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Cancer Immunology, Immunotherapy

Ausgabe 8/2022

Inhalt (20 Artikel)

Associations between immune-related thyroid dysfunction and efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis

  • Review Article

Yee-Ming Melody Cheung, Wei Wang, Bradley McGregor, Ole-Petter Riksfjord Hamnvik

Pediatric glioblastoma: mechanisms of immune evasion and potential therapeutic opportunities

  • Review Article

Rosy Njonkou, Christopher M. Jackson, Graeme F. Woodworth, David S. Hersh

The integration of systemic and tumor PD-L1 as a predictive biomarker of clinical outcomes in patients with advanced NSCLC treated with PD-(L)1blockade agents

  • Original Article

Carlos Zamora Atenza, Geòrgia Anguera, Mariona Riudavets Melià, Letícia Alserawan De Lamo, Ivana Sullivan, Andrés Barba Joaquin, Jorgina Serra Lopez, M. Angels Ortiz, Maria Mulet, Sílvia Vidal, Margarita Majem

Combination immunotherapy including OncoVEXmGMCSF creates a favorable tumor immune micro-environment in transgenic BRAF murine melanoma

  • Original Article

Robyn D. Gartrell, Zoë Blake, Emanuelle M. Rizk, Rolando Perez-Lorenzo, Stuart P. Weisberg, Ines Simoes, Camden Esancy, Yichun Fu, Danielle R. Davari, Luke Barker, Grace Finkel, Manas Mondal, Hanna E. Minns, Samuel W. Wang, Benjamin T. Fullerton, Francisco Lozano, Codruta Chiuzan, Basil Horst, Yvonne M. Saenger

Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice

  • Open Access
  • Original Article

Mélanie Gaignage, Xuhao Zhang, Julie Stockis, Olivier Dedobbeleer, Camille Michiels, Perrine Cochez, Laure Dumoutier, Pierre G. Coulie, Sophie Lucas

Functional virus-specific memory T cells survey glioblastoma

  • Original Article

Jianfang Ning, Noah V. Gavil, Shaoping Wu, Sathi Wijeyesinghe, Eyob Weyu, Jun Ma, Ming Li, Florina-Nicoleta Grigore, Sanjay Dhawan, Alexander G. J. Skorput, Shawn C. Musial, Clark C. Chen, David Masopust, Pamela C. Rosato

Selection of antibody and light exposure regimens alters therapeutic effects of EGFR-targeted near-infrared photoimmunotherapy

  • Original Article

Ryuhei Okada, Takuya Kato, Aki Furusawa, Fuyuki Inagaki, Hiroaki Wakiyama, Daiki Fujimura, Shuhei Okuyama, Hideyuki Furumoto, Hiroshi Fukushima, Peter L. Choyke, Hisataka Kobayashi

A real-world study of the efficacy and safety of anti-PD-1 antibodies plus lenvatinib in patients with advanced gallbladder cancer

  • Original Article

Bangyou Zuo, Xiaobo Yang, Xu Yang, Jin Bian, Junyu Long, Dongxu Wang, Cong Ning, Yanyu Wang, Ziyu Xun, Yunchao Wang, Xin Lu, Yilei Mao, Xinting Sang, Haitao Zhao

Safety, antitumor activity and biomarkers of sugemalimab in Chinese patients with advanced solid tumors or lymphomas: results from the first-in-human phase 1 trial

  • Open Access
  • Original Article

Jifang Gong, Junning Cao, Qingyuan Zhang, Nong Xu, Yanqiu Zhao, Baocai Xing, Zhanhui Miao, Yilong Wu, Hongming Pan, Quanli Gao, Xingya Li, Baorui Liu, Wei Li, Zhidong Pei, Hongqiang Xia, Qinzhou Qi, Hangjun Dai, Qingmei Shi, Jianxin Yang, Jin Li, Lin Shen

Novel inhibitor of hematopoietic cell kinase as a potential therapeutic agent for acute myeloid leukemia

  • Original Article

Fernanda Marconi Roversi, Maura Lima Pereira Bueno, Juliete Aparecida Francisco da Silva, Guilherme Rossi Assis-Mendonça, Cristiane Okuda Torello, Rodrigo Nato Shiraishi, Fernando Viera Pericole, Karla Priscila Ferro, Adriana Santos Silva Duarte, Eduardo Magalhães Rego, Sara Teresinha Olalla Saad

Prognostic value, DNA variation and immunologic features of a tertiary lymphoid structure-related chemokine signature in clear cell renal cell carcinoma

  • Original Article

Wenhao Xu, Chunguang Ma, Wangrui Liu, Aihetaimujiang Anwaier, Xi Tian, Guohai Shi, Yuanyuan Qu, Shiyin Wei, Hailiang Zhang, Dingwei Ye

Alterations of circulating lymphocyte subsets in patients with colorectal carcinoma

  • Open Access
  • Original Article

Johanna Waidhauser, Pia Nerlinger, Tim Tobias Arndt, Stefan Schiele, Florian Sommer, Sebastian Wolf, Phillip Löhr, Stefan Eser, Gernot Müller, Rainer Claus, Bruno Märkl, Andreas Rank

Efficacy of immunotherapy beyond RECIST progression in advanced melanoma: a real-world evidence

  • Original Article

Anna Małgorzata Czarnecka, Paweł Sobczuk, Paweł Rogala, Tomasz Świtaj, Joanna Placzke, Katarzyna Kozak, Anna Mariuk-Jarema, Mateusz Spałek, Monika Dudzisz-Śledź, Paweł Teterycz, Aneta Borkowska, Piotr Rutkowski

Efficacy of an ALDH peptide-based dendritic cell vaccine targeting cancer stem cells

  • Original Article

Fei Liao, Jing Zhang, Yangyang Hu, Alireza Hassani Najafabadi, James J. Moon, Max S. Wicha, Bashir Kaspo, Joel Whitfield, Alfred E. Chang, Qiao Li

Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer

  • Open Access
  • Original Article

Nadja Salomon, Abderaouf Selmi, Christian Grunwitz, Anthony Kong, Eliana Stanganello, Jennifer Neumaier, Jutta Petschenka, Mustafa Diken, Sebastian Kreiter, Özlem Türeci, Ugur Sahin, Fulvia Vascotto

Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells

  • Open Access
  • Original Article

Emily Cluff, Carina C. Magdaleno, Emyly Fernandez, Trenton House, Srividya Swaminathan, Archana Varadaraj, Narendiran Rajasekaran

Oral administration of a whole glucan particle (WGP)-based therapeutic cancer vaccine targeting macrophages inhibits tumor growth

  • Original Article

Liuyang He, Yu Bai, Lei Xia, Jie Pan, Xiao Sun, Zhichao Zhu, Jun Ding, Chunjian Qi, Cui Tang

Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

  • Open Access
  • Original Article

Julia Femel, Luuk van Hooren, Melanie Herre, Jessica Cedervall, Falk Saupe, Elisabeth J. M. Huijbers, Danielle R. J. Verboogen, Matthias Reichel, Victor L. Thijssen, Arjan W. Griffioen, Lars Hellman, Anna Dimberg, Anna-Karin Olsson

A phase I dose-escalation, safety/tolerability, and preliminary efficacy study of the intratumoral administration of GEN0101 in patients with advanced melanoma

  • Open Access
  • Clinical Trial Report

Eiji Kiyohara, Atsushi Tanemura, Kazuma Sakura, Toshihiro Nakajima, Akira Myoui, Naoya Yamazaki, Yoshio Kiyohara, Ichiro Katayama, Manabu Fujimoto, Yasufumi Kaneda

Immune-related adverse events of COVID-19 vaccination in skin cancer patients receiving immune-checkpoint inhibitor treatment

Sophia B. Strobel, Devayani Machiraju, Katharina A. Kälber, Jessica C. Hassel

Neu im Fachgebiet Onkologie

Hohe Rezidivraten bei jungen Krebskranken

Metastatische Rezidive sind bei Jugendlichen und jungen Erwachsenen mit Krebs häufig und verschlechtern die Prognose deutlich. Eine umfassende Kohortenstudie aus Kalifornien zeigt klare Unterschiede nach Tumorart, Stadium und Diagnosejahr.

Rezidiviertes Grad-3-Astrozytom: Kann ein Antiparasitenmittel die Prognose verbessern?

Daten der Phase-III-Studie STELLAR sprechen für eine klinisch relevante Aktivität der Therapiekombination aus Eflornithin und Lomustin bei Personen mit rezidivierten Grad-3-Astrozytomen. Besonderheiten im Studiendesgin machen die Interpretation indes nicht ganz leicht.

Woran versterben Super-Ager?

Auch wer in subjektiv guter Verfassung 80 Jahre oder älter wird, verstirbt letztlich an ähnlichen Ursachen wie weniger Fitte. Dafür sprechen zumindest Daten aus dem US-amerikanischen National Health Interview Survey.

Krebsimmuntherapie: Herzrisiko mit hs-Troponin T abschätzen

Serielle hs-TnT-Auswertungen könnten bei Personen, die mit Immuncheckpointhemmern behandelt werden, dabei helfen, kardiovaskuläre Therapierisiken besser einzuschätzen. Dafür sprechen zumindest retrospektive Daten aus den USA.        

Update Onkologie

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Bildnachweise
Junger Mann im Computertomographen/© Vladislav / Stock.adobe.com (Symbolbild mit Fotomodell), MRT: Pilozytisches Astrozytom bei 10-jährigem Mädchen/© Springer Medizin, Ältere Frau mit Hanteln/© Satjawat / Stock.adobe.com (Symbolbild mit Fotomodell)