Recent advances in percutaneous techniques have allowed them to emerge as an attractive alternative to surgery in select patients. Left atrial appendage closure has emerged as a novel therapeutic option in patients an nonvalvular atrial fibrillation who cannot take anticoagulation therapy. Furthermore, percutaneous mitral valve procedures have shown promising results in high risk patients. These percutaneous procedures require multimodality imaging for preprocedural planning and during the procedure. Computed tomography has emerged as an attractive imaging modality prior to percutaneous procedures given its ability to perform comprehensive assessment of cardiac and extracardiac structures. This review assesses the role of computed tomography as it pertains to left atrial appendage occlusion and mitral valve transcatheter procedures.