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Erschienen in: BMC Cardiovascular Disorders 1/2017

Open Access 01.12.2017 | Case report

Cardiac amyloidosis mimicking severe aortic valve stenosis – a case report demonstrating diagnostic pitfalls and role of dobutamine stress echocardiography

verfasst von: Tim Salinger, Kai Hu, Dan Liu, Sebastian Herrmann, Kristina Lorenz, Georg Ertl, Peter Nordbeck

Erschienen in: BMC Cardiovascular Disorders | Ausgabe 1/2017

Abstract

Background

Aortic valve stenosis is a common finding diagnosed with high sensitivity in transthoracic echocardiography, but the examiner often finds himself confronted with uncertain results in patients with moderate pressure gradients and concomitant systolic heart failure. While patients with true-severe low-gradient aortic valve stenosis with either reduced or preserved left ventricular systolic function are primarily candidates for valve replacement, there is a relevant proportion of patients with pseudo-severe aortic valve stenosis anticipated not to benefit but actually rather deteriorate by interventional therapy or surgery.

Case presentation

In this article we present a case report of a male patient with pseudo-severe aortic valve stenosis due to cardiac amyloidosis highlighting the diagnostic schedule. The patient underwent stress echocardiography because of discrepant findings in transthoracic echocardiography and cardiac catheterization regarding the severity of aortic valve stenosis. After evaluation of the results, it became clear that he had a need for optimum heart failure medication and implantation of a cardiac resynchronization therapy defibrillator.

Conclusion

Due to the pitfalls in conventional as well as invasive diagnostics at rest, Stress echocardiography should be considered part of the standard optimum diagnostic spectrum in all unclear or borderline cases in order to confirm the correct diagnosis and constitute optimal therapy.
Abkürzungen
AS
Aortic stenosis
AV
Aortic valve
AVR
Aortic valve replacement
CRT-D
Cardiac resynchronization therapy defibrillator
LVEF
Left- ventricular- ejection- fraction

Background

Stenosis of the aortic valve (AS) is the most common valvular disease in elderly persons today. Previous studies have reported prevalence for moderate or severe AS of 5–8% in a population older than 74 years [1, 2]. While current guidelines recommend conservative medical treatment in patients with mild and moderate AS [3], severe AS is highly recommended for surgical treatment especially in symptomatic patients, because of the poor prognosis of this disease entity in patients under conservative therapy [3, 4]. In elderly patients ≥80 years with severe AS, 3-year mortality has been described to be approximately 40% [5].
The diagnostic cornerstone in the differentiation between moderate and severe AS is transthoracic echocardiography. By convenient use of this widely available, non-invasive, and cost saving imaging technique, the experienced echocardiographer is able to determine the transvalvular pressure gradients and calculate the valve area with high diagnostic accuracy in most patients [3]. However, diagnostic accuracy can be considerably diminished in certain patients. This particularly refers to patients with a decreased left-ventricular-ejection-fraction (LVEF), occasionally leading to low transvalvular pressure gradients even if the opening area of the valve is indeed severely restricted, as e.g. confirmed by transesophageal echocardiography, usually referred to as low-gradient AS [6]. On the other hand, an echocardiographically confirmed severely diminished aortic valve opening area in this patient group might also be functional due to the profoundly reduced LV stroke volume leading to incomplete opening of the aortic valve, usually referred to as pseudo-severe AS [7]. Some patients may also have low aortic valve pressure gradient and severe AS, but preserved LVEF [8]. This so called paradoxical low-flow, low gradient AS is particularly difficult to diagnose and standard diagnostics often lead to false results and inadequate therapy [9]. While conclusive differentiation of the before mentioned disease entities is highly important for therapy planning in this patient group with high procedural risk during aortic valve replacement (AVR), it often represents a diagnostic dilemma for the cardiologist particularly in case of combined valvular diseases or myocardial comorbidities since even invasive measurements are often inconclusive in such cases.

Case presentation

An 82 year old male patient was referred to our cardiological department for treatment of aortic valve stenosis. The patient was in substantially reduced general condition with dyspnoe on insignificant loads (NYHA III) and edemas of hands and feet. Physical examination revealed a grade 3/6 systolic ejection murmur with radiation to the carotid arteries. There had been multiple hospitalizations in the past 6 month because of recurrent cardiac decompensations. Previously known comorbidities were chronic heart failure for unknown reason, atrial fibrillation, pulmonary hypertension and chronic obstructive pulmonary disease. Cardiovascular risk factors were arterial hypertension, diabetes, and former nicotine abuse. Biochemical tests revealed a moderately decreased glomerular filtration rate (54 ml/min/1.73qm), slightly increased creatinine (1.35 mg/dl) and increased high sensitivity troponin (98.5 pg/ml). NT-proBNP was 5473 pg/ml.
The patient underwent transthoracic echocardiography for staging severity of the aortic valve stenosis, which revealed borderline results (peak aortic jet velocity 2.8 m/s, mean aortic jet velocity 2.1 m/s, peak aortic pressure gradient 31 mmHG, mean aortic pressure gradient 19 mmHG, calculated aortic valve area 0.9 cm2). Global left ventricular systolic function was highly reduced (LVEF Simpson 4CH = 29%), stroke volume index was 24 ml/qm. Global longitudinal strain was -7.3%. Apical sparing, which could be a sign for cardiac amyloidosis [10] was not present. Transthoracic echocardiography also revealed diastolic dysfunction (e = 1.01 m/s; e’ septal = 0.03 m/s; e’lateral = 0.04 m/s; s’septal 0.02 m/s; s’lateral = 0.03 m/s, e/e’ = 28.9). The left atrium was moderately, and the right atrium profoundly enlarged (35 cm2 each, left atrial volume index 67.8 ml/qm). Chest X-ray showed a global enlarged heart, chronic pulmonary congestion, and right-sided pleural effusion (Fig. 1). Coronary angiography showed no significant coronary artery stenosis. Laevocardiography confirmed a highly reduced LVEF and a massively increased left ventricular end-diastolic pressure (33 mmHg), Right heart catheterization showed a normal cardiac output at rest (cardiac index 3.1 l/min*m2) and post-capillary pulmonary hypertension (pulmonary artery mean pressure 44 mmHG, max 66 mmHg, pulmonary capillary wedge pressure 35 mmHG). Invasively measured aortic valve gradients were 25/16 (max/mean) mmHG and the aortic valve opening area was calculated as 1.9 cm2. In transesophageal echocardiography, the opening area of the aortic valve was planimetrically determined as 0.8 cm2, again indicating severe AS (Fig. 2).
Due to discrepant findings in echocardiography and cardiac catheterization regarding the severity of aortic valve stenosis, low-dose dobutamine stress echocardiography was performed (Fig. 3). At rest conditions, there was global hypokinesia with an ejection fraction of 33%. Aortic valve (AV) mean pressure was 16 mmHg referring to a calculated aortic valve opening area of 0,7 cm2. Under peak dobutamine stress (20 mcg/kg/min), LVEF increased to 47% mean and mean AV pressure gradient to 23 mmHg. Left ventricular outflow tract velocity increased more than aortic valve velocity (LVOT/AV 0.2 at rest vs. 0.25 under stress) referring to an enlarged opening area of the aortic valve under stress conditions from 0.7 cm2 to 1.1 cm2. Stroke volume increased by 61.3% to 50 ml. On the basis of these diagnostic findings, AS was classified as pseudo-severe due to systolic dysfunction of the left ventricle with preserved contractile reserve, indicating a non-valvular reason for heart-failure and no indication for valve replacement.
Since the origin of the highly reduced LVEF was still unclear, cardiac MRI was performed, confirming global hypokinesia with a LVEF of 35% and revealing reduced myocardium-to-blood contrast, raising suspicion for presence of a cardiomyopathy (Fig. 4). An endomyocardial biopsy from the intraventricular septum in the right ventricular outflow tract was done, revealing multifocal interstitial transthyretin- related cardiac amyloidosis (ATTR). Because of a newly developed complete left bundle branch block in the ECG (Fig. 5) and the severely reduced LVEF, implantation of a cardiac resynchronization therapy defibrillator (CRT-D), was performed on top of optimum heart failure medication. Regrettably, at short- and medium-term follow-up echocardiography, LVEF did not show relevant improvement, although no signs of cardiac dyssynchrony could be found. However, NYHA improved to NYHA II and in the following 2-year period after device implantation, no more hospitalizations were required. Status of AS in follow-up transthoracic echocardiography 1 year later did not differ from baseline.

Discussion and conclusions

This clinical case highlights the potential value of dobutamine stress echocardiography in anticipated low-grade true-severe AS. After the initial echocardiography showing low LVEF, a mean valvular gradient <40 mmHg and a calculated valve area <1 cm2, the patient was suspected to have low-flow, low-gradient aortic stenosis [3]. This disease entity would normally lead to valve replacement because of the potential benefits in terms of symptoms and survival gained from this procedure [3, 11], but should also be assessed very carefully when planning valve replacement. The American College of Cardiology recommends AVR for “symptomatic patients with severe AS and decreased systolic opening in calcified or congenitally stenotic aortic valves and an aortic velocity of >4.0 m/s or greater, or a mean pressure gradient of 40 mmHg or higher and symptoms of heart failure” [11]. However, in particular patients without contractile reserve have been shown to have exceedingly high operative mortality [12]. Differentiation between patients with low-flow, low-gradient stenosis and those with pseudo-severe stenosis can be very difficult in clinical practice since echocardiographic characteristics might differ only marginally at rest between both groups. Dobutamine stress echocardiography was first used as early as 1995 to distinguish these two subgroups. Based on the results from this study, it was already speculated that a broader use of this method might be clinically useful [13]. In 2001 it was first shown that clinical management of individuals with aortic stenosis and left ventricular dysfunction as well as low or intermediate valve gradients can indeed be improved by dobutamine stress echocardiography, because not only the distinction between patients with severe and non-severe aortic stenosis is improved, but this has indeed relevant implications on clinical outcome [14]. True-severe low-flow, low-gradient stenosis patients primarily benefit from AVR, since the valve itself is the main problem, whereas the primary pathology in pseudo-severe stenosis is located in the myocardium, requiring intensified conservative or specialized treatment based on the underlying disease [15].
In the present case, aortic stenosis of our patient could be clearly classified pseudo-severe by low dose dobutamine stress echocardiography. In the respective guidelines of the European Society of Cardiology, this procedure is not well established, but mentioned as potentially useful for the aforesaid diagnostic indication [3]. It is a widely-used, non-invasive method that can be done not only in-hospital but also in ambulatory patient care. Examination time is actually short and procedural risk has shown to be low [13]. Therefore, the net benefit greatly outweighs potential patient risks, justifying the investment in cases similar to the one described above.
Following stress-echocardiography, we performed cardiac MRI to reveal the origin of high-grade systolic dysfunction in our patient, revealing typical signs of an infiltrative cardiomyopathy such as late gadolinium enhancement [16] and dilated atria as well as a thickened septum and global left ventricular hypertrophy. High sensitive troponin was checked and turned out to be elevated. This serum biomarker has been shown to be a useful but non-specific diagnostic tool in various hereditary or secondary cardiomyopathies such as e.g. Sarcoidosis or Anderson-Fabry disease [17, 18]. In the described case, the final diagnosis ultimately clarifying the etiology of the pathological myocardial findings was made by endomyocardial biopsy from the right ventricle. Histological findings clearly revealed cardiac amyloidosis.
Amyloidosis is a systemic disease which can affect every organ, but especially cardiac involvement is a major determinant in patients prognosis [19]. In general, amyloidosis is considered a rare disease. However, there is a high probability of under-diagnosis particularly in elderly patients, where specific symptoms can be easily misinterpreted as an expression of advanced aging processes. Different studies have also shown that Amyloidosis and AS may occur together in a significant number of patients [2023]. Today, several diagnostic tools are available to rule out whether a patient is indeed affected by cardiac amyloidosis, including the ECG, serum biomarkers, echocardiography, MRI and nuclear medicine imaging techniques [24, 25]. In cases where additional advanced imaging techniques are not available, standard echocardiographic examinations can be expanded by speckle tracking analysis of left ventricular (systolic) function [26]. However, in order to come to a definite diagnosis, current guidelines recommend endomyocardial biopsy [27]. Guidelines for therapy also recommend intensified heart failure therapy in respective patients with mainly systolic dysfunction. However, the impact of device therapy such as CRT-D on top of medical therapy on symptoms and prognosis in cardiac amyloidosis is currently not well investigated.
The presented case highlights some important aspects and pitfalls in diagnosis and treatment of elderly patients with aortic valve stenosis transferred to hospital for aortic valve replacement. While the natural history of low-gradient aortic valve stenosis and concept of optimum therapy including valve replacement is generally better understood today, great care has to be taken not to exaggerate these findings to patients with pseudo-severe aortic valve stenosis. Stress echocardiography should be considered part of the standard optimum diagnostic spectrum in all unclear or borderline cases in order to confirm the correct diagnosis and constitute optimal therapy.

Acknowledgements

Not applicable.

Funding

This work was supported by the Federal Ministry for Education and Research of the Federal Republic of Germany (BMBF 01EO1504, MO6 to Peter Nordbeck). There was no role of the funding body in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

Availability of data and materials

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

Authors’ contributions

Conception and design: TS, PN; analysis and interpretation of data: TS, KH, DL, SH, KL, GE PN; drafting the article: TS, PN; revising the article: TS, KH, DL, SH, KL, GE, PN. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.
The patient gave written consent for the publication of all information contained in this case report and any accompanying images.
Ethics approval was given by the ethics committee of the University of Wuerzburg (AZ 60/14).

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Literatur
1.
Zurück zum Zitat Nkomo VT, et al. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368(9540):1005–11.CrossRefPubMed Nkomo VT, et al. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368(9540):1005–11.CrossRefPubMed
2.
Zurück zum Zitat Lindroos M, et al. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol. 1993;21(5):1220–5.CrossRefPubMed Lindroos M, et al. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol. 1993;21(5):1220–5.CrossRefPubMed
3.
Zurück zum Zitat Joint Task Force on the Management of Valvular Heart Disease of the European Society of, C, et al. Guidelines on the management of valvular heart disease (version 2012). Eur Heart J. 2012;33(19):2451–96.CrossRef Joint Task Force on the Management of Valvular Heart Disease of the European Society of, C, et al. Guidelines on the management of valvular heart disease (version 2012). Eur Heart J. 2012;33(19):2451–96.CrossRef
4.
Zurück zum Zitat Horstkotte D, Loogen F. The natural history of aortic valve stenosis. Eur Heart J. 1988;9(Suppl E):57–64. Horstkotte D, Loogen F. The natural history of aortic valve stenosis. Eur Heart J. 1988;9(Suppl E):57–64.
5.
Zurück zum Zitat Rezzoug N, et al. Prevalence and Prognostic Impact of Valve Area-Gradient Patterns in Patients >/=80 Years With Moderate-to-Severe Aortic Stenosis (from the Prospective BELFRAIL Study). Am J Cardiol. 2015;116(6):925–32.CrossRefPubMed Rezzoug N, et al. Prevalence and Prognostic Impact of Valve Area-Gradient Patterns in Patients >/=80 Years With Moderate-to-Severe Aortic Stenosis (from the Prospective BELFRAIL Study). Am J Cardiol. 2015;116(6):925–32.CrossRefPubMed
6.
Zurück zum Zitat Herrmann S, et al. Differences in natural history of low- and high-gradient aortic stenosis from nonsevere to severe stage of the disease. J Am Soc Echocardiogr. 2015;28(11):1270–82. e4.CrossRefPubMed Herrmann S, et al. Differences in natural history of low- and high-gradient aortic stenosis from nonsevere to severe stage of the disease. J Am Soc Echocardiogr. 2015;28(11):1270–82. e4.CrossRefPubMed
7.
Zurück zum Zitat Fougeres E, et al. Outcomes of pseudo-severe aortic stenosis under conservative treatment. Eur Heart J. 2012;33(19):2426–33.CrossRefPubMed Fougeres E, et al. Outcomes of pseudo-severe aortic stenosis under conservative treatment. Eur Heart J. 2012;33(19):2426–33.CrossRefPubMed
8.
Zurück zum Zitat Kamperidis V, et al. Low gradient severe aortic stenosis with preserved ejection fraction: reclassification of severity by fusion of Doppler and computed tomographic data. Eur Heart J. 2015;36(31):2087–96.CrossRefPubMed Kamperidis V, et al. Low gradient severe aortic stenosis with preserved ejection fraction: reclassification of severity by fusion of Doppler and computed tomographic data. Eur Heart J. 2015;36(31):2087–96.CrossRefPubMed
9.
Zurück zum Zitat Pibarot P, Dumesnil JG. Aortic stenosis suspected to be severe despite low gradients. Circ Cardiovasc Imaging. 2014;7(3):545–51.CrossRefPubMed Pibarot P, Dumesnil JG. Aortic stenosis suspected to be severe despite low gradients. Circ Cardiovasc Imaging. 2014;7(3):545–51.CrossRefPubMed
10.
Zurück zum Zitat Phelan D, et al. Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis. Heart. 2012;98(19):1442–8.CrossRefPubMed Phelan D, et al. Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis. Heart. 2012;98(19):1442–8.CrossRefPubMed
11.
Zurück zum Zitat Nishimura RA, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Thorac Cardiovasc Surg. 2014;148(1):e1–e132.CrossRefPubMed Nishimura RA, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Thorac Cardiovasc Surg. 2014;148(1):e1–e132.CrossRefPubMed
12.
Zurück zum Zitat Monin J-L, et al. Low-Gradient Aortic Stenosis: Operative Risk Stratification and Predictors for Long-Term Outcome: A Multicenter Study Using Dobutamine Stress Hemodynamics. Circulation. 2003;108(3):319–24.CrossRefPubMed Monin J-L, et al. Low-Gradient Aortic Stenosis: Operative Risk Stratification and Predictors for Long-Term Outcome: A Multicenter Study Using Dobutamine Stress Hemodynamics. Circulation. 2003;108(3):319–24.CrossRefPubMed
13.
Zurück zum Zitat de Filippi CR, et al. Usefulness of dobutamine echocardiography in distinguishing severe from nonsevere valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients. Am J Cardiol. 1995;75(2):191–4.CrossRef de Filippi CR, et al. Usefulness of dobutamine echocardiography in distinguishing severe from nonsevere valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients. Am J Cardiol. 1995;75(2):191–4.CrossRef
14.
Zurück zum Zitat Schwammenthal E, et al. Dobutamine echocardiography in patients with aortic stenosis and left ventricular dysfunction: predicting outcome as a function of management strategy. Chest. 2001;119(6):1766–77.CrossRefPubMed Schwammenthal E, et al. Dobutamine echocardiography in patients with aortic stenosis and left ventricular dysfunction: predicting outcome as a function of management strategy. Chest. 2001;119(6):1766–77.CrossRefPubMed
15.
Zurück zum Zitat Clavel MA, et al. Validation of Conventional and Simplified Methods to Calculate Projected Valve Area at Normal Flow Rate in Patients with Low Flow, Low Gradient Aortic Stenosis. The Multicenter TOPAS (True Or Pseudo Severe Aortic Stenosis) Study. Cardiology. 2010;115(4):258. Clavel MA, et al. Validation of Conventional and Simplified Methods to Calculate Projected Valve Area at Normal Flow Rate in Patients with Low Flow, Low Gradient Aortic Stenosis. The Multicenter TOPAS (True Or Pseudo Severe Aortic Stenosis) Study. Cardiology. 2010;115(4):258.
17.
Zurück zum Zitat Baba Y, et al. Usefulness of high-sensitive cardiac troponin T for evaluating the activity of cardiac sarcoidosis. Int Heart J. 2012;53(5):287–92.CrossRefPubMed Baba Y, et al. Usefulness of high-sensitive cardiac troponin T for evaluating the activity of cardiac sarcoidosis. Int Heart J. 2012;53(5):287–92.CrossRefPubMed
19.
Zurück zum Zitat Patel KS, Hawkins PN. Cardiac amyloidosis: where are we today? J Intern Med. 2015;278(2):126–44.CrossRefPubMed Patel KS, Hawkins PN. Cardiac amyloidosis: where are we today? J Intern Med. 2015;278(2):126–44.CrossRefPubMed
20.
Zurück zum Zitat Longhi S, et al. Coexistence of Degenerative Aortic Stenosis and Wild-Type Transthyretin-Related Cardiac Amyloidosis. JACC Cardiovasc Imaging. 2016;9(3):325–7.CrossRefPubMed Longhi S, et al. Coexistence of Degenerative Aortic Stenosis and Wild-Type Transthyretin-Related Cardiac Amyloidosis. JACC Cardiovasc Imaging. 2016;9(3):325–7.CrossRefPubMed
21.
Zurück zum Zitat Nietlispach F, et al. Pathology of transcatheter valve therapy. JACC Cardiovasc Interv. 2012;5(5):582–90.CrossRefPubMed Nietlispach F, et al. Pathology of transcatheter valve therapy. JACC Cardiovasc Interv. 2012;5(5):582–90.CrossRefPubMed
22.
Zurück zum Zitat Galat A, et al. Aortic stenosis and transthyretin cardiac amyloidosis: the chicken or the egg? Eur Heart J. 2016;37(47):3525–3531. Galat A, et al. Aortic stenosis and transthyretin cardiac amyloidosis: the chicken or the egg? Eur Heart J. 2016;37(47):3525–3531.
23.
Zurück zum Zitat Treibel TA, et al. Occult Transthyretin Cardiac Amyloid in Severe Calcific Aortic Stenosis: Prevalence and Prognosis in Patients Undergoing Surgical Aortic Valve Replacement. Circ Cardiovasc Imaging. 2016;9(8). doi:10.1161/CIRCIMAGING.116.005066. Treibel TA, et al. Occult Transthyretin Cardiac Amyloid in Severe Calcific Aortic Stenosis: Prevalence and Prognosis in Patients Undergoing Surgical Aortic Valve Replacement. Circ Cardiovasc Imaging. 2016;9(8). doi:10.​1161/​CIRCIMAGING.​116.​005066.
24.
Zurück zum Zitat Di Bella G, et al. The mosaic of the cardiac amyloidosis diagnosis: role of imaging in subtypes and stages of the disease. Eur Heart J Cardiovasc Imaging. 2014;15(12):1307–15.CrossRefPubMed Di Bella G, et al. The mosaic of the cardiac amyloidosis diagnosis: role of imaging in subtypes and stages of the disease. Eur Heart J Cardiovasc Imaging. 2014;15(12):1307–15.CrossRefPubMed
25.
Zurück zum Zitat Hu K, et al. Impact of monitoring longitudinal systolic strain changes during serial echocardiography on outcome in patients with AL amyloidosis. Int J Cardiovasc Imaging. 2015;31(7):1401–12.CrossRefPubMed Hu K, et al. Impact of monitoring longitudinal systolic strain changes during serial echocardiography on outcome in patients with AL amyloidosis. Int J Cardiovasc Imaging. 2015;31(7):1401–12.CrossRefPubMed
26.
Zurück zum Zitat Ternacle J, et al. Causes and Consequences of Longitudinal LV Dysfunction Assessed by 2D Strain Echocardiography in Cardiac Amyloidosis. JACC Cardiovasc Imaging. 2016;9(2):126–38. Ternacle J, et al. Causes and Consequences of Longitudinal LV Dysfunction Assessed by 2D Strain Echocardiography in Cardiac Amyloidosis. JACC Cardiovasc Imaging. 2016;9(2):126–38.
27.
Metadaten
Titel
Cardiac amyloidosis mimicking severe aortic valve stenosis – a case report demonstrating diagnostic pitfalls and role of dobutamine stress echocardiography
verfasst von
Tim Salinger
Kai Hu
Dan Liu
Sebastian Herrmann
Kristina Lorenz
Georg Ertl
Peter Nordbeck
Publikationsdatum
01.12.2017
Verlag
BioMed Central
Erschienen in
BMC Cardiovascular Disorders / Ausgabe 1/2017
Elektronische ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-017-0519-0

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