A 61-year-old man with clear cell renal cell carcinoma with multiorgan metastases treated with axitinib-pembrolizumab presented for follow-up. Restaging computed tomography (CT) with contrast showed disease progression to multiple organs, including new-onset cardiac metastases (Fig. 1). The patient reported no cardiac-related symptoms, although a transthoracic echocardiogram performed 1 month earlier had shown a pericardial effusion without cardiac metastases. Through shared decision-making, the patient opted to continue immunotherapy but died 1 month later secondary to complications of bowel perforation and brain metastases.
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