Skip to main content
Erschienen in: BMC Cancer 1/2017

Open Access 01.12.2017 | Case report

Cardiac metastasis from colon cancer effectively treated with 5-fluorouracil, leucovorin, and oxaliplatin (modified FOLFOX6) plus panitumumab: a case report

verfasst von: Yoshiki Tsujii, Yoshito Hayashi, Akira Maekawa, Tetsuji Fujinaga, Kengo Nagai, Shunsuke Yoshii, Akihiko Sakatani, Satoshi Hiyama, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara

Erschienen in: BMC Cancer | Ausgabe 1/2017

Abstract

Background

Cardiac metastasis from colorectal cancer is rare. There is little evidence supporting the effectiveness of chemotherapy, and standard therapy for metastatic cardiac tumors has not been established.

Case presentation

A 76-year-old woman presented with a right ventricle tumor that was detected incidentally on screening cardiac ultrasonography. The initial computed tomography (CT) scan showed the cardiac tumor, which was approximately 40 mm in size, and multiple pulmonary nodules. Serum levels of tumor markers CEA and CA19-9 were elevated aberrantly. The suspected primary tumor, a well-differentiated adenocarcinoma of the transverse colon with wild-type KRAS was found by colonoscopy, and treatment with 5-fluorouracil, leucovorin, and oxaliplatin (modified FOLFOX6) plus panitumumab was initiated. After 4 courses of the therapy, a CT scan showed that the cardiac tumor size had markedly decreased and the pulmonary nodules had diminished. The serum levels of CEA and CA19-9 were also markedly decreased. After 12 courses of chemotherapy during 10 months of treatment, the patient continued to show a partial response, and she remained asymptomatic with continuation of the treatment through 15 courses.

Conclusion

To the best of our knowledge, this is the first report of the efficacy of combination therapy using cytotoxic and molecular targeted agents against cardiac metastasis from colon cancer.
Abkürzungen
CRC
Colorectal cancer
CT
Computed tomography
EGFR
Epidermal growth factor receptor
MRI
Magnetic resonance imaging
PET-CT
Positron emission tomography-computed tomography

Background

Colorectal cancer (CRC) is one of the three most commonly diagnosed malignancies worldwide, and it is a leading cause of death due to cancer [1]. The common sites of metastases from CRC are the lymph nodes, liver, and lungs. Autopsy studies have shown that the incidence of cardiac metastasis from CRC is 1.4 to 7.2% [24]. To date, however, only 12 cases of cardiac metastases from CRC have been reported in the English literature [57]. The prognosis for patients with metastatic cardiac tumors is poor, and chemotherapy alone against cardiac metastasis from CRC has rarely been effective [8]. Recently, anti-epidermal growth factor receptor (EGFR) monoclonal antibodies such as cetuximab or panitumumab have provided clinical benefit in patients with KRAS wild-type CRC [9, 10]. We herein present a case of cardiac metastasis from CRC that showed an appreciable response to combination therapy with oxaliplatin-based chemotherapy and panitumumab.

Case presentation

A 76-year-old woman who was incidentally diagnosed with a tumor of the right ventricle by screening cardiac ultrasonography was referred to our hospital for further examination. Chest computed tomography (CT) showed the cardiac tumor, which was approximately 40 mm in size (Fig. 1a), and multiple pulmonary nodules. The patient had elevated serum tumor markers (CEA, 724 ng/mL; and CA19-9, 54 U/mL), and positron emission tomography-computed tomography (PET-CT) showed abnormal uptake of fluorodeoxyglucose in the cardiac mass, the pulmonary nodules, and the transverse colon (Fig. 1b and c). Colonoscopy confirmed a 25-mm type 2 tumor in the transverse colon, which was diagnosed as a well-differentiated adenocarcinoma with wild-type KRAS on histopathological examination (Fig. 1d and e). With regard to the cardiac tumor, dynamic magnetic resonance imaging (MRI) showed an irregular 54- × 32- × 31-mm mass that was nearly isointense to the intact myocardium on both T1-weighted and T2-weighted images and was characterized by a ring enhancement (Fig. 1f and g). The tumor was lateral to the outflow tract of the right ventricle (Fig 1h), fixed to the endocardium, and infiltrated the myocardium. Tissue biopsy was considered unsafe because of the location of the tumor. There were no electrocardiographic abnormalities, and there was no sign of systolic or diastolic dysfunction on the echocardiogram. The left ventricular ejection fraction was 69%, and the Doppler studies showed normal blood flow that was unobstructed by the tumor. The tumor was deemed inoperable by cardiovascular surgeons because of the myocardial invasion. Thus, based on imaging study findings, we diagnosed the heart and lung lesions as cardiac and pulmonary metastases from the primary colon cancer (UICC cT2N0M1b Stage IVb).
The patient was treated with a modified 5-fluorouracil (400 mg/m2 bolus then 2400 mg/m2 46-h infusion), leucovorin (200 mg/m2), and oxaliplatin (85 mg/m2) (mFOLFOX6) regimen plus panitumumab (6 mg/kg) every 2 to 3 weeks. A follow-up CT after 4 courses of chemotherapy showed that the cardiac tumor size decreased from 40 to 26 mm in size (Fig. 2a) and the multiple pulmonary nodules were also diminished. The serum CEA and CA19-9 levels were markedly decreased, from 724 to 29 ng/mL and 54 to 10 U/mL, respectively. The patient tolerated the treatment well. The most severe toxicity according to the common terminology criteria for adverse events (CTCAE, version 4.0) was grade 2 neuropathy that emerged after 6 courses of chemotherapy and was associated with the oxaliplatin. A follow-up MRI after 8 courses of chemotherapy indicated that the patient had sustained a prolonged significant response (Fig. 2b). Oxaliplatin was discontinued after 10 courses of chemotherapy due to neuropathy. The dosage of chemotherapy was also reduced (5-fluorouracil [320 mg/m2 bolus then 1920 mg/m2 46-h infusion], leucovorin [200 mg/m2], and panitumumab [4.8 mg/kg] every 3 or 4 weeks). The patient remained asymptomatic with a prolonged partial response 10 months (12 courses of chemotherapy) after initial treatment (Fig. 2c). However, a follow-up CT after 15 courses of chemotherapy indicated progressive disease. The primary CRC remained undetectable by CT, but the cardiac tumor increased to 31 mm in size. Both the serum CEA and CA19-9 levels continued to increase. Despite our recommendation for further treatment by a second-line regimen, the patient elected to receive only best supportive care. Currently, the patient is alive over 2 years after the diagnosis of the cardiac metastasis.

Discussion and conclusions

Cardiac metastasis from CRC is rare. A progressive metastatic mass of the heart occasionally causes acute heart failure or superior vena cava syndrome, resulting in sudden death [7, 11, 12]. Because the incidence of cardiac metastases was reported to be 1.4 to 7.2% in autopsy studies, echocardiography or cardiac MRI may not be necessary for all CRC patients. However, echocardiography should be performed if advanced CRC patients exhibit any sign of heart disease.
MRI is considered useful for the diagnosis of cardiac tumors [13]. It can accurately recognize the pericardium, the myocardial walls, and the cardiac chambers, thereby allowing for evaluation of infiltration or extension of the tumor. Additionally, reference to the known distinctive appearance is useful for the differential diagnosis [14]. For example, angiosarcoma, which is one of the most common subtypes of sarcomas, has marked signal heterogeneity on T1- and T2-weighed images with hyperintense foci corresponding to intratumoral hemorrhage [15], and the feature of ring enhancement of a lesion, which we observed in the present case has also been documented in previous cases of cardiac metastasis from CRC [5, 6]. Thus, this finding seems valuable in the diagnosis of a secondary malignant cardiac tumor.
Concerning the treatment of cardiac metastasis, several reports emphasize the role of surgery based on significant improvement in survival times [16], and surgical resection for liver and pulmonary metastasis is now generally accepted and performed as a potentially curative treatment [17, 18]. However, the potential survival benefit from cardiac surgery may be counterbalanced by perioperative morbidity and mortality. Therefore, indications for surgery in patients with metastatic cardiac tumors must be carefully considered, particularly for asymptomatic elderly patients or those with other metastatic lesions, such as in this case.
Recently, anti-EGFR monoclonal antibodies (cetuximab or panitumumab) have become widely used and have improved the prognosis for patients with wild-type RAS metastatic CRC. Oxaliplatin-based chemotherapy plus panitumumab showed higher response rates compared to oxaliplatin-based chemotherapy alone, especially in achieving early tumor shrinkage, which is associated with improved progression-free survival and overall survival [19]. In clinical practice, we routinely performed only KRAS mutational analysis because of a lack of health insurance coverage. However, an extended RAS analysis was considered essential for this case; therefore, we conducted an analysis of banked patient tumor specimens, which revealed that the tumor had wild-type KRAS exon 2 (codons 12, 13), exon 3 (codons 59, 61), exon 4 (codons 117, 146) and NRAS exon 2 (codons 12, 13), exon 3 (codons 59, 61), and exon 4 (codons 117, 146). During the past decade, molecular targeted therapy has provided a promising strategy for clinical oncology, and metastatic cardiac tumors originating from renal cell carcinomas have been successfully treated with tyrosine kinase inhibitors (sunitinib or pazopanib) [20, 21]. However, we believe that ours is the first report of significant reduction of a metastatic cardiac tumor from a CRC by the use of molecular targeted agents.
It must be noted that the possibility of a primary cardiac tumor in the present case cannot be denied completely because the diagnosis of metastatic CRC could not be confirmed by biopsy. We treated the cardiac tumor as metastasis from CRC for the following reasons. First, primary tumors of the heart are mostly myxomas. In our patient, the abnormal uptake of fluorodeoxyglucose on the CT-PET scan strongly indicated a malignancy. Next, primary malignant tumors of the heart, such as sarcomas, lymphoma, and mesothelioma, are generally less common than metastases [22], and primary cardiac tumors are known to have the most unfavorable prognosis, as they are rapidly-growing and extremely refractory to chemotherapy [23]. In our patient, the response to chemotherapy, i.e., the tumor shrinkage and the decrease in the serum levels of tumor markers, supported the diagnosis of a metastatic cardiac tumor and indicated that the combination of cytotoxic and molecular targeted chemotherapy may be a suitable treatment for select patients with asymptomatic cardiac CRC metastases.
In conclusion, we encountered a patient who had a cardiac metastasis from CRC that responded well to oxaliplatin-based chemotherapy plus panitumumab. This indicates that the combination of cytotoxic and molecular targeted chemotherapy may be suitable for select patients with asymptomatic metastatic cardiac tumors.

Acknowledgements

We would like to thank Dr. Seiki Hamada (Department of Radiology, Osaka University Graduate School of Medicine) for his valuable advice in interpreting magnetic resonance images of the heart.

Funding

No funding was obtained for this report.

Availability of data and materials

All data are presented in the manuscript.

Authors’ contributions

YT, YH, SH, and SS were involved in all aspects of patient care. YT conducted a literature review and drafted the manuscript with significant contributions from YH, HI, and TT. AM, TF, KN, SY, and AS critically reviewed the manuscript. All authors approved the final manuscript.

Authors’ information

Not applicable.

Competing interests

The authors declare that they have no competing interests.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
Reports describing the case of a single patient are exempt from review by the Osaka University School of Medicine Institutional Review Board.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
Literatur
1.
Zurück zum Zitat Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29.CrossRefPubMed Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29.CrossRefPubMed
3.
Zurück zum Zitat Mukai K, Shinkai T, Tominaga K, Shimosato Y. The incidence of secondary tumors of the heart and pericardium: a 10-year study. Jpn J Clin Oncol. 1988;18(3):195–201.PubMed Mukai K, Shinkai T, Tominaga K, Shimosato Y. The incidence of secondary tumors of the heart and pericardium: a 10-year study. Jpn J Clin Oncol. 1988;18(3):195–201.PubMed
4.
Zurück zum Zitat Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 45-1992. A 75-year-old man with carcinoma of the colon and a right ventricular mass. N Engl J Med. 1992; 327(20):1442-1448. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 45-1992. A 75-year-old man with carcinoma of the colon and a right ventricular mass. N Engl J Med. 1992; 327(20):1442-1448.
5.
Zurück zum Zitat Choi PW, Kim CN, Chang SH, Chang WI, Kim CY, Choi HM. Cardiac metastasis from colorectal cancer: a case report. World J Gastroenterol. 2009;15(21):2675–8.CrossRefPubMedPubMedCentral Choi PW, Kim CN, Chang SH, Chang WI, Kim CY, Choi HM. Cardiac metastasis from colorectal cancer: a case report. World J Gastroenterol. 2009;15(21):2675–8.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Pizzicannella J, Ricci V, Gorla R, Spinapolice E, Esposito A. Isolated cardiac metastasis from colorectal cancer in a 35-year-old man. Case Rep Med. 2012;2012:751761.PubMedPubMedCentral Pizzicannella J, Ricci V, Gorla R, Spinapolice E, Esposito A. Isolated cardiac metastasis from colorectal cancer in a 35-year-old man. Case Rep Med. 2012;2012:751761.PubMedPubMedCentral
7.
Zurück zum Zitat Patel SA, Herfel BM, Nolan MA. Metastatic colon cancer involving the right atrium. Tex Heart Inst J. 2012;39(1):79–83.PubMedPubMedCentral Patel SA, Herfel BM, Nolan MA. Metastatic colon cancer involving the right atrium. Tex Heart Inst J. 2012;39(1):79–83.PubMedPubMedCentral
8.
Zurück zum Zitat Choufani EB, Lazar HL, Hartshorn KL. Two unusual sites of colon cancer metastases and a rare thyroid lymphoma. Case 2. Chemotherapy-responsive right artial metastasis from colon carcinoma. J Clin Oncol. 2001;19(15):3574–5.PubMed Choufani EB, Lazar HL, Hartshorn KL. Two unusual sites of colon cancer metastases and a rare thyroid lymphoma. Case 2. Chemotherapy-responsive right artial metastasis from colon carcinoma. J Clin Oncol. 2001;19(15):3574–5.PubMed
9.
Zurück zum Zitat Van Cutsem E, Köhne CH, Láng I, Folprecht G, Nowacki MP, Cascinu S, Shchepotin I, Maurel J, Cunningham D, Tejpar S, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 2011;29(15):2011–9.CrossRefPubMed Van Cutsem E, Köhne CH, Láng I, Folprecht G, Nowacki MP, Cascinu S, Shchepotin I, Maurel J, Cunningham D, Tejpar S, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 2011;29(15):2011–9.CrossRefPubMed
10.
Zurück zum Zitat Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013;369(11):1023–34.CrossRefPubMed Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013;369(11):1023–34.CrossRefPubMed
11.
Zurück zum Zitat Ogino H, Nishimura N, Kitamura A, Ishikawa G, Okafuji K, Tomishima Y, Jinta T, Yamazoe M, Yang Y, Chohnabayashi N. A patient with lung squamous cell carcinoma presenting with severe cardiac dysfunction similar to dilated cardiomyopathy with left bundle branch block induced by myocardial metastasis. Intern Med. 2014;53(20):2353–7.CrossRefPubMed Ogino H, Nishimura N, Kitamura A, Ishikawa G, Okafuji K, Tomishima Y, Jinta T, Yamazoe M, Yang Y, Chohnabayashi N. A patient with lung squamous cell carcinoma presenting with severe cardiac dysfunction similar to dilated cardiomyopathy with left bundle branch block induced by myocardial metastasis. Intern Med. 2014;53(20):2353–7.CrossRefPubMed
12.
Zurück zum Zitat Sladden D, Yamagata K, Pllaha E, Busuttil W. Squamous cell carcinoma of unknown origin metastasising to the right atrium causing acute heart failure. BMJ Case Rep. 2015;2015:210042. Sladden D, Yamagata K, Pllaha E, Busuttil W. Squamous cell carcinoma of unknown origin metastasising to the right atrium causing acute heart failure. BMJ Case Rep. 2015;2015:210042.
13.
Zurück zum Zitat Motwani M, Kidambi A, Herzog BA, Uddin A, Greenwood JP, Plein S. MR imaging of cardiac tumors and masses: a review of methods and clinical applications. Radiology. 2013;268(1):26–43.CrossRefPubMed Motwani M, Kidambi A, Herzog BA, Uddin A, Greenwood JP, Plein S. MR imaging of cardiac tumors and masses: a review of methods and clinical applications. Radiology. 2013;268(1):26–43.CrossRefPubMed
14.
Zurück zum Zitat Luna A, Ribes R, Caro P, Vida J, Erasmus JJ. Evaluation of cardiac tumors with magnetic resonance imaging. Eur Radiol. 2005;15(7):1446–55.CrossRefPubMed Luna A, Ribes R, Caro P, Vida J, Erasmus JJ. Evaluation of cardiac tumors with magnetic resonance imaging. Eur Radiol. 2005;15(7):1446–55.CrossRefPubMed
15.
Zurück zum Zitat Kaminaga T, Takeshita T, Kimura I. Role of magnetic resonance imaging for evaluation of tumors in the cardiac region. Eur Radiol. 2003;13 Suppl 4:L1–L10.CrossRef Kaminaga T, Takeshita T, Kimura I. Role of magnetic resonance imaging for evaluation of tumors in the cardiac region. Eur Radiol. 2003;13 Suppl 4:L1–L10.CrossRef
16.
Zurück zum Zitat Murphy MC, Sweeney MS, Putnam JB, Walker WE, Frazier OH, Ott DA, Cooley DA. Surgical treatment of cardiac tumors: a 25-year experience. Ann Thorac Surg. 1990;49(4):612–7. discussion 617-618.CrossRefPubMed Murphy MC, Sweeney MS, Putnam JB, Walker WE, Frazier OH, Ott DA, Cooley DA. Surgical treatment of cardiac tumors: a 25-year experience. Ann Thorac Surg. 1990;49(4):612–7. discussion 617-618.CrossRefPubMed
17.
Zurück zum Zitat Abdalla EK, Vauthey JN, Ellis LM, Ellis V, Pollock R, Broglio KR, Hess K, Curley SA. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004;239(6):818–25. discussion 825-817.CrossRefPubMedPubMedCentral Abdalla EK, Vauthey JN, Ellis LM, Ellis V, Pollock R, Broglio KR, Hess K, Curley SA. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004;239(6):818–25. discussion 825-817.CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Suzuki H, Kiyoshima M, Kitahara M, Asato Y, Amemiya R. Long-term outcomes after surgical resection of pulmonary metastases from colorectal cancer. Ann Thorac Surg. 2015;99(2):435–40.CrossRefPubMed Suzuki H, Kiyoshima M, Kitahara M, Asato Y, Amemiya R. Long-term outcomes after surgical resection of pulmonary metastases from colorectal cancer. Ann Thorac Surg. 2015;99(2):435–40.CrossRefPubMed
19.
Zurück zum Zitat Douillard JY, Siena S, Peeters M, Koukakis R, Terwey JH, Tabernero J. Impact of early tumour shrinkage and resection on outcomes in patients with wild-type RAS metastatic colorectal cancer. Eur J Cancer. 2015;51(10):1231–42.CrossRefPubMed Douillard JY, Siena S, Peeters M, Koukakis R, Terwey JH, Tabernero J. Impact of early tumour shrinkage and resection on outcomes in patients with wild-type RAS metastatic colorectal cancer. Eur J Cancer. 2015;51(10):1231–42.CrossRefPubMed
20.
Zurück zum Zitat Schinzari G, Monterisi S, Signorelli D, Cona S, Cassano A, Danza F, Barone C. Cardiac metastasis from renal cell carcinoma successfully treated with pazopanib: impact of TKIs’ antiangiogenic activity. Tumori. 2014;100(6):e298–300.PubMed Schinzari G, Monterisi S, Signorelli D, Cona S, Cassano A, Danza F, Barone C. Cardiac metastasis from renal cell carcinoma successfully treated with pazopanib: impact of TKIs’ antiangiogenic activity. Tumori. 2014;100(6):e298–300.PubMed
21.
Zurück zum Zitat Szmit S, Zagrodzka M, Kurzyna M, Opolski G, Szczylik C. Sunitinib malate, a receptor tyrosine kinase inhibitor, is effective in the treatment of restrictive heart failure due to heart metastases from renal cell carcinoma. Cardiology. 2009;114(1):67–71.CrossRefPubMed Szmit S, Zagrodzka M, Kurzyna M, Opolski G, Szczylik C. Sunitinib malate, a receptor tyrosine kinase inhibitor, is effective in the treatment of restrictive heart failure due to heart metastases from renal cell carcinoma. Cardiology. 2009;114(1):67–71.CrossRefPubMed
22.
Zurück zum Zitat Butany J, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T. Cardiac tumours: diagnosis and management. Lancet Oncol. 2005;6(4):219–28.CrossRefPubMed Butany J, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T. Cardiac tumours: diagnosis and management. Lancet Oncol. 2005;6(4):219–28.CrossRefPubMed
23.
Zurück zum Zitat Hudzik B, Miszalski-Jamka K, Glowacki J, Lekston A, Gierlotka M, Zembala M, Polonski L, Gasior M. Malignant tumors of the heart. Cancer Epidemiol. 2015;39(5):665–72.CrossRefPubMed Hudzik B, Miszalski-Jamka K, Glowacki J, Lekston A, Gierlotka M, Zembala M, Polonski L, Gasior M. Malignant tumors of the heart. Cancer Epidemiol. 2015;39(5):665–72.CrossRefPubMed
Metadaten
Titel
Cardiac metastasis from colon cancer effectively treated with 5-fluorouracil, leucovorin, and oxaliplatin (modified FOLFOX6) plus panitumumab: a case report
verfasst von
Yoshiki Tsujii
Yoshito Hayashi
Akira Maekawa
Tetsuji Fujinaga
Kengo Nagai
Shunsuke Yoshii
Akihiko Sakatani
Satoshi Hiyama
Shinichiro Shinzaki
Hideki Iijima
Tetsuo Takehara
Publikationsdatum
01.12.2017
Verlag
BioMed Central
Erschienen in
BMC Cancer / Ausgabe 1/2017
Elektronische ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-017-3147-2

Weitere Artikel der Ausgabe 1/2017

BMC Cancer 1/2017 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.