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Erschienen in: Familial Cancer 1/2019

10.08.2018 | Short Communication

Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma

verfasst von: Iikki Donner, Riku Katainen, Eevi Kaasinen, Mervi Aavikko, Lauri J. Sipilä, Eero Pukkala, Lauri A. Aaltonen

Erschienen in: Familial Cancer | Ausgabe 1/2019

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Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma with a poor prognosis: the 5-year survival rate is approximately 30%. Somatic driver mutations have been found in TET2, IDH2, DNMT3A, RHOA, FYN, PLCG1, and CD28, whereas germline susceptibility to AITL has to our knowledge not been studied. The homogenous Finnish population is well suited for studies on genetic predisposition. Here, we performed an exome-wide rare variant analysis in 23 AITL patients. No germline mutations were found in the driver genes, implying that they are not frequently involved in genetic AITL predisposition. Potentially pathogenic variants present in at least two patients and showing significant (p < 0.01) enrichment in our sample set were found in ten genes: POLK, PRKCB, ZNF676, PRRC2B, PCDHGB6, GNL3L, TTC36, OTOG, OSGEPL1, and RASSF9. The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma. If validated, our findings would provide new insight into the pathogenesis of AITL, as well as tools for early detection in susceptible individuals.
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Metadaten
Titel
Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma
verfasst von
Iikki Donner
Riku Katainen
Eevi Kaasinen
Mervi Aavikko
Lauri J. Sipilä
Eero Pukkala
Lauri A. Aaltonen
Publikationsdatum
10.08.2018
Verlag
Springer Netherlands
Erschienen in
Familial Cancer / Ausgabe 1/2019
Print ISSN: 1389-9600
Elektronische ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-018-0099-x

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