Introduction
Materials and methods
Antitumor evaluation in vivo
Drug | Dose (mg/kg) | Schedule/route | Percentage increase life span (% ILS) | Percentage long term survivors (% LTS) |
---|---|---|---|---|
Control | Vehicle | Q1D × 5; IP | 0 | 0/5 |
DM-PEN | 90 (> is toxic) | √ | +17 | 0/5 |
DM-BOC-PEN | 90 | √ | +15 | 0/5 |
DM-NBOC-PEN | 90 | √ | +27 | 0/5 |
DM-CHOC-PEN | 135 | √ | +54 | 20 (1/5 CR) |
DM-COC-PEN | 90 | √ | +4 | 0/5 |
DM-acetyl-PEN | 90 | √ | +38 | 0/5 |
(DM-PEN)2–CO | 135 | √ | +15 | 0/5 |
DM-GLUC-PENa
| 135 | √ | +4 | 0/5 |
DM-DMC-PEN | 135 | √ | +21 | 0/5 |
BCNU | 9 (> is toxic) | √ | 33 - +92 | 20 (1/5 CR) |
TMZ | 120 | QD × 5; PO | +59 | 20 (1/5 CR) |
Drug | Dose (mg/kg) | Schedule/route | Percentage increase life span (% ILS) | Percentage long term survivors (% LTS) |
---|---|---|---|---|
Control | Vehicle | QD × 5; IP | 0 | 0/10 |
DM-BOC-PEN | 135 | √ | +23 | 0/5 |
DM-CHOC-PEN | 200 | √ | +53 | 1/6 |
DM-NBOC-PEN | 200 | √ | +13 | 0/5 |
BCNU | 9 (> is toxic) | √ | 33 | 0/5 |
Drug | Dose (mg/kg) | Schedule/route | Percentage increase life span (% ILS) | Percentage long term survivors (% LTS) |
---|---|---|---|---|
Control | Vehicle | QD × 5; IP | 0 | 0/12 |
DM-CHOC-PEN | 25 | √ | +6 to +20 | 16 (1/6 CR) |
DM-PEN | 90 | √ | 60 | 0/5 CR |
PEN | 90 | √ | 88 | 0/5 CR |
BCNU | 6 | √ | 33 | 0/5 CR |
Drug | Dose (mg/kg) | Schedule/route | Disease free | Days delay |
---|---|---|---|---|
Control | Vehicle | Q4D × 3; IP | 0 | 0 |
DM-OOC-PEN | 90 (> is toxic) | √ | 0 | 1.7 |
DM-BOC-PEN | 90 | √ | 0 | 2.2 |
DM-NBOC-PEN | 200 | √ | 0 | 1.7 |
DM-CHOC-PEN | 135 | √ | 0 | 2.8 |
DM-POC-PEN | 90 | √ | 0 | −0.9 |
DM-CFBOC-PEN | 90 | √ | 0 | 1.9 |
DM-EOC-PEN | 200 | √ | 0 | 2.3 |
Drug | Dose (mg/kg) | Schedule/route | Growth delay (T − C) | Tumor-free survivors |
---|---|---|---|---|
Control | Vehicle | Q1D × 5; IP | 0 | 0/5 |
DM-PEN | 135 | √ | >38 | 5/5 |
PEN | 90 | √ | >41 | 5/5 |
DM-MOC-PEN | 90 | √ | >41 | 1/5 |
DM-acetyl-PEN | 90 | √ | >41 | 5/5 |
DM-BOC-PEN | 90 | √ | >34 | 1/5 |
DM-DMC-PEN | 135 | √ | >41 | 5/5 |