Vascular calcification is a risk factor for the pathogenesis of cardiovascular disease and mortality in dialysis patients. Nevertheless, the association between cardiac valve calcification (CVC) and the outcome of dialysis is still illusive. The purpose of this meta-analysis is to evaluate the association between theCVC and cardiovascular or all-cause mortality in dialysis patients.
Literatures involving the baseline CVC and cardiovascular or all-cause mortality in dialysis patients were searchedfrom the PubMed, Embase, as well as two Chinese databases (i.e. Wanfang and CNKI databases). Articles published before November 2016were eligible to the study.
Ten studies involving 2686 participants were included. CVC was correlated with increased risk of cardiovascular mortality (hazard risk [HR]: 2.81; 95% confidence intervals [CI]: 1.92–4.10) and all-cause mortality (HR: 1.73; 95% CI: 1.42–2.11). Subgroup analysis showed an excess risk of all-cause mortality (HR: 1.35; 95% CI: 1.02–1.79) among patients with one CVC, and increased risk of all-cause mortality in patients with two CVCs (HR 2.15; 95% CI 1.57–2.94).
CVC is correlated with higher cardiovascular and all-cause mortality risk in dialysis patients. Regular follow-up monitoring of CVC may be helpful for risk stratification of patients underwent dialysis.
Yamada S, Giachelli CM. Vascular calcification in CKD-MBD: roles for phosphate, FGF23, and Klotho. Bone. 2016 Nov;12 [Epub ahead of print]
Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J ClinEpidemiol. 2009;62(10):1006–12.
Liu G, Long M, Hu X, et al. Effectiveness and safety of warfarin in dialysis patients with atrial fibrillation: a meta-analysis of observational studies. Medicine (Baltimore). 2015;94(50):e2233. CrossRef
Egger M, Smith GD, Altman DG. Systematic reviews in health care: meta-analysis in context. 2nd ed. London: BMJ Publishing Group; 2001. CrossRef
Raggi P, Bellasi A, Gamboa C, et al. All-cause mortality in hemodialysis patients with heart valve calcification. Clin J Am SocNephrol. 2011;6:1990e5.
Wang AY, Wang M, Woo J, et al. Cardiac valve calcification as an important predictor for all-cause mortality and cardiovascular mortality in long-term peritoneal dialysis patients: a prospective study. J Am SocNephrol. 2003;14(1):159–68.
Varma R, Aronow WS, McClung JA, et al. Prevalence of valve calcium and association of valve calcium with coronary artery disease, atherosclerotic vascular disease, and all-cause mortality in 137 patients undergoing hemodialysis for chronic renal failure. Am J Cardiol. 2005;95(6):742–3. CrossRefPubMed
Mohamed BA, Yang W, Litt H, et al. Valvular calcification, inflammation, and mortality in dialysis patients. J Heart Valve Dis. 2013;22(4):584–90. PubMed
ZL LI, He CS, Yh C, et al. Association of heart valve calcification with cardiovascular outcomes in patients on maintenance hemodialysis. J South Med Univ. 2016;36(7):941–6.
Zhong B, Na Y. Influence of cardiac valve calcification to all-cause mortality in chronic hemodialysis patients. J Nephrol Dialy Transplant. 2011;20(6):512–6.
Wang CY. Risk factor analysis of calcification in aortic and mitral valves and survival in maintenance peritoneal dialysis patients[D].Su Zhou: Su Zhou University. 2014:1-48.
KDIGO. Clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Supp. 2009;76(Supp 113s):S1–S130.
Ribeiro S, Ramos A, Brandao A, et al. Cardiac valve calcification in haemodialysis patients: role of calcium-phosphate metabolism. Nephrol Dial Transplant. 1998;13:2037e40. CrossRef
Sayarlioglu H, Acar G, Sahin M, et al. Prevalence and risk factors of valvular calcification in hemodialysis patients. Iran J Kidney Dis. 2013;7(2):129–34. PubMed
Kitamura K, Fujii H, Nakai K, et al. Relationship between cardiac calcification and left ventricular hypertrophy in patients with chronic kidney disease at hemodialysis initiation. Heart Vessel. 2017;21 [Epub ahead of print]
Bellasi A, Ferramosca E, Ratti C, et al. Cardiac valve calcification is a marker of vascular disease in prevalent hemodialysis patients. J Nephrol. 2012;25:211e8. CrossRef
- Cardiac valve calcification and risk of cardiovascular or all-cause mortality in dialysis patients: a meta-analysis
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