Ausgabe 9/2021
Inhalt (26 Artikel)
Metabolic profiles of regulatory T cells in the tumour microenvironment
Disha Rao, Fabienne Verburg, Kathrin Renner, Daniel S. Peeper, Ruben Lacroix, Christian U. Blank
Myeloid cell heterogeneity in lung cancer: implication for immunotherapy
Sabina Sangaletti, Roberto Ferrara, Claudio Tripodo, Marina Chiara Garassino, Mario Paolo Colombo
Bruton’s tyrosine kinase: an emerging targeted therapy in myeloid cells within the tumor microenvironment
Logan Good, Brooke Benner, William E. Carson
Interleukin-7-loaded oncolytic adenovirus improves CAR-T cell therapy for glioblastoma
Jianhan Huang, Meijun Zheng, Zongliang Zhang, Xin Tang, Yaxing Chen, Aijun Peng, Xingchen Peng, Aiping Tong, Liangxue Zhou
IL-36γ-armed oncolytic virus exerts superior efficacy through induction of potent adaptive antitumor immunity
Min Yang, Esther Giehl, Chao Feng, Mathilde Feist, Hongqi Chen, Enyong Dai, Zuqiang Liu, Congrong Ma, Roshni Ravindranathan, David L. Bartlett, Binfeng Lu, Zong Sheng Guo
Platelet-expressed immune checkpoint regulator GITRL in breast cancer
Yanjun Zhou, Jonas S. Heitmann, Kim L. Clar, Korbinian N. Kropp, Martina Hinterleitner, Tobias Engler, André Koch, Andreas D. Hartkopf, Lars Zender, Helmut R. Salih, Stefanie Maurer, Clemens Hinterleitner
Normalization of electroretinogram and symptom resolution of melanoma-associated retinopathy with negative autoantibodies after treatment with programmed death-1 (PD-1) inhibitors for metastatic melanoma
Karam Khaddour, Sangeeta Khanna, Michael Ansstas, Ishaan Jakhar, Sonika Dahiya, Laurin Council, George Ansstas
Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models
Shunsuke Goto, Yukimi Sakoda, Keishi Adachi, Yoshitaka Sekido, Seiji Yano, Masatoshi Eto, Koji Tamada
Anlotinib combined with PD-1 blockade for the treatment of lung cancer: a real-world retrospective study in China
Xiangyu Zhang, Liang Zeng, Yizhi Li, Qinqin Xu, Haiyan Yang, Analyn Lizaso, Xinru Mao, Ren’an Jin, Yu Zeng, Qinglin Li, Jianbo Wang, Yang Li, Yongchang Zhang, Nong Yang
The liposome of trehalose dimycolate extracted from M. bovis BCG induces antitumor immunity via the activation of dendritic cells and CD8+ T cells
Masanobu Shiga, Jun Miyazaki, Kozaburo Tanuma, Yoshiyuki Nagumo, Takayuki Yoshino, Shuya Kandori, Hiromitsu Negoro, Takahiro Kojima, Ryota Tanaka, Naoko Okiyama, Yasuhiro Fujisawa, Miyuki Watanabe, Sho Yamasaki, Hideyasu Kiyohara, Makoto Watanabe, Taka-aki Sato, Hideaki Tahara, Hiroyuki Nishiyama, Ikuya Yano
The cytokine milieu compromises functional capacity of tumor-infiltrating plasmacytoid dendritic cells in HPV-negative but not in HPV-positive HNSCC
Vladimír Koucký, Kamila Hladíková, Eliška Táborská, Jan Bouček, Marek Grega, Radek Špíšek, Anna Fialová
Immune-related adverse events: promising predictors for efficacy of immune checkpoint inhibitors
Li Zhong, Qing Wu, Fuchun Chen, Junjin Liu, Xianhe Xie
PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung
Torsten Goldmann, Sebastian Marwitz, Dörte Nitschkowski, Rosemarie Krupar, Max Backman, Hedvig Elfving, Viktoria Thurfjell, Amanda Lindberg, Hans Brunnström, Linnea La Fleur, Artur Mezheyeuski, Johanna Sofia Margareta Mattsson, Johan Botling, Patrick Micke, Carina Strell
Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas
Pei Yang, Kuanyu Wang, Chuanbao Zhang, Zhiliang Wang, Qi Liu, Jiangfei Wang, Tao Jiang, Xia Shan
Regulatory T cells promote glioma cell stemness through TGF-β–NF-κB–IL6–STAT3 signaling
Shasha Liu, Chaoqi Zhang, Boqiao Wang, Huanyu Zhang, Guohui Qin, Congcong Li, Ling Cao, Qun Gao, Yu Ping, Kai Zhang, Jingyao Lian, Qitai Zhao, Dan Wang, Zhen Zhang, Xuan Zhao, Li Yang, Lan Huang, Bo Yang, Yi Zhang
Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial
Kjetil Boye, Alessandra Longhi, Tormod Guren, Susanne Lorenz, Stine Næss, Michela Pierini, Ingeborg Taksdal, Ingvild Lobmaier, Marilena Cesari, Anna Paioli, Ayca M. Løndalen, Elisabetta Setola, Ivar Hompland, Leonardo A. Meza-Zepeda, Kirsten Sundby Hall, Emanuela Palmerini
Transcriptome of CD8+ tumor-infiltrating T cells: a link between diabetes and colorectal cancer
Reem Saleh, Varun Sasidharan Nair, Khaled Murshed, Mohamed Abu Nada, Eyad Elkord, Ranad Shaheen
Correction to: Transcriptome of CD8+ tumor-infiltrating T cells: a link between diabetes and colorectal cancer
Reem Saleh, Varun Sasidharan Nair, Khaled Murshed, Mohamed Abu Nada, Eyad Elkord, Ranad Shaheen
Prognostic role of the systemic immune–inflammation index in upper tract urothelial carcinoma treated with radical nephroureterectomy: results from a large multicenter international collaboration
Keiichiro Mori, Irene Resch, Noriyoshi Miura, Ekaterina Laukhtina, Victor M. Schuettfort, Benjamin Pradere, Satoshi Katayama, David D’Andrea, Mehdi Kardoust Parizi, Mohammad Abufaraj, Wataru Fukuokaya, Claudia Collà Ruvolo, Stefano Luzzago, Sophie Knipper, Carlotta Palumbo, Pierre I. Karakiewicz, Alberto Briganti, Dmitry V. Enikeev, Morgan Rouprêt, Vitaly Margulis, Shin Egawa, Shahrokh F. Shariat
Heterogeneity of PD-L1 expression between invasive and lepidic components of lung adenocarcinomas
Antonious Hazim, Neil Majithia, Stephen J. Murphy, Dennis Wigle, Marie-Christine Aubry, Aaron S. Mansfield
Development and validation of a PD-L1/PD-1/CD8 axis-based classifier to predict cancer survival of upper tract urothelial carcinoma after radical nephroureterectomy
Junyu Chen, Wenlong Zhong, Meng Yang, Weibin Hou, Xiaofei Wang, Kun Xia, Hao Yu, Meihua Yang, Bingkun Zhou, Bo Wang, Jian Huang, Tianxin Lin
Identification of immune checkpoint and cytokine signatures associated with the response to immune checkpoint blockade in gastrointestinal cancers
Chuanhua Zhao, Lihong Wu, Dandan Liang, Huan Chen, Shoujian Ji, Guanxiong Zhang, Keyan Yang, Ying Hu, Beibei Mao, Tianshu Liu, Yiyi Yu, Henghui Zhang, Jianming Xu
Interplay of stromal tumor-infiltrating lymphocytes, normal colonic mucosa, cancer-associated fibroblasts, clinicopathological data and the immunoregulatory molecules of patients diagnosed with colorectal cancer
Łukasz Zadka, Mariusz Chabowski, Damian Grybowski, Aleksandra Piotrowska, Piotr Dzięgiel
Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15
Shannon L. McArdel, Anne-Sophie Dugast, Maegan E. Hoover, Arjun Bollampalli, Enping Hong, Zafira Castano, Shannon Curtis Leonard, Sneha Pawar, Jennifer Mellen, Kelvin Muriuki, Douglas C. McLaughlin, Nicholas Bayhi, Christopher L. Carpenter, Laurence A. Turka, Thomas J. Wickham, Sivan Elloul
Correlation between melatonin concentration and cytokines in cervical mucus in positive samples for the presence of human papillomavirus
Aron Carlos de Melo Cotrim, Eduardo Luzia França, Jordana Santos Martins, Katleyn Polizeli Galvão Silva, Mahmi Fujimori, Yehya Chakib Ghalfi, Izabela Trindade Machado, Adenilda Cristina Honorio-França, Inês Aparecida Tozetti
First time intravesically administered trifunctional antibody catumaxomab in patients with recurrent non-muscle invasive bladder cancer indicates high tolerability and local immunological activity
Peter Ruf, Hartwig W. Bauer, Alexandra Schoberth, Claudia Kellermann, Horst Lindhofer