Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan

The association of malignancies with dermatomyositis (DM) or polymyositis (PM) has been studied extensively both in Caucasian and Asian populations. Population-based cohort studies in Denmark, Sweden and Finland [1, 2] have demonstrated that DM, and to a lesser extent PM, carries elevated risk of comorbid cancers, in which cancers of the ovary, lung, pancreas, stomach and urinary bladder, as well as hematologic cancers including non-Hodgkin's lymphoma and Hodgkin's lymphoma, are the most relevant [1]. Most comorbid cancers are detected within the first year of diagnosis of idiopathic inflammatory myositis (IIM) [1, 2]. A thorough physical and laboratory work-up for early detection of these cancers is therefore strongly recommended after diagnosis of IIM.

The epidemiologic data on IIM-associated cancer types, however, are scarce and varied in Asian populations. Breast cancer, stomach cancer and nasopharyngeal cancer (NPC) have been reported to be more commonly associated with DM in Korea [3]. Studies in Singapore, Hong Kong, southeastern China and Taiwan have revealed that NPC is the most common cancer associated with DM [4‐7]. Our recent population-based, case-control study demonstrated that DM and PM patients are associated with a sixfold to 10-fold increased chance of cancer compared with control subjects. About two-thirds of comorbid cancers occur after diagnosis of IIM [8].

The present study aimed to investigate the risk of specific cancer types among a DM/PM cohort by IIM subtype, age at diagnosis, and follow-up time, utilizing analyses of standardized incidence ratios (SIRs).

We identified a total of 1,012 patients with DM and 643 patients with PM, all without previous malignancies. The mean ± standard deviation ages at diagnosis of DM and PM were 41.79 ± 18.96 years and 48.38 ± 16.63 years, respectively. Among DM patients, 315 (31.13%) were male and 697 (68.87%) were female. There were 199 (30.94%) male and 444 (69.06%) female patients in the PM group (Table 1). The mean ± standard deviation follow-up times for DM and PM were 5.09 ± 3.72 years and 5.05 ± 3.42 years, respectively.

A total of 95 cancers (9.4%) in DM patients and 33 cancers (4.4%) in PM patients were identified after diagnosis of myositis. The overall cancer risk was significantly elevated among patients with DM (SIR = 5.11, 95% confidence interval [CI] = 5.01 to 5.22), and to a lesser extent among patients with PM (SIR 2.15, 95% CI = 2.08 to 2.22) (Table 2). The SIRs for men and women with DM were 5.44 (95% CI = 5.28 to 5.62) and 5.10 (95% CI = 4.96 to 5.23), respectively. Among PM patients, women had a slightly higher risk than men for the development of malignancies (SIR = 2.36 for women, SIR = 1.84 for men).

With regards to age, a bimodal-pattern distribution of malignancy risk was observed among DM patients. DM patients carried a sustained elevated risk of cancer in every age group, especially in those younger than 60 years and those older than 80 years (Table 2). For PM, younger patients - especially those in their 20s - carried the highest risk of malignancies (SIR = 10.69, 95% CI = 9.99 to 11.60). The malignancy risk was reduced in patients with older age at diagnosis (SIR = 2.61 in those 40 to 59 years old, SIR = 1.91 in those ≥ 60 years old).

Comorbid malignant diseases were mostly detected following the first year of diagnosis, both in DM patients and in PM patients (SIR = 21.30 and SIR = 6.70, respectively). The risk of cancer decreased with follow-up time. For example, the SIRs of cancer in DM during the 1 to 2 years and the 2 to 5 years of observation were 5.08 (95% CI = 4.80 to 5.38) and 2.52 (95% CI = 2.38 to 2.66), respectively. The risk of cancer in PM was reduced to the expected incidence ratios of the general population after 2 years of follow-up (Table 2). The risk remained elevated both in DM and PM patients after 5 years of observation, however, with SIR = 1.37 (95% CI = 1.26 to 1.48) and SIR = 1.99 (95% CI = 1.85 to 2.15), respectively.

The highest risks after diagnosis of DM were for NPC, lung/mediastinum cancers, bone/joint cancers and lymphomas/leukemias. An elevated risk for many other cancers was also observed in DM patients (Table 3). For PM patients, although there were limited cancer cases, the greatest risks were for cancers of the bone and joint, the brain, NPC and melanoma. Elevated risks of leukemia/lymphomas and cancers of the uterus, oropharynx/larynx, urinary bladder, liver, colorectum and pancreas were also observed in PM patients.

A strong association between malignancy and myositis, especially in DM patients, was observed in our study. Most cancer cases were detected within the first year after diagnosis. This observation was consistent with the majority of reports in the literature, suggesting a paraneoplastic nature for IIM. Aggressive surveillance for cancer during that period may have resulted in a detection bias. When cancer cases observed in the first 2 years were excluded, a sustained elevated risk existed among DM patients after 5 years of follow-up (SIR = 1.37) (Table 2) - indicating a true link between these two diseases. The risk of malignancy in PM was reduced to the expected incidence ratio of the general population at 2 years of observation. Although there appeared to be an increased risk of cancer after 5 years of follow-up, the risk could not be adequately assessed because of the small number of cases, resulting in unstable estimates of risk. The lifelong use of immunosuppressive drugs in both diseases may also contribute to an elevated risk of cancer after years of observation. The relationship between cancer and PM needs further exploration. Overall, we suggest that physicians continue to carry out cancer work-ups in myositis patients for at least 5 years in IIM patients.

Only a few reports have focused on the age effect of cancer risk among DM and PM patients. Hill and colleagues indicated increased risks of cancer among DM patients younger than 44 years (SIR = 2.2) and older than 45 years (SIR = 3.1) [1]. There was no such trend, however, in PM patients. Another report from Stockton and colleagues indicated that cancer risk decreases with age in DM patients, but not in PM patients [16]. Those authors did not, however, further discuss the age effect.

In the present article, we demonstrated that the relative risk of cancer in DM remains high in every age group, whereas the risk of cancer in PM is highest in younger patients and decreases with age. Since malignant diseases increase with age among the general population (data not presented), it is reasonable that the higher prevalence of cancer cases among aged patients makes the difference in incidence nonsignificant between older PM patients and older people from the general population. Moreover, the sustained elevated cancer risk in DM patients highlighted the true link between DM and malignancies despite the age effect.

A strong link between DM and NPC was highlighted in the present study, with the SIR reaching as high as 140. A pathogenetic correlation between cancers of the pharynx, especially NPC, and DM has been proposed. NPC is endemic to southeastern Asia and is related to the chronic active infection of Epstein-Barr virus [17‐19]. Three cases of chronic active Epstein-Barr virus infection-induced generalized myositis have been reported [19]. Furthermore, Epstein-Barr virus has been detected in lung specimens from patients with rapidly progressive interstitial pneumonitis in PM/DM [20]. The immune response to Epstein-Barr virus contributes to the coexistence of DM/PM and NPC.

Other comorbid cancers commonly associated with DM are cancers of the lungs/mediastinum, bone/joints and kidney, as well as lymphoma and leukemia, with the SIRs ranging from 5 to 24. In contrast to the most commonly associated cancers, such as those of the lungs and ovaries, as well as lymphoma and leukemia, cases of myositis associated with renal or adrenal carcinomas have rarely been reported [21‐24]. Symptoms and laboratory abnormalities of DM or PM have been reported to be alleviated after surgical intervention for renal cancers [21, 22]. In addition, there are rare occurrences of chondrosarcoma [25], osteosarcoma [26] and thyroid cancers [27, 28] in DM; yet the relationship between these diseases and DM remains unclear.

Several population-based studies have indicated that ovarian cancer is the most commonly associated malignancy in female DM patients, with SIRs ranging from 8.2 to 32 [1, 2, 29, 30], whereas the correlation between ovarian cancer and PM is low. Ovarian carcinoma, however, has not been addressed in studies from Asian populations [4, 6, 31]. The risk of ovarian cancer was elevated in our DM patients, although with a lower SIR (5.33) than in western populations. Only two cases of ovarian cancer were observed in our DM patients, and no cases were observed in our PM patients. Mordel and colleagues reviewed published case reports of ovarian cancer and DM, and revealed that those with DM had a higher rate of advanced ovarian adenocarcinoma (96%) than the general female population with ovarian carcinoma (60 to 70%) [32].

Although there were limited numbers, diverse comorbid cancer types were associated with PM. The most significantly associated cancers included cancers of the bone/joints, nasopharynx and brain, and melanoma. The correlation between these cancers and myositis, however, remains unclear. Malignant melanoma-complicated DM/PM has been frequently reported [33‐37] and the development of myositis in patients with melanoma may serve as a poor prognostic marker [33, 35]. Very few reports have mentioned the correlation of these cancers in PM. Actually, the true association of these cancers in PM is doubtful and the risk of these cancers may be overestimated in the present study due to the very small number of cases.

An underlying mechanism of the association between IIM and malignancies remains unclear. A model of crossover immunity for the development of cancer-associated myositis has been proposed recently [38‐40]. Common antigenic myositis-specific autoantigens were expressed in both tumor cells and undifferentiated myoblasts. Myositis-specific autoantigen expression in a nascent tumor leads to the generation of both specific T cells and B cells against those antigens, and then to successful anti-tumor immunity. In a subset of patients, subsequent muscle damage from a variety of potential causes (such as viral infection, trauma, toxin exposure) may lead to muscle damage and regeneration, and may reactivate immune responses previously generated in the initial anti-tumor response. The crossover immunity between tumor cells and myofibroblasts may result in the parallel clinical course of both diseases [41‐44].

Until now, no population-based studies have provided evidence for the causal relationship between IIM and malignancies. A lower risk of cancer has been reported in patients who previously received cytotoxic treatment for inflammatory myopathies [29, 45]. In the present article, we demonstrated that the cancer risk in myositis patients decreases with time - which favors the role of the inflammatory nature, rather than lifelong immunosuppressive treatment, in the development of malignancies.

A limitation of the registry-based database is the possible misclassification of IIM. Due to the lack of specific diagnostic codes, amyopathic DM and inclusion body myositis - which have been reported to be associated with malignancies - were not identified in our study. The risk of cancer in IIM might therefore be underestimated. An individually tailored screening for malignancy in IIM patients has been recommended according to age, sex, ethnicity and subset of IIM. In brief, we strongly suggest conducting a thorough physical and laboratory check-up for detecting malignancies for at least 5 years following the diagnosis of IIM, especially in DM patients. In addition to the lungs and ovaries and lymphoma/leukemia, we recommend that special attention be paid to the risk of NPC and cancers of the renal system in DM and PM patients. A nasopharyngeal endoscopy examination should be routinely performed in all IIM patients. A thorough physical examination including palpation of thyroid glands, breast and lymph nodes will assist in the early detection of occult cancers. Mammography, breast ultrasonography and the Papanicolaou test are essential in female IIM patients. A more detailed history-taking and physical examinations, including symptoms of headache, neurologic signs, soreness of bones and joints, and skin examination, should be mandatory in PM patients.

Patients with DM and PM carry an elevated risk of various cancers in Taiwan. We suggest thorough physical and laboratory tests for malignancies, especially those of the nasopharynx, for at least 5 years of follow-up.