Background
Methods
Patients
Study design
Collection of clinical data
Measurement of DC and AC
Assessment of HRV
Statistical analysis
Results
Clinical characteristics of the patients
Variable | Non-VT group (n = 48) | VT group (n = 22) | P |
---|---|---|---|
Gender (male) | 31 (64.5 %) | 15 (68.2 %) | 0.77 |
Age (years) | 61.2 ± 11.4 | 60.6 ± 11.8 | 0.86 |
BUN (mmol/L) | 6.0 ± 1.5 | 6.1 ± 1.2 | 0.84 |
Cr (μmol/L) | 76.3 ± 15.8 | 77.1 ± 15.2 | 0.82 |
FBG (mmol/L) | 5.0 ± 0.9 | 5.1 ± 0.8 | 0.79 |
TC (mmol/L) | 4.8 ± 0.6 | 4.7 ± 0.7 | 0.83 |
LVEF (%) | 59.8 ± 6.4 | 58.7 ± 6.5 | 0.87 |
β2 agonist use | 45 (93.8 %) | 20 (90.9 %) | 1.00 |
Anticholinergic use | 40 (83.3 %) | 19 (86.4 %) | 1.00 |
Hormone replacement therapy | 36 (75.0 %) | 17 (77.3 %) | 0.84 |
Calcium antagonist use | 15 (31.2 %) | 10 (45.5 %) | 0.25 |
Amiodarone use | 5 (10.4 %) | 15 (68.2 %) | <0.05 |
Smoker | 10 (20.8 %) | 6 (27.3 %) | 0.64 |
PH | 7.40 ± 0.05 | 7.41 ± 0.08 | 0.13 |
PaO2(mmHg) | 60.5 ± 5.9 | 59.8 ± 5.3 | 0.73 |
PaCO2(mmHg) | 49.4 ± 5.6 | 50.5 ± 5.9 | 0.43 |
Serum K+(mmol/L) | 4.2 ± 0.4 | 4.1 ± 0.4 | 0.25 |
Serum Na + (mmol/L) | 138.8 ± 3.3 | 139.7 ± 3.2 | 0.12 |
Serum Cl-(mmol/L) | 99.8 ± 2.0 | 98.8 ± 2.2 | 0.06 |
mMRC Grade 0 | 10 (20.8 %) | 5 (22.7 %) | 0.88 |
mMRC Grade 1 | 15 (31.2 %) | 6 (27.3 %) | 0.80 |
mMRC Grade 2 | 12 (25 %) | 5 (22.7 %) | 0.87 |
mMRC Grade 3 | 8 (16.7 %) | 4 (18.2 %) | 0.89 |
mMRC Grade 4 | 3 (6.3 %) | 2 (9.1 %) | 0.69 |
Comparison of general Holter recordings characteristics between the VT and non-VT groups
Variable | Non-VT group (n = 48) | VT group (n = 22) | P |
---|---|---|---|
Average heart rate (beats/min) | 79.5 ± 13.8 | 81.2 ± 15.8 | 0.83 |
Minimal heart rate (beats/min) | 70.5 ± 13.6 | 73.8 ± 15.3 | 0.86 |
Maximal heart rate (beats/min) | 90.1 ± 16.4 | 94.8 ± 17.2 | 0.86 |
Mean ventricular premature beats | 1257.3 ± 251.7 | 1326.2 ± 268.5 | 0.83 |
Ventricular premature complexes ≥ 30/h | 19 (39.6 %) | 9 (40.9 %) | 0.92 |
Non-sustained VT | 0 | 20 | |
Sustained VT | 0 | 2 |
Comparison of DC, AC and HRV parameters between the VT and non-VT groups
Variable | Non-VT group (n = 48) | VT group (n = 22) |
P
|
---|---|---|---|
DC (ms) | 5.62 ± 1.75 | 4.13 ± 1.72 | 0.036 |
AC (ms) | -5.82 ± 1.84 | -4.76 ± 1.69 | 0.040 |
SDNN (ms) | 78.7 ± 22.1 | 68.2 ± 19.8 | 0.041 |
SDANN (ms) | 68.7 ± 11.0 | 58.5 ± 10.5 | 0.043 |
rMSSD (ms) | 21.3 ± 8.2 | 14.6 ± 6.2 | 0.045 |
LF (ms2) | 1152.2 ± 440.5 | 1250.2 ± 408.6 | 0.068 |
HF (ms2) | 221.5 ± 34.1 | 210.8 ± 27.6 | 0.071 |
LF/HF ratio | 5.1 ± 2.0 | 5.9 ± 2.5 | 0.070 |
Correlations of DC and AC with HRV parameters in the VT group
Variable | DC | AC | ||
---|---|---|---|---|
r
|
P
|
r
|
P
| |
SDNN (ms) | 0.716 | <0.001 | -0.682 | <0.001 |
SDANN (ms) | 0.595 | 0.005 | -0.567 | 0.006 |
rMSSD (ms) | 0.571 | 0.007 | -0.548 | 0.008 |
LF (ms2) | -0.518 | 0.038 | 0.413 | 0.057 |
HF (ms2) | 0.486 | 0.043 | -0.398 | 0.062 |
LF/HF ratio | -0.458 | 0.041 | 0.387 | 0.060 |