Carcinoma ex Pleomorphic Adenoma of the Nasal Cavity
- 01.12.2011
- Case Report
Erschienen in:
- Verfasst von
- Ashley Cimino-Mathews
- Brian M. Lin
- Steven S. Chang
- Kofi D. Boahene
- Justin A. Bishop
- Erschienen in
- Head and Neck Pathology | Ausgabe 4/2011
Abstract
Background
Carcinoma ex pleomorphic adenoma (CXPA) is a malignant epithelial neoplasm arising in a benign mixed tumor (i.e., pleomorphic adenoma or PA); it accounts for approximately 3–4% of all salivary gland neoplasms. CXPA is exceedingly rare in the nasal cavity, with only three cases previously documented.
Methods
We report two cases of women presenting with masses of the nasal cavity. The tumors were resected and evaluated grossly and by routine microscopy.
Results
Both patients presented with nasal obstruction, and one patient reported epistaxis. Grossly, the tumors were 2.5 and 3 cm in greatest dimension, respectively. In each case, microscopic examination of the tumor revealed an infiltrating carcinoma arising in association with foci of benign PA. The carcinoma types were adenoid cystic carcinoma and high grade adenocarcinoma, not otherwise specified. Both cases were widely (i.e., >1.5 mm) invasive beyond the preexisting PA. The findings were diagnostic of CXPA.
Conclusions
Carcinomatous transformation of a PA in the nasal cavity is extremely rare, but does occur. Accordingly, PAs of this site should be thoroughly sampled and closely examined to exclude the possibility of malignant transformation.
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- Titel
- Carcinoma ex Pleomorphic Adenoma of the Nasal Cavity
- Verfasst von
-
Ashley Cimino-Mathews
Brian M. Lin
Steven S. Chang
Kofi D. Boahene
Justin A. Bishop
- Publikationsdatum
- 01.12.2011
- Verlag
- Springer US
- Erschienen in
-
Head and Neck Pathology / Ausgabe 4/2011
Elektronische ISSN: 1936-0568 - DOI
- https://doi.org/10.1007/s12105-011-0262-2
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