Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende Patientenratgeber
Erweiterte Suche
Anmelden
nach oben
Inflammopharmacology
Erschienen in:

23.11.2021 | Review

Cardiac inflammation and fibrosis following chemo/radiation therapy: mechanisms and therapeutic agents

verfasst von: Run Yang, Changming Tan, Masoud Najafi

Erschienen in: Inflammopharmacology | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

The incidence of cardiovascular disorders is one of the most concerns among people who underwent cancer therapy. The heart side effects of cancer therapy may occur during treatment to some years after the end of treatment. Some epidemiological studies confirm that heart diseases are one of the most common reasons for mortality among patients that were received treatment for cancer. Experimental studies and also clinical investigations indicate that inflammatory changes such as pericarditis, myocarditis, and also fibrosis are key mechanisms of cardiac diseases following chemotherapy/radiotherapy. It seems that chronic oxidative stress, massive cell death, and chronic overproduction of pro-inflammatory and pro-fibrosis cytokines are the key mechanisms of cardiovascular diseases following cancer therapy. Furthermore, infiltration of inflammatory cells and upregulation of some enzymes such as NADPH Oxidases are a hallmark of heart diseases after cancer therapy. In the current review, we aim to explain how radiation or chemotherapy can induce inflammatory and fibrosis-related diseases in the heart. We will explain the cellular and molecular mechanisms of cardiac inflammation and fibrosis following chemo/radiation therapy, and then review some adjuvants to reduce the risk of inflammation and fibrosis in the heart.
Literatur
Aisenberg AC (1999) Problems in Hodgkin’s disease management. Blood 93(3):761–779PubMed
Alanazi AM, Fadda L, Alhusaini A, Ahmad R, Hasan IH, Mahmoud AM (2020) Liposomal resveratrol and/or carvedilol attenuate doxorubicin-induced cardiotoxicity by modulating inflammation, oxidative stress and S100A1 in rats. Antioxidants 9(2):159PubMedCentral
Alhazzani K, Alotaibi MR, Alotaibi FN, Aljerian K, As Sobeai HM, Alhoshani AR, Alanazi AZ, Alanazi WA, Alswayyed M (2021) Protective effect of valsartan against doxorubicin-induced cardiotoxicity: histopathology and metabolomics in vivo study. J Biochem Mol Toxicol 35(9):22842
Armenian SH, Armstrong GT, Aune G, Chow EJ, Ehrhardt MJ, Ky B, Moslehi J, Mulrooney DA, Nathan PC, Ryan TD, van der Pal HJ, van Dalen EC, Kremer LCM (2018) Cardiovascular disease in survivors of childhood cancer: insights into epidemiology, pathophysiology, and prevention. J Clin Oncol 36(21):2135–2144PubMedPubMedCentral
Arunachalam S, Nagoor Meeran MF, Azimullah S, Sharma C, Goyal SN, Ojha S (2021) Nerolidol attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/MAPK signaling pathways in doxorubicin-induced acute cardiotoxicity in rats. Antioxidants 10(6):984PubMedPubMedCentral
Aryafar T, Amini P, Rezapoor S, Shabeeb D, Eleojo Musa A, Najafi M, Shirazi A (2020) Modulation of radiation-induced NADPH oxidases in rat’s heart tissues by melatonin. J Biomed Phys Eng 11(4):465–472
Bache Robert J, Chen Y (2014) NOX2-induced myocardial fibrosis and diastolic dysfunction. J Am Coll Cardiol 63(24):2742–2744PubMed
Basavaraju SR, Easterly CE (2002) Pathophysiological effects of radiation on atherosclerosis development and progression, and the incidence of cardiovascular complications. Med Phys 29(10):2391–2403PubMed
Baselet B, Sonveaux P, Baatout S, Aerts A (2019) Pathological effects of ionizing radiation: endothelial activation and dysfunction. Cell Mol Life Sci 76(4):699–728PubMed
Borthwick LA (2016) The IL-1 cytokine family and its role in inflammation and fibrosis in the lung. Semin Immunopathol 38(4):517–534PubMedPubMedCentral
Bouillon K, Haddy N, Delaloge S, Garbay J-R, Garsi J-P, Brindel P, Mousannif A, Lê MG, Labbe M, Arriagada R (2011) Long-term cardiovascular mortality after radiotherapy for breast cancer. J Am Coll Cardiol 57(4):445–452PubMed
Bradshaw PT, Stevens J, Khankari N, Teitelbaum SL, Neugut AI, Gammon MD (2016) Cardiovascular disease mortality among breast cancer survivors. Epidemiology 27(1):6–13PubMedPubMedCentral
Cappetta D, Esposito G, Piegari E, Russo R, Ciuffreda LP, Rivellino A, Berrino L, Rossi F, De Angelis A, Urbanek K (2016) SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy. Int J Cardiol 205:99–110PubMed
Cervelli T, Panetta D, Navarra T, Andreassi MG, Basta G, Galli A, Salvadori PA, Picano E, Del Turco S (2014) Effects of single and fractionated low-dose irradiation on vascular endothelial cells. Atherosclerosis 235(2):510–518PubMed
Chang SH, Lee KJ, Koo H (2004) The radioprotective effect and mechanism of captopril on radiation induced-heart damage in rats. Radiat Oncol J 22(1):40–54
Chang A, Nasti TH, Khan MK, Parashar S, Kaufman JL, Boise LH, Lonial S, Ahmed R, Nooka AK (2018) Myocarditis with radiotherapy and immunotherapy in multiple myeloma. J Oncol Pract 14(9):561–564PubMed
Chen L, Yan K-P, Liu X-C, Wang W, Li C, Li M, Qiu C-G (2018) Valsartan regulates TGF-β/Smads and TGF-β/p38 pathways through lncRNA CHRF to improve doxorubicin-induced heart failure. Arch Pharmacal Res 41(1):101–109
Cheng D, Chen L, Tu W, Wang H, Wang Q, Meng L, Li Z, Yu Q (2020) Protective effects of valsartan administration on doxorubicin-induced myocardial injury in rats and the role of oxidative stress and NOX2/NOX4 signaling. Mol Med Rep 22(5):4151–4162PubMedPubMedCentral
Chera BS, Rodriguez C, Morris CG, Louis D, Yeung D, Li Z, Mendenhall NP (2009) Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkin’s lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy. Int J Radiat Oncol Biol Phys 75(4):1173–1180PubMed
Chiabrando JG, Bonaventura A, Vecchié A, Wohlford GF, Mauro AG, Jordan JH, Grizzard JD, Montecucco F, Berrocal DH, Brucato A, Imazio M, Abbate A (2020) Management of acute and recurrent pericarditis: JACC state-of-the-art review. J Am Coll Cardiol 75(1):76–92PubMed
Cho BJ, Feld R, Leighl N, Opitz I, Anraku M, Tsao M-S, Hwang DM, Hope A, de Perrot M (2014) A feasibility study evaluating Surgery for Mesothelioma After Radiation Therapy: the “SMART” approach for resectable malignant pleural mesothelioma. J Thorac Oncol 9(3):397–402PubMed
Choi SH, Kim M, Lee HJ, Kim EH, Kim CH, Lee YJ (2016) Effects of NOX1 on fibroblastic changes of endothelial cells in radiation-induced pulmonary fibrosis. Mol Med Rep 13(5):4135–4142PubMedPubMedCentral
Christidi E, Brunham LR (2021) Regulated cell death pathways in doxorubicin-induced cardiotoxicity. Cell Death Dis 12(4):339PubMedPubMedCentral
Cinamon G, Grabovsky V, Winter E, Franitza S, Feigelson S, Shamri R, Dwir O, Alon R (2001) Novel chemokine functions in lymphocyte migration through vascular endothelium under shear flow. J Leukoc Biol 69(6):860–866PubMed
Collins-Underwood JR, Zhao W, Sharpe JG, Robbins ME (2008) NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. Free Radical Biol Med 45(6):929–938
Conklin KA (2000) Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutr Cancer 37:1–18PubMed
Conklin KA (2005) Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity. Integr Cancer Ther 4(2):110–130PubMed
Cui Q, Wang J-Q, Assaraf YG, Ren L, Gupta P, Wei L, Ashby CR Jr, Yang D-H, Chen Z-S (2018) Modulating ROS to overcome multidrug resistance in cancer. Drug Resist Updates 41:1–25
da Silva RMFL (2019) Effects of radiotherapy in coronary artery disease. Curr Atheroscler Rep 21(12):1–8
De Ruysscher D, Faivre-Finn C, Nackaerts K, Jordan K, Arends J, Douillard J-Y, Ricardi U, Peters S (2020) Recommendation for supportive care in patients receiving concurrent chemotherapy and radiotherapy for lung cancer. Ann Oncol 31(1):41–49PubMed
Dhesi S, Chu MP, Blevins G, Paterson I, Larratt L, Oudit GY, Kim DH (2013) Cyclophosphamide-induced cardiomyopathy: a case report, review, and recommendations for management. J Investig Med High Impact Case Rep 1(1):2324709613480346–2324709613480346PubMedPubMedCentral
Dorn GW 2nd (2009) Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling. Cardiovasc Res 81(3):465–473PubMed
Fan Z, Han Y, Ye Y, Liu C, Cai H (2017) l-carnitine preserves cardiac function by activating p38 MAPK/Nrf2 signalling in hearts exposed to irradiation. Eur J Pharmacol 804:7–12PubMed
Farhood B, Aliasgharzadeh A, Amini P, Saffar H, Motevaseli E, Rezapoor S, Nouruzi F, Shabeeb D, Musa AE, Ashabi G, Mohseni M, Moradi H, Najafi M (2019a) Radiation-induced dual oxidase upregulation in rat heart tissues: protective effect of melatonin. Medicina (lithuania) 55(7):317
Farhood B, Goradel NH, Mortezaee K, Khanlarkhani N, Salehi E, Nashtaei MS, Shabeeb D, Musa AE, Fallah H, Najafi M (2019b) Intercellular communications-redox interactions in radiation toxicity; potential targets for radiation mitigation. J Cell Commun Signal 13(1):3–16PubMed
Farhood B, Ashrafizadeh M, Khodamoradi E, Hoseini-Ghahfarokhi M, Afrashi S, Musa AE, Najafi M (2020a) Targeting of cellular redox metabolism for mitigation of radiation injury. Life Sci 250:117570PubMed
Farhood B, Hoseini-Ghahfarokhi M, Motevaseli E, Mirtavoos-Mahyari H, Musa AE, Najafi M (2020b) TGF-β in radiotherapy: mechanisms of tumor resistance and normal tissues injury. Pharmacol Res 155:104745PubMed
Frey MK, Arfsten H, Pavo N, Han E, Kastl S, Hülsmann M, Gyöngyösi M, Bergler-Klein J (2021) Sacubitril/valsartan is well tolerated in patients with longstanding heart failure and history of cancer and improves ventricular function: real-world data. Cardio-Oncology 7(1):35PubMedPubMedCentral
Fu X, Tang J, Wen P, Huang Z, Najafi M (2021) Redox interactions-induced cardiac toxicity in cancer therapy. Arch Biochem Biophys 708:108952PubMed
Fubini B, Hubbard A (2003) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radical Biol Med 34(12):1507–1516
Fung C, Fossa SD, Milano MT, Sahasrabudhe DM, Peterson DR, Travis LB (2015) Cardiovascular disease mortality after chemotherapy or surgery for testicular nonseminoma: a population-based study. J Clin Oncol 33(28):3105–3115PubMedPubMedCentral
Gibb AA, Lazaropoulos MP, Elrod JW (2020) Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation. Circ Res 127(3):427–447PubMedPubMedCentral
González A, Schelbert EB, Díez J, Butler J (2018) Myocardial interstitial fibrosis in heart failure: biological and translational perspectives. J Am Coll Cardiol 71(15):1696–1706PubMed
Group EBCTC (2000) Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet 355(9217):1757–1770
Hatch M, Cardis E (2017) Somatic health effects of chernobyl: 30 years on. Eur J Epidemiol 32(12):1047–1054PubMed
Haubner F, Ohmann E, Pohl F, Prantl L, Strutz J, Gassner HG (2013) Effects of radiation on the expression of adhesion molecules and cytokines in a static model of human dermal microvascular endothelial cells. Clin Hemorheol Microcirc 54(4):371–379PubMed
He H, Luo Y, Qiao Y, Zhang Z, Yin D, Yao J, You J, He M (2018) Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ. Food Funct 9(8):4404–4418PubMed
Huang S, Che J, Chu Q, Zhang P (2020) The role of NLRP3 inflammasome in radiation-induced cardiovascular injury. Front Cell Develop Biol 8:140
Iborra-Egea O, Gálvez-Montón C, Roura S, Perea-Gil I, Prat-Vidal C, Soler-Botija C, Bayes-Genis A (2017) Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach. NPJ Syst Biol Appl 3:12–12PubMedPubMedCentral
Ibrahim MA, Ashour OM, Ibrahim YF, El-Bitar HI, Gomaa W, Abdel-Rahim SR (2009) Angiotensin-converting enzyme inhibition and angiotensin AT(1)-receptor antagonism equally improve doxorubicin-induced cardiotoxicity and nephrotoxicity. Pharmacol Res 60(5):373–381PubMed
Imaizumi M, Furukawa K, Ohishi W, Hida A (2018) Thyroid diseases among atomic bomb survivors. Radiat Prot Dosimetry 182(1):62–66PubMed
Imanaka-Yoshida K (2020) Inflammation in myocardial disease: from myocarditis to dilated cardiomyopathy. Pathol Int 70(1):1–11PubMed
Jia L-X, Qi G-M, Liu O, Li T-T, Yang M, Cui W, Zhang W-M, Qi Y-F, Du J (2013) Inhibition of platelet activation by clopidogrel prevents hypertension-induced cardiac inflammation and fibrosis. Cardiovasc Drugs Ther 27(6):521–530PubMedPubMedCentral
Katamura M, Iwai-Kanai E, Nakaoka M, Okawa Y, Ariyoshi M, Mita Y, Nakamura A, Ikeda K, Ogata T, Ueyama T (2014) Curcumin attenuates doxorubicin-induced cardiotoxicity by inducing autophagy via the regulation of JNK phosphorylation. J Clin Exp Cardiolog 5(09):1–8
Kelly DJ, Cox AJ, Gow RM, Zhang Y, Kemp BE, Gilbert RE (2004) Platelet-derived growth factor receptor transactivation mediates the trophic effects of angiotensin II in vivo. Hypertension 44(2):195–202PubMed
Khaled S, Gupta KB, Kucik DF (2012) Ionizing radiation increases adhesiveness of human aortic endothelial cells via a chemokine-dependent mechanism. Radiat Res 177(5):594–601PubMed
Khan R, Sheppard R (2006) Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 118(1):10–24PubMedPubMedCentral
Khodamoradi E, Hoseini-Ghahfarokhi M, Amini P, Motevaseli E, Shabeeb D, Musa AE, Najafi M, Farhood B (2020) Targets for protection and mitigation of radiation injury. Cell Mol Life Sci 77(16):3129–3159PubMed
Kim Y-J, Ko H, Park J-S, Han I-H, Amor EC, Lee JW, Yang HO (2010) Dimethyl cardamonin inhibits lipopolysaccharide-induced inflammatory factors through blocking NF-κB p65 activation. Int Immunopharmacol 10(9):1127–1134PubMed
Kim M, Choi SH, Jin YB, Lee HJ, Ji YH, Kim J, Lee YS, Lee YJ (2013) The effect of oxidized low-density lipoprotein (ox-LDL) on radiation-induced endothelial-to-mesenchymal transition. Int J Radiat Biol 89(5):356–363PubMed
Kingery JR, Hamid T, Lewis RK, Ismahil MA, Bansal SS, Rokosh G, Townes TM, Ildstad ST, Jones SP, Prabhu SD (2017) Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure. Basic Res Cardiol 112(2):19PubMedPubMedCentral
Kolivand S, Amini P, Saffar H, Rezapoor S, Motevaseli E, Najafi M, Nouruzi F, Shabeeb D, Musa AE (2019) Evaluating the radioprotective effect of curcumin on rat’s heart tissues. Curr Radiopharm 12(1):23–28PubMed
Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH (2019) Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review. J Am Coll Cardiol 73(2):190–209PubMedPubMedCentral
Lavine KJ, Pinto AR, Epelman S, Kopecky BJ, Clemente-Casares X, Godwin J, Rosenthal N, Kovacic JC (2018) The macrophage in cardiac homeostasis and disease: JACC macrophage in CVD series (part 4). J Am Coll Cardiol 72(18):2213–2230PubMedPubMedCentral
Lee Y, Gustafsson AB (2009) Role of apoptosis in cardiovascular disease. Apoptosis 14(4):536–548PubMed
Lin J, Fang L, Li H, Li Z, Lyu L, Wang H, Xiao J (2019) Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress. Eur J Pharmacol 859:172490PubMed
Lipshultz SE, Rifai N, Dalton VM, Levy DE, Silverman LB, Lipsitz SR, Colan SD, Asselin BL, Barr RD, Clavell LA, Hurwitz CA, Moghrabi A, Samson Y, Schorin MA, Gelber RD, Sallan SE (2004) The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med 351(2):145–153PubMed
Little MP, Azizova TV, Hamada N (2021) Low-and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology. Int J Radiat Biol 97(6):782–803PubMed
Liu G, Liu Y, Wang R, Hou T, Chen C, Zheng S, Dong Z (2016) Spironolactone attenuates doxorubicin-induced cardiotoxicity in rats. Cardiovasc Ther 34(4):216–224PubMed
Liu LK, Ouyang W, Zhao X, Su SF, Yang Y, Ding WJ, Luo DX, He ZX, Lu B (2017) Pathogenesis and prevention of radiation-induced myocardial fibrosis. Asian Pac J Cancer Prev 18(3):583PubMedPubMedCentral
Ma ZG, Yuan YP, Wu HM, Zhang X, Tang QZ (2018) Cardiac fibrosis: new insights into the pathogenesis. Int J Biol Sci 14(12):1645–1657PubMedPubMedCentral
Ma Z-G, Kong C-Y, Wu H-M, Song P, Zhang X, Yuan Y-P, Deng W, Tang Q-Z (2020a) Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice. Theranostics 10(24):11013–11025PubMedPubMedCentral
Ma Z, Xu L, Liu D, Zhang X, Di S, Li W, Zhang J, Reiter RJ, Han J, Li X (2020b) Utilizing melatonin to alleviate side effects of chemotherapy: a potentially good partner for treating cancer with ageing. Oxid Med Cell Longev 2020:1
Mancilla TR, Iskra B, Aune GJ (2019) Doxorubicin-induced cardiomyopathy in children. comprehensive. Physiology 9(3):905
Marinko T (2019) Pericardial disease after breast cancer radiotherapy. Radiol Oncol 53(1):1
Martín-Garcia A, López-Fernández T, Mitroi C, Chaparro-Muñoz M, Moliner P, Martin-Garcia AC, Martinez-Monzonis A, Castro A, Lopez-Sendon JL, Sanchez PL (2020) Effectiveness of sacubitril–valsartan in cancer patients with heart failure. ESC Heart Fail 7(2):763–767PubMedPubMedCentral
Mauch P, Kalish L, Marcus K, Shulman L, Krill E, Tarbell N, Silver B, Weinstein H, Come S, Canellos G (1995) Long-term survival in Hodgkin’s disease relative impact of mortality, second tumors, infection, and cardiovascular disease. Cancer J Sci Am 1(1):33–42PubMed
Medhora M, Gao F, Jacobs ER, Moulder JE (2012) Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors. Respirology (carlton, Vic) 17(1):66–71
Meng L, Lin H, Zhang J, Lin N, Sun Z, Gao F, Luo H, Ni T, Luo W, Chi J (2019) Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3. J Mol Cell Cardiol 136:15–26PubMed
Miles A, Liaskou E, Eksteen B, Lalor PF, Adams DH (2008) CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Am J Physiol Gastrointest Liver Physiol 294(5):G1257-1267PubMed
Milgrom-Hoffman M, Harrelson Z, Ferrara N, Zelzer E, Evans SM, Tzahor E (2011) The heart endocardium is derived from vascular endothelial progenitors. Development (cambridge, England) 138(21):4777–4787
Min SS, Wierzbicki AS (2017) Radiotherapy, chemotherapy and atherosclerosis. Curr Opin Cardiol 32(4):441–447PubMed
Mortezaee K, Goradel NH, Amini P, Shabeeb D, Musa AE, Najafi M, Farhood B (2019a) NADPH oxidase as a target for modulation of radiation response; implications to carcinogenesis and radiotherapy. Curr Mol Pharmacol 12(1):50–60PubMed
Mortezaee K, Najafi M, Farhood B, Ahmadi A, Shabeeb D, Musa AE (2019b) NF-κB targeting for overcoming tumor resistance and normal tissues toxicity. J Cell Physiol 234(10):17187–17204PubMed
Mortezaee K, Shabeeb D, Musa AE, Najafi M, Farhood B (2019c) Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization. Curr Clin Pharmacol 14(1):41–53PubMed
Mukhopadhyay P, Rajesh M, Bátkai S, Kashiwaya Y, Hasko G, Liaudet L, Szabó C, Pacher P (2009a) Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am J Physiol-Heart Circ Physiol 296(5):H1466–H1483PubMedPubMedCentral
Mukhopadhyay P, Rajesh M, Bátkai S, Kashiwaya Y, Haskó G, Liaudet L, Szabó C, Pacher P (2009b) Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am J Physiol Heart Circ Physiol 296(5):H1466-1483PubMedPubMedCentral
Nabavi SM, Nabavi SF, Sureda A, Xiao J, Dehpour AR, Shirooie S, Silva AS, Baldi A, Khan H, Daglia M (2019) Anti-inflammatory effects of melatonin: a mechanistic review. Crit Rev Food Sci Nutr 59(sup1):S4–S16PubMed
Najafi M, Cheki M, Amini P, Javadi A, Shabeeb D, Eleojo MA (2019) Evaluating the protective effect of resveratrol, Q10, and alpha-lipoic acid on radiation-induced mice spermatogenesis injury: a histopathological study. Int J Reprod Biomed 17(12):907–914PubMedPubMedCentral
Najafi M, Shayesteh MRH, Mortezaee K, Farhood B, Haghi-Aminjan H (2020) The role of melatonin on doxorubicin-induced cardiotoxicity: a systematic review. Life Sci 241:117173PubMed
Nakayama H, Otsu K (2018) Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases. Biochem J 475(5):839–852PubMed
Olaussen KA, Dunant A, Fouret P, Brambilla E, André F, Haddad V, Taranchon E, Filipits M, Pirker R, Popper HH (2006) DNA repair by ERCC1 in non–small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med 355(10):983–991PubMed
Ongnok B, Chattipakorn N, Chattipakorn SC (2020) Doxorubicin and cisplatin induced cognitive impairment: the possible mechanisms and interventions. Exp Neurol 324:113118PubMed
Ostovaneh MR, Ambale-Venkatesh B, Fuji T, Bakhshi H, Shah R, Murthy VL, Tracy RP, Guallar E, Wu CO, Bluemke DA (2018) Association of liver fibrosis with cardiovascular diseases in the general population: the multi-ethnic study of atherosclerosis (MESA). Circulation 11(3):e007241PubMed
Palmai-Pallag T, Bachrati CZ (2014) Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle. Microbes Infect 16(10):822–832PubMed
Pao T-H, Chang W-L, Chiang N-J, Lin C-Y, Lai W-W, Tseng Y-L, Lin F-C (2020) Pericardial effusion after definitive concurrent chemotherapy and intensity modulated radiotherapy for esophageal cancer. Radiat Oncol 15(1):1–10
Parajuli N, Patel VB, Wang W, Basu R, Oudit GY (2014) Loss of NOX2 (gp91phox) prevents oxidative stress and progression to advanced heart failure. Clin Sci (london, England: 1979) 127(5):331–340
Parichatikanond W, Luangmonkong T, Mangmool S, Kurose H (2020) Therapeutic targets for the treatment of cardiac fibrosis and cancer: focusing on TGF-β signaling. Front Cardiovasc Med 7:34PubMedPubMedCentral
Paszat LF, Mackillop WJ, Groome PA, Boyd C, Schulze K, Holowaty E (1998) Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries. J Clin Oncol 16(8):2625–2631PubMed
Peretto G, Sala S, Rizzo S, De Luca G, Campochiaro C, Sartorelli S, Benedetti G, Palmisano A, Esposito A, Tresoldi M (2019) Arrhythmias in myocarditis: state of the art. Heart Rhythm 16(5):793–801PubMed
Piccioli P, Rubartelli A (2013) The secretion of IL-1β and options for release. Semin Immunol 25(6):425–429PubMed
Ping Z, Peng Y, Lang H, Xinyong C, Zhiyi Z, Xiaocheng W, Hong Z, Liang S (2020) Oxidative stress in radiation-induced cardiotoxicity. Oxid Med Cell Longev 2020:3579143PubMedPubMedCentral
Pinsky DJ, Aji W, Szabolcs M, Athan ES, Liu Y, Yang YM, Kline RP, Olson KE, Cannon PJ (1999) Nitric oxide triggers programmed cell death (apoptosis) of adult rat ventricular myocytes in culture. Am J Physiol-Heart Circ Physiol 277(3):H1189–H1199
Piroth MD, Baumann R, Budach W, Dunst J, Feyer P, Fietkau R, Haase W, Harms W, Hehr T, Krug D (2019) Heart toxicity from breast cancer radiotherapy. Strahlenther Onkol 195(1):1–12PubMed
Pohlers D, Brenmoehl J, Löffler I, Müller CK, Leipner C, Schultze-Mosgau S, Stallmach A, Kinne RW, Wolf G (2009) TGF-β and fibrosis in different organs—molecular pathway imprints. Biochimica Et Biophysica Acta (BBA) Mol Basis Dis 1792(8):746–756
Poznyak AV, Grechko AV, Orekhova VA, Khotina V, Ivanova EA, Orekhov AN (2020) NADPH oxidases and their role in atherosclerosis. Biomedicines 8(7):206PubMedCentral
Qi W, Boliang W, Xiaoxi T, Guoqiang F, Jianbo X, Gang W (2020) Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling. Biomed Pharmacother 122:109547PubMed
Ratosa I, Pantar MI (2019) Cardiotoxicity of mediastinal radiotherapy. Rep Pr Oncol Radiother 24(6):629–643
Rutqvist LE, Lax I, Fornander T, Johansson H (1992) Cardiovascular mortality in a randomized trial of adjuvant radiation therapy versus surgery alone in primary breast cancer. Int J Radiat Oncol Biol Phys 22(5):887–896PubMed
Safi M, Kanesvaran R, Alradhi M, Al-Danakh A, Ping F, Al-Sabai N, Shan X, Liu J (2020) Overall survival in heart disease–related death in non-small cell lung cancer patients: nonimmunotherapy versus immunotherapy era: population-based study. Front Oncol 10:1866
Sagar S, Liu PP, Cooper LT Jr (2012) Myocarditis. Lancet 379(9817):738–747PubMed
Saleh MA, Antar SA, Hazem RM, El-Azab MF (2020) Pirfenidone and vitamin D ameliorate cardiac fibrosis induced by doxorubicin in ehrlich ascites carcinoma bearing mice: modulation of monocyte chemoattractant protein-1 and Jun N-terminal kinase-1 pathways. Pharmaceuticals 13(11):348PubMedCentral
Schett G, Dayer J-M, Manger B (2016) Interleukin-1 function and role in rheumatic disease. Nat Rev Rheumatol 12(1):14–24PubMed
Schöllnberger H, Eidemüller M, Cullings HM, Simonetto C, Neff F, Kaiser JC (2018) Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors: 1950–2003. Radiat Environ Biophys 57(1):17–29PubMed
Shaty MH, Arif IS, Al-Ezzi MI, Hanna DB (2018) Metformin attenuate fibrosis in both acute and chronic doxorubicin cardiotoxicity in rabbits. J Pharm Sci Res 10(6):1559–1565
Shin H-J, Kwon H-K, Lee J-H, Gui X, Achek A, Kim J-H, Choi S (2015) Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53. Sci Rep 5(1):15798PubMedPubMedCentral
Siwik DA, Pagano PJ, Colucci WS (2001) Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am J Physiol Cell Physiol 280(1):C53-60PubMed
Spallarossa P, Altieri P, Garibaldi S, Ghigliotti G, Barisione C, Manca V, Fabbi P, Ballestrero A, Brunelli C, Barsotti A (2006) Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: the role of MAP kinases and NAD(P)H oxidase. Cardiovasc Res 69(3):736–745PubMed
Sparano JA (1999) Doxorubicin/taxane combinations: cardiac toxicity and pharmacokinetics. Semin Oncol 26(3 Suppl 9):14–19PubMed
Stewart FA, Seemann I, Hoving S, Russell NS (2013) Understanding radiation-induced cardiovascular damage and strategies for intervention. Clin Oncol (r Coll Radiol (great Br)) 25(10):617–624
Sugihara T, Hattori Y, Yamamoto Y, Qi F, Ichikawa R, Sato A, Liu MY, Abe K, Kanno M (1999) Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation. Circulation 100(6):635–641PubMed
Sun Z, Schriewer J, Tang M, Marlin J, Taylor F, Shohet RV, Konorev EA (2016) The TGF-β pathway mediates doxorubicin effects on cardiac endothelial cells. J Mol Cell Cardiol 90:129–138PubMed
Sun X, Chen G, Xie Y, Jiang D, Han J, Chen F, Song Y (2020) Qiliqiangxin improves cardiac function and attenuates cardiac remodelling in doxorubicin-induced heart failure rats. Pharm Biol 58(1):417–426PubMedPubMedCentral
Suzuki H, Wildhirt S, Dudek R, Narayan K, Bailey A, Bing R (1996) Induction of apoptosis in myocardial infarction and its possible relationship to nitric oxide synthase in macrophages. Tissue Cell 28(1):89–97PubMed
Swamy AV, Gulliaya S, Thippeswamy A, Koti BC, Manjula DV (2012) Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J Pharmacol 44(1):73PubMedPubMedCentral
Taunk NK, Haffty BG, Kostis JB, Goyal S (2015) Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol 5:39PubMedPubMedCentral
Thyagarajan A, Sahu RP (2018) Potential contributions of antioxidants to cancer therapy: immunomodulation and radiosensitization. Integr Cancer Ther 17(2):210–216PubMed
Tromp J, Boerman LM, Sama IE, Maass SW, Maduro JH, Hummel YM, Berger MY, de Bock GH, Gietema JA, Berendsen AJ (2020) Long-term survivors of early breast cancer treated with chemotherapy are characterized by a pro-inflammatory biomarker profile compared to matched controls. Eur J Heart Fail 22(7):1239–1246PubMed
Tsai T-H, Lin C-J, Hang C-L, Chen W-Y (2019) Calcitriol attenuates doxorubicin-induced cardiac dysfunction and inhibits endothelial-to-mesenchymal transition in mice. Cells 8(8):865PubMedCentral
van der Veen SJ, Ghobadi G, de Boer RA, Faber H, Cannon MV, Nagle PW, Brandenburg S, Langendijk JA, van Luijk P, Coppes RP (2015) ACE inhibition attenuates radiation-induced cardiopulmonary damage. Radiother Oncol 114(1):96–103PubMed
Van Linthout S, Tschöpe C (2017) Inflammation–cause or consequence of heart failure or both? Curr Heart Fail Rep 14(4):251–265PubMedPubMedCentral
Wang Y, Liu Q, Zhao W, Zhou X, Miao G, Sun C, Zhang H (2017) NADPH oxidase activation contributes to heavy ion irradiation-induced cell death. Dose-Response 15(1):1559325817699697PubMedPubMedCentral
Wang B, Wang H, Zhang M, Ji R, Wei J, Xin Y, Jiang X (2020a) Radiation-induced myocardial fibrosis: mechanisms underlying its pathogenesis and therapeutic strategies. J Cell Mol Med 24(14):7717–7729PubMedPubMedCentral
Wang X, Wang Q, Li W, Zhang Q, Jiang Y, Guo D, Sun X, Lu W, Li C, Wang Y (2020b) TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of dihydrotanshinone I in doxorubicin-induced cardiotoxicity. J Exp Clin Cancer Res 39(1):93PubMedPubMedCentral
Weberpals J, Jansen L, Müller OJ, Brenner H (2018) Long-term heart-specific mortality among 347 476 breast cancer patients treated with radiotherapy or chemotherapy: a registry-based cohort study. Eur Heart J 39(43):3896–3903PubMed
Weidig P, McMaster D, Bayraktutan U (2004) High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells. Diabetes Obes Metab 6(6):432–441PubMed
West AP, Shadel GS (2017) Mitochondrial DNA in innate immune responses and inflammatory pathology. Nat Rev Immunol 17(6):363–375PubMedPubMedCentral
Wong FL, Yamada M, Sasaki H, Kodama K, Hosoda Y (1999) Effects of radiation on the longitudinal trends of total serum cholesterol levels in the atomic bomb survivors. Radiat Res 151(6):736–746PubMed
Wortel RC, Mizrachi A, Li H, Markovsky E, Enyedi B, Jacobi J, Brodsky O, Cao J, Lippert AR, Incrocci L, Mulhall JP, Haimovitz-Friedman A (2019) Sildenafil protects endothelial cells from radiation-induced oxidative stress. J Sex Med 16(11):1721–1733PubMedPubMedCentral
Wu C, Lin D, Ma F, Jiang F, Wang Y (2021) New progress in elucidating the relationship between cancer therapy and cardiovascular toxicity. BioSci Trends 15(4):211–218PubMed
Yahyapour R, Amini P, Saffar H, Rezapoor S, Motevaseli E, Cheki M, Farhood B, Nouruzi F, Shabeeb D, Musa AE (2018a) Metformin protects against radiation-induced heart injury and attenuates the upregulation of dual oxidase genes following rat’s chest irradiation. Int J Mol Cell Med 7(3):193PubMedPubMedCentral
Yahyapour R, Shabeeb D, Cheki M, Musa AE, Farhood B, Rezaeyan A, Amini P, Fallah H, Najafi M (2018b) Radiation protection and mitigation by natural antioxidants and flavonoids: Implications to radiotherapy and radiation disasters. Curr Mol Pharmacol 11(4):285–304PubMed
Yarom R, Harper IS, Wynchank S, van Schalkwyk D, Madhoo J, Williams K, Salie R, Genade S, Lochner A (1993) Effect of captopril on changes in rats’ hearts induced by long-term irradiation. Radiat Res 133(2):187–197PubMed
Yu W, Qin X, Zhang Y, Qiu P, Wang L, Zha W, Ren J (2020) Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner. Cardiovasc Diagn Ther 10(4):752PubMedPubMedCentral
Yun S-M, Kim S-H, Kim E-H (2019) The molecular mechanism of transforming growth factor-β signaling for intestinal fibrosis: a mini-review. Front Pharmacol 10:162–162PubMedPubMedCentral
Zeng C, Duan F, Hu J, Luo B, Huang B, Lou X, Sun X, Li H, Zhang X, Yin S, Tan H (2020) NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy. Redox Biol 34:101523–101523PubMedPubMedCentral
Zhang J, Lei W, Chen X, Wang S, Qian W (2018) Oxidative stress response induced by chemotherapy in leukemia treatment. Mol Clin Oncol 8(3):391–399PubMedPubMedCentral
Zhao Y, McLaughlin D, Robinson E, Harvey AP, Hookham MB, Shah AM, McDermott BJ, Grieve DJ (2010) Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with doxorubicin chemotherapy. Can Res 70(22):9287–9297
Zorc-Pleskovic R, Alibegović A, Zorc M, Milutinović A, Radovanović N, Petrović D (2006) Apoptosis of cardiomyocytes in myocarditis. Folia Biol 52(1–2):6–9
Metadaten
Titel
Cardiac inflammation and fibrosis following chemo/radiation therapy: mechanisms and therapeutic agents
verfasst von
Run Yang
Changming Tan
Masoud Najafi
Publikationsdatum
23.11.2021
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology / Ausgabe 1/2022
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-021-00894-9

Weitere Artikel der Ausgabe 1/2022

NSAIDs and Kelleni’s protocol as potential early COVID-19 treatment game changer: could it be the final countdown?

Anti-inflammatory potential of cannabidiol (CBD) on combination of caecal slurry, LPS, and E. coli-induced systemic inflammatory response syndrome (SIRS) in Sprague Dawley Rats

  • Original Article

Protective effect of methyl gallate on murine antigen-induced arthritis by inhibiting inflammatory process and bone erosion

  • Original Article

Can we predict unresponsiveness to methotrexate in rheumatoid arthritis? A pharmacogenetic study

  • Original Article

Therapeutic benefits of flavonoids against neuroinflammation: a systematic review

  • Review

Covid-19: pharmacotherapeutic insights on various curative approaches in terms of vulnerability, comorbidities, and vaccination