Background
Established risk factor | Traviset al. [[3]] | Milneet al. [[4]] | Campaet al. [[6]] | Nickelset al. [[5]] | Barrdahlet al. [[7]] | Schoepset al. [[12]] |
---|---|---|---|---|---|---|
Age at menarche (years) | X | X | X | X | X | X |
Age at first birth (years) | X | X | Xa
| X | ||
Parous (% and/or number of live births) | X | X | X | Xa
| X | X |
Breast fed (% in parous women) | X | X | ||||
Menopausal status (% post-menopausal) | X | |||||
Age at natural menopause (years) | X | X | X | |||
Use of oral contraceptives (yes/no or duration) | X | X | X | |||
Use of HRT (yes/no or duration) | X | X | X | Xb
| ||
Body Mass Index (kg/m2) | X | X | X | X | X | Xc
|
Height (m) | X | X | X | X | X | |
Alcohol consumption (g per day) | X | X | X | X | X | |
Smoking (pack-years) | X | X | X | |||
Family history of BC | X | X | X | |||
Physical activity (hours per week) | X |
GxE interactions between previously reported SNPs and established risk factors for BC
Reference | Study | SNPs | ERFs | Cases | Controls | Strongest interaction | Interaction effect size | UnadjustedP
|
---|---|---|---|---|---|---|---|---|
Travis et al. [3] | Million women | 12 | 10 | 7,610 | 10,196 |
CASP8-rs1045485; alcohol consumptiona
| 1.24 | 0.003 |
Milne et al. [4] | BCAC (1) | 12 | 4 | 26,349 | 32,208 |
LSP1- rs3817198; parity | 1.05 | 0.002 |
Campa et al. [6] | BPC3 (1) | 17 | 9 | 8,576 | 11,892 | 5p12-rs10941679; use of estrogen only HRT | 1.22 | 0.0072 |
Nickels et al. [5] | BCAC (2) | 23 | 10 | 34,793 | 41,099 |
LSP1- rs3817198; parity | 1.06 | 2.4 × 10-6
|
1p11.2-rs11249433; ever parous | 1.16 | 5.3 × 10-5
| ||||||
CASP8-rs17468277; alcohol consumptiona
| 1.59 | 3.1 × 10-4
| ||||||
Barrdahl et al. [7] | BPC3 (2) | 39 | 10 | 16,285 | 19,376 | 6q25-rs2046210; alcohol consumptiona
| 1.11 | 0.002 |
Schoeps et al. [12] | BCAC | 71,527 | 10 | 34,475 | 34,786 | 21q22.12-rs10483028 and rs2242714; postmenopausal BMI | 0.84 | 3.2 × 10-5
|