signature integrating programmed cell death and mitochondrial function in renal clear cell carcinoma: identification of PIF1 as a novel target
- Open Access
- Research
Guangyang Cheng, Zhaokai Zhou, Shiqi Li, Fu Peng, Shuai Yang, Chuanchuan Ren
Harnessing TAGAP to improve immunotherapy for lung squamous carcinoma treatment by targeting c-Rel in CD4+ T cells
- Open Access
- Research
Peian Cai, Haibo Sun, Tongmeng Jiang, Huawei Li, Dejing Huang, Xiaopei Hao, Wei Wang, Wenqun Xing, Guanghui Liang
Generation of frameshift-mutated TGFβR2-specific T cells in healthy subjects following administration with cancer vaccine candidate FMPV-1/GM-CSF in a phase 1 study
- Open Access
- Research
Else Marit Inderberg, Nand Singh, Robert Miller, Sarah Arbe-Barnes, Henrik K. Eriksen, Berit lversen, Hedvig Vidarsdotter Juul, Jon Amund Eriksen, Karianne Risberg Handeland
Comprehensive analysis and experimental validation of disulfidptosis-associated prognostic signature and immune microenvironment characterization of gastric cancer
- Open Access
- Research
Huangjie Zhang, Jinguo Hu, Yuanqiang Li, Yanyang Liu, Huize Shen, Zeng Wang, Qinglin Li
Cytotoxic lymphocytes induced by engineered human dendritic cells mediate potent anti-leukemia activity
- Open Access
- Research
Chenchen Zhao, Bei Jia, Yixing Jiang, Hiroko Shike, Charyguly Annageldiyev, Joseph Cioccio, Kentaro Minagawa, Shin Mineishi, WChristopher Ehmann, Todd D. Schell, Hua Cheng, Hong Zheng
Study on pathological factors affecting the sensitivity of neoadjuvant therapy in hypopharyngeal cancer
- Open Access
- Research
Gaofei Yin, Nuan Li, Xiaohong Chen, Yang Zhang, Zhigang Huang, Wei Guo
Comparison of neoadjuvant chemoimmunotherapy with planned surgery and concurrent chemoradiation followed by immunotherapy for potentially resectable stage III non-small-cell lung cancer: a retrospective study
- Open Access
- Research
Yana Qi, Xiaoyang Zhai, Qinhao Xu, Yuqin Jin, Yingfan Guo, Miaoqing Zhao, Hui Zhu, Hongbo Guo
Monitoring peripheral blood data supports the prediction of immunotherapy response in advanced non-small cell lung cancer based on real-world data
- Open Access
- Research
Ana D. Ramos-Guerra, Benito Farina, Jaime Rubio Pérez, Anna Vilalta-Lacarra, Jon Zugazagoitia, Germán Peces-Barba, Luis M. Seijo, Luis Paz-Ares, Ignacio Gil-Bazo, Manuel Dómine Gómez, María J. Ledesma-Carbayo
From silent partners to potential therapeutic targets: macrophages in colorectal cancer
- Open Access
- Review
Hayat Khizar, Kamran Ali, Jianwei Wang
Microsatellite instability-high status as a pan-cancer biomarker for immunotherapy efficacy
- Open Access
- Brief Report
Thierry Landre, Gaëtan Des Guetz
Spatial transcriptomics reveals prognostically LYZ+ fibroblasts and colocalization with FN1+ macrophages in diffuse large B-cell lymphoma
- Open Access
- Research
Liyuan Dai, Ning Lou, Liling Huang, Lin Li, Le Tang, Yuankai Shi, Xiaohong Han
Continuous immunotherapy beyond disease progression in patients with advanced non-small cell and small cell lung cancer
- Open Access
- Research
Jing Cheng, Wenwen Kang, Yueying Chen, Luyun Pan, Hedong Han, Tangfeng Lv
Revealing the role of regulatory b cells in cancer: development, function and treatment significance
- Open Access
- Review
Ruyu Ye, Sijia Li, Yuxiao Li, Kaixin Shi, Li Li
A tumor-binding antibody with cross-reactivity to viral antigens
- Open Access
- Brief Report
Michael J. Campa, Elizabeth B. Gottlin, Kevin Wiehe, Edward F. Patz Jr.
Distinct profiles of osteoclast and dendritic cell-mediated expansion and functional activation of NK and T cells
- Open Access
- Research
Kawaljit Kaur, Anahid Jewett
Single-cell transcriptome sequencing reveals the immune microenvironment in bronchoalveolar lavage fluid of checkpoint inhibitor-related pneumonitis
- Open Access
- Research
Linpeng Zheng, Fenglin Lin, Dingqin Cai, Longyao Zhang, Chenrui Yin, Yaxian Qi, Lingyou Sun, Lingchen Li, Xiewan Chen, Jianbo Zhu, Jianguo Sun
Association of lymphocyte subsets percentage with prognosis for recurrent or metastatic nasopharyngeal carcinoma patients receiving PD-L1 inhibitors
- Open Access
- Research
Jianming Diao, Zhigong Wei, Yiyan Pei, Junyou Ge, Yan Qing, Youneng Wei, Ye Chen, Xingchen Peng
Stratification of the immunotypes of tongue squamous cell carcinoma to improve prognosis and the response to immune checkpoint inhibitors
- Open Access
- Research
Yuya Su, Ryo Ouchi, Pissacha Daroonpan, Miwako Hamagaki, Tohru Ikeda, Noji Rika, Naoto Nishii, Fumihiko Tsushima, Yoshihito Kano, Takahiro Asakage, Makoto Noguchi, Hiroyuki Harada, Miyuki Azuma
Identification of intratumoral microbiome-driven immune modulation and therapeutic implications in diffuse large B-cell lymphoma
- Open Access
- Research
Zheng Yijia, Xiaoyu Li, Lina Ma, Siying Wang, Hong Du, Yun Wu, Jing Yu, Yunxia Xiang, Daiqin Xiong, Huiting Shan, Yubo Wang, Zhi Wang, Jianping Hao, Jie Wang
NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer
- Open Access
- Research
Yiran Yang, Leiqun Cao, Xin Xu, Dan Li, Yiran Deng, Lan Li, Bingjie Zeng, Haixia Jiang, Liang Shan, Yiwen Huang, Yunhua Xu, Lifang Ma
Development of a T cell engaging bispecific antibody targeting long non-coding RNA PVT1
- Open Access
- Research
Hirotaka Kato, Tomohide Tsukahara, Kenji Murata, Hiromu Nishikata, Yuka Mizue, Takashi Sasaya, Terufumi Kubo, Takayuki Kanaseki, Yoshihiko Hirohashi, Atsushi Oyagi, Tatsuo Maeda, Akihiro Miyazaki, Toshihiko Torigoe
Exploring the role of TIGIT in patients with Small Cell Lung Cancer as a novel predictor of prognosis and immunotherapy response
- Open Access
- Research
Li Liu, Peng Wu, Bingzhi Wang, Jiyan Dong, Chaoqi Zhang, Wenchao Liu, Jianming Ying
LPIN3 promotes colorectal cancer growth by dampening intratumoral CD8+ T cell effector function
- Open Access
- Research
Xiaoming Zhang, Hao Fang, Wenliang Wu, Congqing Jiang, Haizhou Wang, Yifei Shi
Prostaglandin F2 receptor negative regulator as a potential target for chimeric antigen receptor-T cell therapy for glioblastoma
- Open Access
- Research
Hideki Kuroda, Noriyuki Kijima, Tetsuro Tachi, Shunya Ikeda, Koki Murakami, Tomoyoshi Nakagawa, Moto Yaga, Kanji Nakagawa, Reina Utsugi, Ryuichi Hirayama, Yoshiko Okita, Naoki Kagawa, Naoki Hosen, Haruhiko Kishima
Clofazimine enhances anti-PD-1 immunotherapy in glioblastoma by inhibiting Wnt6 signaling and modulating the tumor immune microenvironment
- Open Access
- Research
Yuze Zhao, Yuguang Song, Weiping Li, Jiangping Wu, Zhengbao Zhao, Tingli Qu, Hong Xiao, Manyuan Wang, Min Zhu, Peiming Zheng, Huili Wan, Qingkun Song, Huixia Zheng, Shuo Wang
Effectiveness, safety, and patterns of use of camrelizumab in advanced esophageal cancer: an individual patient data pooled analysis of 987 patients from three prospective cohort studies
- Open Access
- Research
Zhihao Lu, Guoping Sun, Jiancheng Li, Jun Zhao, Zishu Wang, Dong Qian, Zhe Yang, Na Li, Junsheng Wang, Shuanghu Yuan, Yusheng Wang, Suyi Li, Zhen Yang, Fengming Ran, Yinghua Ji, Shaojin Zhu, Yanqiao Zhang, Chen Wang, Lixin Wan, Rongrong Zheng, Wenjie Deng, Fengzhuo Cheng, Lin Shen
PRMT5 highly expressed on CD16 + CD56- natural killer cells is correlated with NK cells exhaustion in colorectal cancer mesenchyme
- Open Access
- Research
Zunzhen Nie, Juanjuan Chang, Zhiqin Yang, Kaixuan Zeng, Yuangang Liu, Qian Tu, Chao Wang, Qingguo Yan, Hai Shi, Ying Guo
Microbial dysbiosis with tryptophan metabolites alteration in lower respiratory tract is associated with clinical responses to anti-PD-1 immunotherapy in advanced non-small cell lung cancer
- Open Access
- Research
Xiang-xiang Chen, Qing Ju, Dan Qiu, Ying Zhou, Yuan Wang, Xin-xin Zhang, Jing-geng Li, Min Wang, Ning Chang, Xiang-rui Xu, Yi-bo Zhang, Tong Zhao, Ke Wang, Yong Zhang, Jian Zhang
ZEB1 transcription factor induces tumor cell PD-L1 expression in melanoma
- Open Access
- Brief Report
Chloé Wirbel, Simon Durand, Félix Boivin, Maud Plaschka, Valentin Benboubker, Maxime Grimont, Laetitia Barbollat-Boutrand, Garance Tondeur, Brigitte Balme, Olivier Harou, Anaïs Eberhardt, Stéphane Dalle, Jonathan Lopez, Julie Caramel
Clinical significance of peripheral T-cell repertoire in head and neck squamous cell carcinoma treated with cetuximab and nivolumab
- Open Access
- Research
Xuefeng Wang, Tingyi Li, Robbert J. C. Slebos, Ritu Chaudhary, Jose A. Guevara-Patino, Marcelo Bonomi, Nabil F. Saba, Christine H. Chung
Combination therapy with expanded natural killer cells and atezolizumab exerts potent antitumor immunity in small cell lung cancer
- Open Access
- Research
Manh-Cuong Vo, Van-Tan Nguyen, Van-Dinh-Huan Tran, Hyung-Joo Oh, Sung-Hoon Jung, Woo Kyun Bae, Je-Jung Lee, In-Jae Oh
Preclinical investigation of anti-tumor efficacy of allogeneic natural killer cells combined with cetuximab for head and neck squamous cell carcinoma
- Open Access
- Research
Chaeyeon Kim, Mina Han, Gamin Kim, Wonrak Son, Jeongah Kim, Minchan Gil, Yong-Hee Rhee, Nam Suk Sim, Chang Gon Kim, Hye Ryun Kim
Neoantigen-based mRNA vaccine exhibits superior anti-tumor activity compared to synthetic long peptides in an in vivo lung carcinoma model
- Open Access
- Research
Cao Minh Nguyen, Trung T. Vu, Minh Nguyen Nguyen, Thao-Suong Tran-Nguyen, Chi Thien Huynh, Quang Thanh Ha, Hoai-Nghia Nguyen, Le Son Tran
