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Journal of Clinical Immunology

Erschienen in:

10.05.2019 | CME Review

CAPS and NLRP3

verfasst von: Laela M. Booshehri, Hal M. Hoffman

Erschienen in: Journal of Clinical Immunology | Ausgabe 3/2019

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Abstract

Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system inflammation. Gain-of-function mutations in NLRP3 in CAPS patients lead to activation of the cryopyrin inflammasome, resulting in the inappropriate release of inflammatory cytokines including IL-1β and CAPS-related inflammatory symptoms. Several mechanisms have been identified that are important for the normal regulation of the cryopyrin inflammasome in order to prevent uncontrolled inflammation. Investigators have taken advantage of some of these pathways to develop and apply novel targeted therapies, which have resulted in improved quality of life for patients with this orphan disease.

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Titel: CAPS and NLRP3
verfasst von: Laela M. Booshehri
Hal M. Hoffman
Publikationsdatum: 10.05.2019
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 3/2019
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-019-00638-z

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