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Clinical & Experimental Metastasis

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11.07.2018 | Review

Cancer initiation and progression within the cancer microenvironment

verfasst von: Stanley P. Leong, Athena Aktipis, Carlo Maley

Erschienen in: Clinical & Experimental Metastasis | Ausgabe 5-6/2018

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Abstract

Within the cancer microenvironment, the growth and proliferation of cancer cells in the primary site as well as in the metastatic site represent a global biological phenomenon. To understand the growth, proliferation and progression of cancer either by local expansion and/or metastasis, it is important to understand the cancer microenvironment and host response to cancer growth. Melanoma is an excellent model to study the interaction of cancer initiation and growth in relationship to its microenvironment. Social evolution with cooperative cellular groups within an organism is what gives rise to multicellularity in the first place. Cancer cells evolve to exploit their cellular environment. The foundations of multicellular cooperation break down in cancer because those cells that misbehave have an evolutionary advantage over their normally behaving neighbors. It is important to classify evolutionary and ecological aspects of cancer growth, thus, data for cancer growth and outcomes need to be collected to define these parameters so that accurate predictions of how cancer cells may proliferate and metastasize can be developed.

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Titel: Cancer initiation and progression within the cancer microenvironment
verfasst von: Stanley P. Leong
Athena Aktipis
Carlo Maley
Publikationsdatum: 11.07.2018
Verlag: Springer Netherlands
Erschienen in: Clinical & Experimental Metastasis / Ausgabe 5-6/2018
Print ISSN: 0262-0898
Elektronische ISSN: 1573-7276
DOI: https://doi.org/10.1007/s10585-018-9921-y

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