Skip to main content
main-content

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Oral Health 1/2015

Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes

Zeitschrift:
BMC Oral Health > Ausgabe 1/2015
Autoren:
Dorota Olczak-Kowalczyk, Beata Pyrżak, Maria Dąbkowska, Małgorzata Pańczyk-Tomaszewska, Grażyna Miszkurka, Izabela Rogozińska, Ewa Swoboda-Kopeć, Dariusz Gozdowski, Angelika Kalińska, Anna Piróg, Małgorzata Mizerska-Wasiak, Maria Roszkowska-Blaim
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

DOK – came up with the study idea, carried out the clinical studies, took part in the sequence alignment, drafted the manuscript, read and approved the final manuscript. BP – carried out the clinical studies, took part in the drafting of the manuscript, read and approved the final manuscript. MD – carried out the clinical studies, took part in the drafting of the manuscript, read and approved the final manuscript. MPT – carried out the clinical studies, took part in the drafting of the manuscript, read and approved the final manuscript. GM – carried out the clinical studies, took part in the drafting of the manuscript, read and approved the final manuscript. IR – carried out the clinical studies, took part in the drafting of the manuscript, read and approved the final manuscript. ESK – carried out the microbiological research, took part in the drafting of the manuscript, read and approved the final manuscript. DG – took part in sequence alignment and study design and performed the statistical analysis. AK – carried out the clinical studies, took part in the drafting of the manuscript, read and approved the final manuscript. AP – carried out the clinical studies, took part in the drafting of the manuscript, read and approved the final manuscript. MMW – carried out the clinical studies, took part in the drafting of the manuscript, read and approved the final manuscript. MRB – carried out the clinical studies, took part in the drafting of the manuscript, read and approved the final manuscript. All authors read approved the final manuscript.

Abstract

Background

Diabetes and Nephrotic syndrome (NS) promote plaque-related gingivitis and yeast-like fungal infections.
The study assesses the impact of Candida spp. and general disease- or treatment-related factors on plaque-related gingivitis severity in children and adolescents with Nephrotic syndrome /diabetes.

Methods

Body mass index (BMI), BMI standard deviation score, and oral cavity (Plaque Index – PLI, Gingival Index – GI, mucosa status, presence and Candida enzymatic activity) were assessed in 96 patients (32 with NS: 30- immunosuppressive treatment, 35 - type 1 diabetes, and 29 generally healthy), aged; 3–18 years. Laboratory included cholesterol and triglyceride measurements; in diabetic subjects– glycated haemoglobin, in NS: total protein, albumin, creatinine, haemoglobin, haematocrit, white cell count, urinary protein excretion. Medical records supplied information on disease duration and treatment. A statistical analysis was performed; Kendall Tau coefficient, chi-square test, t-test, and multiple regression analysis ( P < 0.05).

Results

Candida spp. often occurred in healthy patients, but oral candidiasis was found only in the NS and diabetes groups (9.37% and 11.43%). Gingivitis occurred more frequently in patients with NS/diabetes. Gingivitis severity was correlated with PLI, age, and yeast enzyme activity in NS – to with immunosuppressive treatment with >1 drug, drug doses, treatment duration, lipid disorders, and BMI; in diabetes, with blood glucose and glycated haemoglobin >8%.

Conclusion

Poor hygiene control is the main cause of gingivitis. Gingivitis severity is most likely related to age, lipid disorders and increase in body mass. Candida spp., in uncompensated diabetes and in those using immunosuppressive treatment, might intensify plaque-related gingivitis.
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2015

BMC Oral Health 1/2015 Zur Ausgabe

Neu im Fachgebiet Zahnmedizin

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise